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    • 7. 发明公开
    • SYSTEM AND METHOD FOR CONFOCAL RAMAN-SPECTROSCOPIC MEASUREMENTS OF BIOLOGICAL SAMPLES
    • 用于生物样本的共焦拉曼光谱测量的系统和方法
    • EP3182099A1
    • 2017-06-21
    • EP15200489.1
    • 2015-12-16
    • rap.ID Particle Systems GmbH
    • GOEDE, KarstenHOLZ, LotharLANKERS, MarkusVALET, Oliver K.
    • G01N21/65G01J3/44
    • G01N21/03G01J3/44G01N21/65G01N33/483G01N2021/0385G01N2021/0389G01N2201/0846G01N2201/10
    • The invention relates to a system (1) for confocal Raman-spectroscopic measurements, comprising at least the following components:
      - a sample chamber (10), wherein said sample chamber (10) is configured to house a sample (2) in a closed chamber volume (12) of the sample chamber (10),
      - an excitation light source (3),
      - an objective lens (4), configured to focus excitation light (32) of the excitation light source (3) through a ceiling portion (11) of the sample chamber (10) in a focal volume (31) in the chamber volume (12) and to collect inelastically scattered light (33) stemming from the focal volume (31),
      - a confocal detection arrangement (20), comprising means for a confocal detection (22, 23) of a Raman signal comprised in the inelastically scattered light (33) from the focal volume (31), and a detector (21) that is configured to detect and to record said Raman signal,
      wherein the distance (5) between the ceiling portion (11) of the sample chamber (10) and the focal volume (31) is greater than one millimetre during operation of the system (1).
    • 本发明涉及用于共焦拉曼光谱测量的系统(1),其至少包括以下组件: - 样品室(10),其中所述样品室(10)被配置为将样品(2) (10)的腔室容积(12), - 激励光源(3), - 物镜(4),其配置为将激励光源(3)的激励光(32)聚焦通过天花板部分 (12)中的聚焦体积(31)中的样本室(10)的样本(11),并且收集源自所述聚焦容积(31)的非弹性散射光(33), - 共焦检测装置(20) ,包括用于包括在来自所述聚焦容积(31)的所述非弹性散射光(33)中的拉曼信号的共焦检测(22,23)的装置,以及配置成检测并记录所述拉曼信号 ,其中样品室(10)的顶部(11)与聚焦体积(31)之间的距离(5)为i 在系统(1)的操作期间大于1毫米。