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1. 发明专利

RU2632019C2 СПОСОБ ПОЛУЧЕНИЯ НАНОЧАСТИЦ ПОЛИСАХАРИДОВ 未知
公开(公告)号：RU2632019C2
公开(公告)日：2017-10-02
申请号：RU2014133962
申请日：2013-03-12
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , B82B1/00
摘要： Изобретениеотноситсяк способуполучениянаночастицизполисахаридови ихпроизводныхпутемспецифическогоокисленияполисахаридныхцепейи присоединениягидрофобныхсоединений. Описанспособполучениянаночастицполисахаридови ихпроизводных, ихчастичногоокислениядляполученияальдегидныхгруппи прикреплениясоединенийс аминогруппойилидругойгруппойс R-NH, которыереагируютс альдегиднойгруппой, вкоторомполисахаридс молекулярноймассойдо 1000 кДаилиегопроизводноеокисляется, чтобыполучитьальдегидныегруппы, поканебудетполученастепеньокисления 5% до 55% сахарныхцепей, изатемпокрайнеймереоднонанообразующеевещество, котороепослеприкрепленияальдегиднойгруппыпроявляетгидрофобныесвойства, выбираютизгруппы, включающей: алифатическиеилиароматическиеорганическиеамины, содержащиеот 4 до 20 атомовуглерода, амидыи гидразидыалифатическихи ароматическихорганическихкислот, содержащиеот 4 до 20 атомовуглерода, гидрофобныеаминокислоты, фосфатидилэтаноламин, ипоменьшеймереоднодействующеевещество, содержащеепокрайнеймереоднуамино-, амидо- илигидразиднуюгруппу, добавляетсяв растворокисленногополисахаридав водеилив смесиводыи органическогорастворителя, реакциюпроводятпри pH раствораот 1 до 9, притемпературеот 10 до 100°C, причемобщеемолярноеотношениеаминогруппк альдегиднымгруппамсоставляетот 20 до 0,5. Такжеописанананочастица. Техническийрезультат: разработанспособприготовленияполисахаридныхнаночастицв мягкихусловиях, чтобыобеспечитьковалентныесвязитерапевтическихсоединений, которыечувствительнык агрессивнойсреде. 2 н. и 18 з.п. ф-лы, 2 ил., 8 пр.

2. 发明专利

CA2866682C PROCESS FOR THE PREPARATION OF POLYSACCHARIDE NANOPARTICLES 未知
公开(公告)号：CA2866682C
公开(公告)日：2016-05-17
申请号：CA2866682
申请日：2013-03-12
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , A61K9/51 , A61K47/36 , C08B11/12 , C08B37/00 , C08B37/02 , C08B37/08 , C08L1/28 , C08L5/02 , C08L5/08
摘要： The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and an organic solvent, carrying the reaction out at pH of the solution from 1 to 9, at the temperature of from 10 to 100°C, wherein the total molar ratio of amino groups to aldehyde groups is from 20 to 0,5.

3. 发明专利

CA2866682A1 PROCESS FOR THE PREPARATION OF POLYSACCHARIDE NANOPARTICLES 未知
公开(公告)号：CA2866682A1
公开(公告)日：2013-09-19
申请号：CA2866682
申请日：2013-03-12
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , A61K9/51 , A61K47/36 , C08B11/12 , C08B37/00 , C08B37/02 , C08B37/08 , C08L1/28 , C08L5/02 , C08L5/08
摘要： The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and an organic solvent, carrying the reaction out at pH of the solution from 1 to 9, at the temperature of from 10 to 100°C, wherein the total molar ratio of amino groups to aldehyde groups is from 20 to 0,5.

4. 发明专利

AU2013232850B2 Process for the preparation of polysaccharide nanoparticles 未知
公开(公告)号：AU2013232850B2
公开(公告)日：2016-01-07
申请号：AU2013232850
申请日：2013-03-12
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , A61K9/51 , A61K47/36 , C08B11/12 , C08B37/00 , C08B37/02 , C08B37/08 , C08L1/28 , C08L5/02 , C08L5/08
摘要： The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and an organic solvent, carrying the reaction out at pH of the solution from 1 to 9, at the temperature of from 10 to 100°C, wherein the total molar ratio of amino groups to aldehyde groups is from 20 to 0,5.

5. 发明专利

IN1651MUN2014A PROCESS FOR THE PREPARATION OF POLYSACCHARIDE NANOPARTICLES 未知
公开(公告)号：IN1651MUN2014A
公开(公告)日：2015-05-29
申请号：IN1651MUN2014
申请日：2014-08-14
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , A61K9/51 , A61K47/36
摘要： The process for the preparation of nanoparticles from polysaccharides and derivatives thereof by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R NH2 bond which react with aldehyde groups comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0 1% to 80% of the sugar rings is obtained then adding at least one nanoparticle forming agent which after attachment of the aldehyde group exhibits hydrophobic properties selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms hydrophobic amino acids phosphatidylethanolamine and at least one active substance containing at least one amino amido or hydrazide group to the solution of the oxidized polysaccharide in water or a mixture of water and an organic solvent carrying the reaction out at pH of the solution from 1 to 9 at the temperature of from 10 to 100°C wherein the total molar ratio of amino groups to aldehyde groups is from 20 to 0 5.

6. 发明专利

AU2013232850A1 Process for the preparation of polysaccharide nanoparticles 未知
公开(公告)号：AU2013232850A1
公开(公告)日：2014-09-11
申请号：AU2013232850
申请日：2013-03-12
申请人： NANOVELOS SP Z O O
发明人： CIACH TOMASZ , WASIAK IGA
IPC分类号： C08B1/12 , A61K9/51 , A61K47/36 , C08B11/12 , C08B37/00 , C08B37/02 , C08B37/08 , C08L1/28 , C08L5/02 , C08L5/08
摘要： The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and an organic solvent, carrying the reaction out at pH of the solution from 1 to 9, at the temperature of from 10 to 100°C, wherein the total molar ratio of amino groups to aldehyde groups is from 20 to 0,5.

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