专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

KR810001701B1 PROCESS FOR THE PREPARATION OF N-ALKYL ARYLAMINES 失效
公开(公告)号：KR810001701B1
公开(公告)日：1981-10-27
申请号：KR790002163
申请日：1979-06-30
申请人： LONZA AG
发明人： BERGAMIN R
IPC分类号： C07B61/00 , B01J23/00 , C07C67/00 , C07C209/00 , C07C209/18 , C07C211/48 , C07C85/06
摘要： N-alkylarylamines were prepd. by gas-phase reaction of arylamines with alkanols in a molar ratio of 0.5:1-20 at 180-450≦̸C over Cu on silicate. Thus, 29.4 wt. parts 1:1 MeOH-Ph-NH2 was pumped over Cu/silicate in a solid bed reactor at 25≦̸C and 42 sec contact time to give PhNHMe 21.4, PhNMe2 0.2, PhNH2 3, and MeOH 0.2 wt. parts, corresponding to 86% PhNH2 conversion and 97.7 % yield.

2. 发明专利

JP2010106025A Process for preparation of (1s, 4r)-or (1r, 4s)-4-(2-amino-6-chloro-9h-purine-9-yl)-2-cyclopentene-1-methanol 审中-公开
标题翻译：（1S，4R）-OR（1R，4S）-4-（2-氨基-6-氯-L9-嘌呤-9-基）-2-环戊烯-1-甲醇的制备方法
公开(公告)号：JP2010106025A
公开(公告)日：2010-05-13
申请号：JP2009256399
申请日：2009-11-09
申请人： Lonza Ag , ロンザリミテッドLonza Limited
发明人： BERNEGGER CHRISTINE DR , URBAN EVA-MARIA , BIRCH OLWEN MARY DR , BURGDORF KURT , BRUX FRANK , ETTER KAY-SARA , BOSSARD PIERRE DR , BRIEDEN WALTER DR , DUC LAURENT DR , GORDON JOHN , O'MURCHU COLM DR , GUGGISBERG YVES DR
IPC分类号： C07C231/18 , C12P41/00 , C07B53/00 , C07C231/20 , C07C233/23 , C07C271/24 , C07D209/94 , C07D233/04 , C07D233/74 , C07D235/02 , C07D237/06 , C07D239/70 , C07D473/32 , C07D473/40 , C12N1/20 , C12P13/00 , C12P13/02 , C12P17/18 , C12R1/01 , C12R1/05 , C12R1/06 , C12R1/09 , C12R1/19 , C12R1/38
CPC分类号： C07C231/18 , C07B2200/07 , C07C233/23 , C07C271/24 , C07C2601/10 , C07D209/94 , C12P13/001 , C12P13/02 , C12P17/182
摘要： PROBLEM TO BE SOLVED: To provide a process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative useful for a medicinal intermediate.
SOLUTION: The process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative (XIII) represented by formula XIII includes the first stage wherein one of a racemic substance or an optically active isomer of 4-amino-2-cyclopentene carboxylic acid is acylated with a carboxylic acid halide to prepare a 4-acylamino-2-cyclopentene carboxylic acid derivative and the second stage wherein the acylamino-2-cyclopentene carboxylic acid derivative is reduced. In the formula, R
1 is 1-4C alkyl, etc.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供制备用于药用中间体的4-（羟甲基）-2-环戊烯衍生物的方法。解决方案：由式XIII表示的4-（羟甲基）-2-环戊烯衍生物（XIII）的制备方法包括第一阶段，其中外消旋物质或4-氨基-2- 环戊烯羧酸用羧酸卤化物酰化以制备4-酰氨基-2-环戊烯羧酸衍生物，其中酰基氨基-2-环戊烯羧酸衍生物被还原的第二阶段。在该式中，R 1 是1-4C烷基等。权利要求：（C）2010，JPO＆INPIT

3. 发明专利

JP2004000283A Biotechnological method for producing biotin 有权
公开(公告)号：JP2004000283A
公开(公告)日：2004-01-08
申请号：JP2003312645
申请日：2003-09-04
申请人： Lonza Ag , ロンザア−ゲ−
发明人： BIRCH OLWEN , BRASS JOHANN , FUHRMANN MARTIN , SHAW NICHOLAS
IPC分类号： C12N15/09 , C07K14/195 , C12N1/21 , C12N9/00 , C12N15/52 , C12N15/67 , C12P17/18 , C12P21/02 , C12R1/19
CPC分类号： C12P17/186 , C12N15/52 , C12N15/67
摘要： PROBLEM TO BE SOLVED: To provide a biotechnological method for producing biotin having high yield of biotin and being economical consequently. SOLUTION: The invention relates to a DNA fragment including genes bioB, bioF, bioC, bioD and bioA for biotechnological synthesis of the biotin obtained from Enterobacter or genetic variants functionally equal to the genes and mutants. The invention relates to a DNA fragment that these genes are arranged in the same transcriptional direction in the transcription unit. The invention also relates to microorganisms including these DNA fragments and plasmids, and a method for producing the biotin by using these microorganisms. COPYRIGHT: (C)2004,JPO

4. 发明专利

JPH11246444A PRODUCTION OF ETHYNYLCYCLOPROPANE 失效
公开(公告)号：JPH11246444A
公开(公告)日：1999-09-14
申请号：JP34479298
申请日：1998-12-04
申请人： LONZA AG
发明人： MICHEL DOMINIQUE DR , HANSELMANN PAUL
IPC分类号： B01J21/04 , C07B61/00 , C07C1/20 , C07C1/22 , C07C13/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject ethynylcyclopropane by subjecting 1,1-di(methoxyethyl)cyclopropane to the two-stage demethanolation reaction in no need of the low-temperature reactions with almost no occurrence of waste product. SOLUTION: In the first stage, methanol is removed from (1,1-di(methoxyethyl) cyclopropane of formula I to prepare (1-methoxyethenyl)cyclopropane of formula II. In the second stage, methanol is removed from the compound of formula II again to give the objective compound of formula III. In a preferred embodiment, the fist stage reaction is carried out in the presence of a heterogenous catalyst. This heterogenous catalyst is preferably a neutral aluminum oxide that is commercially available for the purpose of chromatography. The second stage is carried out in the presence of 2 equivalent amount of strong base. The strong base is preferably an alkyl lithium such as n-butyl lithium.

5. 发明专利

JPH10114743A PRODUCTION OF 1-ACYL-4-ARYLPIPERIDINE 失效
公开(公告)号：JPH10114743A
公开(公告)日：1998-05-06
申请号：JP24732397
申请日：1997-09-11
申请人： LONZA AG
发明人： BRIEDEN WALTER DR , LOETSCHER DIDIER , NAUGHTON ANDREW DR
IPC分类号： C07D211/02 , B01J27/08 , B01J31/24 , C07B61/00 , C07D211/20 , C07D211/82
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound which is an intermediate for synthesizing a pharmaceutically active component by reacting an aryl magnesium halide, a very inexpensive starting material, in the presence of a copper compound with a reaction product obtained through the reaction of pyridine and an acyl halide, and subsequently hydrogenating the reaction product. SOLUTION: An aryl magnesium halide of the formula R MgX (X is Cl, Br or I; R is an aryl, etc.) is made to react in the presence of a copper compound with 1-acylpyridinium halide produced through the reaction between pyridine and an acyl halide of the formula R COX (X is Cl or Br; R is a 1-6C alkyl, a 1-6C alkoxy, an aryl, etc.) to obtain a 1-acyl-4-aryl 1,4- dihydropyridine of formula I. Subsequently, the compound of formula I is hydrogenated in the presence of a homogeneous catalyst to obtain a 1-acyl-4- arylpyridine of formula II.

6. 发明专利

JPH1045726A PRODUCTION OF OPTICALLY ACTIVE PIPERAZINE-2-CARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JPH1045726A
公开(公告)日：1998-02-17
申请号：JP9926297
申请日：1997-04-16
申请人： LONZA AG
发明人： FUCHS RUDOLF
IPC分类号： B01J31/24 , C07B61/00 , C07D241/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for a substance having pharmacological activities by asymmetrically hydrogenating a corresponding pyrazinecarboxylic acid derivative. SOLUTION: A pyrazinecarboxylic acid derivative of formula II (X is hydroxyl, a 1-6C alkoxy or a group of the formula NR R ; R and R are each H, a 1-6C alkyl, a 3-6C cycloalkyl, an aryl, an amino-protecting group; R and R form a saturated hetero ring with a nitrogen atom) is asymmetrically hydrogenated in the presence of an optical active rhodium complex to give the objective compound of formula I. The rhodium complex compound is obtained by reacting RH(I) complex with optically active metallocenylphosphine. The compound of formula I is useful as a synthetic intermediate for a HIV protease inhibitor. The compound of formula I is obtained without requiring an expensive reagent since optical resolution of a racemic compound is not carried out.

7. 发明专利

JPH107655A PRODUCTION OF ARYLAMIDE OF HETEROCYCLIC AROMATIC CARBOXYLIC ACID 失效
公开(公告)号：JPH107655A
公开(公告)日：1998-01-13
申请号：JP6135897
申请日：1997-03-14
申请人： LONZA AG
发明人： RODUIT JEAN-PAUL , KALBERMATTEN GEORGES
IPC分类号： C07D241/18 , B01J31/22 , B01J31/24 , C07B61/00 , C07D213/56 , C07D213/643 , C07D213/81 , C07D239/26 , C07D239/28 , C07D241/24 , C07D251/24
摘要： PROBLEM TO BE SOLVED: To obtain an arylamide of heterocyclic aromatic carboxylic acid at a nearly stoichiometric yield from an easily available heterocyclic aromatic halide by its reaction with carbon monoxide and an aromatic amine in the presence of a catalyst and a base. SOLUTION: This arylamide of heterocyclic aromatic carboxylic acid of formula IV is obtained by a reaction of a halide of formula I (A is N or a CR ; A is N or a CR ; A is N or CR ; A is N or CR ; A is N or CR ; R -R are each H, or a 1-4C alkyl or aryl; provided that at least one of A -A is N, and that two nitrogen atoms do not directly combine with each other; X is Cl, Br or I) with CO and an amine of formula II (R is H or a 1-4C alkyl; R is an aromatic group or heterocyclic aromatic group) in the presence of a base and a complex of a diphosphine of formula III (R is H or a 1-4C alkyl; R -R are each a secondary or tertiary 3-6C alkyl, etc.; Y is O, etc.; Q is a bridged organic group, etc.) with palladium. The presence of the above- mentioned complex secures a nearly stoichiometric yield of the product of formula IV.

8. 发明专利

JPH08319278A PRODUCTION OF OPTICALLY ACTIVE PIPERAZINE-2-CARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JPH08319278A
公开(公告)日：1996-12-03
申请号：JP12879296
申请日：1996-05-23
申请人： LONZA AG
发明人： RUDORUFU FUTSUKUSU , JIYANNPOORU RODEYUI
IPC分类号： B01J31/22 , B01J31/28 , C07B53/00 , C07D241/04

9. 发明专利

JPH07215975A PREPARATION OF IMIDAZOPYRIDINE DERIVATIVE 失效
公开(公告)号：JPH07215975A
公开(公告)日：1995-08-15
申请号：JP29755094
申请日：1994-11-30
申请人： LONZA AG
发明人： DEBUIDO ERU KUO , MARUTEIN AIAA , JIYANNPOORU RODEYUI , ARAN BUERITSUHI
IPC分类号： B01J31/04 , C07B61/00 , C07D471/04

10. 发明专利

JPH072791A PREPARATION OF METHYLOLHYDANTION 失效
公开(公告)号：JPH072791A
公开(公告)日：1995-01-06
申请号：JP15603093
申请日：1993-05-21
申请人： LONZA AG
发明人： TOOMASU II FUARINA , DAGURASU EI BAAGU
IPC分类号： C07B61/00 , B01J27/236 , C07D233/72 , C07D233/74 , C07D233/78
摘要： There are provided methods for producing solid anhydrous methylolhydantoins. Initially, an aqueous stirrable medium is dehydrated and heated to yield a substantially anhydrous stirrable melt. The aqueous stirrable medium includes (A) a solute selected from the group consisting of (i) a dimethyloldimethylhydantoin, (ii) a hydantoin reactant, (iii) a formaldehyde source reactant, or (iv) a combination of any of the foregoing; and (B) optionally a catalyst. A molten system is then provided by adding, to the stirrable melt, a reactant mixture which includes (A)(i) the same or a different hydantoin reactant, (ii) a substantially anhydrous formaldehyde source reactant which may be the same as or different than the formaldehyde source reactant, or (iii) a combination thereof; and (B) optionally, the same or a different catalyst; wherein the molten system includes (i) at least one hydantoin reactant and (ii) at least one dehydrated formaldehyde source reactant or substantially anhydrous formaldehyde source reactant. The at least one hydantoin reactant and the at least one dehydrated formaldehyde source reactant or substantially anhydrous formaldehyde source reactant in the molten system are reacted, while reaction water is removed, to yield anhydrous molten methylolhydantoin. Finally, the molten methylolhydantoin is solidified. Alternatively, solid anhydrous methylolhydantoin is produced by reacting, in an aqueous stirrable medium as above, a reactant mixture of (i) the same or a different hydantoin reactant, (ii) a substantially anhydrous formaldehyde source reactant which may be the same as or different than the formaldehyde source reactant, or (ii) a combination thereof and (iv) optionally, the same as or different catalyst; wherein (i) at least one hydantoin reactant and (ii) at least one formaldehyde source reactant or substantially anhydrous formaldehyde reactant is present; while heating to at least the melting temperature of the methylolhydantoin and while removing substantially all water; to yield a molten methylolhydantoin; and subsequently solidifying the molten methylolhydantoin. These methods can be practiced as batch processes or as semi-continuous processes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式