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1. 发明申请

WO2007055578A1 CYCLIC ANTIMICROBIAL PEPTIDES DERIVED FROM LACTOFERRIN 审中-公开
标题翻译：从LACTOFERRIN衍生的循环抗微生物肽
公开(公告)号：WO2007055578A1
公开(公告)日：2007-05-18
申请号：PCT/NL2006/050284
申请日：2006-11-10
申请人： LEIDS UNIVERSITAIR MEDISCH CENTRUM , FEITSMA, Rolf Ide Johannes , NIBBERING, Peter Hendricus , DRIJFHOUT, Jan Wouter
发明人： FEITSMA, Rolf Ide Johannes , NIBBERING, Peter Hendricus , DRIJFHOUT, Jan Wouter
IPC分类号： C07K7/64 , A61K38/12 , A61P31/04
CPC分类号： C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K14/79
摘要： The present invention relates to cyclic compounds, preferably cyclic peptides, that at least comprise a stretch of positively charged amino acids, at some distance thereof an aromatic amino acid. The aromatic amino acid may be immediately followed by an amino acid with a thiol-group in the side chain. The cyclic compounds show a dramatic increase in antimicrobial activity as compared linear versions having the same amino acid sequence, in particular under physiological salt conditions. The cyclic compounds show antimicrobial activity against a broad spectrum of microbes and may be used in both prophylactic and therapeutic methods against infectious diseases.
摘要翻译：本发明涉及环状化合物，优选环状肽，其至少包含一段带正电荷的氨基酸，其一定距离处为芳族氨基酸。芳族氨基酸可以紧接着在侧链中具有硫醇基的氨基酸。与具有相同氨基酸序列的线性形式相比，特别是在生理盐条件下，环状化合物显示出抗微生物活性的显着增加。环状化合物显示对广谱微生物的抗微生物活性，并可用于预防和治疗传染病的方法。

2. 发明申请

WO2020055247A1 ARTERIOVENOUS GRAFT SYSTEM, ARTERIOVENOUS VALVE DEVICE AND METHOD TO IMPLANT AN ARTERIOVENOUS GRAFT SYSTEM 审中-公开
公开(公告)号：WO2020055247A1
公开(公告)日：2020-03-19
申请号：PCT/NL2019/050589
申请日：2019-09-11
申请人： ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM
发明人： GEELHOED, Wouter Jan , VAN DER BOGT, Koen Elzert Adriaan , ROTMANS, Joris Ivo
IPC分类号： A61F2/06 , A61F2/24 , A61M1/36 , A61M39/02 , A61M39/22
摘要： The invention provides a subcutaneous arteriovenous graft system, comprising an arteriovenous graft having an arterial end, a venous end opposite to the arterial end and an internal volume between the arterial end and the venous end, and a valve device that can be arranged in an open state, in which fluid flow through the graft is possible and a closed state in which the fluid flow through the arteriovenous graft is blocked.The valve device is constructed to decrease, in the closed state of the valve device, the internal volume of the complete graft to substantially zero.

3. 发明申请

WO2017135815A1 ANALOGUE TO DIGITAL DATA CONVERTER 审中-公开
标题翻译：模拟数字数据转换器
公开(公告)号：WO2017135815A1
公开(公告)日：2017-08-10
申请号：PCT/NL2017/050061
申请日：2017-02-01
申请人： TECHNISCHE UNIVERSITEIT DELFT , TECHNOLOGIESTICHTING STW , PUBLIEKRECHTELIJK RECHTSPERSOON ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM
发明人： BES, Cees Jeroen , SERDIJN, Wouter Anton , LOTFI, Reza
IPC分类号： H03M1/12 , H03M1/18 , H03M1/14 , H03M1/48 , H03M1/36
CPC分类号： H03M1/1295 , H03M1/145 , H03M1/181 , H03M1/361 , H03M1/48
摘要： Analogue to digital data converter (ADC) (1) comprising an analogue signal input (2) and a digital signal output (3), wherein an analogue amplifier (4) is provided in a signal path (6) from the analogue signal input (2) to the digital signal output (3), and comprising a processor (5) that receivingly connects to the analogue amplifier (4) and forms a feedback loop with said analogue amplifier (4), wherein the processor (5) provides an analogue offset signal that modifies an analogue signal in the signal path (6) from the analogue signal input to the digital signal output (3), wherein both the input signal and the analogue offset signal are provided to the analogue amplifier (4) through separate circuit elements (C1, C3), and the processor (5) comprises control logic (11) for switches (phi1 - phi5) that are arranged to connect a charge-injecting organ, preferably a charged capacitor (C3), to the input (7) of the analogue amplifier (4) so as to provide the analogue off-set signal to the analogue amplifier (4).
摘要翻译：包括模拟信号输入端（2）和数字信号输出端（3）的模数数据转换器（ADC）（1），其中模拟放大器（4）设置在信号路径 6）从模拟信号输入（2）到数字信号输出（3），并且包括接收连接到模拟放大器（4）并与所述模拟放大器（4）形成反馈回路的处理器（5），其中处理器（5）提供模拟偏移信号，该模拟偏移信号从输入到数字信号输出（3）的模拟信号修改信号路径（6）中的模拟信号，其中输入信号和模拟偏移信号都被提供给模拟放大器（4）通过分离的电路元件（C1，C3），并且处理器（5）包括用于开关（ph1-ph5）的控制逻辑（11），其被布置为连接电荷注入器件，优选地为充电电容器 C3）连接到模拟放大器（4）的输入端（7），以提供模拟偏置信号到模拟放大器（4）。

4. 发明授权

US11352389B2 Treatment of haematological malignancies 有权
公开(公告)号：US11352389B2
公开(公告)日：2022-06-07
申请号：US16627230
申请日：2018-06-28
申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)
发明人： Marieke Griffioen , J. H. Frederik Falkenburg
IPC分类号： C07K7/06 , A61P35/02 , A61K35/17 , A61K35/761 , C07K14/47 , C07K14/725 , C12N15/86 , A61K39/00
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM1 positive haematological malignancy. Corresponding methods and uses are also provided.

5. 发明申请

WO2008143506A1 TEST AND CALIBRATION DEVICE 审中-公开
标题翻译：测试和校准设备
公开(公告)号：WO2008143506A1
公开(公告)日：2008-11-27
申请号：PCT/NL2008/050298
申请日：2008-05-21
申请人： PUBLIEKRECHTEIIJKE RECHTSPERSOON ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM , SCHOT, Robert , STERK, Peter Jan , VAN DER PLAS, Dirk Teunis , SLATS, Annelies Margaretha
发明人： SCHOT, Robert , STERK, Peter Jan , VAN DER PLAS, Dirk Teunis , SLATS, Annelies Margaretha
IPC分类号： A61B5/093
CPC分类号： A61B5/085 , A61B5/087
摘要： The invention pertains to a device for testing the lung function in a subject, comprising a pump for providing a gas flow, an actuator for driving said pump, a sensor for determining a flow parameter of said gas flow, and a control unit, operationally coupled to said sensor for receiving at least one flow parameter from said sensor and operationally coupled to said actuator for controlling said actuator, said control unit having a processor and software for calculating a passive inspiration manoeuvre following an active inspiration manoeuvre using said flow parameters.
摘要翻译：本发明涉及一种用于测试受试者的肺功能的装置，包括用于提供气流的泵，用于驱动所述泵的致动器，用于确定所述气流的流量参数的传感器，以及控制单元，到所述传感器，用于从所述传感器接收至少一个流量参数并且可操作地耦合到所述致动器以控制所述致动器，所述控制单元具有处理器和软件，用于使用所述流动参数在主动吸气机动之后计算被动吸气机动。

6. 发明申请

WO2008142521A2 FUNCTIONAL ASSAY TO INVESTIGATE UNCLASSIFIED SEQUENCE VARIANTS OF MISMATCH REPAIR GENES 审中-公开
标题翻译：调查错配维修基因未经排序的序列变量的功能测定
公开(公告)号：WO2008142521A2
公开(公告)日：2008-11-27
申请号：PCT/IB2008/001218
申请日：2008-05-15
申请人： ACADEMISCH ZIEKENHUIS LEIDEN LEIDS UNIVERSITAIR MEDISCH CENTRUM , DE WIND, Niels , DROST, Mark
发明人： DE WIND, Niels , DROST, Mark
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q2525/131 , C12Q2521/514
摘要： The present invention relates to methods of conducting in vitro functional mismatch repair assays, in order to detect whether a mismatch repair gene from a test subject, is incapable of functioning, when the mismatch repair gene comprises a mutation. Such assays are of use in detecting whether or not a subject may be predisposed or have an increased risk of developing cancer, such as hereditary nonpolyposis colorectal cancer (HNPCC).
摘要翻译：本发明涉及当错配修复基因包含突变时进行体外功能性错配修复测定的方法，以便检测来自测试受试者的错配修复基因是否不能起作用。这种测定法可用于检测受试者是否易患或具有发展癌症的风险增加，例如遗传性非息肉性结肠直肠癌（HNPCC）。

7. 发明申请

WO2005007890A2 MEANS AND METHODS FOR DETECTING A RISK OF INFARCTION RELATED TO ATHEROSCLEROSIS 审中-公开
标题翻译：用于检测与ATHEROSCLEROSIS相关的感染风险的手段和方法
公开(公告)号：WO2005007890A2
公开(公告)日：2005-01-27
申请号：PCT/NL2004/000520
申请日：2004-07-21
申请人： ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM , LEIDS UNIVERSITAIR MEDISCH CENTRUM , REITSMA, Pieter, Hendrik , ROSENDAAL, Frits, Richard
发明人： REITSMA, Pieter, Hendrik , ROSENDAAL, Frits, Richard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention provides a method for determining whether a subject is at risk of undergoing an infarction related to atherosclerosis comprising measuring an inflammation parameter in a sample obtained from said subject and determining whether the value of said inflammation parameter is indicative for said risk. Said sample preferably comprises a whole blood sample. More preferably, said inflammation parameter comprises an inflammation parameter of a cell and/or derivative thereof present in said sample, such as the amount of protein and/or RNA present upon and/or within such cells/derivatives. Additionally, an excreted product produced by said cell/derivative may be measured. The invention furthermore provides a method for quantifying at least one target nucleic acid in a sample, comprising incubating said sample with at least one probe capable of annealing to said target nucleic acid, amplifying annealed probes and quantifying said probes, characterized in that said sample comprises a whole blood sample.
摘要翻译：本发明提供了一种用于确定受试者是否处于与动脉粥样硬化相关的梗死的风险的方法，包括测量从所述受试者获得的样品中的炎症参数，并确定所述炎症参数的值是否表示所述风险。所述样品优选包含全血样品。更优选地，所述炎症参数包括存在于所述样品中的细胞和/或其衍生物的炎症参数，例如存在于所述细胞/衍生物之间和/或内的蛋白质和/或RNA的量。此外，可以测量由所述细胞/衍生物产生的排泄物。本发明还提供了一种用于定量样品中的至少一种靶核酸的方法，包括用至少一种能够对所述靶核酸退火的探针孵育所述样品，扩增退火探针和定量所述探针，其特征在于所述样品包含全血样品。

8. 发明申请

WO2019004831A8 TREATMENT OF HAEMATOLOGICAL MALIGNANCIES 审中-公开
公开(公告)号：WO2019004831A8
公开(公告)日：2019-01-03
申请号：PCT/NL2018/050421
申请日：2018-06-28
申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)
发明人： GRIFFIOEN , Marieke , FALKENBURG, J. H. Frederik
IPC分类号： C07K14/725 , C07K14/47 , A61K48/00 , A61K39/00 , A61K2039/5154 , A61K2039/525 , A61K2039/53 , A61K2039/572 , A61K2039/585 , A61K2039/6006 , A61K35/17 , A61K35/761 , A61P35/02 , C07K14/4748 , C07K14/7051 , C07K7/06 , C12N15/86 , C12N2740/10043
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔΝΡΜ 1 positive haematological malignancy. Corresponding methods and uses are also provided.

9. 发明申请

WO2009050573A3 VIRAL MODIFICATION OF REOVIRIDAE 审中-公开
公开(公告)号：WO2009050573A3
公开(公告)日：2009-04-23
申请号：PCT/IB2008/002758
申请日：2008-10-16
申请人： ACADEMISCH ZIEKENHUIS LEIDEN LEIDS UNIVERSITAIR MEDISCH CENTRUM , HOEBEN, Robert, Cornelis , VAN DEN WOLLENBERG, Diana, Johanna, Maria
发明人： HOEBEN, Robert, Cornelis , VAN DEN WOLLENBERG, Diana, Johanna, Maria
IPC分类号： C07K14/14 , A61K35/76 , C12N7/02 , A61K39/15
摘要： The present invention provides a reverse genetics system for viruses belonging to the Reoviridae (i.e. Reoviruses), various uses thereof, genetically modified Reoviruses, Reovirus selection/production and propagation systems, medicaments and vaccines.

10. 发明申请

US20220193258A1 RECOMBINANT AAV-CRUMBS HOMOLOGUE COMPOSITION AND METHODS FOR TREATING LCA-8 AND PROGRESSIVE RP 有权
公开(公告)号：US20220193258A1
公开(公告)日：2022-06-23
申请号：US17558052
申请日：2021-12-21
申请人： Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum
发明人： Jan Wijnholds , Lucie Pierrette Francoise Pellissier
IPC分类号： A61K48/00 , C07K14/47 , C12N15/86 , C12N15/864 , C07K14/705
摘要： The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.

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