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1. 发明申请

WO2019175605A1 CHIMERIC FC RECEPTOR BINDING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2019175605A1
公开(公告)日：2019-09-19
申请号：PCT/GB2019/050744
申请日：2019-03-15
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： PLEASS, Richard John , BLUNDELL, Patricia Ann
IPC分类号： C07K16/00 , A61P31/16
摘要： The present invention relates to chimeric proteins, to compositions comprising such proteins and to the medical uses of such proteins and compositions. In particular the proteins or compositions of the invention may be used in the prevention or treatment of autoimmune diseases or inflammatory diseases, or for the prevention or treatment of diseases mediated through binding of sialic acid dependent receptors, or as vaccines or as anti-cancer agents. One aspect of the invention relates to a chimeric Fc receptor binding protein which comprises two chimeric polypeptide chains, wherein each chimeric polypeptide chain comprises an immunoglobulin G heavy chain constant region, a tailpiece region and a hinge region, wherein the amino acid sequence of each polypeptide chain possess a sugar moiety at or close to the N-terminus and a sugar moiety at or close to the C- terminus, and their use in the treatment or prevention of a disease mediated by a pathogen that relies on sialic acid receptors interactions.

2. 发明申请

WO2018134685A3 COMPOUNDS 审中-公开
公开(公告)号：WO2018134685A3
公开(公告)日：2018-07-26
申请号：PCT/IB2018/000216
申请日：2018-01-17
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE , THE UNIVERSITY OF LIVERPOOL , EISAI R&D MANAGEMENT CO., LTD.
发明人： WARD, Stephen A. , TAYLOR, Mark J. , O'NEILL, Paul M. , HONG, Weiqian David , BENAYOUD, Farid
IPC分类号： C07D487/04 , C07D495/04 , A61P31/04 , A61P33/00 , A61K31/517
摘要： The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

3. 发明申请

WO2017103615A1 COMBINATION PRODUCT 审中-公开
标题翻译：组合产品
公开(公告)号：WO2017103615A1
公开(公告)日：2017-06-22
申请号：PCT/GB2016/053972
申请日：2016-12-16
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： BIAGINI, Giancarlo A. , WARD, Stephen A. , NIXON, Gemma L. , O'NEILL, Paul M.
IPC分类号： A61K31/47 , A61K31/4709 , A61P31/06 , A61P31/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K2300/00
摘要： The present invention relates to a combination therapeutic product comprising one or more respiratory electron transport chain inhibitors and a cytochrome bd inhibitor, as defined herein, or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical compositions comprising the combination therapeutic product and to the use of the combination therapeutic product in the treatment of mycobacterial infections, such as tuberculosis.
摘要翻译：本发明涉及包含一种或多种如本文所定义的呼吸电子转运链抑制剂和细胞色素bd抑制剂或其药学上可接受的盐的组合治疗产品。本发明还涉及包含组合治疗产品的药物组合物，以及组合治疗产品在治疗分枝杆菌感染例如结核病中的用途。

4. 发明申请

WO2016112317A1 TREATMENT OF FILARIAL DISEASES 审中-公开
标题翻译：治疗疾病
公开(公告)号：WO2016112317A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012687
申请日：2016-01-08
申请人： ABBVIE INC. , LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： VON GELDERN, Thomas, W. , KEMPF, Dale, J. , MARSH, Kennan, C. , TAYLOR, Mark, John , WARD, Stephen, Andrew , FORD, Louise , TURNER, Joseph
IPC分类号： A61K31/365 , C07H17/00 , C07H17/08
CPC分类号： A61K31/7048 , A61K31/365 , C07H17/08 , Y02A50/421
摘要： The present invention pertains to prevention of and/or treatment for filariasis. In particular, the present invention pertains to the use of tylosin A and its analogs and derivatives to prevent or treat filarial worm infection and/or diseases associated with filarial worm infection. The present invention also pertains to pharmaceutical compositions comprising tylosin A or an analog or derivative thereof for use in preventing or treating filarial worm infection and/or diseases associated with filarial worm infection.
摘要翻译：本发明涉及丝虫病的预防和/或治疗。特别地，本发明涉及泰乐菌素A及其类似物和衍生物用于预防或治疗丝虫感染和/或与丝虫感染有关的疾病的用途。本发明还涉及包含泰乐菌素A或其类似物或衍生物用于预防或治疗丝虫感染和/或与丝虫感染有关的疾病的药物组合物。

5. 发明申请

WO2013078302A1 METHODS FOR DIAGNOSING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS 审中-公开
标题翻译：用于诊断人类免疫缺陷病毒感染的方法
公开(公告)号：WO2013078302A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066244
申请日：2012-11-21
申请人： CORNELL UNIVERSITY , LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： RUSSELL, David, G. , MWANDUMBA, Henry , JAMBO, Kondwani
IPC分类号： C12Q1/68 , C12Q1/70 , C12Q1/00
CPC分类号： C12Q1/703 , C12Q1/70 , C12Q2543/10
摘要： Provided is a method for identifying human immunodeficiency virus (HIV) in a sample. The invention involves use of a plurality of fluorescently labeled oligonucleotide probes and flow cytometry to detect the presence or absence of HIV in macrophages that are obtained from a mucosal surface. The invention is particularly useful for detecting HIV infection prior to seroconversion.
摘要翻译：提供了一种在样品中鉴定人类免疫缺陷病毒（HIV）的方法。本发明涉及使用多个荧光标记的寡核苷酸探针和流式细胞术来检测从粘膜表面获得的巨噬细胞中是否存在HIV。本发明特别可用于在血清转化之前检测HIV感染。

6. 发明申请

WO2010109172A1 MANNICH BASE TETRAOXANES (MANNOXANES) AND PHENOL SUBSTITUTED ANALOGUES 审中-公开
标题翻译：曼尼酯碱基四羧酸（MANNOXANES）和酚取代的类似物
公开(公告)号：WO2010109172A1
公开(公告)日：2010-09-30
申请号：PCT/GB2010/000530
申请日：2010-03-23
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE , THE UNIVERSITY OF LIVERPOOL , AMEWU, Richard , MARTI, Francesc , WARD, Stephen, Andrew , O'NEILL, Paul
发明人： AMEWU, Richard , MARTI, Francesc , WARD, Stephen, Andrew , O'NEILL, Paul
IPC分类号： C07D323/04 , C07D413/10 , C07D413/12 , A61K31/539 , A61P33/06
CPC分类号： C07D323/04 , A61K31/539 , C07D405/12 , Y02A50/411
摘要： The present invention relates to dispiro tetraoxane compounds of formula (VII) which may find application in the treatment of malaria.
摘要翻译：本发明涉及可用于治疗疟疾的式（Ⅶ）的四氢化四恶烷化合物。

7. 发明申请

WO2017191439A1 MONOMERIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：单体蛋白质及其用途
公开(公告)号：WO2017191439A1
公开(公告)日：2017-11-09
申请号：PCT/GB2017/051212
申请日：2017-04-28
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： PLEASS, Richard , BLUNDELL, Patricia
IPC分类号： C07K16/00 , A61K39/395 , C07K14/435 , C12N15/62
摘要： Provided are proteins comprising two chimeric polypeptide chains; wherein each chimeric polypeptide chain comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; and an immunoglobulin tailpiece region. The amino acid sequence and glycosylation of the tailpiece region of the proteins is adapted, as compared to the sequence and glycosylation of wild-type immunoglobulin, to inhibit polymerisation of the protein. The adaptation of the amino acid sequence may be the loss of a cysteine residue, for example the cysteine residue corresponding to residue 248 of SEQ ID NO: 1. The proteins may be used in intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG) therapy. They may be used in the prevention or treatment of a disease mediated through binding of sialic acid-dependent receptors. Proteins of the invention may be used in the prevention and/or treatment of autoimmune or inflammatory diseases. The proteins may be conjugated to an immune modulator, and in such cases are suitable for vaccine use.
摘要翻译：提供了包含两条嵌合多肽链的蛋白质; 其中每个嵌合多肽链包含含有两个免疫球蛋白G重链恒定区的Fc受体结合部分; 和免疫球蛋白尾部区域。与野生型免疫球蛋白的序列和糖基化相比，蛋白质尾部区域的氨基酸序列和糖基化适合于抑制蛋白质的聚合。氨基酸序列的适应可以是缺失半胱氨酸残基，例如对应于SEQ ID NO：1的残基248的半胱氨酸残基。蛋白质可用于静脉内免疫球蛋白（IVIG）或皮下免疫球蛋白（SCIG）治疗。它们可用于预防或治疗通过结合唾液酸依赖性受体介导的疾病。本发明的蛋白质可用于预防和/或治疗自身免疫疾病或炎症疾病。蛋白质可以与免疫调节剂结合，并且在这种情况下适用于疫苗使用。

8. 发明申请

WO2015063455A1 MOSQUITO BED NET ASSEMBLY 审中-公开
公开(公告)号：WO2015063455A1
公开(公告)日：2015-05-07
申请号：PCT/GB2014/053154
申请日：2014-10-23
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： MCCALL, Philip, John
IPC分类号： A47C29/00 , A45F3/52 , A01N25/34
CPC分类号： A47C29/006 , A01M1/20 , A01M2200/012 , A01N25/34 , A01N43/30 , A45F3/52 , Y02A50/372
摘要： Mosquito bed net assembly 10a-h includes a mosquito bed net (12) impregnated with a first insecticide and a barrier member 16a-h located above an upper surface (14) of the bed net (12) and being impregnated with a second insecticide. In use, bed net assembly 16a-h increases the likelihood of delivering a lethal dosage of insecticide to mosquitoes flying in frequently-visited areas of a bed net, without increased attendant health risk to a user.
摘要翻译：蚊帐网组件10a-h包括浸渍有第一杀虫剂的蚊帐网（12）和位于床网（12）的上表面（14）上方并且浸渍有第二杀虫剂的阻挡构件16a-h。在使用中，床网组件16a-h增加了将致死剂量的杀虫剂递送到在床网的经常访问的区域中飞行的蚊子的可能性，而不会增加对使用者的健康危害。

9. 发明申请

WO2012069856A1 ANTIMALARIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2012069856A1
公开(公告)日：2012-05-31
申请号：PCT/GB2011/052345
申请日：2011-11-28
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE , O'NEILL, Paul , BIAGINI, Giancarlo , WARD, Stephen A. , BERRY, Neil Graham , NIXON, Gemma , AMEWU, Richard K. , PIDATHALA, Chandrakala , HONG, Weiqian David , GIBBONS, Peter , LEUNG, Suet Ching , PACOREL, Bénédicte , SHARMA, Raman , LAWRENSON, Alexandre S. , SHONE, Alison E. , SRIVASTAVA, Abhishek , WARMAN, Ashley J.
发明人： O'NEILL, Paul , BIAGINI, Giancarlo , WARD, Stephen A. , BERRY, Neil Graham , NIXON, Gemma , AMEWU, Richard K. , PIDATHALA, Chandrakala , HONG, Weiqian David , GIBBONS, Peter , LEUNG, Suet Ching , PACOREL, Bénédicte , SHARMA, Raman , LAWRENSON, Alexandre S. , SHONE, Alison E. , SRIVASTAVA, Abhishek , WARMAN, Ashley J.
IPC分类号： C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D215/233 , A61K31/47 , A61K31/4709 , A61P33/06
CPC分类号： C07D401/04 , C07D215/233 , C07D401/10 , C07D401/14
摘要： The present invention relates to antimalarial compounds. More specifically, the present invention relates to novel substituted quinolone derivatives of formula (I) and related quinoline derivatives of formula (II) as defined herein that possess potent antimalarial activity. The present invention also relates to processes for the preparation of these quinolone and quinoline derivatives, to pharmaceutical compositions comprising them and to their use as therapeutic agents for the treatment and/or prevention of malaria.
摘要翻译：本发明涉及抗疟疾化合物。更具体地说，本发明涉及式（I）的新型取代喹诺酮衍生物和如本文所定义的具有强抗疟活性的式（II）的相关喹啉衍生物。本发明还涉及制备这些喹诺酮和喹啉衍生物的方法，包括它们的药物组合物及其作为治疗和/或预防疟疾的治疗剂的用途。

10. 发明申请

WO2016009232A1 POLYMERIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：聚合蛋白及其用途
公开(公告)号：WO2016009232A1
公开(公告)日：2016-01-21
申请号：PCT/GB2015/052098
申请日：2015-07-20
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： PLEASS, Richard , BLUNDELL, Patricia
IPC分类号： C07K16/46 , A61K39/395
CPC分类号： C07K16/46 , C07K2317/21 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/60 , C07K2317/94 , C07K2319/00
摘要： Provided are polymeric proteins that comprise two or more polypeptide monomer units, each monomer unit comprising two chimeric protein chains. Each chimeric polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions,wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit. Each chimeric protein chain also comprises a modified immunoglobulin M tailpiece region, wherein the amino acid sequence of each chimeric polypeptide monomer comprises an alteration of the primary structure as compared to the native sequences from which the immunoglobulin G heavy chain constant region or immunoglobulin M tailpiece region are derived, and the alteration changes the number of glycosylation sites in a manner that promotes polymerisation. This promotion of polymerisation may lead to the generation of tetrameric, hexameric, and even dodecameric forms of the proteins. The proteins are suitable formedical uses,such as in the prevention or treatment of autoimmune diseases such as idiopathic thrombocytopenia. Also provided are methods of treatment using the polymeric proteins, and pharmaceutical compositions comprising the polymeric proteins.
摘要翻译：提供包含两个或更多个多肽单体单元的聚合蛋白质，每个单体单元包含两个嵌合蛋白质链。每个嵌合多肽单体单元包含Fc受体结合部分，其包含两个免疫球蛋白G重链恒定区，其中每个免疫球蛋白G重链恒定区包含通过二硫键与免疫球蛋白G重链常数的半胱氨酸残基连接的半胱氨酸残基相邻多肽单体单元的区域。每个嵌合蛋白链还包含修饰的免疫球蛋白M尾部区域，其中每个嵌合多肽单体的氨基酸序列与免疫球蛋白G重链恒定区或免疫球蛋白M尾端区域的天然序列相比包含一级结构的改变并且改变以促进聚合的方式改变糖基化位点的数目。聚合的这种促进可能导致四聚体，六聚体，甚至十二聚体形式的蛋白质的产生。蛋白质是合适的形式用途，例如预防或治疗自身免疫性疾病如特发性血小板减少症。还提供了使用聚合蛋白的治疗方法和包含聚合蛋白的药物组合物。

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