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    • 8. 发明授权
    • Nanoscale particles having an iron oxide-containing core enveloped by at least two shells
    • 具有包含至少两个壳的含氧化铁芯的纳米级颗粒
    • US06979466B2
    • 2005-12-27
    • US10391356
    • 2003-03-17
    • Christoph LesniakThomas SchiestelHelmut SchmidtAndreas Jordan
    • Christoph LesniakThomas SchiestelHelmut SchmidtAndreas Jordan
    • A61K9/16A61K41/00A61P35/00A61K9/51
    • A61K41/0052
    • The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.
    • 本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。 所述颗粒包含(优选超顺磁性)含氧化铁的芯和围绕所述芯的至少两个壳。 与核心相邻的(最内侧)壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团 和/或用于将所述核吸收到细胞内部。 外壳由具有中性和/或阴离子基团的物质组成,其允许纳米级颗粒以外面的形式出现在外部,具有中性或负电荷,并且比人或动物组织更快地分解 最内层的壳体,并且在其中露出壳下面,但是仍然足够缓慢,以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。