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1. 发明申请

WO2005029467A1 A METHOD FOR RECOVERING TARGET SPEECH BASED ON AMPLITUDE DISTRIBUTIONS OF SEPARATED SIGNALS 审中-公开
标题翻译：基于分离信号幅度分布的目标语音恢复方法
公开(公告)号：WO2005029467A1
公开(公告)日：2005-03-31
申请号：PCT/JP2004/012898
申请日：2004-08-31
申请人： KITAKYUSHU FOUNDATION FOR THE ADVANCEMENT OF INDUSTRY, SCIENCE AND TECHNOLOGY , KINKI UNIVERSITY , GOTANDA, Hiromu , KANEDA, Keiichi , KOYA, Takeshi
发明人： GOTANDA, Hiromu , KANEDA, Keiichi , KOYA, Takeshi
IPC分类号： G10L21/02
CPC分类号： G10L21/0272 , G10L25/27
摘要： The present invention provides a method for recovering target speech based on shapes of amplitude distributions of split spectra obtained by use of blind signal separation. This method includes: a first step of receiving target speech emitted from a sound source and a noise emitted from another sound source and forming mixed signals of the target speech and the noise at a first microphone and at a second microphone; a second step of performing the Fourier transform of the mixed signals from the time domain to the frequency domain, decomposing the mixed signals into two separated signals U 1 and U 2 by use of the Independent Component Analysis, and, based on transmission path characteristics of the four different paths from the two sound sources to the first and second microphones, generating the split spectra v 11 , V 12 , v 21 and v 22 from the separated signals U 1 and U 2 ; and a third step of extracting estimated spectra Z* corresponding to the target speech to generate a recovered spectrum group of the target speech, wherein the split spectra v 11 , v 12 , V 21 , and v 22 are analyzed by applying criteria based on the shape of the amplitude distribution of each of the split spectra v 11 , V 12 , v 21 , and v 22 , and performing the inverse Fourier transform of the recovered spectrum group from the frequency domain to the time domain to recover the target speech.
摘要翻译：本发明提供一种基于通过使用盲信号分离获得的分离频谱的振幅分布的形状来恢复目标语音的方法。该方法包括：接收从声源发出的目标语音和从另一声源发出的噪声的第一步骤，并在第一麦克风和第二麦克风处形成目标语音和噪声的混合信号; 执行从时域到频域的混合信号的傅里叶变换的第二步骤，通过使用独立分量分析将混合信号分解成两个分离的信号U1和U2，并且基于四个信号的传输路径特性从两个声源到第一和第二麦克风的不同路径，从分离的信号U1和U2产生分离频谱v11，V12，v21和

2. 发明专利

HK1142360A1 PROTEIN EXHIBITING ACTIVITY OF PYRETHRIN BIOSYNTHETIC ENZYME, GENE ENCODING THE PROTEIN, AND VECTOR BEARING THE GENE 未知
公开(公告)号：HK1142360A1
公开(公告)日：2010-12-03
申请号：HK10107787
申请日：2010-08-16
申请人： AN EDUCATIONAL FOUNDATION KINKI UNIVERSITY , DAINIPPON JOCHUGIKU KK
发明人： MATSUDA KAZUHIKO , KIKUTA YUKIO
IPC分类号： C12N20060101
摘要： The present invention relates to an enzyme determining amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyrethrin by applying such creative techniques to plant bodies with faster growth aiming to provide a method to efficiently produce pyrethrin; and the enzyme is a gene encoding a protein of the following (i) or (ii): (i) a protein consisting of an amino acid sequence shown in Sequence No. 1; or (ii) a protein consisting of an amino acid sequence including one ormore of a substitution, deletion, insertion, and/or addition of amino acid in the amino acid sequence shown in Sequence No. 1, in which the protein exhibits activity of pyrethrin biosynthetic enzyme.

3. 发明专利

DE602005008913D1 未知
公开(公告)号：DE602005008913D1
公开(公告)日：2008-09-25
申请号：DE602005008913
申请日：2005-03-02
申请人： KINKI UNIVERSITY HIGASHIOSAKA , NAT UNIV CORP NARA INST
发明人： YOKOTA AKIHO , SHIGEOKA SHIGERU , TOMIZAWA KEN-ICHI
IPC分类号： C12N15/82 , A01H1/00 , C12N9/16
摘要： An object of the present invention is to provide a transformed plant which has high photosynthesis activity, and has promoted growth and productivity as compared with a wild strain, and has no fear of diffusion of an introduced gene by pollens, by expressing a trait of a specified gene by chloroplast technology in a higher plant. According to the present invention, there is provided a transformed plant using a gene recombinant vector having an expression cassette for enhancing photosynthesis activity, containing a DNA fragment comprising a gene encoding a protein having fructose-1,6-bisphosphatase sedoheptulose-1,7-bisphosphatase activities between a nucleotide sequence complementary to the chloroplast gene rbcL and the chloroplast gene aacD.

4. 发明专利

ES2452641T3 Proteína con la actividad de la enzima biosintética piretrina, gen codificador de la proteína y vector portador del gen 未知
公开(公告)号：ES2452641T3
公开(公告)日：2014-04-02
申请号：ES09007069
申请日：2009-05-27
申请人： EDUCATIONAL FOUNDATION KINKI UNIVERSITY , DAINIPPON JOCHUGIKU KK
发明人： MATSUDA KAZUHIKO , KIKUTA YUKIO
IPC分类号： C12N9/14 , C07K14/415 , C12N9/10
摘要： Método para producir una enzima biosintética de piretrina de una proteína con un peso molecular de aproximadamente 40.000, donde la materia prima de la enzima es una solución enzimática cruda preparada a partir de una flor de piretro; donde se utiliza (1R)-trans-crisantemoil-CoA y (S)-piretrolona como sustratos para una ensayo que confirma una función activa de la enzima biosintética del piretro; donde la enzima biosintética de piretro se produce mediante un procedimiento de purificación que incluye los pasos secuenciales de: obtener un precipitado de fraccionamiento de proteína cruda con precipitación de sulfato de amonio; someter el precipitado a una purificación cruda mediante un método por lotes utilizando una resina hidrófoba; purificar la solución enzimática obtenida mediante la purificación cruda por cromatografía de intercambio aniónico; purificar por cromatografía hidrófoba; y purificar por filtración en gel.

5. 发明专利

HRP20140168T1 PROTEIN KOJI POKAZUJE AKTIVNOST PIRETRINSKOG BIOSINTETSKOG ENZIMA, GEN KOJI KODIRA PROTEIN I VEKTOR KOJI NOSI GEN 未知
公开(公告)号：HRP20140168T1
公开(公告)日：2015-04-24
申请号：HRP20140168
申请日：2014-02-25
申请人： EDUCATIONAL FOUNDATION KINKI UNIVERSITY , DAINIPPON JOCHUGIKU KK
发明人： MATSUDA KAZUHIKO , KIKUTA YUKIO
IPC分类号： C12N9/14 , C07K14/415 , C12N9/10

6. 发明专利

DE3786206T2 未知
公开(公告)号：DE3786206T2
公开(公告)日：1993-10-21
申请号：DE3786206
申请日：1987-07-24
申请人： KINKI UNIVERSITY HIGASHIOSAKA , SHOWA ALUMINIUM CO LTD
发明人： TSUJIMURA DAIJIRO , KAGEN HIDEKI , TSUKAMOTO KENJI , KIKUCHI SHIGEYUKI
IPC分类号： A61B18/00 , A61B18/24 , B23K26/06 , B23K26/42 , G02B6/42 , A61B17/36 , A61N5/06

7. 发明专利

DE3786206D1 未知
公开(公告)号：DE3786206D1
公开(公告)日：1993-07-22
申请号：DE3786206
申请日：1987-07-24
申请人： KINKI UNIVERSITY HIGASHIOSAKA , SHOWA ALUMINIUM CO LTD
发明人： TSUJIMURA DAIJIRO , KAGEN HIDEKI , TSUKAMOTO KENJI , KIKUCHI SHIGEYUKI
IPC分类号： A61B18/00 , A61B18/24 , B23K26/06 , B23K26/42 , G02B6/42 , A61B17/36 , A61N5/06

8. 发明申请

WO2015048804A3 PROTEIN BIOMARKER AND USES THEREOF 审中-公开
公开(公告)号：WO2015048804A3
公开(公告)日：2015-04-02
申请号：PCT/US2014/058460
申请日：2014-09-30
申请人： DAIICHI SANKYO CO., LTD. , U3 PHARMA GMBH , KINKI UNIVERSITY , AMGEN, INC.
发明人： SCHNEIDER, Matthias , BLUM, Sabine , YONESAKA, Kimio , NAKAGAWA, Kazuhiko , FREEMAN, Daniel J. , BECKMAN, Robert Allen , JIN, Xiaoping , MENDELL-HARARY, Renee Jeanne
IPC分类号： A61K39/395
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.

9. 发明申请

WO2015048802A2 PROTEIN BIOMARKER AND USES THEREOF 审中-公开
标题翻译：蛋白质生物标志物及其用途
公开(公告)号：WO2015048802A2
公开(公告)日：2015-04-02
申请号：PCT/US2014/058453
申请日：2014-09-30
申请人： DAIICHI SANKYO CO., LTD. , U3 PHARMA GMBH , KINKI UNIVERSITY , MENDELL-HARARY, Renee Jeanne
发明人： MENDELL-HARARY, Renee Jeanne , SCHNEIDER, Matthias , BLUM, Sabine , KIMIO, Yonesaka , NAKAGAWA, Kazuhiko , FREEMAN, Daniel J. , BECKMAN, Robert Allen , XIAOPING, Jin
IPC分类号： G01N33/574 , C07K16/28
CPC分类号： C07K16/32 , A61K31/517 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/76 , G01N33/5695 , G01N33/57423 , G01N2333/4756
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.
摘要翻译：本发明涉及鉴定和治疗携带肿瘤或其他疾病的人类受试者的方法，其包括评估人类受试者中蛋白质水平的HRG基因表达，并且施用包含抗HER3 对其在蛋白质水平的HRG基因表达被评估为高的人受试者的抗体。本发明还涉及鉴定携带肿瘤或其他疾病的人类受试者的方法，所述方法包括评估人类受试者中蛋白质水平的HRG基因表达，并且阻止对其人类受试者的HRG基因表达的包含抗HER3抗体的治疗在蛋白质水平被评估为低。本发明还涉及进行ELISA的方法，包括使固体表面与多种溶液接触的顺序步骤，每种溶液依次包含捕获抗体，封闭剂，怀疑含有分析物的样品，检测抗体和酶结合物，其中固体表面在每个连续步骤后经受洗涤过程。

10. 发明申请

WO2005029463A1 A METHOD FOR RECOVERING TARGET SPEECH BASED ON SPEECH SEGMENT DETECTION UNDER A STATIONARY NOISE 审中-公开
标题翻译：基于静音噪声下的语音分段检测的方法来恢复目标语音
公开(公告)号：WO2005029463A1
公开(公告)日：2005-03-31
申请号：PCT/JP2004/012899
申请日：2004-08-31
申请人： KITAKYUSHU FOUNDATION FOR THE ADVANCEMENT OF INDUSTRY, SCIENCE AND TECHNOLOGY , KINKI UNIVERSITY , GOTANDA, Hiromu , KANEDA, Keiichi , KOYA, Takeshi
发明人： GOTANDA, Hiromu , KANEDA, Keiichi , KOYA, Takeshi
IPC分类号： G10L11/02
CPC分类号： G10L21/0208 , G10L25/78
摘要： Method for recovering target speech by extracting signal components falling in a speech segment, which is determined based on separated signals obtained through the Independent Component Analysis, thereby minimizing the residual noise in the recovered target speech. The present method comprises: the first step of receiving target speech emitted from a sound source and a noise emitted from another sound source and extracting estimated spectra Y* corresponding to the target speech by use of the Independent Component Analysis; the second step of separating from the estimated spectra Y* an estimated spectrum series group y* in which the noise is removed by applying separation judgment criteria based on the kurtosis of the amplitude distribution of each of estimated spectrum series in Y*; the third step of detecting a speech segment and a noise segment of the total sum F of all the estimated spectrum series in y* by applying detection judgment criteria based on a predetermined threshold value T that is determined by the maximum value of F; and the fourth step of extracting components falling in the speech segment from the estimated spectra Y* to generate a recovered spectrum group of the target speech for recovering the target speech.
摘要翻译：通过提取基于通过独立分量分析获得的分离信号确定的落在语音段中的信号分量来恢复目标语音的方法，从而使恢复的目标语音中的残余噪声最小化。本方法包括：接收从声源发出的目标语音和从另一声源发出的噪声的第一步骤，并通过使用独立分量分析提取对应于目标语音的估计频谱Y *; 通过基于Y *中的每个估计频谱序列的振幅分布的峰度应用分离判断标准，从估计频谱Y *中除去噪声被去除的估计频谱系Y *的第二步骤; 基于由最大值F确定的预定阈值T，通过应用检测判断基准来检测y *中所有估计频谱序列的总和F的语音段和噪声段的第三步骤; 以及从估计的光谱Y *中提取掉在语音段中的分量的第四步骤，以产生用于恢复目标语音的目标语音的恢复的频谱组。

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