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    • 6. 发明申请
    • PROTECTED LITHIUM ELECTRODES FOR ELECTRO-TRANSPORT DRUG DELIVERY
    • 用于电输送药物递送的受保护的锂电极
    • WO2008067409A2
    • 2008-06-05
    • PCT/US2007/085802
    • 2007-11-28
    • POLYPLUS BATTERY COMPANYVISCO, Steven J.NIMON, Yevgeniy, S.
    • VISCO, Steven J.NIMON, Yevgeniy, S.
    • A61K33/00A61N1/30
    • A61K33/00A61K33/24A61N1/0436A61N1/044A61N1/0448A61N1/306
    • This invention provides new and novel devices and methods for administering lithium (Li) ions to a mammalian subject, especially the delivery of lithium (Li) ions to a body component for example across a body or tissue surface such as skin or a mucosal membrane, or for delivery of lithium ions directly to bodily fluids in a controllable and reproducible manner. In certain embodiments the device comprises a donor electrode that is a donor of a lithium ion; a protective architecture that is ionically conductive to the lithium ion, configured for application to a skin surface and positioned to isolate said donor electrode from the skin surface; and a counter electrode assembly configured for application to a skin surface, where said counter electrode assembly comprises a counter electrode operably coupled to said donor electrode.
    • 本发明提供了用于向哺乳动物对象施用锂(Li)离子的新型和新型装置和方法,特别是将锂(Li)离子递送至例如穿过身体或组织表面的身体组分 如皮肤或粘膜,或用于以可控和可重现的方式将锂离子直接递送至体液。 在某些实施方式中,该装置包括作为锂离子供体的供体电极; 离子导电至锂离子的保护性结构,被配置用于施加到皮肤表面并被定位成将所述供体电极与皮肤表面隔离; 以及配置用于施加到皮肤表面的对电极组件,其中所述对电极组件包括可操作地耦合到所述供体电极的对电极。