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1. 发明申请

WO2015084676A1 FLOW CYTOMETER 审中-公开
标题翻译：流量计
公开(公告)号：WO2015084676A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/067682
申请日：2014-11-26
申请人： IRIS INTERNATIONAL, INC.
发明人： CHEN, Yong, Qin
IPC分类号： G01N15/14 , G01N21/53
CPC分类号： G01N15/1436 , G01N15/1459 , G01N21/53 , G01N21/645 , G01N21/85 , G01N2015/1493
摘要： The disclosed flow cytometer includes a laser diode ("LD") based optical subsystem for impinging a beam of light upon particles passing through a viewing zone, a composite microscope objective for gathering and imaging light scattered from or fluoresced by particles passing through the viewing zone, a fluidic subsystem for supplying a liquid sheath flow to the viewing zone, a peristaltic pump for injecting into the liquid sheath flow a liquid sample flow carrying particles that passes together with the liquid sheath flow through the viewing zone, a multimode optical fiber that receives scattered and fluoresced light from the viewing zone that the composite microscope objective gathers and images, and a wavelength division multiplexer for optically separating into color bands light received via the optical fiber.
摘要翻译：所公开的流式细胞仪包括基于激光二极管（“LD”）的光学子系统，用于将光束撞击通过观察区的颗粒，用于收集和成像通过观察区的颗粒散射或发出的光的复合显微镜物镜用于向观察区域提供液体鞘流的流体子系统，用于向液体鞘内注入的蠕动泵流动携带与液体鞘流一起通过观察区的颗粒的液体样品流;多模光纤，其接收复合显微镜物镜收集的观察区的散射和发出的光，以及用于光学分离成经由光纤接收的光束的波分复用器。

2. 发明申请

WO2018067770A1 DYNAMIC FOCUS SYSTEM AND METHODS 审中-公开
标题翻译：动态聚焦系统和方法
公开(公告)号：WO2018067770A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055245
申请日：2017-10-05
申请人： IRIS INTERNATIONAL, INC.
发明人： LU, Jiuliu , QIAN, Bian , WANDERS, Bart J. , GOOD, Ken , RILEY, John
IPC分类号： G01N15/14 , G02B21/24 , G02B27/36 , G01N15/10
摘要： A method for dynamic focusing is presented that can be performed by a dynamic focusing controller that can receive images from the image capture device, and for each image, determine a border of the particle within the image, and calculate a pixel intensity ratio of the image based on the border of the particle. The dynamic focusing controller can also calculate a median pixel intensity ratio from the pixel intensity ratios for each image, determine a focal distance direction based on the median pixel intensity ratio, calculate a focal distance based on the median pixel intensity ratio when the focal distance direction is positive, and calculate the focal distance based on a median border width when the focal distance direction is negative. The autofocusing controller can then send an instruction to the focusing mechanism to adjust the image capture device by the focal distance in the focal distance direction.
摘要翻译：提出了一种用于动态聚焦的方法，其可以由动态聚焦控制器执行，该动态聚焦控制器可以从图像捕获设备接收图像，并且对于每个图像确定图像内的粒子的边界，以及基于粒子的边界计算图像的像素强度比。动态聚焦控制器还可以根据每个图像的像素强度比计算中值像素强度比，基于中值像素强度比确定焦距方向，基于中值像素强度比计算焦距，是正的，并且在焦距方向为负时基于中值边界宽度来计算焦距。自动对焦控制器然后可以向聚焦机构发送指令以通过焦距方向上的焦距调整图像捕捉设备。

3. 发明申请

WO2018039216A1 SYSTEM AND METHOD OF CLASSIFICATION OF BIOLOGICAL PARTICLES 审中-公开
标题翻译：系统和分类生物颗粒的方法
公开(公告)号：WO2018039216A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/047993
申请日：2017-08-22
申请人： IRIS INTERNATIONAL, INC.
发明人： RAMIREZ, Carlos , CADAVID, Steven , ZHOU, Jindan
IPC分类号： G06F19/00 , G06T7/00
摘要： A method and system for classification of cells and particles in a biological sample using an automated image-based feature extraction and classification architecture. A method operates by applying a mask or series of masks to an image, extracting features from the unmasked portions of the image based on the content and location of colored pixels, selecting a subset of the extracted features, and mapping the subset of the extracted features into a classifier architecture. In a majority of cases, the first level model architecture provides an accurate identification of the cell or particle. In a minority of cases, the classification of the cell or particle requires a second level step requiring the use of numerical or categorical values from the first level in combination with a second level model.
摘要翻译：使用自动化的基于图像的特征提取和分类体系结构来分类生物样本中的细胞和粒子的方法和系统。一种方法通过将掩模或一系列掩模应用于图像，基于彩色像素的内容和位置从图像的未掩盖部分提取特征，选择提取的特征的子集以及将提取的特征的子集映射分类器体系结构。在大多数情况下，第一级模型架构提供了细胞或颗粒的准确识别。在少数情况下，细胞或颗粒的分类需要第二级步骤，要求使用第一级的数值或分类值以及第二级模型。

4. 发明申请

WO2017044290A1 PARTICLE ANALYSIS SYSTEMS AND METHODS 审中-公开
标题翻译：粒子分析系统和方法
公开(公告)号：WO2017044290A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/047697
申请日：2016-08-19
申请人： IRIS INTERNATIONAL, INC.
发明人： TINDEL, Jon F. , YANG, Jun
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G06F19/326 , G06F19/00 , G06F19/32 , G16H15/00
摘要： In some embodiments, a method is provided for returning medical data comprising a test result from a particle analyzer including receiving a clinical data query in an initial format from an input object. After receiving the clinical data query, transforming the clinical data query into multiple different query types, each different query type having a different format from the initial format, each different query type for querying a different medical database or object graph in memory. Querying the medical databases using one of the query types based on the medical database. In response to the querying, receiving the data sets from the medical databases including the test result from the particle analyzer. Once data sets are received, output at least some information from the data sets.
摘要翻译：在一些实施例中，提供了一种用于返回包括来自粒子分析仪的测试结果的医学数据的方法，包括从输入对象接收初始格式的临床数据查询。收到临床数据查询后，将临床数据查询转换为多种不同的查询类型，每种不同的查询类型与初始格式不同，每种不同的查询类型用于查询不同的医疗数据库或内存中的对象图。使用基于医疗数据库的查询类型之一查询医疗数据库。响应于查询，从医学数据库接收包含粒子分析仪测试结果的数据集。一旦接收到数据集，就从数据集中输出至少一些信息。

5. 发明申请

WO2014151879A3 METHOD OF CAPTURING BACTERIA ON POLYLYSINE-COATED MICROSPHERES 审中-公开
标题翻译：在聚赖氨酸包被的微球上捕获细菌的方法
公开(公告)号：WO2014151879A3
公开(公告)日：2014-09-25
申请号：PCT/US2014/026608
申请日：2014-03-13
申请人： IRIS INTERNATIONAL, INC.
发明人： JABLONSKI, Edward , HULLE, Carl
IPC分类号： G01N33/569 , C07K14/00 , C07K19/00 , C07K17/06
摘要： The present disclosure relates to compositions, methods, and kits for the detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using polylysine-coated particles to capture microorganisms such as bacteria.
摘要翻译：本公开涉及用于检测，分离和/或分离微生物的组合物，方法和试剂盒。具体而言，本公开涉及使用聚赖氨酸涂覆的颗粒来捕获微生物例如细菌的组合物，方法和试剂盒。

6. 发明申请

WO2014146063A2 HEMATOLOGY SYSTEMS AND METHODS 审中-公开
标题翻译： HEMATOLOGY系统和方法
公开(公告)号：WO2014146063A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/030942
申请日：2014-03-18
申请人： IRIS INTERNATIONAL, INC.
发明人： WANDERS, Bart, J. , FARRELL, Gregory A. , ADAMS, Thomas, H. , GRONER, Warren , ZHAO, Xiaodong , JORDAN, Brett , CREMINS, Jack , QUON, Carol
IPC分类号： G01N15/14
CPC分类号： G01N33/4915 , G01N15/1404 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N33/5091 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058 , G01N2201/12
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.
摘要翻译：本公开的方面和实施方案提供用于分析样品中包含的颗粒的颗粒分析仪的颗粒和/或细胞内细胞器取向剂。示例性的颗粒和/或细胞内细胞器取向剂包括水溶液，粘度调节剂和/或缓冲液。实施方案还包括用于分析含有颗粒的样品的系统，组合物和方法。可以通过数字图像处理器对诸如血细胞的颗粒进行分类和计数。数字显微镜照相机可以例如使用某些聚焦技术引导到限定对称变窄的流动路径的流动池中，其中样品流在由鞘液层之间的流动和粘度参数平坦化的带中流动。可以使用动态范围扩展过程和系统收集和分析血细胞图像。

7. 发明申请

WO2014145984A1 METHOD AND COMPOSITION FOR STAINING AND SAMPLE PROCESSING 审中-公开
标题翻译：用于染色和样品处理的方法和组合
公开(公告)号：WO2014145984A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030851
申请日：2014-03-17
申请人： IRIS INTERNATIONAL INC.
发明人： CREMINS, Jack , QUON, Carol
IPC分类号： G01N15/14 , G01N15/10 , G01N1/30 , G01N1/31
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.
摘要翻译：本公开涉及使用能够在单一步骤中快速染色细胞的颗粒造影剂组合物的染色方法。颗粒造影剂组合物可以由一种或多种颗粒造影剂，一种或多种渗透剂和一种或多种固定剂的组合组成。颗粒造影剂组合物可以包括结晶紫，新亚甲基蓝，皂苷和戊二醛。

8. 发明申请

WO2013184851A1 METHOD FOR DETERMINING RECURRENCE OR STABLE DISEASE AFTER TREATMENT FOR PROSTATE CANCER 审中-公开
标题翻译：治疗前列腺癌后确定复发或稳定疾病的方法
公开(公告)号：WO2013184851A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044385
申请日：2013-06-05
申请人： IRIS INTERNATIONAL, INC.
发明人： KLEM, Robert , MCDERMED, Jonathan , SAUNDERS, Russ , JABLONSKI, Edward , ADAMS, Thomas , SARNO, Mark
IPC分类号： G01N33/53 , G01N33/574 , C12N15/113
CPC分类号： G01N33/5091 , G01N33/57434 , G01N33/689 , G01N2800/54 , G01N2800/56
摘要： This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have prostate cancer recurrence or stable disease.
摘要翻译：本发明描述了用于具有低功能敏感性的PSA测定中的组合物和方法，其可用于例如在治疗后检测前列腺疾病的早期复发以及确定患者是否患有前列腺癌复发或稳定疾病。

9. 发明申请

WO2013106778A3 NON-EQUILIBRIUM TWO-SITE ASSAYS FOR LINEAR, ULTRASENSITIVE ANALYTE DETECTION 审中-公开
公开(公告)号：WO2013106778A3
公开(公告)日：2013-07-18
申请号：PCT/US2013/021320
申请日：2013-01-11
申请人： IRIS INTERNATIONAL, INC.
发明人： JABLONSKI, Edward , ADAMS, Thomas H. , DRIVER, David , RYDER, Thomas Brendan
IPC分类号： C12Q1/68 , G01N33/543
摘要： Methods and kits related to non-equilibrium, ultrasensitive two-site assays for detecting analytes are provided. In one aspect, a two-site assays for detecting analytes under non-equilibrium analyte binding conditions, using low concentrations of reporter specificity molecule (e.g., reporter antibody) and kits for performing the same is provided. In another aspect, methods for selecting antibodies or specificity molecules with low dissociation constants for use as reporter antibodies in non-equilibrium two-site immunoassays, including two-site immuno-PCR assays, and assays performed with those antibodies, are also provided.

10. 发明申请

WO2016060691A1 SYSTEMS AND METHODS FOR IMAGING FLUID SAMPLES 审中-公开
标题翻译：用于成像流体样品的系统和方法
公开(公告)号：WO2016060691A1
公开(公告)日：2016-04-21
申请号：PCT/US2014/061221
申请日：2014-10-17
申请人： IRIS INTERNATIONAL, INC.
发明人： WANDERS, Bart J.
IPC分类号： G01N15/14 , G01N15/00
CPC分类号： G01N15/1463 , A61B5/0059 , G01N15/1404 , G01N15/1425 , G01N15/1459 , G01N21/05 , G01N21/85 , G01N2015/0065 , G01N2015/1409 , G01N2015/144
摘要： Systems and methods for imaging a plurality of blood fluid samples or other types of samples include processing at least a portion of a sample to enhance imageability of certain particles in that portion and subsequently imaging the sample portion. In some instances, processing and imaging of various samples may be staged in a manner to optimize throughput of the system or method.
摘要翻译：用于对多个血液样品或其他类型的样品进行成像的系统和方法包括处理样品的至少一部分以增强该部分中某些颗粒的成像能力，并随后对样品部分进行成像。在一些情况下，可以以优化系统或方法的吞吐量的方式分级各种样品的处理和成像。

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