专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

ES2031276T3 未知
公开(公告)号：ES2031276T3
公开(公告)日：1992-12-01
申请号：ES88630052
申请日：1988-03-16
申请人： NEOPROBE CORPORATION (A DELAWARE CORPORATION)
发明人： DENEN, DENNIS J. , THURSTON, MARLIN O. , RAMSEY, RAYMOND C.
IPC分类号： G01T1/161 , H03F3/193
摘要： A detector particularly suited for use in immuno-guided surgery capable of detecting very faint gamma emissions and thereby localizing cancerous tumor. The detector employs a hand manipular probe (12) within which is contained a crystal (60 Fig. 2) such as cadmium telluride which is secured in a light tight compressively restrained environment employing compliant yet conductive components which also serve to exhibit varying accoustical impedance to impinging microphonic effects. A preamplifier is incorporated within the probe device itself which employs an integrator stage front end combining a field effect transistor and bipolar device with a very small feedback capacitance of less than one picofarad. A bootstrap technique is utilized to enhance the amplification of the bipolar amplification stage. Pulse related signals outputted from the device are normalized and compared to produce pulse data which are analyzed. In one mode of operation a siren effect is employed to guide the surgeon towards emission sources.

2. 发明申请

WO1988007209A1 DETECTOR AND LOCALIZER FOR LOW ENERGY RADIATION EMISSIONS 审中-公开
标题翻译：用于低能量辐射排放的探测器和本地化机构
公开(公告)号：WO1988007209A1
公开(公告)日：1988-09-22
申请号：PCT/US1988001021
申请日：1988-03-17
申请人： NEOPROBE CORPORATION
发明人： NEOPROBE CORPORATION , DENEN, Dennis, J. , THURSTON, Marlin, O. , RAMSEY, Raymond, C.
IPC分类号： G01T01/161
CPC分类号： A61B6/425 , A61B6/4258 , A61B6/4423 , G01T1/161 , H03F3/1935 , H03F2200/261
摘要： A detector (10) particularly suited for use in immuno-guided surgery capable of detecting very faint gamma emissions and thereby localizing cancerous tumor. The detector employs a hand manipular probe (12) within which is contained a crystal (58) such as cadmium telluride which is secured in a light tight compressively restrained environment employing compliant yet conductive components (68, 70, 72) which also serve to exhibit varying acoustical impedance to impinging microphonic effects. A preamplifier (110) is incorporated within the probe device itself which employs an integrator stage front end (116) combining a field effect transistor (Q1) and bipolar device (Q2) with a very small feedback capacitance of less than one picofarad. A bootstrap technique (Q3) is utilized to enhance the amplification of the bipolar amplification stage. Pulse related signals outputted from the device are normalized (204) and compared (236, 238) to produce pulse data which are analyzed. In one mode of operation a siren effect is employed to guide the surgeon towards emission sources.

3. 发明申请

WO2010087959A1 COMPOSITIONS FOR RADIOLABELING DIETHYLENETRIAMINEPENTAACETIC ACID (DTPA)-DEXTRAN 审中-公开
标题翻译：用于放射性二甲基氨基苯甲酸（DTPA）-DEXTRAN的组合物
公开(公告)号：WO2010087959A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/000222
申请日：2010-01-28
申请人： NEOPROBE CORPORATION , MAGNESON, Gerald, Ross , ORAHOOD, Richard, Cushman
发明人： MAGNESON, Gerald, Ross , ORAHOOD, Richard, Cushman
IPC分类号： G21C1/00
CPC分类号： C07B59/005 , A61K51/0491 , A61K51/065 , C07B59/001 , C07B59/004 , C07B63/04 , C07B2200/05 , G01N33/534 , G01N33/60
摘要： The subject invention relates to the compositions for radiolabeling Diethylenetriaminepentaacetic Acid (DTPA)-dextran with Technetium-99m and for stabilizing the DTPA-dextran Cold Kit. The composition contains Stannous Chloride ions to reduce 99m Tc-pertechnetate, Ascorbic Acid to reduce stannic ions to stannous ions to maintain a reducing environment, α,α-Trehalose to add bulk and to stabilize the lyophilized composition without interfering with the radiochemical yield, and Glycine to transchelate Technetium-99m under highly acidic conditions to facilitate radiolabeling DTPA-dextran with high radiochemical purity. In addition, the invention pertains to methods for making and using the compositions. The reconstitution of the lyophilized composition by 99m Tc-pertechnetate, resulting in radiolabeled 99m Tc- DTPA-dextran in a composition between pH 3 to 4. This invention contains a Diluent vial, which when used will shift the pH to a moderately acidic pH, which would provide less pain on injection and ease-of-use to clinical practioners for adjusting its potency.
摘要翻译：本发明涉及用锝-99m放射性标记二亚乙基三胺五乙酸（DTPA） - 葡聚糖并用于稳定DTPA-葡聚糖冷试剂盒的组合物。该组合物含有氯化亚锡离子以减少99mTc-高锝酸盐，抗坏血酸将亚锡离子还原成亚锡离子以维持还原环境，a，海藻糖增加体积并稳定冻干组合物而不干扰放射化学产率，甘氨酸在高酸性条件下将锝-99m转化，以便放射性标记具有高放射化学纯度的DTPA-葡聚糖。此外，本发明涉及制备和使用组合物的方法。通过99mTc-高锝酸盐重构冻干组合物，得到在pH3-4之间的组合物中放射性标记的99mTc-DTPA-葡聚糖。本发明含有稀释剂小瓶，当使用时可将pH转移至中等酸性pH，为临床工作者提供更少的注射痛苦和易用性，以调整其效力。

4. 发明申请

WO2010132056A1 STACKED CRYSTAL ARRAY FOR DETECTION OF PHOTON EMISSIONS 审中-公开
标题翻译：用于检测光子发射的堆叠晶体阵列
公开(公告)号：WO2010132056A1
公开(公告)日：2010-11-18
申请号：PCT/US2009/043882
申请日：2009-05-14
申请人： CALL, John , NEOPROBE CORPORATION
发明人： CALL, John
IPC分类号： G01T1/20
CPC分类号： G01T1/161
摘要： A stacked crystal array (46) includes a plurality of crystal slices (20) and a plurality of interconnects (22). The interconnects (22) have electrically conductive, spaced-apart and generally parallel elements (34) joined by electrically conductive spacers (36) extending generally orthogonally therebetween, the spacers (36) being rotationally offset from each other by a predetermined angle. The array (46) further includes a plurality of electrical insulators (24) and an electrically insulative housing (26) having a plurality of slots (40). The crystal slices (20), insulators (24) and interconnects (22) are arranged in the housing (26) to form an assembly wherein the crystal slices (20) are coupled together in a parallel electrical circuit. The assembly provides photon absorption comparable to a monolithic crystal having a thickness generally equivalent to the sum of the thicknesses of the crystal slices (20), but at a lower bias voltage.
摘要翻译：叠层晶体阵列（46）包括多个晶片（20）和多个互连（22）。互连（22）具有导电的，间隔开的和大致平行的元件（34），所述元件（34）通过其间大致垂直延伸的导电间隔件（36）连接，所述间隔件（36）以预定角度彼此旋转偏移。阵列（46）还包括多个电绝缘体（24）和具有多个槽（40）的电绝缘壳体（26）。晶体片（20），绝缘体（24）和互连（22）布置在壳体（26）中以形成其中晶体片（20）以并联电路耦合在一起的组件。组件提供与具有通常等于晶体片（20）的厚度之和但在较低偏压下的厚度的单体晶体相当的光子吸收。

5. 发明申请

WO2009158490A1 SURGICAL PROBE APPARATUS AND SYSTEM 审中-公开
标题翻译：外科手术装置和系统
公开(公告)号：WO2009158490A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048644
申请日：2009-06-25
申请人： NEOPROBE CORPORATION , MCFERRON, Richard
发明人： MCFERRON, Richard
IPC分类号： G01T1/24
CPC分类号： G01T1/161 , A61B6/4258
摘要： A system (10) for detecting and locating sources of radiation emissions. A hand-held probe (12) includes a detector (18) configured to generate a low-level electrical signal (26) relating to a radiation source (54) proximate the detector, and a probe wireless link (24) configured to transmit a message (56) containing gamma data relating to the low-level electrical signal. An instrumentation console (14) includes a housing (46), an integral console wireless link (32) within the housing and configured to receive the message (56) transmitted by the probe wireless link (24), a receiver (38) electrically coupled to the console wireless link to convert the message to corresponding electrical display signals (48), and a visually perceivable display (34) electrically coupled to the receiver to convert the electrical display signals to a visually perceivable display relating to the amount of radiation detected.
摘要翻译：一种用于检测和定位辐射源的源的系统（10）。手持探针（12）包括检测器（18），其被配置为产生与靠近检测器的辐射源（54）有关的低电平电信号（26）;以及探针无线链路（24）消息（56）包含与低电平电信号有关的伽马数据。仪器控制台（14）包括壳体（46），壳体内的整体式控制台无线连接（32），并且被配置为接收由探头无线链路（24）传输的消息（56），电接收到所述控制台无线链路以将所述消息转换成相应的电显示信号（48），以及电耦合到所述接收器的视觉上可感知的显示器（34），以将所述电显示信号转换成与检测到的辐射量相关的视觉上可感知的显示。

6. 发明申请

WO2009140443A1 HAND-HELD INTRA-OPERATIVE DETECTION OF FLUORESCENCE LABELED COMPOUNDS AND ANTIBODIES 审中-公开
标题翻译：荧光标记化合物和抗体的手持操作检测
公开(公告)号：WO2009140443A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/043868
申请日：2009-05-13
申请人： CHAPMAN, Gregg , NEOPROBE CORPORATION
发明人： CHAPMAN, Gregg
IPC分类号： G01J3/30
CPC分类号： G01J1/02 , A61B5/0059 , A61B5/415 , A61B5/418 , G01J1/0219 , G01J1/0228 , G01J1/0233 , G01J1/04 , G01J1/0411 , G01J1/58 , G01N21/645 , G01N2201/0221
摘要： A hand-held probe (10) for intra-operative detection of fluorescence labeled compounds includes a housing (62) comprising a handle (64) and a columnar portion (66), and a power source (12) within the housing (62) A light emission source (16) proximate the columnar portion (66) of the housing (62) is configured to fluoresce at least one of predetermined compounds and predetermined antibodies An excitation switch (34) proximate the handle (64) selectably activates the light emission source (16) A detector (18) receives fluorescent light emissions directed toward the columnar portion (66) from at least one of the compounds and antibodies and converts the fluorescent light emissions to a corresponding emission electrical signal A controller (20) within the housing (62) receives the emission electrical signal from the detector (18) and converts the emission electrical signal to a corresponding data signal.
摘要翻译：用于手术中检测荧光标记化合物的手持式探针（10）包括包括手柄（64）和柱状部分（66）的壳体（62）和壳体（62）内的电源（12）邻近壳体（62）的柱状部分（66）的发光源（16）被配置为使预定化合物和预定抗体中的至少一种发荧光。靠近手柄（64）的激发开关（34）可选地激活光发射源极（16）检测器（18）从至少一个化合物和抗体接收指向柱状部分（66）的荧光发射，并将荧光发射转换成相应的发射电信号A内的控制器（20）（62）从检测器（18）接收发射电信号，并将发射电信号转换成对应的数据信号。

7. 发明授权

EP0371903B1 Detector and localizer for low energy radiation emissions 失效
标题翻译：探测器定位弱辐射发射
公开(公告)号：EP0371903B1
公开(公告)日：1996-04-10
申请号：EP89630158.7
申请日：1989-09-21
申请人： NEOPROBE CORPORATION
发明人： Denen, Dennis Joseph
IPC分类号： G01T1/161
CPC分类号： G01T1/161 , A61B6/4258

8. 发明公开

EP0284542A1 Detector and localizer for low energy radiation emissions 失效转让
标题翻译： Detektor zur Lokalisierung schwacher Strahlungsemissionen。
公开(公告)号：EP0284542A1
公开(公告)日：1988-09-28
申请号：EP88630052.4
申请日：1988-03-16
申请人： NEOPROBE CORPORATION (A Delaware Corporation)
发明人： Denen, Dennis J. , Thurston, Marlin O. , Ramsey, Raymond C.
IPC分类号： G01T1/161
CPC分类号： A61B6/425 , A61B6/4258 , A61B6/4423 , G01T1/161 , H03F3/1935 , H03F2200/261
摘要： A detector particularly suited for use in immuno-guided surgery capable of detecting very faint gamma emissions and thereby localizing cancerous tumor. The detector employs a hand manipular probe (12) within which is contained a crystal (60 Fig. 2) such as cadmium telluride which is secured in a light tight compressively restrained environment employing compliant yet conductive components which also serve to exhibit varying accoustical impedance to impinging microphonic effects. A preamplifier is incorporated within the probe device itself which employs an integrator stage front end combining a field effect transistor and bipolar device with a very small feedback capacitance of less than one picofarad. A bootstrap technique is utilized to enhance the amplification of the bipolar amplification stage. Pulse related signals outputted from the device are normalized and compared to produce pulse data which are analyzed. In one mode of operation a siren effect is employed to guide the surgeon towards emission sources.
摘要翻译：特别适用于能够检测非常微弱的γ发射并由此定位癌性肿瘤的免疫指导手术的检测器。检测器采用手操纵探针（12），其中包含晶体（60图2），例如碲化镉，其被固定在紧密的压缩约束环境中，使用顺应性导电组件，其也用于表现出改变的声阻抗撞击麦克风效应。在探针器件本身内部并入前置放大器，其采用组合场效应晶体管和双极器件的积分器级前端，其具有小于1皮法的非常小的反馈电容。利用自举技术来增强双极放大级的放大。对从器件输出的脉冲相关信号进行归一化和比较，以产生被分析的脉冲数据。在一种操作模式中，采用警笛效应来引导外科医生朝向排放源。

9. 发明申请

US20100196272A1 COMPOSITIONS FOR RADIOLABELING DIETHYLENETRIAMINEPENTAACETIC ACID (DTPA)-DEXTRAN 审中-公开
标题翻译：用于放射性二甲基氨基苯甲酸（DTPA）-DEXTRAN的组合物
公开(公告)号：US20100196272A1
公开(公告)日：2010-08-05
申请号：US12362778
申请日：2009-01-30
申请人： Gerald Ross Magneson , Richard Cushman Orahood
发明人： Gerald Ross Magneson , Richard Cushman Orahood
IPC分类号： A61K51/04
CPC分类号： C07B59/005 , A61K51/0491 , A61K51/065 , C07B59/001 , C07B59/004 , C07B63/04 , C07B2200/05 , G01N33/534 , G01N33/60
摘要： The subject invention relates to the compositions for radiolabeling Diethylenetriaminepentaacetic Acid (DTPA)-dextran with Technetium-99m and for stabilizing the DTPA-dextran Cold Kit. The composition contains Stannous Chloride ions to reduce 99mTc-pertechnetate, Ascorbic Acid to reduce stannic ions to stannous ions to maintain a reducing environment, α,α-Trehalose to add bulk and to stabilize the lyophilized composition without interfering with the radiochemical yield, and Glycine to transchelate Technetium-99m under highly acidic conditions to facilitate radiolabeling DTPA-dextran with high radiochemical purity. In addition, the invention pertains to methods for making and using the compositions. The reconstitution of the lyophilized composition by 99mTc-pertechnetate, resulting in radiolabeled 99mTc-DTPA-dextran in a composition between pH 3 to 4. This invention contains a Diluent vial, which when used will shift the pH to a moderately acidic pH, which would provide less pain on injection and ease-of-use to clinical practioners for adjusting its potency.
摘要翻译：本发明涉及用锝-99m放射性标记二亚乙基三胺五乙酸（DTPA） - 葡聚糖并用于稳定DTPA-葡聚糖冷试剂盒的组合物。该组合物含有氯化亚锡离子以减少99mTc-高锝酸盐，抗坏血酸将亚锡离子还原成亚锡离子以保持还原环境，α，α-海藻糖增加体积并稳定冻干组合物而不干扰放射化学产率，甘氨酸在高度酸性条件下将锝-99m转移以便放射性标记具有高放射化学纯度的DTPA-葡聚糖。此外，本发明涉及制备和使用组合物的方法。通过99mTc-高锝酸盐重构冻干组合物，得到在pH3-4之间的组合物中放射性标记的99mTc-DTPA-葡聚糖。本发明含有稀释剂小瓶，其使用时将pH值移至中等酸性pH值，为临床工作者提供更少的注射痛苦和易用性，以调整其效力。

10. 外观设计

USD400249S Console for controlling a radiation probe 失效
公开(公告)号：USD400249S
公开(公告)日：1998-10-27
申请号：US77957
申请日：1997-10-14
申请人： Mark E. Holubar , Michael J. Sidi
设计人： Mark E. Holubar , Michael J. Sidi

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式