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1. 发明专利

JP2009005708A Genetic analysis system and method 审中-公开
标题翻译：遗传分析系统与方法
公开(公告)号：JP2009005708A
公开(公告)日：2009-01-15
申请号：JP2008195647
申请日：2008-07-30
申请人： Perlegen Sciences Inc , パーレジェンサイエンスインク.
发明人： COX DAVID R , MARGUS BRADLEY A , PATIL NILA
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6827 , C12Q2565/125 , C12Q2565/501
摘要： PROBLEM TO BE SOLVED: To provide improved systems and methods for performing genetic analyses. SOLUTION: The method for performing genetic analysis comprises the steps of performing full genomic DNA scans on the genetic DNA from among a plurality of individuals to identify genetic variants for those variants, but not based on a full genetic DNA scan; the scanning variants alone, in additional individuals to identify which of the genetic variants is caused in the individuals; and based on the results, identifying the blocks of the variants that tend to be inherited together. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于进行遗传分析的改进的系统和方法。解决方案：用于进行遗传分析的方法包括以下步骤：对多个个体中的遗传DNA进行全基因组DNA扫描，以鉴定那些变体的遗传变体，但不是基于完全遗传DNA扫描; 单独的扫描变体，在另外的个体中以鉴定在个体中引起哪些遗传变异体; 并基于结果，识别易于一起遗传的变体的块。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2013240344A Method for genetic analysis 审中-公开
标题翻译：遗传分析方法
公开(公告)号：JP2013240344A
公开(公告)日：2013-12-05
申请号：JP2013151528
申请日：2013-07-22
申请人： Perlegen Sciences Inc , パーレジェンサイエンスインク.
发明人： COX DAVID R , MCCAMISH MARK
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/00
CPC分类号： G06F19/18 , G06F19/24 , G06Q50/24
摘要： PROBLEM TO BE SOLVED: To provide a method for determining an individual's risk of developing or exhibiting a multifactorial trait based on the individual's genotype at a plurality of polymorphic loci that are factors in expression of the multifactorial trait.SOLUTION: The present application discloses methods for determining an individual's risk of developing or exhibiting a multifactorial trait by a step of determining a score for the individual based on the individual's genotype at a plurality of biallelic polymorphic loci, and a step of comparing that score with at least one threshold value.
摘要翻译：要解决的问题：提供一种在多因素基因座上确定个体在多因素基因座上的发生或展现多因素性状的风险的方法，所述多态性位点是多因素性状表达的因素。解决方案：本申请公开了用于通过基于所述个体的多基因多态性位点处的个体的基因型确定个体得分的步骤，以及将所述评分与至少一个阈值进行比较的步骤来确定个体发展或表现多因素性状的风险。

3. 发明专利

JP2003052383A Method for genomic analysis 审中-公开
标题翻译：基因分析方法
公开(公告)号：JP2003052383A
公开(公告)日：2003-02-25
申请号：JP2002099196
申请日：2002-04-01
申请人： Perlegen Sciences Inc , パーレジェンサイエンシーズインコーポレイテッド
发明人： PATIL NILA , COX DAVID R , BERNO ANTHONY J , HINDS DAVID A
IPC分类号： G01N33/53 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N33/00 , G01N33/566 , G06F19/22 , G06F19/24
CPC分类号： G06F19/22 , C12Q1/6827 , G06F19/24 , Y10T436/143333
摘要： PROBLEM TO BE SOLVED: To provide a method for human genomic analysis. SOLUTION: This method for identifying variations occurring in the human genome and a method for relating the variations with the genetic basis of diseases and drug response are provided. In particular, identification of individual SNPs, determination of SNP haplotype blocks and patterns and further use of the SNP haplotype blocks and patterns are provided to dissect the genetic bases of the diseases and drug response. The method is useful for the whole genomic analysis.
摘要翻译：待解决的问题：提供人类基因组分析方法。解决方案：提供了用于鉴定人类基因组中发生的变异的方法以及将变异与疾病和药物反应的遗传基础相关联的方法。特别地，提供了单个SNP的鉴定，SNP单倍型区块和模式的确定以及SNP单倍型区块和模式的进一步使用以解剖疾病和药物反应的遗传基础。该方法可用于整个基因组分析。

4. 发明专利

BRPI0708439A2 未知
公开(公告)号：BRPI0708439A2
公开(公告)日：2011-05-31
申请号：BRPI0708439
申请日：2007-03-01
申请人： PERLEGEN SCIENCES INC
发明人： RICE JOHN , KONVICKA KAREL , SACCONE SCOTT , BALLINGER DENNIS , BIERUT LAURA JEAN
IPC分类号： C12Q1/68
摘要： Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.

5. 发明专利

CA2631621A1 Markers for breast cancer 未知
公开(公告)号：CA2631621A1
公开(公告)日：2007-06-07
申请号：CA2631621
申请日：2006-11-29
申请人： CAMBRIDGE ENTPR LTD , PERLEGEN SCIENCES INC
发明人： COX DAVID , BALLINGER DENNIS , PONDER BRUCE , EASTON DOUG
IPC分类号： C12Q1/68 , C12M1/34 , C12P19/34

6. 发明专利

AU785425B2 Methods of genomic analysis 未知
公开(公告)号：AU785425B2
公开(公告)日：2007-05-17
申请号：AU2746002
申请日：2002-03-19
申请人： PERLEGEN SCIENCES INC
发明人： PATIL NILA , COX DAVID R , BERNO ANTHONY J , HINDS DAVID A , FODOR STEPHEN P A
IPC分类号： G01N33/53 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N33/00 , G01N33/566 , G06F19/22 , G06F19/24
摘要： The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.

7. 发明专利

CA2592176A1 MARKERS FOR METABOLIC SYNDROME OBESITY AND INSULIN RESISTANCE 未知
公开(公告)号：CA2592176A1
公开(公告)日：2006-06-15
申请号：CA2592176
申请日：2005-12-08
申请人： PERLEGEN SCIENCES INC
发明人： HOCKETT RICHARD , COX DAVID , BALLINGER DENNIS , KIRKWOOD SANDRA
IPC分类号： C12Q1/68
摘要： Correlations between polymorphisms and metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Methods of diagnosing and treating metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Systems and kits for disgnosis and treatment of metabolic syndrome, treatment-emergent weight gain, obesity and insulin resistance are provided.

8. 发明专利

IS6316A Aðferð til erfðafræðilegra greininga 未知
公开(公告)号：IS6316A
公开(公告)日：2002-09-30
申请号：IS6316
申请日：2002-03-20
申请人： PERLEGEN SCIENCES INC
发明人： PATIL NILA , COX DAVID R , BERNO ANTHONY J , HINDS DAVID A , FODOR STEPHEN P A
IPC分类号： G01N33/53 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12P19/34 , G01N33/00 , G01N33/566 , G06F19/22 , G06F19/24 , C12Q1/68

9. 发明专利

MX2008011185A MARCADORES PARA ADICCION. 未知
公开(公告)号：MX2008011185A
公开(公告)日：2008-09-10
申请号：MX2008011185
申请日：2007-03-01
申请人： PERLEGEN SCIENCES INC
发明人： BALLINGER DENNIS , KONVICKA KAREL , BIERUT LAURA JEAN , RICE JOHN , SACCONE SCOTT
IPC分类号： C12Q1/68
摘要： Se proporcionan correlaciones entre polimorfismos y adicción. Se proporcionan métodos de diagnóstico, pronóstico y tratamiento de adicción. Se proporcionan sistemas y kits para diagnostico, pronóstico y tratamiento de adicción. También se proporcionan métodos para identificar moduladores de adicción.

10. 发明专利

CA2623938A1 METHODS AND COMPOSITIONS FOR SCREENING AND TREATMENT OF DISORDERS OF BLOOD GLUCOSE REGULATION 未知
公开(公告)号：CA2623938A1
公开(公告)日：2007-04-05
申请号：CA2623938
申请日：2006-09-29
申请人： PERLEGEN SCIENCES INC
发明人： MCCAMISH MARK A
IPC分类号： C12Q1/68
摘要： In one aspect, the invention provides a method of screening and, optionally, treatment of an individual suffering from an insulin resistance disorder by screening an individual in need of treatment for an insulin resistance disorder for one or more genetic variations indicating a predisposition to a response to an insulin sensitizer; and, optionally, administering or not administering an insulin sensitizer to the individual based on the results of the screening. The insulin sensitizer for which the individual is screened and the insulin sensitizer that is administered or not administered may be the same or different. In another aspect, the invention provides methods comprising identifying one or more genetic variations, e.g., one or more single nucleotide polymorphisms, that at least partly differentiate between a subset of a plurality of individuals who experience a response when administered an insulin sensitizer, and a subset of said plurality of individuals who do not experience a response when administered the insulin sensitizer. The invention also provides nucleic acids, polypeptides, antibodies, kits, and business methods associated with these screening and association methods.

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