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1. 发明申请

WO2022256957A1 POLYURETHANE COATED POLYOLEFIN FILM AND METHOD FOR MAKING IT 审中-公开
公开(公告)号：WO2022256957A1
公开(公告)日：2022-12-15
申请号：PCT/CN2021/098559
申请日：2021-06-07
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , CHEN, Gaobing , BAI, Chenyan , PAN, Jianping , WU, Jie , CASARRUBIAS, Juan Carlos
发明人： CHEN, Gaobing , BAI, Chenyan , PAN, Jianping , WU, Jie , CASARRUBIAS, Juan Carlos
IPC分类号： C08J7/046 , B32B27/32
摘要： Provided herein is a laminate, comprising a polyolefin-based substrate film having a first inner surface and a first outer surface, and a polyurethane-based top coating having a second inner surface and a second outer surface, wherein the first inner surface is in contact with the second inner surface, wherein the polyurethane-based top coating is formed by mixing an isocyanate-terminated component and a hydroxyl-terminated component and coating the mixture onto the first inner surface of the polyolefin-based substrate film. Also provided are methods of preparing the laminate, articles comprising the laminate and use of the laminate in the packaging of a product.

2. 发明申请

WO2022021187A1 MULTILAYER STRUCTURES, LAMINATES, AND RELATED ARTICLES 审中-公开
公开(公告)号：WO2022021187A1
公开(公告)日：2022-02-03
申请号：PCT/CN2020/105716
申请日：2020-07-30
申请人： DOW GLOBAL TECHNOLOGIES LLC , LV, Bo , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , FENG, Jichang
发明人： LV, Bo , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , FENG, Jichang
IPC分类号： B32B27/08 , B32B27/32 , B32B7/022
摘要： Provided are multilayer structures, laminates and articles formed from such structures. In one aspect, a multilayer structure comprises (a) a multilayer polyethylene film, wherein an outer layer of the film comprises a polymer blend of at least one ethylene-based polymer and at least one ethylene acid copolymer, wherein the difference between the melt index (I2) of the ethylene acid copolymer and the ethylene-based polymer is less than 18, and wherein the acid content of the polymer blend is greater than 0.2%; and (b) a metal layer comprising a metal deposited on the outer layer of the polyethylene film.

3. 发明申请

WO2020112700A1 9-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE 审中-公开
公开(公告)号：WO2020112700A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063136
申请日：2019-11-26
申请人： MERCK SHARP & DOHME CORP. , LARSEN, Matthew, A. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , HOOVER, Andrew, J. , LIU, Ping , LIU, Kun , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun , ZHANG, Yonglian
发明人： LARSEN, Matthew, A. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , HOOVER, Andrew, J. , LIU, Ping , LIU, Kun , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun , ZHANG, Yonglian
IPC分类号： A61P35/00 , C07D487/04 , A61K31/519
摘要： In its many embodiments, the present invention provides certain 9-substituted amino triazolo quinazoline compounds of the structural Formula (I): (I), and pharmaceutically acceptable salts thereof, wherein, ring A, R1 and R2 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

4. 发明申请

WO2020000340A1 BIAXIALLY-ORIENTED POLYETHYLENE MULTILAYER FILM WITH MATTE SURFACE 审中-公开
公开(公告)号：WO2020000340A1
公开(公告)日：2020-01-02
申请号：PCT/CN2018/093540
申请日：2018-06-29
申请人： DOW GLOBAL TECHNOLOGIES LLC , WANG, Gang , YUN, Xiaobing , PAN, Jianping , XU, Jingyi
发明人： WANG, Gang , YUN, Xiaobing , PAN, Jianping , XU, Jingyi
IPC分类号： B32B27/32 , B32B27/08 , B32B27/12 , B32B9/04 , B65D65/40
摘要： A biaxially-oriented polyethylene (BOPE) multilayer film comprises a skin layer with a matte surface and a core, the skin layer with a matte surface comprising, in weight percent (wt%) based upon the weight of the skin layer: (1) from 20 to 80 wt% of an ethylene-based polymer, and (2) from 80 to 20 wt% of a propylene-based polymer; each of the ethylene-based polymer and the propylene-based polymer having a storage modulus, with a difference between the storage modulus of the ethylene-based polymer and the propylene-based polymer of greater than (>) 40 megaPascals (MPa) at 110℃ and >18 MPa at 120℃.

5. 发明申请

WO2018129669A1 POLYMER BLENDS FOR USE IN MULTILAYER STRUCTURE AND MULTILAYER STRUCTURES COMPRISING SAME 审中-公开
公开(公告)号：WO2018129669A1
公开(公告)日：2018-07-19
申请号：PCT/CN2017/070834
申请日：2017-01-11
申请人： DOW GLOBAL TECHNOLOGIES LLC , LIU, Andong , LIAO, Guihong , PAN, Jianping , GAO, Peng , CHEN, Hongyu , ZHANG, Yi
发明人： LIU, Andong , LIAO, Guihong , PAN, Jianping , GAO, Peng , CHEN, Hongyu , ZHANG, Yi
IPC分类号： C08L23/08 , C09J123/08 , C08J5/18
摘要： Polymer blends can be used in a multilayer structure and to multilayer structures comprising one or more layers formed from such blends. In one aspect, a polymer blend comprises (a) a copolymer comprising ethylene and at least one of acrylic acid and methacrylic acid having an acid content of 2 to 21 weight percent based on the weight of the copolymer, wherein the amount of copolymer (a) comprises 20-80 weight percent of the blend based on the total weight of the blend, and (b) a copolymer comprising ethylene and at least one of methyl acrylate and ethyl acrylate having an acrylate content of 5 to 30 weight percent based on the weight of the copolymer, wherein the amount of copolymer (b) comprises 10 to 50 weight percent of the blend based on the total weight of the blend, wherein the amount of copolymer (a) and copolymer (b) is at least 70 weight percent of the blend based on the total weight of the blend.

6. 发明申请

WO2017000339A1 MULTILAYER STRUCTURES AND ARTICLES COMPRISING THE SAME 审中-公开
标题翻译：多层结构和包含该结构的文章
公开(公告)号：WO2017000339A1
公开(公告)日：2017-01-05
申请号：PCT/CN2015/085647
申请日：2015-07-31
申请人： DOW GLOBAL TECHNOLOGIES LLC , YUN, Xiaobing , PAN, Jianping , WANG, Gang
发明人： YUN, Xiaobing , PAN, Jianping , WANG, Gang
IPC分类号： B32B27/30 , B29C55/12
CPC分类号： B32B27/32 , B29C47/0004 , B29C47/0021 , B29C47/0057 , B29C47/065 , B29C55/06 , B29C55/12 , B29C55/28 , B32B7/04 , B32B7/12 , B32B27/08 , B32B27/304 , B32B27/308 , B32B27/327 , B32B27/36 , B32B2274/00 , B32B2307/31 , B32B2307/518 , B32B2307/54 , B32B2307/72 , B32B2307/732 , B32B2553/00
摘要： Embodiments of the present invention relate to multilayer structures and articles formed therefrom. In one aspect, a multilayer structure comprises (a) a biaxially oriented polyethylene film comprising a linear low density polyethylene having a density of 0.910 to 0.940 g/cm 3 , wherein the ultimate elongation in the machine direction of the biaxially oriented polyethylene film is at least 2 times greater than the ultimate elongation in the cross direction, and wherein the ultimate tensile strength of the biaxially oriented polyethylene film is at least 60 MPa in at least one of the machine direction and the cross direction; (b) an adhesive layer; and (c) a sealant film, wherein the ultimate elongation of the sealant film is at least 300％in at least one of the machine direction and the cross direction, wherein the ultimate tensile strength of the sealant film is less than 50 MPa in at least one of the machine direction and the cross direction, and wherein the sealant film has a heat seal initiation temperature of 105℃or less; wherein the sealant film is laminated to the biaxially oriented polyethylene film by the adhesive. In some embodiments, the sealant film comprises at least one layer comprising at least 30 percent by weight of a polyolefin plastomer, a polyolefin elastomer, an ultra low density polyethylene, an ethylene acetate copolymer, an ethylene acrylic acid copolymer, or an ethylene acrylate copolymer.
摘要翻译：本发明的实施例涉及由其形成的多层结构和制品。一方面，多层结构包括（a）双轴取向的聚乙烯膜，其包含密度为0.910至0.940g / cm 3的线性低密度聚乙烯，其中双轴取向聚乙烯膜的机器方向的极限伸长率至少为在横向上的极限伸长率大2倍，双轴取向聚乙烯膜的极限拉伸强度在纵向和横向的至少一个方向上至少为60MPa。（b）粘合层; 和（c）密封膜，其中在机器方向和横向方向中的至少一个方面，密封膜的极限伸长率至少为300％，其中密封膜的极限拉伸强度小于50MPa 机器方向和横向方向中的至少一个，并且其中密封膜的热封起始温度为105℃以下; 其中通过粘合剂将密封膜层压到双轴取向的聚乙烯膜上。在一些实施方案中，密封剂膜包括至少一层，其包含至少30重量％的聚烯烃塑性体，聚烯烃弹性体，超低密度聚乙烯，乙酸乙烯酯共聚物，乙烯丙烯酸共聚物或乙烯丙烯酸酯共聚物。

7. 发明申请

WO2008103351A3 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译：异源ASPARTYL蛋白酶抑制剂
公开(公告)号：WO2008103351A3
公开(公告)日：2009-07-23
申请号：PCT/US2008002182
申请日：2008-02-20
申请人： SCHERING CORP , PHARMACOPEIA INC , ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA JR ROBERT D , CALDWELL JOHN , CUMMING JARED N , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , LIU XIAOXIANG , HUANG YING , LI GUOQING , PAN JIANPING , MISIASZEK JEFFREY A , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT , LAI GAIFA , DUO JINGQI , QU CHUANXING , SHAO YUEFEI
发明人： ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA JR ROBERT D , CALDWELL JOHN , CUMMING JARED N , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , LIU XIAOXIANG , HUANG YING , LI GUOQING , PAN JIANPING , MISIASZEK JEFFREY A , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT , LAI GAIFA , DUO JINGQI , QU CHUANXING , SHAO YUEFEI
IPC分类号： C07D233/88 , A61K31/513 , A61P25/28 , C07D239/22 , C07D401/06 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, -C(=S)-, -S(O)-, -S(O)2-, -C(=O)-, -O-, -C(R6)(R7)-, -N(R5)- or -C(=N(R5))-; X is -O-, -N(R5)- or -C(R6)(R7)-; provided that when X is -O-, U is not -O-, -S(O)-, -S(O)2-, -C(=O)- or -C(=NR5)-; U is a bond, -S(O)-, -S(O)2-, -C(O)-, -O-, -P(O)(OR15)-, -C(=NR5)-, -(C(R6)(R7))b- or -N(R5)-; wherein b is 1 or 2; provided that when W is -S(O)-, -S(O)2-, -O-, or -N(R5)-, U is not -S(O)-, -S(O)2-, -O-, or -N(R5)-; provided that when X is -N(R5)- and W is -S(O)-, -S(O)2-, -O-, or -N(R5)-, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula (I). Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中W是一个键，-C（= S） - ， - S（O） - ， - S（O） - ， - （= O） - ， - O - ， - C（R6）（R7） - ， - N（R5） - 或-C（= N（R5） X是-O - ， - N（R 5） - 或-C（R 6）（R 7） - ; 条件是当X是-O-时，U不是-O-，-S（O） - ， - S（O）2 - ， - C（= O） - 或-C（= NR5） - ; U是一个键，-S（O） - ， - S（O）2 - ， - C（O） - ， - O - ， - O（OR）（C（R6）（R7））b-或-N（R5） - ; 其中b为1或2; 条件是当W是-S（O） - ， - S（O）2 - ， - O-或-N（R 5） - 时，U不是-S（O） - ， - S（O） -O-或-N（R 5） - ; 条件是当X为-N（R5） - 且W为-S（O） - ， - S（O）2 - ， - O-或-N（R5） - 时，则U不为键; 并且R1，R2，R3，R4，R5，R6和R7如说明书中所定义; 和包含式（I）化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

8. 发明申请

WO2005014540A1 CYCLIC AMINE BASE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT 审中-公开
标题翻译：具有杂环取代基的循环胺碱基1抑制剂
公开(公告)号：WO2005014540A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/025748
申请日：2004-08-04
申请人： SCHERING CORPORATION , PHARMACOPEIA DRUG DISCOVERY, INC. , CUMMING, Jared, N. , HUANG, Ying , LI, Guoqing , ISERLOH, Ulrich , STAMFORD, Andrew , STRICKLAND, Corey , VOIGT, Johannes, H. , WU, Yusheng , PAN, Jianping , GUO, Tao , HOBBS, Douglas, W. , LE, Thuy, X., H. , LOWRIE, Jeffrey, F.
发明人： CUMMING, Jared, N. , HUANG, Ying , LI, Guoqing , ISERLOH, Ulrich , STAMFORD, Andrew , STRICKLAND, Corey , VOIGT, Johannes, H. , WU, Yusheng , PAN, Jianping , GUO, Tao , HOBBS, Douglas, W. , LE, Thuy, X., H. , LOWRIE, Jeffrey, F.
IPC分类号： C07D207/26
CPC分类号： C04B35/632 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed are novel compounds of the formula (I)or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is formula (I) X is -0-, -C(R 14 )2- or -N(R)-; Z is -C(R 14 )2- or -N(R)-; t is 0, 1, 2 or 3; each R and R 2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R 14 is H, alkyl, alkenyl, alkynyl, halo, -CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, -OR35, - N(R 24 )(R 25 ) or -SR 35 ; R 41 is alkyl, cycloalkyl, -S0 2 (alkyl), -C(O)-alkyl, -C(O)-cycloalkyl or -alkyl-NH-C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula (I). Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
摘要翻译：公开了式（I）的新化合物或其药学上可接受的盐或溶剂化物，其中R 1是式（I）X是-O-，-C（R 14）2 - 或-N（R ） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地是H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，N（R 24）（R 25）或-SR 35; R 41是烷基，环烷基，-SO 2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH 3; 其余变量如本说明书中所定义。还公开了包含式I化合物的药物组合物和用式（I）化合物治疗认知或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包括式I化合物与用于治疗认知或神经变性疾病的其它药剂的组合。

9. 发明申请

WO2023077496A1 LAMINATE WITH SUPERIOR BARRIER PERFORMANCE AND PREPARATION METHOD THEREOF 审中-公开
公开(公告)号：WO2023077496A1
公开(公告)日：2023-05-11
申请号：PCT/CN2021/129194
申请日：2021-11-08
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , BAI, Chenyan , WANG, Gang , DU, Zhe , WANG, Fanji , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , WANG, Kaili , ZHAO, Lianjiang , CHEN, Gaobing
发明人： BAI, Chenyan , WANG, Gang , DU, Zhe , WANG, Fanji , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , WANG, Kaili , ZHAO, Lianjiang , CHEN, Gaobing
IPC分类号： B32B27/12 , B32B27/40 , C08G18/10 , C08G18/46 , C09J175/04
摘要： A laminate, an article comprising the laminate and a method for preparing the laminate are provided. The present disclosure relates to a laminate, comprising a first substrate comprising a metalized polyethylene-based (PE based) film; a second substrate comprising a polyethylene terephthalate-based film or a polypropylene-based film; and, an adhesive layer adhering the first substrate to the second substrate, wherein the adhesive layer is derived from a two-component solvent-based polyurethane adhesive composition; wherein the concentration of fatty acids or fatty acid derivatives in the metalized PE-based film is less than 300ppm, based on the total weight of the metalized PE-based film, wherein the two-component solvent-based polyurethane adhesive composition comprises a polyester polyol component and a polyisocyanate component, wherein the polyester polyol component has about 40wt%-60 wt %of aromatic rings in the backbone, based on the total weight of the polyester polyol and a molecular weight (Mw) between 5,000 and 50,000; and wherein the weight ratio of the polyester polyol component to the polyisocyanate component is from 100: 5 to 100: 30.

10. 发明申请

WO2023077495A1 LAMINATE MATERIAL WITH SUPERIOR BARRIER PERFORMANCE AND PREPARATION METHOD THEREOF 审中-公开
公开(公告)号：WO2023077495A1
公开(公告)日：2023-05-11
申请号：PCT/CN2021/129192
申请日：2021-11-08
申请人： DOW GLOBAL TECHNOLOGIES LLC , WANG, Gang , BAI, Chenyan , DU, Zhe , WANG, Fanji , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , ZHU, Jianliang , QIU, Huan
发明人： WANG, Gang , BAI, Chenyan , DU, Zhe , WANG, Fanji , YUN, Xiaobing , PAN, Jianping , XU, Jingyi , ZHU, Jianliang , QIU, Huan
IPC分类号： B32B15/085 , B32B7/12 , B32B27/00 , C09J175/06
摘要： Provided are a laminate material, an article comprising the laminate material and a method for preparing the laminate material. The laminate material, comprises a first substrate comprising at least one metalized PE-based film, a second substrate comprising at least one PE-based film, and an adhesve layer adhering the first substrate to the second substrate, wherein the adhesive layer is derived from a two-component solvent-based polyurethane adhesive composition, and wherein the concentration of fatty acids or fatty acid derivatives in the metalized PE-based film is less than 300ppm, based on the total weight of the metalized PE-based film. The two-component solvent-based polyurethane adhesive composition comprises a polyester polyol component and a polyisocyanate component, wherein the polyol component has 40wt%-60wt% of aromatic rings in the backbone, based on the total weight of the polyester polyol and a Mw between 5,000 and 50,000, and wherein the weight ratio of the polyester polyol component to polyisocyanate component is from 100:5 to 100:30.

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