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1. 发明专利

TW200827362A 克里鮑林素(cripowellins)及其衍生物於治療腫瘤疾病之用途 USES OF CRIPOWELLINS AND DERIVATIVES THEREOF IN THE TREATMENT OF TUMORAL DISEASES 审中-公开
简体标题：克里鲍林素(cripowellins)及其衍生物于治疗肿瘤疾病之用途 USES OF CRIPOWELLINS AND DERIVATIVES THEREOF IN THE TREATMENT OF TUMORAL DISEASES
公开(公告)号：TW200827362A
公开(公告)日：2008-07-01
申请号：TW096134850
申请日：2007-09-19
申请人：英特梅德發現有限公司 INTERMED DISCOVERY GMBH
发明人：馬提亞斯葛靈 GEHLING, MATTHIAS , 歐拉夫韋伯 WEBER, OLAF
IPC分类号： C07D , A61K , C07H , A61P
CPC分类号： A61K31/55 , A61K31/7052
摘要：本發明係關於克里鮑黴素(cripowellins)及其衍生物在製備用以治療腫瘤疾病之醫藥組合物上的用途。
简体摘要：本发明系关于克里鲍霉素(cripowellins)及其衍生物在制备用以治疗肿瘤疾病之医药组合物上的用途。

2. 发明申请

WO2011151298A1 PRODUCTION OF FATTY ACIDS BY HETEROLOGOUS EXPRESSION OF GENE CLUSTERS FROM MYXOBACTERIA 审中-公开
标题翻译：从MYXOBACTERIA通过异源表达基因簇产生脂肪酸
公开(公告)号：WO2011151298A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/058863
申请日：2011-05-30
申请人： INTERMED DISCOVERY GMBH , WENZEL, Silke , RACHID, Shwan , GEMPERLEIN, Katja , MÜLLER, Rolf
发明人： WENZEL, Silke , RACHID, Shwan , GEMPERLEIN, Katja , MÜLLER, Rolf
IPC分类号： C12P7/64 , C12N9/02 , C12N9/10 , C12N15/52
CPC分类号： C12P7/6427 , C12N9/001 , C12N9/1029 , C12N15/52 , C12P7/64 , C12Y103/01009 , C12Y203/01051 , Y02P20/52
摘要： The invention relates to a process for producing one or more polyunsaturated fatty acids by means of heterologous gene expression comprising the steps of providing a production organism which comprises a heterologous gene cluster encoding a polyunsaturated fatty acid biosynthetic pathway encompassing a subsequence ER encoding an enoylreductase and a subsequence AT encoding an acyltransferase, growing the production organism in the presence of a fermentable carbon source whereby one or more polyunsaturated fatty acids are produced, and optionally recovering the one or more polyunsaturated fatty acids.
摘要翻译：本发明涉及通过异源基因表达产生一种或多种多不饱和脂肪酸的方法，包括提供生产生物体的步骤，所述生物体包含编码多不饱和脂肪酸生物合成途径的异源基因簇，其包含编码烯酰基还原酶的亚序列ER，和亚序列AT编码酰基转移酶，在可发酵碳源的存在下生长生产生物体，从而产生一种或多种多不饱和脂肪酸，以及任选地回收一种或多种多不饱和脂肪酸。

3. 发明申请

WO2010063451A3 PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA 审中-公开
公开(公告)号：WO2010063451A3
公开(公告)日：2010-06-10
申请号：PCT/EP2009/008560
申请日：2009-12-01
申请人： INTERMED DISCOVERY GMBH , STADLER, Marc , ROEMER, Ernst , MÜLLER, Rolf , GARCIA, Ronald O. , PISTORIUS, Dominik , BRACHMANN, Alexander
发明人： STADLER, Marc , ROEMER, Ernst , MÜLLER, Rolf , GARCIA, Ronald O. , PISTORIUS, Dominik , BRACHMANN, Alexander
IPC分类号： C12P7/64 , C12N1/20
摘要： The present invention provides a method for producing ω-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.

4. 发明申请

WO2010063451A2 PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA 审中-公开
标题翻译：通过MYXOBACTERIA生产OMEGA-3脂肪酸
公开(公告)号：WO2010063451A2
公开(公告)日：2010-06-10
申请号：PCT/EP2009008560
申请日：2009-12-01
申请人： INTERMED DISCOVERY GMBH , STADLER MARC , ROEMER ERNST , MUELLER ROLF , GARCIA RONALD O , PISTORIUS DOMINIK , BRACHMANN ALEXANDER
发明人： STADLER MARC , ROEMER ERNST , MUELLER ROLF , GARCIA RONALD O , PISTORIUS DOMINIK , BRACHMANN ALEXANDER
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , C12R1/01
摘要： The present invention provides a method for producing ?-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.
摘要翻译：本发明提供通过培养适用于所述方法的特异性粘液细菌染色剂和粘液菌菌株来生产α-3多不饱和脂肪酸的方法。

5. 发明申请

WO2012079721A8 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
公开(公告)号：WO2012079721A8
公开(公告)日：2012-06-21
申请号：PCT/EP2011/006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
发明人： GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

6. 发明申请

WO2009021622A1 EXTRACTS WITH LIVER-X-RECEPTOR MODULATORS, COMPOUNDS AND THEIR USE ESPECIALLY IN WEIGHT CONTROL 审中-公开
标题翻译：与肝脏受体调节剂，化合物及其在体重控制中特别有用的提取物
公开(公告)号：WO2009021622A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/006226
申请日：2008-07-29
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , ROEMER, Ernst , HENKEL, Thomas
发明人： GROTHE, Torsten , ROEMER, Ernst , HENKEL, Thomas
IPC分类号： A61K31/085 , A61K31/215 , A61K31/343 , A61K36/79 , A61K36/57 , A61P3/04 , A61P3/06
CPC分类号： A61K31/36 , A61K31/085 , A61K31/09 , A61K31/215 , A61K31/222 , A61K31/343 , A61K36/57 , A61K36/79
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra , Illicium , Kadsura, Steganotaenia and Magnolia , alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament for the treatment of obesity, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in the regulation of body weight and/or fat loss and/or for the management of obesity.
摘要翻译：本发明涉及分别使用来自植物或植物部分的提取物和/或一种或多种天然化合物的用途或方法（特别是关于动物，特别是人类），选自五味子，Illicium，Kadsura，Steganotaenia和Magnolia的属，单独或作为补充作为活性成分，用于调节体重和/或脂肪减少和/或用于肥胖的管理，人或动物中使用所述提取物和/或天然化合物或混合物来制造用于调节体重和/或脂肪损失的药物或营养制剂，和/或用于肥胖的管理在人类或动物中。上述提取物和/或化合物还可用于减少受试者中的一种或多种不利代谢参数。本发明还涉及用于治疗或制备用于治疗肥胖症的药物及其制备的所述提取物和/或化合物。它还涉及包含可用于调节体重和/或脂肪减少和/或用于肥胖的管理的所述提取物和/或天然化合物的药物或营养制剂。

7. 发明申请

WO2008034580A3 USES OF CRIPOWELLINS AND THE DERIVATIVES THEREOF FOR THE TREATMENT OF TUMOR DISEASES 审中-公开
标题翻译： CRIPOWELLINEN学报TUMÖRERKRANKUNGEN的处理使用及其衍生物
公开(公告)号：WO2008034580A3
公开(公告)日：2008-08-07
申请号：PCT/EP2007008110
申请日：2007-09-17
申请人： INTERMED DISCOVERY GMBH , GEHLING MATTHIAS , WEBER OLAF
发明人： GEHLING MATTHIAS , WEBER OLAF
IPC分类号： A61K31/55 , A61K31/7052 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/55 , A61K31/7052
摘要： The invention relates to the use of cripowellins and the derivatives thereof for producing medicaments utilized for treating tumor diseases.
摘要翻译：本发明涉及使用Cripowellinen的和用于制备药物的肿瘤疾病的治疗及其衍生物。

8. 发明申请

WO2012167920A1 LONG CHAIN GLYCOLIPIDS USEFUL TO AVOID PERISHING OR MICROBIAL CONTAMINATION OF MATERIALS 审中-公开
标题翻译：长链甘露糖苷有助于避免物质的微生物污染或微生物污染
公开(公告)号：WO2012167920A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/002399
申请日：2012-06-06
申请人： INTERMED DISCOVERY GMBH , STADLER, Marc , BITZER, Jens , KÖPCKE, Bärbel , REINHARDT, Kathrin , MOLDENHAUER, Jana
发明人： STADLER, Marc , BITZER, Jens , KÖPCKE, Bärbel , REINHARDT, Kathrin , MOLDENHAUER, Jana
IPC分类号： A01N43/14 , A01N63/02 , C07H15/04 , C12P19/44
CPC分类号： A01N43/16 , A01N63/04 , A23B4/20 , A23B5/14 , A23B7/154 , A23B9/26 , A23L2/44 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/99 , A61Q5/02 , A61Q17/005 , C07H15/04 , C12P19/44
摘要： The invention relates to the use of, and methods of use employing, certain glycolipid compounds as defined in detail below and having preservative or antimicrobial properties, novel compounds of the glycolipid class, and related invention embodiments. The compounds have the formula (I) wherein m is (3) to (5), n is (2) to (5), o is (0) or (1) and p is (3) to (17), with the proviso that the sum m + n + o + p is not less than (14); and R is a carbohydrate moiety bound via one of its carbon atoms to the binding oxygen, and/or a physiologically, especially pharmaceutically or nutraceutically or cosmetically, acceptable salt thereof, or an ester thereof, as such or in the form of a composition, where the compound may be present in open chain form and/or in the form of a lactone.
摘要翻译：本发明涉及使用以下详细定义的具有防腐或抗微生物性质的某些糖脂化合物的使用和使用方法，糖脂类的新型化合物和相关的发明实施方案。化合物具有式（I）其中m为（3）至（5），n为（2）至（5），o为（0）或（1），p为（3）至（17）条件是总和m + n + o + p不小于（14）; 并且R是通过其碳原子之一与结合氧结合的碳水化合物部分，和/或其生理学上，特别是其药学上或药学上可接受的盐或其酯，或者以组合物的形式，其中化合物可以以开链形式和/或以内酯的形式存在。

9. 发明申请

WO2011085979A1 USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS 审中-公开
标题翻译：在治疗肥胖和相关疾病和非治疗可治疗条件下使用三酯酸酯酶
公开(公告)号：WO2011085979A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/000110
申请日：2011-01-13
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , ROEMER, Ernst , WABNITZ, Philipp
发明人： GROTHE, Torsten , ROEMER, Ernst , WABNITZ, Philipp
IPC分类号： C07D307/93 , A61K31/343 , A61P3/04 , A61P3/06 , A61K8/49
CPC分类号： C07D307/93 , A61K8/4973 , A61K8/97 , A61K31/365 , A61K36/28 , A61Q19/06
摘要： A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic - including prophylactic - treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
摘要翻译：式I的化合物，其中符号如剩余说明书中所定义，或两种或更多种式I化合物的混合物，用作治疗性包括预防性治疗温血动物的活性成分用于调节体重（优选）和/或脂肪减少（优选）和/或用于管理肥胖症和/或改善总胆固醇HDL / LDL比率; 其中式I的化合物可以以互变异构体的形式，以酯和/或溶剂合物的形式以游离形式存在，以药物和/或营养学上可接受的盐的形式存在，以及相关的发明实施例。

10. 发明申请

WO2012079721A1 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
标题翻译：具有LXR激动剂的TERPENOID SPIRO KETAL化合物活性，与他们的使用和配方
公开(公告)号：WO2012079721A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
发明人： GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.
摘要翻译：本发明涉及分别使用提取物和/或特别是一种或多种天然螺三萜类化合物及其衍生物的用途或方法（特别是涉及动物，特别是人类，需要这种治疗）特别是从作为活性成分的单独或作为补充剂的姬松茸物种获得的风疹家族，用于预防和/或治疗治疗响应肝脏X受体的调节的疾病，病症或病症，在人或其他哺乳动物和/或使用所述提取物和/或天然化合物或混合物来治疗所述疾病，病症或病症，以及相应的治疗方法或其在制造药物或制剂中的用途用于所述治疗的营养制剂。本发明还涉及用于治疗或制备用于预防和/或治疗所述病症，障碍或病症的药物（包括营养药物）的所述提取物和/或化合物，以及他们的准备。它还涉及包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

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