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1. 发明公开

EP2103484A3 Left/right turn indicator for vehicle 审中-公开
标题翻译：车辆左/右转信号
公开(公告)号：EP2103484A3
公开(公告)日：2010-03-10
申请号：EP09003218.6
申请日：2009-03-05
申请人： Noguchi, Hiroshi
发明人： Noguchi, Hiroshi
IPC分类号： B60Q1/14 , B60Q1/38
CPC分类号： B60Q1/143 , B60Q1/38 , B60Q2300/054 , B60Q2300/142
摘要： In response to a left turn operation of a turn signal lever (19) when left and right headlights (12,13) provided on the left and right sides of a front part of a vehicle (10) are turned on, a left turn signal light is turned on, and, at the same time, a left main light is made into a turned-off state corresponding to left turn indication. When a right turn operation of the turn signal lever (19) is performed, a right turn signal light is turned on, and, at the same time, a right main light is made into a turned-off state corresponding to right turn indication in response to this operation. In a dark environment such as nighttime, oncoming vehicles and pedestrians can surely know the left or right turning of the vehicle based on the change in the main lights from a normal lighting state to the turned-off state.

2. 发明公开

EP2103484A2 Left/right turn indicator for vehicle 审中-公开
标题翻译：联系人/ rechter BlinkerfürFahrzeuge
公开(公告)号：EP2103484A2
公开(公告)日：2009-09-23
申请号：EP09003218.6
申请日：2009-03-05
申请人： Noguchi, Hiroshi
发明人： Noguchi, Hiroshi
IPC分类号： B60Q1/14 , B60Q1/38
CPC分类号： B60Q1/143 , B60Q1/38 , B60Q2300/054 , B60Q2300/142
摘要： In response to a left turn operation of a turn signal lever (19) when left and right headlights (12,13) provided on the left and right sides of a front part of a vehicle (10) are turned on, a left turn signal light is turned on, and, at the same time, a left main light is made into a turned-off state corresponding to left turn indication. When a right turn operation of the turn signal lever (19) is performed, a right turn signal light is turned on, and, at the same time, a right main light is made into a turned-off state corresponding to right turn indication in response to this operation. In a dark environment such as nighttime, oncoming vehicles and pedestrians can surely know the left or right turning of the vehicle based on the change in the main lights from a normal lighting state to the turned-off state.
摘要翻译：响应于当设置在车辆（10）的前部的左侧和右侧的左右前照灯（12,13）被打开时转向信号杆（19）的左转操作，左转信号光被打开，并且同时，左主光被制成对应于左转指示的关闭状态。当转向信号杆（19）的右转操作被执行时，右转信号灯被接通，并且同时将右主灯变成对应于右转指示的关闭状态回应这个操作。在夜间黑暗的环境中，迎面而来的车辆和行人可以根据主灯从正常点灯状态到关闭状态的变化确定地知道车辆的左转或右转。

3. 发明专利

CA2026803A1 MONOCLONAL ANTIBODY TO EXOTOXIN A OF PSEUDOMONAS AERUGINOSA 未知
公开(公告)号：CA2026803A1
公开(公告)日：1991-04-05
申请号：CA2026803
申请日：1990-10-03
申请人： OHTSUKA HIROSHI , OCHI HIROSHI , NOGUCHI HIROSHI , YOKOTA SHINICHI , KOHZUKI TSUNEO , IRIE KENJI
发明人： OHTSUKA HIROSHI , OCHI HIROSHI , NOGUCHI HIROSHI , YOKOTA SHINICHI , KOHZUKI TSUNEO , IRIE KENJI
IPC分类号： A61K38/00 , A61K39/395 , A61K39/40 , A61P31/04 , C07K16/12 , C12N5/10 , C12P21/08 , C12R1/91
摘要： Human monoclonal antibody to exotoxin A of Pseudomonas aeruginosa, process for producing the antibody, pharmaceutical preparation containing the antibody, and method for treating P. aeruginosa infections by the use of the antibody.

5. 发明专利

BRPI0900901A2 未知
公开(公告)号：BRPI0900901A2
公开(公告)日：2009-12-01
申请号：BRPI0900901
申请日：2009-03-18
申请人： NOGUCHI HIROSHI
发明人： NOGUCHI HIROSHI
IPC分类号： B60Q1/34
摘要： In response to a left turn operation of a turn signal lever (19) when left and right headlights (12,13) provided on the left and right sides of a front part of a vehicle (10) are turned on, a left turn signal light is turned on, and, at the same time, a left main light is made into a turned-off state corresponding to left turn indication. When a right turn operation of the turn signal lever (19) is performed, a right turn signal light is turned on, and, at the same time, a right main light is made into a turned-off state corresponding to right turn indication in response to this operation. In a dark environment such as nighttime, oncoming vehicles and pedestrians can surely know the left or right turning of the vehicle based on the change in the main lights from a normal lighting state to the turned-off state.

6. 发明专利

CA2015246A1 HUMAN MONOCLONAL ANTIBODY, AND ITS PRODUCTION AND USE 未知
公开(公告)号：CA2015246A1
公开(公告)日：1990-10-24
申请号：CA2015246
申请日：1990-04-24
申请人： OCHI HIROSHI , OHTSUKA HIROSHI , YOKOTA SHINICHI , NOGUCHI HIROSHI , TERASHIMA MASAZUMI , UEZUMI IKUKO , IRIE KENJI
发明人： OCHI HIROSHI , OHTSUKA HIROSHI , YOKOTA SHINICHI , NOGUCHI HIROSHI , TERASHIMA MASAZUMI , UEZUMI IKUKO , IRIE KENJI
IPC分类号： G01N33/569 , A61K38/00 , A61K39/395 , A61P31/04 , C07K16/12 , C12N5/10 , C12N15/02 , C12P19/44 , C12P21/08 , C12R1/91 , G01N33/577 , A61K39/40 , C12N5/20
摘要： HUMAN MONOCLONAL ANTIBODY, AND ITS PRODUCTION AND USE A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Commitee's Classification, and the epitope of which is located at the common structure in the O-antigen of Pseudomonas aeruginosa of serotypes A and H. A hybridoma producing said human monoclonal antibody, and processes for preparing said hybridoma and antibody are also provided.

7. 发明专利

CA2035848A1 HUMAN MONOCLONAL ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR THE TREATMENT OF PSEUDOMONAS INFECTINS 未知
公开(公告)号：CA2035848A1
公开(公告)日：1991-08-09
申请号：CA2035848
申请日：1991-02-06
申请人： KOHZUKI TSUNEO , UEZUMI IKUKO , IRIE KENJI , OCHI HIROSHI , HORIGOME KAZUHIKO , NOGUCHI HIROSHI
发明人： KOHZUKI TSUNEO , UEZUMI IKUKO , IRIE KENJI , OCHI HIROSHI , HORIGOME KAZUHIKO , NOGUCHI HIROSHI
IPC分类号： C12N5/10 , A61K38/00 , A61K39/395 , C07K16/12 , C12N15/02 , C12N15/09 , C12P21/08 , A61K39/40
摘要： A human monoclonal antibody to P. aeruqinosa, a process for producing the antibody, a pharmaceutical preparation comprising the antibody, and a method for preventing and treating infectious diseases and encdotoxin shocks caused by P. aeruginosa by administrating the preparation to a subject to be treated.

8. 发明申请

WO1995018150A1 NOVEL HUMAN CILIARY NEUROTROPHIC FACTOR 审中-公开
标题翻译：新人类神经营养因子
公开(公告)号：WO1995018150A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002269
申请日：1994-12-27
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , INOUE, Makoto , KIKUCHI, Kaoru , ISHIGE, Yoko , ITO, Akira , KIMURA, Toru , NAKAYAMA, Chikao , NOGUCHI, Hiroshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： A modification of a human ciliary neurotrophic factor (human CNTF) wherein the amino acid residue of the amino acid sequence corresponding to at least the 153rd amino acid residue of the amino acid sequence of a natural human CNTF has been replaced by another amino acid residue has an activity equal or superior to that of a natural human CNTF. Hence it is expected as a useful therapeuticc agent reduced in the side effects such as the occurrence of autoantibodies caused by ample administration thereof, body weight decrease, anorexia, dry cough, and boredom. The invention also provides a D1 cap region modification of alpha -helix-rich cytokines analogous to human CNTF, such as GH, PRL, EPC, G-CSF, LIF, IL-6, IL-2, IL-4, and GM-CSF.
摘要翻译：人类睫状神经营养因子（人CNTF）的修饰，其中对应于天然人CNTF的氨基酸序列的至少153个氨基酸残基的氨基酸序列的氨基酸残基已经被另一个氨基酸残基替代，与天然人类CNTF相当或优于其他活性的活性。因此，预期作为减少副作用的有用的治疗剂，例如由其充分施用，体重减轻，厌食，干咳和无聊引起的自身抗体的发生。本发明还提供类似于人CNTF的例如GH，PRL，EPC，G-CSF，LIF，IL-6，IL-2，IL-4和GM-1的富含α-螺旋的细胞因子的D1帽区修饰， CSF。

9. 发明申请

WO1993011238A1 HUMANIZED B-B10, AN ANTI-IL2 RECEPTOR ANTIBODY 审中-公开
标题翻译：人类B-B10，抗IL2受体抗体
公开(公告)号：WO1993011238A1
公开(公告)日：1993-06-10
申请号：PCT/JP1992001583
申请日：1992-12-03
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , BIOTEST PHARMA GMBH , INNOTHERAPIE LABORTOIRES , NAKATANI, Tomoyuki , GOMI, Hideyuki , WIJDENES, John , NOGUCHI, Hiroshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , BIOTEST PHARMA GMBH , INNOTHERAPIE LABORTOIRES
IPC分类号： C12N15/13
CPC分类号： C07K16/2866 , A61K38/00 , C07K16/465 , C07K2317/24
摘要： A humanized antibody is provided, which is obtained by transplantation of the complementarity determining region of a mouse monoclonal antibody B-B10 specific to a human IL-2 receptor into a human antibody. The antibody has a very low antigenicity, and therefore, it is useful for treatment of carcinoma expressing IL-2 receptor.
摘要翻译：提供通过将人IL-2受体特异性的小鼠单克隆抗体B-B10的互补决定区移植到人抗体中而获得的人源化抗体。抗体具有非常低的抗原性，因此可用于治疗表达IL-2受体的癌症。

10. 发明申请

WO1998027982A1 COMPOSITION CONTAINING ASCORBIC ACID 审中-公开
标题翻译：含有抗坏血酸的组合物
公开(公告)号：WO1998027982A1
公开(公告)日：1998-07-02
申请号：PCT/JP1997004662
申请日：1997-12-17
申请人： SUMITOMO PHARMACEUTICALS CO., LTD. , NOGUCHI, Hiroshi , TAIJI, Mutsuo , YAMAGA, Hiroshi , ITAKURA, Yasushi , ICHIHARA, Junji
发明人： SUMITOMO PHARMACEUTICALS CO., LTD.
IPC分类号： A61K31/375
CPC分类号： C07F9/65515 , A61K31/375 , A61K31/665 , C07C279/26 , Y10S514/922 , Y10S514/936 , A61K2300/00
摘要： L-Ascorbic acid, its derivatives, or salts thereof can lower the blood lactic acid level and, therefore are useful as a remedy for lactic acidosis, etc., caused by the administration of amoxapine, theophyleine, methoformin, phenformin, buformin, nalidixic acid, hopantenic acid, azidothymidine, dideoxycytidine, high-calorie transfusion, propylene glycol, ethylene glycol, xylitol, fructose, sorbitol, etc.
摘要翻译： L-抗坏血酸及其衍生物或其盐可以降低血液乳酸水平，因此可用作由阿莫沙平，异佛尔酮，甲氧甲酰胺，苯乙双胍，丁香豆素，萘啶酸施用引起的乳酸性酸中毒等，泼尼酸，叠氮胸苷，双脱氧胞苷，高热量输血，丙二醇，乙二醇，木糖醇，果糖，山梨糖醇等。

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