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1. 发明公开

EP1702072A4 GENETIC THERAPY AND GENETIC MODIFICATION USING NEOCENTROMERIC MINICHROMOSOMES 审中-公开
标题翻译：基因治疗和转基因使用NEOZENTROMER MINI染色体
公开(公告)号：EP1702072A4
公开(公告)日：2007-03-21
申请号：EP03767310
申请日：2003-12-23
申请人： MURDOCH CHILDRENS RES INST
发明人： CHOO ANDY , SAFFERY RICHARD ERIC , WONG LEE HWA
IPC分类号： C12N15/85 , A61K48/00 , C12N15/12 , C12N15/79 , C12N15/82 , C12N15/90
CPC分类号： A61K48/005 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2800/30 , C12N2830/002 , C12N2830/003 , C12N2830/15 , C12N2830/46
摘要： The present invention provides a target region within a mammalian, avian, plant or other eukaryotic chromosome or an artificial or engineered chromosomal construct which is capable of carrying and expressing a heterologous gene or other genetic molecule of interest. The gene or genetic molecule of interest is expressed in a region of the chromosome which corresponds to or which immediately adjoins or is proximal to a centromeric or neocentromeric region or a functional derivative thereof or a latent, synthetic or hybrid form thereof. A method for facilitating genetic therapy or genetic modification or other applications are also provided including protein production for proteomic therapy in a mammal, avian species or plant or other higher eukaryotes.

2. 发明公开

EP2680921A4 TRANSCUTANEOUS STIMULATION METHOD AND SYSTEM 失效
标题翻译： VERFAHREN UND SYSTEMFÜRTRANSKUTANE STIMULATION
公开(公告)号：EP2680921A4
公开(公告)日：2014-09-10
申请号：EP12752697
申请日：2012-03-02
申请人： MURDOCH CHILDRENS RES INST
发明人： SOUTHWELL BRIDGET RAE , HUTSON JOHN MEDWYN , TAN ANDRE YI FENG
IPC分类号： A61N1/24 , A61N1/36 , A61N1/375 , G06F15/00
CPC分类号： A61N1/36007 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/36014
摘要： A method of treating a waste evacuation dysfunction comprising administering transcutaneous electrical stimulation (TES) to at least one lower pelvic and/or sacral region for a specific treatment regimens. Also disclosed is a system for configuring a stimulation device to deliver transcutaneous electrical stimulation (TES) the system comprising: a computing device storing or having access to a plurality or TES settings and comprising a user interface to enable authorized selection of at least on of the TES settings for provision of TES by the stimulation device according to the at least one selected TES setting and the stimulation device communicatively coupled to the computing device to receive and store the selected at least one TES setting the stimulation device being of a size to be readily carried on a body and configured to selectively provide current to external electrode according to the one TES setting.
摘要翻译：一种治疗废物排泄功能障碍的方法，其包括对至少一个下盆骨和/或骶骨区域进行经皮电刺激（TES）用于特定治疗方案。还公开了一种用于配置刺激装置以递送经皮电刺激（TES）的系统，所述系统包括：计算装置，其存储或具有对多个或TES设置的访问，并且包括用户界面，以使得至少能够 TES设置，用于根据所述至少一个选择的TES设置由刺激装置提供TES，以及通信地耦合到所述计算设备的所述刺激装置，以接收和存储所选择的至少一个TES设置，所述刺激装置具有容易的尺寸承载在主体上并被配置为根据一个TES设置选择性地向外部电极提供电流。

3. 发明公开

EP2603609A4 TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS 失效
标题翻译： BEHANDLUNG UND DIAGNOSE EPIGENETISCHERSTÖRUNGENUND ERKRANKUNGEN
公开(公告)号：EP2603609A4
公开(公告)日：2013-11-27
申请号：EP11815911
申请日：2011-08-11
申请人： MURDOCH CHILDRENS RES INST
发明人： GODLER DAVID EUGENY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/68 , C12Q2600/154 , G06F19/24

4. 发明公开

EP1765990A4 THERAPEUTIC, PROPHYLACTIC AND DIAGNOSTIC AGENTS FOR HEPATITIS B 审中-公开
标题翻译：治疗药物，丙肝药物联合治疗药物GEGEN HEPATITIS B
公开(公告)号：EP1765990A4
公开(公告)日：2008-07-09
申请号：EP05742151
申请日：2005-05-19
申请人： MELBOURNE HEALTH , MURDOCH CHILDRENS RES INST
发明人： LOCARNINI STEPHEN , VISVANATHAN KUMAR
IPC分类号： C12N7/00 , A61K38/00 , A61K38/16 , A61K39/00 , C07K14/02 , C12N15/12 , C12N15/51 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/706 , A61K38/162 , A61K39/00 , C07K14/005 , C12N2730/10122 , C12Q2600/158

5. 发明公开

EP1354055A4 NEOCENTROMERE-BASED MINI-CHROMOSOMES OR ARTIFICIAL CHROMOSOMES 审中-公开
标题翻译： ON NEOZENTROMEREN BASED MINI染色体或人工染色体
公开(公告)号：EP1354055A4
公开(公告)日：2004-07-07
申请号：EP01271443
申请日：2001-12-20
申请人： MURDOCH CHILDRENS RES INST
发明人： CHOO KONG-HONG ANDY , WONG LEE HWA , SAFFERY RICHARD ERIC
IPC分类号： G01N33/53 , A61K31/7088 , A61K48/00 , C12N5/10 , C12N15/09 , C12N15/68 , C12N15/85 , C12Q1/68 , G01N33/566 , C12N15/64 , C12N15/79
CPC分类号： C12N15/68 , A61K48/00 , C12N15/85 , C12N2800/204 , C12N2800/30
摘要： The present invention is directed generally to a defined or isolated nucleic acid molecule encompassing a neocentreomere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic mini-chromosomes and artificial chromosomes including mammalian (e.g. human) and non-mammalian mini-chromosomes and artificial chromosomes. The present invention further provides a telomere-associated chromosome truncation (TACT) approach to develop mini-chromosomes, but is not limited to this approach. It is directed to any truncation approach that produces a neocentromere-containing mini-chromosome, or any transfection approach using cloned or pre-fabricated DNA that provides neocentromere function in the construction of artificial chromosome. Such mini-chromosomes and artificial chromosomes are useful in a range of genetic therapies.

6. 发明公开

EP2723902A4 TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS 审中-公开
标题翻译：治疗和诊断的表观遗传紊乱和疾病
公开(公告)号：EP2723902A4
公开(公告)日：2015-02-18
申请号：EP12803257
申请日：2012-06-22
申请人： MURDOCH CHILDRENS RES INST
发明人： GODLER DAVID EUGENY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/136 , C12Q2600/154 , G06F19/22

7. 发明公开

EP2393351A4 SEX-DETERMINATION AND METHODS OF SPECIFYING SAME 审中-公开
标题翻译：性别遗产的心情和方法INDICATION
公开(公告)号：EP2393351A4
公开(公告)日：2012-09-26
申请号：EP10738167
申请日：2010-02-08
申请人： UNIV MELBOURNE , MURDOCH CHILDRENS RES INST
发明人： SINCLAIR ANDREW , SMITH CRAIG , LOWENTHAL JOHN WILLIAM , MOORE ROBERT JOHN , DORAN TIMOTHY JAMES
IPC分类号： A01K67/02 , A01D19/00 , A01K67/027 , C07K14/465 , C12N15/85
CPC分类号： A01K67/02 , A01K67/0275 , A01K2217/00 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C07K14/465 , C12N15/8509 , C12N2799/027 , G06Q99/00

8. 发明公开

EP1390501A4 DETERMINATION OF A GENETIC PREDISPOSITION FOR BEHAVIOURAL DISORDERS 审中-公开
标题翻译：测定遗传易感性行为障碍
公开(公告)号：EP1390501A4
公开(公告)日：2005-03-30
申请号：EP02719561
申请日：2002-05-03
申请人： MURDOCH CHILDRENS RES INST , DELATYCKI MARTIN
发明人： WILLIAMSON ROBERT , DAHL HANS-HENRIK , FORREST SUSAN MARY , WILCOX STEPHEN ANDREW , DE SILVA MICHELLE GINA , ELLIOTT KATHERINE SEYMOUR , LYNCH MICHAEL
IPC分类号： C07K14/47 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/705 , C07K14/47 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2800/305
摘要： A molecular marker of a behavioural disorder, including Attention Deficit Hyperactivity Disorder (ADHD) and intellectual disorders and its use in the diagnosis of a behavioural disorder or an assessment of a likelihood that a subject may develop the behavioural disorder. The molecular marker may be in the form of a proteinaceous molecule or a genetic sequence.

9. 发明公开

EP1354059A4 METHOD FOR DETECTING WHETHER AN ORGANISM IS HOMOZYGOUS OR HETEROZYGOUS USING LABELLED PRIMERS AND RFLP 有权
标题翻译：检测方法THEREFOR无论是有机体纯合子或杂标有底漆和RFLP
公开(公告)号：EP1354059A4
公开(公告)日：2004-07-07
申请号：EP01271449
申请日：2001-12-20
申请人： MURDOCH CHILDRENS RES INST
发明人： SIEMERING KIRBY
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/44 , C12Q1/68 , G01N33/58 , G01N37/00
CPC分类号： C12Q1/683 , C12Q2565/519 , C12Q2525/131 , C12Q2521/131
摘要： The invention is a method for detecting whether an organism is homozygous or heterozygous in a target nucleotide. The method combines hybridization of two differently labelled probes A and B on either side of a restriction site, restriction endonuclease digestion, and detection of the labels in the resulting digest. If an organism is: homozygous then the labels will be present in the ratio 1:1 or 1:0; or if heterozygous then the labels will be present in the ratio 1:2. Either immobilized array technology or electrophoretic separation may be used.

10. 发明申请

WO0250288A9 NEOCENTROMERE-BASED MINI-CHROMOSOMES OR ARTIFICIAL CHROMOSOMES 审中-公开
标题翻译：基于NEOCENTROMERE的微型色素或人造色素
公开(公告)号：WO0250288A9
公开(公告)日：2003-08-07
申请号：PCT/AU0101644
申请日：2001-12-20
申请人： MURDOCH CHILDRENS RES INST , CHOO KONG-HONG ANDY , WONG LEE HWA , SAFFERY RICHARD ERIC
发明人： CHOO KONG-HONG ANDY , WONG LEE HWA , SAFFERY RICHARD ERIC
IPC分类号： G01N33/53 , A61K31/7088 , A61K48/00 , C12N5/10 , C12N15/09 , C12N15/68 , C12N15/85 , C12Q1/68 , G01N33/566 , C12N15/64 , C12N15/79 , C12N15/81 , C12N15/82
CPC分类号： C12N15/68 , A61K48/00 , C12N15/85 , C12N2800/204 , C12N2800/30
摘要： The present invention is directed generally to a defined or isolated nucleic acid molecule encompassing a neocentreomere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic mini-chromosomes and artificial chromosomes including mammalian (e.g. human) and non-mammalian mini-chromosomes and artificial chromosomes. The present invention further provides a telomere-associated chromosome truncation (TACT) approach to develop mini-chromosomes, but is not limited to this approach. It is directed to any truncation approach that produces a neocentromere-containing mini-chromosome, or any transfection approach using cloned or pre-fabricated DNA that provides neocentromere function in the construction of artificial chromosome. Such mini-chromosomes and artificial chromosomes are useful in a range of genetic therapies.
摘要翻译：本发明一般涉及包含新中间体或其功能衍生物或其潜在的，合成的或杂交形式的限定或分离的核酸分子，其特别地用于开发一系列真核细小染色体和包括哺乳动物的人造染色体（例如人类）和非哺乳动物微型染色体和人造染色体。本发明还提供了端粒相关染色体截短（TACT）方法来开发微型染色体，但不限于此。它涉及产生含有新中心体的微型染色体的任何截短方法，或使用在人造染色体构建中提供新中心体功能的克隆或预先制备的DNA的任何转染方法。这种微型染色体和人造染色体可用于一系列遗传疗法。

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