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1. 发明专利

JP2012093366A Method of therapy 有权
标题翻译：治疗方法
公开(公告)号：JP2012093366A
公开(公告)日：2012-05-17
申请号：JP2011269612
申请日：2011-12-09
申请人： Immunaid Pty Ltd , イミュネイドピーティーワイリミテッド
发明人： ASHDOWN MARTIN LEONARD
IPC分类号： G01N33/68 , A61K31/337 , A61K31/475 , A61K39/00 , A61K39/395 , A61K45/00 , A61P31/14 , A61P31/18 , A61P35/00 , G01N33/50 , G01N33/569 , G01N33/574
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737
摘要： PROBLEM TO BE SOLVED: To provide methods for treating diseases such as cancer and HIV infection, and methods of determining when a therapy to treat a disease characterized by production of regulator cells should be administered to a patient.SOLUTION: The method includes a process of monitoring patients or samples obtained from the patients regarding at least one of a) the number and/or activity of effector cells, b) the number and/or activity of regulator cells, c) molecules associated with diseases, and d) immune markers.
摘要翻译：待解决的问题：提供治疗诸如癌症和HIV感染之类的疾病的方法，以及确定何时治疗以治疗细胞产生为特征的疾病的治疗方法应该给予患者。解决方案：该方法包括监测从患者获得的患者或样品中关于效应细胞的数量和/或活性中的至少一个的方法，b）调节细胞的数量和/或活性，c）与疾病相关的分子，以及d）免疫标记物。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2013035859A Therapeutic strategy for treating autoimmune and degenerative disease 审中-公开
标题翻译：用于治疗自身免疫性疾病和变应性疾病的治疗策略
公开(公告)号：JP2013035859A
公开(公告)日：2013-02-21
申请号：JP2012211628
申请日：2012-09-26
申请人： Immunaid Pty Ltd , イミューンネイドピーティーワイリミテッド
发明人： ASHDOWN MARIA LUISA , ASHDOWN MARTIN LEONARD
IPC分类号： A61K45/00 , A61K39/00 , A61P25/28 , A61P37/06 , A61P43/00
CPC分类号： A61K39/0005 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/4745 , A61K39/0007 , A61K2039/505 , A61K2039/515 , A61K2039/58 , C07D305/14 , C07D471/18 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2875 , C07K2317/75 , C12N15/1136 , G01N33/5005 , G01N33/564 , G01N33/56972 , G01N33/6869 , G01N33/6893 , G01N2333/5428 , G01N2800/24 , G01N2800/245
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic strategy for treating symptoms of autoimmune diseases, degenerative diseases, graft-versus-host diseases, and the like.SOLUTION: A therapeutic pharmaceutical is disclosed for diseases linked to the production of effector T cells, the pharmaceutical including an agent that inhibits production of effector T cells and regulates functions and/or activity of the cells. The therapy includes steps of: analyzing periodical changes in the immune system by monitoring a patient; and exposing the patient to an agent to treat the disease. The disease is an autoimmune disease or transplant rejection. The agent is selected from the group consisting of anti-proliferative drugs, anti-metabolic drugs, radiation, dsRNA and antibodies. The agent is administered when, or just before, effector T cells begin clonally expanding, so as to prevent effector T cells from enlarging and/or to reduce or eliminate the number of effector T cells.
摘要翻译：待解决的问题：提供治疗自身免疫疾病，退行性疾病，移植物抗宿主病等症状的治疗策略。公开了治疗性药物用于与效应T细胞的产生相关的疾病，该药物包括抑制效应T细胞产生并调节细胞功能和/或活性的药剂。该疗法包括以下步骤：通过监测患者分析免疫系统的周期性变化; 并将患者暴露于药物以治疗疾病。该疾病是一种自身免疫性疾病或移植排斥反应。该药剂选自抗增生药物，抗代谢药物，辐射剂，dsRNA和抗体。所述药剂在效应T细胞开始克隆扩增时或之前施用，以便防止效应T细胞扩大和/或减少或消除效应T细胞的数量。版权所有（C）2013，JPO＆INPIT

3. 发明申请

WO2003070270A1 STRATEGY FOR RETROVIRAL IMMUNOTHERAPY 审中-公开
标题翻译：退行性免疫治疗策略
公开(公告)号：WO2003070270A1
公开(公告)日：2003-08-28
申请号：PCT/AU2003/000207
申请日：2003-02-18
申请人： IMMUNAID PTY LTD , ASHDOWN, Martin, Leonard
发明人： ASHDOWN, Martin, Leonard
IPC分类号： A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/542 , A61K2039/545 , C12N2740/16034
摘要： The present inventor has noted that at least two populations of immune cells are produced in response to retroviruses which infect mammals. More particularly, the immune system of a mammal infected with a retrovirus is capable of mounting an immune response against the virus through a group of cells herein generally referred to as "effector cells", however, a second population of cells are also produced which regulate the "effector cells", herein generally referred to as "regulator cells" (or suppressor cells), limiting the mammal's ability to effectively control or eradicate the retroviral infection. Accordingly, the present invention utilizes these observations to provide methods for treating a mammal with a retroviral infection. Furthermore, the present inventor has found that acute phase inflammatory markers can be used to detect and monitor an"effector cell" response to retroviral antigens.
摘要翻译：本发明人已经注意到，响应于感染哺乳动物的逆转录病毒，产生至少两个免疫细胞群体。更具体地，用逆转录病毒感染的哺乳动物的免疫系统能够通过本文通常被称为“效应细胞”的一组细胞来施加针对病毒的免疫应答，然而，也产生调节第二细胞群本文中通常称为“调节细胞”或抑制细胞的“效应细胞”限制了哺乳动物有效控制或根除逆转录病毒感染的能力。因此，本发明利用这些观察来提供用于治疗具有逆转录病毒感染的哺乳动物的方法。此外，本发明人已经发现急性期炎症标记物可用于检测和监测对逆转录病毒抗原的“效应细胞”应答。

4. 发明申请

WO2005040816A1 METHOD OF THERAPY 审中-公开
标题翻译：治疗方法
公开(公告)号：WO2005040816A1
公开(公告)日：2005-05-06
申请号：PCT/AU2004/001456
申请日：2004-10-22
申请人： IMMUNAID PTY LTD , ASHDOWN, Martin, Leonard
发明人： ASHDOWN, Martin, Leonard
IPC分类号： G01N33/68
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737 , G06F19/00
摘要： Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.
摘要翻译：许多疾病与调节细胞的产生有关。本发明涉及免疫系统在这些疾病中循环的观察。基于这些观察，本发明提供了治疗诸如癌症和HIV感染之类疾病的方法。本发明还涉及确定何时将治疗以治疗细胞产生为特征的疾病的治疗施用于患者的方法。

5. 发明申请

WO2010135781A1 METHODS OF TREATING DISEASES 审中-公开
标题翻译：治疗疾病的方法
公开(公告)号：WO2010135781A1
公开(公告)日：2010-12-02
申请号：PCT/AU2010/000649
申请日：2010-05-27
申请人： IMMUNAID PTY LTD , ASHDOWN, Martin, Leonard , ROBINSON, Andrew
发明人： ASHDOWN, Martin, Leonard , ROBINSON, Andrew
IPC分类号： G01N33/48 , G01N33/68 , G01N33/574 , G06N3/00
CPC分类号： G06F19/12 , A61B5/41 , A61B5/413 , A61B5/4836 , A61B5/7267 , A61K31/495 , G01N33/564 , G01N33/57407 , G01N33/68 , G01N2333/4737 , G01N2800/042 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/24 , G06F19/34 , G16H50/50
摘要： The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.
摘要翻译：本发明涉及用于分析在受试者中循环的生物标志物的计算机实现的方法和系统。在一些其它方面，本发明涉及分析生物标志物，其在治疗疾病之后至少最初增加或减少受试者的量。在其它方面，本发明涉及用于确定施用治疗以治疗受试者的疾病的优选时间的计算机实现的方法和系统。本发明还涉及实现该方法的计算机程序产品。此外，本发明涉及确定在免疫系统循环的受试者中治疗疾病的时机的方法。

6. 发明申请

WO2006026821A1 THERAPEUTIC STRATEGY FOR TREATING AUTOIMMUNE AND DEGENERATIVE DISEASES 审中-公开
标题翻译：治疗自身免疫性疾病和变应性疾病的治疗策略
公开(公告)号：WO2006026821A1
公开(公告)日：2006-03-16
申请号：PCT/AU2005/001364
申请日：2005-09-08
申请人： IMMUNAID PTY LTD , ASHDOWN, Maria, Luisa , ASHDOWN, Martin, Leonard
发明人： ASHDOWN, Maria, Luisa , ASHDOWN, Martin, Leonard
IPC分类号： G01N33/48
CPC分类号： A61K39/0005 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/4745 , A61K39/0007 , A61K2039/505 , A61K2039/515 , A61K2039/58 , C07D305/14 , C07D471/18 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2875 , C07K2317/75 , C12N15/1136 , G01N33/5005 , G01N33/564 , G01N33/56972 , G01N33/6869 , G01N33/6893 , G01N2333/5428 , G01N2800/24 , G01N2800/245 , G06F19/00
摘要： Numerous diseases have been linked to the production of effector cells. The present invention relates to the realization that effector cells are cycling in these diseases. In addition, the present invention relates to the determination that regulator cells are cycling in degenerative diseases. Based on these realizations, the present invention provides methods for treating conditions such as autoimmune diseases, degenerative diseases, and graft-versus-host disease. The present invention also relates to methods of determining when therapy should be administered to a patient.
摘要翻译：许多疾病与效应细胞的产生有关。本发明涉及在这些疾病中效应细胞循环的认识。此外，本发明涉及调节细胞在退行性疾病中循环的测定。基于这些实现，本发明提供了治疗诸如自身免疫疾病，退行性疾病和移植物抗宿主病之类疾病的方法。本发明还涉及确定何时应当向患者施用治疗的方法。

7. 发明申请

WO2003068257A1 CANCER THERAPY 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO2003068257A1
公开(公告)日：2003-08-21
申请号：PCT/AU2003/000187
申请日：2003-02-14
申请人： IMMUNAID PTY LTD , ASHDOWN, Martin, Leonard
发明人： ASHDOWN, Martin, Leonard
IPC分类号： A61K39/00
CPC分类号： A61K31/4745 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for treating a cancer patient. The methods rely on theobservation that cells of the immune system which target a tumour cell ("effector cells") clonallyexpand before a population of "regulator" or "suppressor" cells which down-regulate the activity of the immune cells which target the tumour cell. Methods are provided herein which stimulate effector cell production and also provides means for inhibiting the production of, limiting thefunction of, and/or destroying, regulator cells, in the treatment of cancer.
摘要翻译：本发明提供了治疗癌症患者的方法。该方法依赖于观察，即靶向肿瘤细胞“效应细胞”的免疫系统的细胞在调节靶向肿瘤细胞的免疫细胞的活性的“调节剂”或“抑制”细胞群体之前克隆扩增。本文提供了刺激效应细胞产生的方法，并且还提供用于抑制调节细胞在癌症治疗中的产生，限制和/或破坏调节细胞的功能的方法。

8. 发明申请

US20120156225A1 METHOD OF THERAPY 有权
标题翻译：治疗方法
公开(公告)号：US20120156225A1
公开(公告)日：2012-06-21
申请号：US13396254
申请日：2012-02-14
申请人： Martin Leonard ASHDOWN
发明人： Martin Leonard ASHDOWN
IPC分类号： A61K39/395 , A61N5/00 , A61K31/513 , A61P35/00 , G01N33/566 , A61K31/713
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737 , G06F19/00
摘要： Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.
摘要翻译：许多疾病与调节细胞的产生有关。本发明涉及免疫系统在这些疾病中循环的观察。基于这些观察，本发明提供了治疗诸如癌症和HIV感染之类疾病的方法。本发明还涉及确定何时将治疗以治疗细胞产生为特征的疾病的治疗施用于患者的方法。

9. 发明授权

US08524651B2 Method of therapy 有权
标题翻译：治疗方法
公开(公告)号：US08524651B2
公开(公告)日：2013-09-03
申请号：US13396254
申请日：2012-02-14
申请人： Martin Leonard Ashdown
发明人： Martin Leonard Ashdown
IPC分类号： A01N61/00
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737 , G06F19/00
摘要： Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.
摘要翻译：许多疾病与调节细胞的产生有关。本发明涉及免疫系统在这些疾病中循环的观察。基于这些观察，本发明提供了治疗诸如癌症和HIV感染之类疾病的方法。本发明还涉及确定何时将治疗以治疗细胞产生为特征的疾病的治疗施用于患者的方法。

10. 发明申请

US20140051100A1 METHOD OF THERAPY 审中-公开
公开(公告)号：US20140051100A1
公开(公告)日：2014-02-20
申请号：US14061937
申请日：2013-10-24
申请人： ImmunAid Pty. Ltd.
发明人： Martin Leonard Ashdown
IPC分类号： G01N33/543
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737
摘要： Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

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