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    • 4. 发明申请
    • OLEAGINOUS OINTMENT
    • OLEAGOOUS OINTMENT
    • WO1993012783A1
    • 1993-07-08
    • PCT/JP1992001716
    • 1992-12-25
    • KUREHA CHEMICAL INDUSTRY CO., LTD.CHIBA, TadahikoONO, SaichiKIMURA, Fumihiko
    • KUREHA CHEMICAL INDUSTRY CO., LTD.
    • A61K31/35
    • A61K31/35A61K9/0014A61K47/14
    • An oleaginous ointment wherein a pharmacologically active compound has an improved percutaneous absorbability and which comprises (a) 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl -2H-1-benzopyran-2-carboxylic acid, represented by formula (I), or a salt or ester thereof as the pharmacologically active component, (b) an oleaginous ointment base, and (c) a percutaneous absorption promoter, preferably a higher fatty acid ester and/or a surfactant which are/is liquid at 35 DEG C. The percutaneous absorbability of the active component can be improved while retaining high skin coverage and low skin irritation inherent in ordinary oleaginous ointment bases, thus being suitable for treating inflammatory skin diseases, in particular, psoriasis.
    • 一种含油软膏,其中药理活性化合物具有改善的经皮吸收性,并且包含(a)7- [3-(4-乙酰基-3-甲氧基-2-丙基苯氧基)丙氧基] -3,4-二氢-8-丙基 - 由式(I)表示的2H-1-苯并吡喃-2-羧酸或其盐或酯作为药理活性成分,(b)含油软膏基质,(c)经皮吸收促进剂,优选较高 脂肪酸酯和/或表面活性剂在35℃下是液体的。可以改善活性成分的经皮吸收性,同时保持普通含油软膏基质固有的高皮肤覆盖和低皮肤刺激性,因此适合于治疗炎症 皮肤病,特别是牛皮癣。