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1. 发明申请

WO2017159705A1 MYOCARDIAL EXCITATION DETERMINING APPARATUS 审中-公开
标题翻译：心肌激动确定装置
公开(公告)号：WO2017159705A1
公开(公告)日：2017-09-21
申请号：PCT/JP2017/010287
申请日：2017-03-14
申请人： SHIGA UNIVERSITY OF MEDICAL SCIENCE , NIHON KOHDEN CORPORATION , TSUCHIYA Takeshi , NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
发明人： TSUCHIYA Takeshi , ASHIHARA Takashi , TAKIZAWA Koji , NISHIHARA Tatsuo , SUZUKI Nobuhiro , IWANAGA Yuuho , OTA Akio , NAKAZAWA Kazuo , INADA Shin
IPC分类号： A61B5/00 , A61B5/046 , A61N1/40
摘要： A myocardial excitation determining apparatus which can support the determination of excitation dynamics of the myocardium during atrial fibrillation is provided. A myocardial excitation determining apparatus has: an acquiring section 2 which acquires an intracardiac electrocardiogram of a subject; a processing section 3 which computes to produce visualized data indicating a state of excitation in the myocardium, based on the intracardiac electrocardiogram; and a determining section 4 which determines the type of excitation dynamics of the myocardium based on the visualized data.
摘要翻译：提供了一种心肌兴奋确定装置，其能够支持心房颤动期间心肌激励动态的确定。心肌激励判定装置具有：获取部2，其获取被检体的心内心电图; 处理部分3，其基于心内心电图计算以产生指示心肌中的激励状态的可视化数据; 以及确定部分4，其基于可视化数据确定心肌的激励动力学的类型。

2. 发明申请

WO2022170000A1 METHODS, ASSAYS AND COMPOSITIONS FOR MEASURING BRAIN DAMAGE OR HARM DURING SURGERY 审中-公开
公开(公告)号：WO2022170000A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015155
申请日：2022-02-03
申请人： NANOSOMIX, INC. , NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
发明人： MITSUHASHI, Masato , TADOKORO, Takahiro , YSHITANI, Kenji
IPC分类号： G01N33/53 , G01N33/531 , A61K35/30 , A61K39/395 , A61P25/28
摘要： The present disclosure relates to methods and assays for quantifying brain-derived exosomes in biological samples from subjects before, during, and after surgery. The disclosure also provides methods and compositions for measuring and/or prognosing brain damage during surgery. The compositions and methods of the disclosure are also useful for preventing and/or treating brain damage in subjects undergoing surgery and predicting postoperative cognitive dysfunction (POCD) and/or predicting postoperative delirium (POD).

3. 发明申请

WO2021016663A1 KLF INDUCED CARDIOMYOGENESIS 审中-公开
公开(公告)号：WO2021016663A1
公开(公告)日：2021-02-04
申请号：PCT/AU2020/050775
申请日：2020-07-30
申请人： VICTOR CHANG CARDIAC RESEARCH INSTITUTE , NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
发明人： KIKUCHI, Kazu , OGAWA, Masahito
IPC分类号： A61P9/00 , A61K48/00 , A61K38/17 , C12N5/071 , C12N15/63
摘要： The technology relates to a method for inducing cardiomyogenesis comprising administering a therapeutically effective amount of either or both of KLF1 and KLF2b to increase the level of KLF1 and/or KLF2b in the cardiomyocytes thereby inducing cardiomyogenesis.

4. 发明公开

EP3360573A1 MEDICINAL DRUG FOR PREVENTING OR INHIBITING ACUTE KIDNEY INJURY 无效
公开(公告)号：EP3360573A1
公开(公告)日：2018-08-15
申请号：EP16853615.9
申请日：2016-10-05
申请人： National Cerebral and Cardiovascular Center
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K45/00 , A61K31/18 , A61K31/381 , A61K31/44 , A61K45/06 , A61P13/12
CPC分类号： A61K31/18 , A61K31/34 , A61K31/381 , A61K31/44 , A61K45/00 , A61K45/06 , A61K2300/00 , A61P13/12
摘要： The present invention provides a novel medicament for preventing or inhibiting acute kidney injury, the medicament comprising, as an active ingredient, an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof, and being used for treatment or prevention of acute kidney injury. Also, the present invention provides a novel method for preventing or inhibiting acute kidney injury, the method comprising administering, to a patient, an effective amount of an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof in combination with an anticancer agent and/or an antitumor agent.

5. 发明公开

EP3127554A1 MEDICINE FOR SUPPRESSING MALIGNANT TUMOR METASTASIS 审中-公开
标题翻译： ARZNEIMITTEL ZUR HEMMUNG MALIGNER TUMORMETASTASEN
公开(公告)号：EP3127554A1
公开(公告)日：2017-02-08
申请号：EP15773890.7
申请日：2015-04-03
申请人： National Cerebral and Cardiovascular Center , Mitsubishi Tanabe Pharma Corporation
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K45/00 , A61K31/18 , A61P35/04 , A61P43/00
CPC分类号： A61K31/5375 , A61K9/0053 , A61K31/18 , A61K31/192 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/438 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/454 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/554 , A61K45/06
摘要： Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.
摘要翻译：提供了用于抑制或预防恶性肿瘤如癌的转移的新型药物，用于抑制或预防恶性肿瘤转移的新型治疗或预防方法等。该药物包含非肽类血管紧张素2型受体激动剂作为活性成分。在药物中，非肽类血管紧张素2型受体激动剂可以是例如磺酰丙酰胺化合物。药物可以是与抗癌剂和/或抗肿瘤剂组合使用的药物。

6. 发明授权

EP2298365B1 MEDICAL COMPOSITION AND MEDICAL KIT 有权转让
标题翻译：药物组合物及医疗用试剂盒
公开(公告)号：EP2298365B1
公开(公告)日：2015-07-29
申请号：EP09770253.4
申请日：2009-06-26
申请人： Osaka City University , Japan Health Sciences Foundation
发明人： FUKUMOTO, Shinya , KOYAMA, Hidenori , NISHIZAWA, Yoshiki , FURUZONO, Tsutomu , OKADA, Masahiro
IPC分类号： A61L27/00 , A61L27/32 , A61L27/56 , A61L27/58
CPC分类号： A61L27/3804 , A61K9/16 , A61K31/74 , A61L27/32 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2300/426

7. 发明公开

EP2819041A2 Diagnosis assistance apparatus, diagnosis assistance method, and diagnosis assistance program 审中-公开
标题翻译：诊断辅助设备，辅助的诊断方法和诊断工具
公开(公告)号：EP2819041A2
公开(公告)日：2014-12-31
申请号：EP14171547.4
申请日：2014-06-06
申请人： National Cerebral and Cardiovascular Center , Nihon Kohden Corporation
发明人： Nakazawa, Kazuo , Iwata, Michiaki , Hayashi, Miyuki , Yoshida, Tatsuo , Nishihara, Tatsuo , Takizawa, Koji
IPC分类号： G06F19/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G16H15/00 , G16H50/20
摘要： A diagnosis assistance apparatus for assisting a diagnosis using schemas includes a storage section that stores a plurality of different schemas each configured by a figure representing a body region, an acquiring section that acquire results of a plurality of examinations that are performed on an examination target, a schema refining section that refines a schema of a body region related to a disease that is predicted from the acquired examination results, from the schemas step-by-step in accordance with progress of the examinations, and a displaying section that displays the schema refined by the schema refining section.

8. 发明公开

EP2799544A1 METHOD FOR PRODUCING CELL HAVING NUCLEIC ACID INTRODUCED THEREIN 失效
标题翻译： VERFAHREN ZUR ERZEUGUNG VON ZELLEN MIT DARINEINGEFÜHRTENNUKLEINSÄUREN
公开(公告)号：EP2799544A1
公开(公告)日：2014-11-05
申请号：EP12863681.8
申请日：2012-12-26
申请人： National Cerebral and Cardiovascular Center , Bridgestone Corporation
发明人： NAKAYAMA, Yasuhide , IWAI, Ryosuke , NEMOTO, Yasushi
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C12N15/87 , B82Y5/00 , C12N15/09
摘要： A method for producing a cell having nucleic acid introduced therein and having low cytotoxicity is useful in primary cells and slowly dividing cells, for which nucleic acid introduction is difficult with conventional techniques. A method for introducing nucleic acid into a cell includes the steps of mixing a nucleic acid with a temperature sensitive material at a temperature lower than the cloud point of the temperature sensitive material, the temperature sensitive material being formed by adding 2-amino-2-hydroxymethyl-1,3-propanediol to a temperature-sensitive polymer material having 2-N,N-dimethylaminoethyl methacrylate and/or a derivative thereof as the main polymer component, flow coating a culture vessel with the resulting mixed liquid, and culturing a cell suspension provided to the culture vessel at a temperature higher than the cloud point.
摘要翻译：用于生产具有导入其中并具有低细胞毒性的核酸的细胞的方法可用于原代细胞和用于常规技术难以进行核酸引入的缓慢分裂细胞。将核酸引入细胞的方法包括以下步骤：在低于感温材料的浊点的温度下将核酸与感温材料混合，所述温度敏感材料通过加入2-氨基-2- 羟甲基-1,3-丙二醇加入到具有2-N，N-二甲基氨基乙基甲基丙烯酸酯和/或其衍生物作为主要聚合物组分的温度敏感性聚合物材料中，将所得混合液体流过培养容器，并培养细胞在高于浊点的温度下提供给培养容器的悬浮液。

9. 发明公开

EP2662026A1 Cardiac output monitoring system and cardiac output measurement method 审中-公开
标题翻译： Überwachungssystemdes Herzminutenvolumens und MessverfahrenfürHerzminutenvolumen
公开(公告)号：EP2662026A1
公开(公告)日：2013-11-13
申请号：EP13166623.2
申请日：2013-05-06
申请人： Seiko Epson Corporation , National Cerebral and Cardiovascular Center
发明人： Aoki, Mikio , Uemura, Kazunori , Sugimachi, Masaru
IPC分类号： A61B8/06 , A61B5/029
CPC分类号： A61B8/065 , A61B5/029 , A61B5/1075 , A61B8/461 , A61B8/467 , A61B8/5223 , A61B8/54
摘要： A processing device included in a cardiac output monitoring system includes an arterial diameter measurement ultrasonic probe that is attached to a neck of a subject, and measures the diameter of the carotid artery, and an arterial diameter measurement control section. A carotid artery diameter control section analyzes an ultrasonic echo to calculate the diameter of the artery (DOA), and outputs the diameter of the artery (DOA) to an ejection time/mean arterial pressure calculation section. The ejection time/mean arterial pressure calculation section calculates the ejection time (ET) from a temporal change in the diameter of the artery (DOA), and calculates the cardiac output. The temporal change waveform of the diameter of the artery (DOA) is clearer than the waveform of the blood flow velocity in the aorta or the ventricular outflow tract measured using an ultrasonic Doppler method, and the ejection time (ET) can be automatically calculated with high accuracy.
摘要翻译：包括在心输出量监视系统中的处理装置包括：附着于被检体颈部的动脉直径测定用超声波探头，测定颈动脉的直径和动脉直径测定控制部。颈动脉直径控制部分析超声回波以计算动脉直径（DOA），并将动脉直径（DOA）输出到喷射时间/平均动脉压计算部。喷射时间/平均动脉压计算部根据动脉直径（DOA）的时间变化计算出射时间（ET），并计算心输出量。动脉直径（DOA）的时间变化波形比使用超声多普勒法测量的主动脉或心室流出道中的血流速度的波形更清晰，并且可以自动计算喷射时间（ET）高准确率。

10. 发明公开

EP2662022A1 Method of extracting contour of tomogram 无效
标题翻译： Verfahren zum Auszug der Kontur eines Tomogramms
公开(公告)号：EP2662022A1
公开(公告)日：2013-11-13
申请号：EP12167018.6
申请日：2012-05-07
申请人： National Cerebral and Cardiovascular Center , NIHON MEDI-PHYSICS CO., LTD.
发明人： Iida, Hidehiro , Nakazawa, Mayumi
IPC分类号： A61B6/03 , G06T7/00 , G06T11/00
CPC分类号： A61B6/037 , A61B6/501 , A61B6/5205 , G06T7/12 , G06T7/136 , G06T11/005 , G06T2207/10081
摘要： In order to provide a method of generating an accurate contour image from projection data of a nuclear medicine image of a subject,contour information is extracted from nuclear medicine projection data on a subject not subjected to a scattering correction and an absorption correction by performing a pixel value binarization processing based on a threshold scheme. If necessary, an interpolation processing is performed before reconstructing an image through an image reconstruction processing. Based on the reconstructed image, a second binarization processing is performed to generate a contour image.
摘要翻译：为了提供从对象的核医学图像的投影数据生成准确的轮廓图像的方法，从不经受散射校正的受试者和通过执行像素的吸收校正的核医学投影数据中提取轮廓信息基于阈值方案的价值二值化处理。如果需要，在通过图像重构处理重建图像之前执行内插处理。基于重构图像，执行第二二值化处理以生成轮廓图像。

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