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1. 发明专利

JPH08224303A PLASTIC SYRINGE IN WHICH CONTRAST MEDIA IS ALREADY FILLED AND STERILIZED,AND ITS MANUFACTURE 失效
公开(公告)号：JPH08224303A
公开(公告)日：1996-09-03
申请号：JP33661695
申请日：1995-12-25
申请人： MALLINCKRODT MEDICAL INC
发明人： REIMONDO DABURIYU JIYAAGENZU J , RICHIYAADO JII JIYONSON , REROI AARU NATSUDORAA
IPC分类号： A61L2/06 , A61L2/07 , A61M5/178 , A61M5/28 , B65B3/00
摘要： PROBLEM TO BE SOLVED: To provide a pre filled, sterile, especially sterilized at the last process, plastic syringe by autoclaving it, keeping both outside and inside pressure of assembled and sealed syringe equal. SOLUTION: After removing foreign substances and pollutant from the top end seal 26 of plastic injector 20 and its piston, pollutant on the top end seal 26 and piston is destroyed. Top seal 26, position, and barrel 22 are given lubricant. Seal 26 is assembled into nozzle 24 of barrel 22, fluid substance is poured from open end into barrel 22. A piston is assembled into open end 28 to seal injector and its content. Assembled injector and its content are autoclave, keeping both outside and inside pressure equal.

2. 发明专利

JPH09135900A ALREADY FILLED STERILIZED PLASTIC SYRINGE 失效
公开(公告)号：JPH09135900A
公开(公告)日：1997-05-27
申请号：JP33661295
申请日：1995-12-25
申请人： MALLINCKRODT MEDICAL INC
发明人： REIMONDO DABURIYU JIYAAGENZU J , RICHIYAADO JII JIYONSON , REROI AARU NATSUDORAA
IPC分类号： A61L2/06 , A61L2/07 , A61M5/178 , A61M5/28 , B65B3/00
摘要： PROBLEM TO BE SOLVED: To sterilize a syringe without straining the syringe together with the content of the syringe by autoclaving the syringe, of which a barrel is filled with a desiring amount of a liquid substance and which is sealed by assembling a piston, while keeping the pressure of the outside of syringe at the same level as the pressure of the syringe content. SOLUTION: After treatment with silicone, a tip seal 26 is attached to a nozzle 24 of a barrel 22. After the empty barrel 22 is purged with nitrogen, the barrel is filled with the content 34. Successively, a piston 32 is attached to an open upper end 28 of the barrel 22 to seal the content 34 is the syringe. After that, the resultant syringe is sent for autoclaving. The syringe and the content 34 are heated and sterilized under pressure in an autoclave in which steam and air are mixed. At this time, in order to avoid strain of the barrel 22, if necessary, compressed air is selectively added as to keep the pressure in the autoclave, in other words, the pressure to the outer surface of the filled syringe, at almost same level as the pressure of the content 34.

3. 发明专利

JPH08224302A ALREADY FILLED AND STERILIZED PLASTIC SYRINGE 失效
公开(公告)号：JPH08224302A
公开(公告)日：1996-09-03
申请号：JP33661995
申请日：1995-12-25
申请人： MALLINCKRODT MEDICAL INC
发明人： REIMONDO DABURIYU JIYAAGENZU J , RICHIYAADO JII JIYONSON , REROI AARU NATSUDORAA
IPC分类号： A61L2/06 , A61L2/07 , A61M5/178 , A61M5/28 , B65B3/00
摘要： PROBLEM TO BE SOLVED: To provide a pre-filled sterile, especially sterilized at least process, plastic syringe by autoclaving it, keeping both outside and inside pressure of assembled and sealed syringe equal. SOLUTION: After removing foreign substances and pollutant from the top end seal 26 of plastic syringe 20 and its piston, pollutant on the top end seal 26 and the piston is destroyed. Foreign substance and exothermic substance is removed from a barrel 22 by washing the barrel 22. Top seal 26, piston, and the barrel 22 are given lubricant. Seal 26 is assembled into nozzle 24 of the barrel 22, and fluid substance is poured from open end into barrel 22. A piston is assembled into open end 28 to seal injector and its content. Assembled syringe and its content are autoclaved, keeping both outside and inside pressure of the syringe equal.

4. 发明专利

JP2007007436A Hot-keeping blanket which is used in pediatrics 审中-公开
标题翻译：用于保健的热保护用品
公开(公告)号：JP2007007436A
公开(公告)日：2007-01-18
申请号：JP2006243176
申请日：2006-09-07
申请人： Mallinckrodt Medical Inc , マリンクロット・メディカル・インコーポレイテッド
发明人： KAPPEL THOMAS F , CHIVETTA DENNIS S , DICKERHOFF SCOTT D , METZLER PHILIP M
IPC分类号： A61F7/00 , A61F7/08 , A47G9/02 , A61B19/00 , A61F7/02
CPC分类号： A61F7/0097 , A61B90/04 , A61B2090/049 , A61F2007/006 , A61F2007/0282
摘要： PROBLEM TO BE SOLVED: To provide a blanket for a forcible hot air convection method which can be used especially for pediatric patients. SOLUTION: This blanket (10) which is used by the forcible air convection method is made into a size which is suitable for pediatric patients. The blanket (10) can be used on the upper side and the lower side of a patient, and thus, the use in an operation room or the use outside of the operation room becomes easier. Also, the blanket (10) which is used by the forcible air convection method has non-combustibility and laser-proof property. In addition, a method to prevent the body temperature from coming down and rising, and a method to manufacture the blanket which is used by the forcible air convection method are provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供可用于儿科患者的强制热空气对流方法的毯子。
解决方案：将强制空气对流方法使用的毯子（10）制成适合儿科患者的尺寸。毯子（10）可以在患者的上侧和下侧使用，因此，在手术室中的使用或手术室外的使用变得更容易。此外，由强制空气对流方法使用的毯子（10）具有不燃烧性和耐
激光性。此外，还提供了一种防止体温下降和升高的方法，以及制造通过强制空气对流方法使用的毯子的方法。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JPH08511765A 失效
公开(公告)号：JPH08511765A
公开(公告)日：1996-12-10
申请号：JP50941194
申请日：1993-10-04
申请人： MALLINCKRODT MEDICAL INC , UNIV MICHIGAN
IPC分类号： A61K51/00 , A61K51/08

6. 发明专利

JPH0634827B2 失效
公开(公告)号：JPH0634827B2
公开(公告)日：1994-05-11
申请号：JP29684586
申请日：1986-12-15
申请人： MALLINCKRODT MEDICAL INC
发明人： REIMONDO DABURYU JAAGENZU JUNI , RICHAADO JII JONSON , REROI AARU NATSUDORAA
IPC分类号： A61L2/06 , A61L2/07 , A61M5/178 , A61M5/28 , B65B3/00

7. 发明专利

JPH0920785A NONIONIC PARAMAGNETIC ION COMPLEX AND COMPLEXING AGENT FOR FORMING THE SAME 失效
公开(公告)号：JPH0920785A
公开(公告)日：1997-01-21
申请号：JP19711695
申请日：1995-07-11
申请人： MALLINCKRODT MEDICAL INC
发明人： ROBAATO UORUTAA UEEBAA , MASUNEIDAA PII PERIAZAMII
IPC分类号： A61K49/00 , A61K49/06 , C07C237/06 , C07C237/08 , C07C239/20 , C07F5/00 , C07F7/28 , C07F9/00 , C07F11/00 , C07F13/00 , C07F15/02 , C07F15/04 , C07F15/06 , C09K3/00 , G01N24/00 , G01R33/28

8. 发明申请

WO1997042978A1 'DELTA'1,2BICYCLO[4,4,0] FUNCTIONAL DYES FOR CONTRAST ENHANCEMENT IN OPTICAL IMAGING 审中-公开
标题翻译： DELTA <1,2> BICYCLO [4,4,0]功能对比度增强光学成像
公开(公告)号：WO1997042978A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008385
申请日：1997-05-09
申请人： MALLINCKRODT MEDICAL, INC.
发明人： MALLINCKRODT MEDICAL, INC. , FUNG, Ella, Y. , RAJAGOPALAN, Raghavan
IPC分类号： A61K49/00
CPC分类号： A61K49/0032
摘要： This invention provides functional dyes of general formula (1) wherein R , R , and R may be the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R )(R ) wherein R and R are independently hydrogen or C1-C10 alkyl, C1-C10 acyl, and R and R are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR , or -S-; R and R may be the same or different and are selected from the group consisting of C1-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercaptoalkyl and -(CH2)m-N(R )(R ); W and W may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR and C(R )(R ); and m is about 0-10; R is hydrogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R )(R ); R and R are independently hydrogen, C1-C10 alkyl, C1-C10 alkoxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 carboxyalkyl, C1-C10 alkoxycarbonyl, and -(CH2)m-N(R )(R ); and A or B may be the same or different and are selected from the group consisting of -(CH2)m, -C(R )(R ), -(CH2)m-N(R )(R ), -O-, -S-, or -NR .
摘要翻译：本发明提供通式（1）的功能性染料，其中R 1，R 2和R 5可以相同或不同，并且选自氢，C1-C10烷基，C1- C10烷氧基，羟基，C1-C10羟基烷基，C1-C10烷氧基烷基，C1-C10芳基，羧基，C1-C10羧基烷基，卤素，硝基，C1-C10烷氧基羰基，巯基，C1-C10巯基烷基，C1-C10烷硫基，和 - （CH 2）m N（R 6）（R 7）（R 7）其中R 6和R 7独立地是氢或C 1 -C 10烷基，C 1 -C 10酰基和R 6， 7>能够形成可以任选被-O-，-NR 8或-S-取代的5,6或7元环; R 3和R 4可以相同或不同，并且选自C1-C10烷基，C1-C10羟基烷基，C1-C10烷氧基烷基，C1-C10芳基，C1-C10羧基烷基，C1- C10烷基磺酸酯，巯基烷基和 - （CH 2）m N（R 6）（R 7）; W 1和W 2可以相同或不同，并且选自-S-，-O-，-Se - ， - Te-，-NR 8和C（R 9） >）（R <10>）; m为约0-10; R 8是氢，C 1 -C 10烷基，C 1 -C 10烷氧基，C 1 -C 10巯基烷基，羟基，C 1 -C 10羟基烷基，C 1 -C 10烷氧基烷基，C 1 -C 10芳基，C 1 -C 10羧烷基，C 1 -C 10烷氧基羰基，C 1 -C 10烷硫基和 - （CH 2）m N（R 6）（R 7）; R 9和R 10独立地是氢，C 1 -C 10烷基，C 1 -C 10烷氧基，C 1 -C 10羟基烷基，C 1 -C 10烷氧基烷基，C 1 -C 10羧基烷基，C 1 -C 10烷氧基羰基和 - （CH 2）m N [R <6>）（R <7>）; 并且A或B可以相同或不同，并且选自 - （CH 2）m，-C（R 9）（R 10）， - （CH 2）m N（R 6）（R 7），-O-，-S-或-NR 8。

9. 发明申请

WO1997037702A1 BRONCHOASPIRATION TUBE HAVING SOFT AND HARD PORTIONS 审中-公开
标题翻译：具有软硬件的BRONCHOASPIRATION管
公开(公告)号：WO1997037702A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005686
申请日：1997-04-04
申请人： MALLINCKRODT MEDICAL, INC. , GIBERTONI, Lucio , BERGAMASCHI, Paolo
发明人： MALLINCKRODT MEDICAL, INC.
IPC分类号： A61M05/00
CPC分类号： A61M25/0054 , A61M16/0463 , A61M25/0009 , A61M2025/0081
摘要： A Bronchoaspiration tube for removing secretions from the tracheal tubes and from the upper portion of the respiratory tract, including a tubular element (1) provided with at least two portions or regions (2, 3) having different hardness values.
摘要翻译：一种用于从气管和从呼吸道上部除去分泌物的支气管吸管，包括设置有具有不同硬度值的至少两个部分或区域（2,3）的管状元件（1）。

10. 发明申请

WO1996040292A1 A METHOD FOR PREPARING RADIOLABELED PEPTIDES 审中-公开
标题翻译：一种制备放射性肽的方法
公开(公告)号：WO1996040292A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009706
申请日：1996-06-07
申请人： MALLINCKRODT MEDICAL, INC.
发明人： MALLINCKRODT MEDICAL, INC. , SRINIVASAN, Ananthachari
IPC分类号： A61K51/00
CPC分类号： A61K51/088 , A61K51/083 , C07C227/18 , Y02P20/55 , C07C229/16 , C07C229/24
摘要： A method for radiolabelling peptides using polyaminocarboxylate ligands having suitable protecting groups such that they can be added to peptides by standard solid phase or solution phase peptide synthetic chemistry and can be deprotected using standard cleavage/deprotection reagents and produce the peptide/chelate conjugate as a high purity monoaddition product is provided. The cleaved and deprotected ligand-peptide molecules can then be labeled with lanthanide or actinide radionuclides. The protected polyaminocarboxylate ligands form mono-anhydrides or mono-active esters under solid phase or solution phase conditions and permit only the desired monoaddition chelate-peptide conjugate to be formed.
摘要翻译：使用具有合适的保护基的聚氨基羧酸盐配体放射性标记肽的方法，使得它们可以通过标准固相或溶液相肽合成化学物质加入到肽中，并且可以使用标准的切割/去保护试剂去保护，并产生高/低的肽/螯合物缀合物提供纯度单加成产物。然后可以用镧系元素或锕系元素放射性核素标记裂解和去保护的配体 - 肽分子。保护的多氨基羧酸盐配体在固相或溶液相条件下形成单酸酐或单官能酯，并且仅允许形成所需的单加成螯合物 - 肽缀合物。

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