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1. 发明专利

CA2645488C FORMULATIONS COMPRISING RAPAMYCIN AND METHODS USING SAME FOR VASCULAR PERMEABILITY-RELATED DISEASES OR CONDITIONS 未知
公开(公告)号：CA2645488C
公开(公告)日：2014-09-02
申请号：CA2645488
申请日：2007-03-23
申请人： MACUSIGHT INC
发明人： KLEINMAN DAVID M , NIVAGGIOLI THIERRY , GERRITSEN MARY , WEBER DAVID A
IPC分类号： A61K31/436 , A61P7/10 , A61P9/10 , A61P11/00 , A61P27/02 , A61P31/16 , A61P43/00
摘要： Described herein are formulations, methods and uses of a therapeutic agent in the preparation of a formulation for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability. The formulation may comprise the therapeutic agent rapamycin or a pharmaceutically acceptable salt thereof. The disease or condition is selected from the group consisting of neuroretinitis, vasculitis, toxic metabolic brain edema, hemangiomas, von Hippel Lindau disease, angioneurotic edema, snake bite, high altitude cerebral edema (HACE), high altitude pulmonary edema (HAPE), hyponatremic brain edema, corneal edema, congestive heart failure, pulmonary edema, acute respiratory distress syndrome (ARDS), pemphigous, tuberous sclerosis, scleritis, blepharitis, and exudative retinal detachment.

2. 发明申请

WO2007112052A3 FORMULATIONS AND METHODS FOR VASCULAR PERMEABILITY-RELATED DISEASES OR CONDITIONS 审中-公开
标题翻译：用于血管渗透性相关疾病或病症的制剂和方法
公开(公告)号：WO2007112052A3
公开(公告)日：2008-04-03
申请号：PCT/US2007007353
申请日：2007-03-23
申请人： MACUSIGHT INC , KLEINMAN DAVID M , NIVAGGIOLI THIERRY , GERRITSEN MARY , WEBER DAVID A
发明人： KLEINMAN DAVID M , NIVAGGIOLI THIERRY , GERRITSEN MARY , WEBER DAVID A
IPC分类号： A61K31/436 , A61P7/10 , A61P9/10 , A61P11/00 , A61P27/02 , A61P31/16 , A61P43/00
CPC分类号： A61K31/436 , A61K47/10
摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
摘要翻译：本文描述了用于治疗，抑制，预防，延迟发作或引起与血管通透性有关的疾病或病症消退的制剂和方法。

3. 发明申请

WO2007092620A3 STABLE FORMULATIONS, AND METHODS OF THEIR PREPARATION AND USE 审中-公开
标题翻译：稳定的制剂及其制备和使用方法
公开(公告)号：WO2007092620A3
公开(公告)日：2009-03-26
申请号：PCT/US2007003573
申请日：2007-02-09
申请人： MACUSIGHT INC , MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , TAKHAR SUDEEP KAUR
发明人： MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , TAKHAR SUDEEP KAUR
IPC分类号： A61K9/00 , A61K9/08 , A61K31/445 , A61K45/00 , A61P27/02 , B01D19/00 , B01F3/04
CPC分类号： A61K31/436 , A61K31/445 , A61K31/4745 , A61K33/00 , A61K45/06 , B01F13/02
摘要： Described herein are formulations comprising therapeutic agents, including but not limited to formulations comprising rapamycin, pharmaceutical formulations, unit dose forms, kits, methods of preparing formulations, and methods of using formulations. Such formulations and methods have increased stability.
摘要翻译：本文描述的是包含治疗剂的制剂，包括但不限于包含雷帕霉素的制剂，药物制剂，单位剂量形式，试剂盒，制剂的制备方法和使用制剂的方法。这些制剂和方法具有增加的稳定性。

4. 发明申请

WO2007092620A2 STABLE FORMULATIONS, AND METHODS OF THEIR PREPARATION AND USE 审中-公开
标题翻译：稳定的制剂及其制备和使用方法
公开(公告)号：WO2007092620A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003573
申请日：2007-02-09
申请人： MACUSIGHT, INC. , MUDUMBA, Sreenivasu , NIVAGGIOLI, Thierry , TAKHAR, Sudeep, Kaur
发明人： MUDUMBA, Sreenivasu , NIVAGGIOLI, Thierry , TAKHAR, Sudeep, Kaur
CPC分类号： A61K31/436 , A61K31/445 , A61K31/4745 , A61K33/00 , A61K45/06 , B01F13/02
摘要： Described herein are formulations comprising therapeutic agents, including but not limited to formulations comprising rapamycin, pharmaceutical formulations, unit dose forms, kits, methods of preparing formulations, and methods of using formulations. Such formulations and methods have increased stability.
摘要翻译：本文描述的是包含治疗剂的制剂，包括但不限于包含雷帕霉素的制剂，药物制剂，单位剂量形式，试剂盒，制剂的制备方法和使用制剂的方法。这些制剂和方法具有增加的稳定性。

5. 发明专利

BRPI0608152A2 未知
公开(公告)号：BRPI0608152A2
公开(公告)日：2009-11-10
申请号：BRPI0608152
申请日：2006-02-09
申请人： MACUSIGHT INC
发明人： DOR PHILIPPE JM , MUDUMBA SREENIVASU , WEBER DAVID A , NIVAGGIOLI THIERRY
IPC分类号： A61K31/44
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.

6. 发明专利

CA2635797A1 STABLE FORMULATIONS, AND METHODS OF THEIR PREPARATION AND USE 未知
公开(公告)号：CA2635797A1
公开(公告)日：2007-08-16
申请号：CA2635797
申请日：2007-02-09
申请人： MACUSIGHT INC
发明人： MUDUMBA SREENIVASU , TAKHAR SUDEEP KAUR , NIVAGGIOLI THIERRY
IPC分类号： A61K31/436 , A61K9/08 , A61K45/00 , A61K47/34 , A61P27/02
摘要： Described herein are formulations comprising therapeutic agents, including but not limited to formulations comprising rapamycin, pharmaceutical formulations, unit dose forms, kits, methods of preparing formulations, and methods of using formulations. Such formulations and methods have increased stability.

7. 发明专利

AU2004274026A1 Transscleral delivery 未知
公开(公告)号：AU2004274026A1
公开(公告)日：2005-03-31
申请号：AU2004274026
申请日：2004-09-20
申请人： MACUSIGHT INC
发明人： MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , COOPER EUGENE R , KLEINMAN DAVID M , DOR PHILIPPE JM
IPC分类号： A61K31/436 , A61K9/00
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.

8. 发明专利

BRPI0607606B1 formulação líquida 未知
公开(公告)号：BRPI0607606B1
公开(公告)日：2021-06-22
申请号：BRPI0607606
申请日：2006-02-09
申请人： MACUSIGHT INC , SANTEN PHARMA CO LTD
发明人： DAVID A WEBER , PHILIPPE JM DOR , SIDIQ MOHAMMED FAROOQ , SREENIVASU MUDUMBA , THIERRY NIVAGGIOLI
IPC分类号： A61K31/44
摘要： formulações líquidas para tratamento de doenças ou condições. doenças e condições associadas aos tecidos do corpo, incluindo, sem limitação, tecidos no olho, podem ser eficazmente tratadas, evitadas, inibidas, terem seu início retardado ou a regressão causada por administração de agentes terapêuticos àqueles tecidos. são aqui descritas formulações líquidas que liberam diversos agentes terapêuticos, incluindo, sem limitação, rapamicina, a um indivíduo por um período de tempo prolongado; formulações líquidas que formam uma massa não dispersa quando colocadas em um meio aquoso de um indivíduo; formulações líquidas de formação de massa não dispersa que formam um gel ou uma substância semelhante a um gel em um meio aquoso; formulações liquidas que compreendem um agente terapêutico e vários polímeros; e métodos para liberação de agentes terapêuticos a um indivíduo por um período de tempo prolongado usando as formulações liquidas. a formulação líquida pode ser colocada em um meio aquoso de um indivíduo, incluindo, sem limitação, por meio de administração intra-ocular ou periocular, ou colocação próxima a um local de uma doença ou condição a ser tratada em um indivíduo. o método pode ser usado para administrar rapamicina para o tratamento ou prevenção de angiogênese, neovascularização coroidiana ou degeneração macular relacionada à idade, ou degeneração macular relacionada à idade na forma úmida em um indivíduo. as formulações líquidas podem compreender rapamicina ou outros agentes terapêuticos.

9. 发明专利

CA2597596C LIQUID FORMULATIONS OF RAPAMYCIN FOR INTRAOCULAR DELIVERY 未知
公开(公告)号：CA2597596C
公开(公告)日：2014-09-09
申请号：CA2597596
申请日：2006-02-09
申请人： MACUSIGHT INC
发明人： MUDUMBA SREENIVASU , DOR PHILIPPE J M , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ MOHAMMED
IPC分类号： A61K31/44
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non- dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.

10. 发明专利

BRPI0609432A2 未知
公开(公告)号：BRPI0609432A2
公开(公告)日：2010-04-06
申请号：BRPI0609432
申请日：2006-03-21
申请人： MACUSIGHT INC
发明人： MUDUMBA SREENIVASU , DOR PHILIPPE J M , WEBER DAVID A , FAROOQ SIDIQ MOHAMMED , NIVAGGIOLI THIERRY
IPC分类号： A61K31/436 , A61K9/00 , A61P27/02
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are solid drug delivery systems and methods for providing extended delivery of therapeutic agents to such tissues. A solid drug delivery system may be placed in a subject, including but not limited to placement between the sclera and the conjunctiva or transscleral placement. Described methods may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, age-related macular degeneration, or wet age-related macular degeneration in a subject. The solid drug delivery devices may comprise rapamycin or other therapeutic agents. Also described are methods of treating ocular diseases or disorders by administering an antiproliferative agent, including but not limited to rapamycin, proximal to an ocular device.

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