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1. 发明申请

WO2010140769A3 APPARATUS FOR MEASURING BIODATA AND METHOD FOR MEASURING BIODATA USING AN ALGORITHM FOR IMPROVING REPRODUCIBILITY 审中-公开
标题翻译：用于测量生物数据的装置和使用用于提高重现性的算法来测量生物数据的方法
公开(公告)号：WO2010140769A3
公开(公告)日：2011-01-20
申请号：PCT/KR2010002407
申请日：2010-04-19
申请人： INFOPIA CO LTD , BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM , LEE YOON-HEE
发明人： BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM , LEE YOON-HEE
IPC分类号： A61B5/145
CPC分类号： A61B5/14546 , A61B5/1455 , G01N33/48785 , G06F19/30 , G06F19/34 , G06F19/3406 , G16H40/63
摘要： Disclosed are an apparatus for measuring biodata and a method for measuring biodata using an algorithm for improving reproducibility. The method for measuring biodata, according to one embodiment of the present invention, involves: determining whether or not a reaction is stabilized on the basis of the mean ratio of the change in a predetermined section of the early stage of measurement to determine a reaction ending time; and adding a correction value to the value measured at the determined reaction ending time to obtain a final measurement value, thereby reducing measurement errors and improving reproducibility and data reliability.
摘要翻译：公开了一种用于测量生物数据的装置和使用用于提高再现性的算法来测量生物数据的方法。根据本发明的一个实施方案，生物量测定方法包括：基于测量初期的预定部分的变化的平均比例来确定反应是否稳定以确定反应结束时间; 并在确定的反应结束时间上添加校正值以获得最终测量值，从而减少测量误差并提高再现性和数据可靠性。

2. 发明申请

WO2016117725A1 MOLECULAR DIAGNOSTIC CARTRIDGE 审中-公开
标题翻译：分子诊断盒
公开(公告)号：WO2016117725A1
公开(公告)日：2016-07-28
申请号：PCT/KR2015/000693
申请日：2015-01-23
申请人： INFOPIA CO., LTD.
发明人： BAE, Byeong Woo , HWANG, In Kyoung , PARK, Seong Min , KIM, Eun Ja
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L2300/0803 , B01L2300/0809 , B01L2300/0867 , B01L2400/0487 , B01L2400/0644
摘要： Provided is a molecular diagnostic cartridge. The molecular diagnostic cartridge according to one aspect of the present invention includes a first housing comprising a plurality of processing chambers continuously connected to process a sample, a washing chamber for washing and a discharging chamber connected to at least one of the plurality of processing chambers and the washing chamber, and having a discharging port through which a solution is discharged; and a second housing disposed under the first housing, and comprising a waste chamber configured to accommodate a waste solution and a target chamber configured to accommodate a target solution, and movably provided so that one of the waste chamber and the target chamber is selectively connected with the discharging port.
摘要翻译：提供分子诊断盒。根据本发明的一个方面的分子诊断盒包括：第一壳体，包括连续连接以处理样品的多个处理室，用于洗涤的洗涤室和连接到所述多个处理室中的至少一个处理室的排出室;以及洗涤室，并且具有排出口，溶液通过该排出口排出; 以及第二壳体，设置在所述第一壳体下方，并且包括废物室，所述废物室被构造成容纳废液和被配置为容纳目标溶液的目标室，并且可移动地设置成使得所述废物室和所述目标室中的一个选择性地与排放口。

3. 发明申请

WO2010008238A3 AN IMMUNOCHROMATOGRAPHY DETECTION SENSOR COMPRISING OPTICAL WAVEGUIDE AND A DETECTION METHOD USING THE SAME 审中-公开
公开(公告)号：WO2010008238A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009/003960
申请日：2009-07-17
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , INFOPIA CO., LTD. , SHIN, Yong Beom , KIM, Min Gon , BAE, Byeong Woo
发明人： SHIN, Yong Beom , KIM, Min Gon , BAE, Byeong Woo
IPC分类号： G01N30/95
摘要： The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of optical waveguide and the colored conjugate in the band formed on the membrane, and thus the absorbance signal from the colored conjugate is greatly amplified to improve the sample detection sensitivity, and a detection method using the same.

4. 发明申请

WO2009048217A1 REACTION CASSETTE FOR MEASURING THE CONCENTRATION OF GLYCATED HEMOGLOBIN AND MEASURING METHOD THEREOF 审中-公开
标题翻译：用于测定糖化血红蛋白浓度的反应试剂及其测定方法
公开(公告)号：WO2009048217A1
公开(公告)日：2009-04-16
申请号：PCT/KR2008/003587
申请日：2008-06-24
申请人： INFOPIA CO., LTD. , BAE, Byeong-woo , LEE, Sung-dong , KIM, Min-sun , YOO, Jae-hyun , KIM, Hyoung-soo , LEE, Ki-won , HONG, Ju-pyo
发明人： BAE, Byeong-woo , LEE, Sung-dong , KIM, Min-sun , YOO, Jae-hyun , KIM, Hyoung-soo , LEE, Ki-won , HONG, Ju-pyo
IPC分类号： G01N33/49
CPC分类号： G01N33/723 , B01L3/502 , B01L2200/0621 , B01L2400/0457 , G01N33/54306 , G01N33/726
摘要： A reaction cassette for a glycated hemoglobin meter and a measuring method thereof are provided. The reaction cassette for the glycated hemoglobin meter includes: a first zone receiving a first reagent and a blood sample; a second zone receiving a second reagent; a reaction zone in which the blood sample reacts with the first reagent, or through which the second reagent passes to react with a first blood sample mixture obtained by reacting the blood sample with the first reagent; and a measurement zone measuring an amount of total hemoglobin in the first blood sample mixture, or measuring an amount of glycated hemoglobin in a second blood sample mixture obtained by reacting the first blood sample mixture with the second reagent, wherein the blood sample, the first reagent, and the second reagent move between the reaction zone and the measurement zone according to a rotation angle of the reaction cassette when the reaction cassette is rotated. Therefore, since the reaction cassette rotates automatically, it is possible to measure the amount of glycated hemoglobin in a blood sample through simple manipulation and reduce a manufacturing time. Furthermore, since reagents are supplied to the reaction cassette from a separate reagent pack, it is possible to resolve storage and distribution problems of the reaction cassette, which occur when reagents are stored in the reaction cassette.
摘要翻译：提供了糖化血红蛋白计的反应盒及其测定方法。糖化血红蛋白计的反应盒包括：接收第一试剂和血液样品的第一区; 接收第二试剂的第二区域; 血液样品与第一试剂反应的反应区域，或第二试剂通过的反应区域与通过使血液样品与第一试剂反应获得的第一血液样品混合物反应; 以及测量第一血液样品混合物中的总血红蛋白量的测量区域，或者测量通过使第一血液样品混合物与第二试剂反应获得的第二血液样品混合物中的糖化血红蛋白的量，其中，血液样品，第一试剂，第二试剂在反应盒旋转时根据反应盒的旋转角度在反应区和测量区之间移动。因此，由于反应盒自动旋转，因此可以通过简单的操作来测量血液样品中的糖化血红蛋白的量，并减少制造时间。此外，由于将试剂从单独的试剂盒供给到反应盒中，因此可以解决当试剂储存在反应盒中时发生的反应盒的储存和分配问题。

5. 发明申请

WO2004029605A1 APPARATUS AND METHOD FOR MEASURING REACTION RESULT OF SAMPLES ON BIOSENSOR 审中-公开
标题翻译：用于测量生物传感器样品的反应结果的装置和方法
公开(公告)号：WO2004029605A1
公开(公告)日：2004-04-08
申请号：PCT/KR2002/001853
申请日：2002-10-04
申请人： INFOPIA CO., LTD. , BAE, Byung-Woo , LEE, Heon-Kwon , LEE, Sung-Dong , KIM, Won-Dong , SONG, Jung-Shik , YOO, Jin-A
发明人： BAE, Byung-Woo , LEE, Heon-Kwon , LEE, Sung-Dong , KIM, Won-Dong , SONG, Jung-Shik , YOO, Jin-A
IPC分类号： G01N27/00
CPC分类号： G01N27/3274 , G01N27/3273
摘要： Disclosed are an apparatus and a method for determining whether or not a biosensor comprising two working electrodes and one reference electrode is well manufactured, and for rapidly and accurately quantifying a specific substance contained in a biological sample. The method comprises the steps of: sequentially supplying the respective working electrodes with power supply voltage; sequentially detecting the amounts of current flowing in the respective working electrodes by virtue of the supplied power supply voltage; re-supplying the two working electrodes with power supply voltage after a predetermined time to redetect the amounts of current flowing in the respective working electrodes; reading concentrations corresponding to the amounts of current detected from a memory, and calculating an average value from the read concentrations; and checking whether or not the concentrations read from memory are within a predetermined critical range to display an error message or the calculated average value.
摘要翻译：公开了一种用于确定包括两个工作电极和一个参比电极的生物传感器是否被良好地制造并且用于快速和准确地定量生物样品中包含的特定物质的装置和方法。该方法包括以下步骤：向相应的工作电极依次提供电源电压; 通过提供的电源电压依次检测在各个工作电极中流动的电流量; 在预定时间之后将两个工作电极重新供给电源电压以重新检测在各个工作电极中流动的电流量; 读取与存储器检测到的电流量相对应的浓度，并根据读取的浓度计算平均值; 并且检查从存储器读取的浓度是否在预定的临界范围内，以显示错误消息或所计算的平均值。

6. 发明申请

WO2003005015A1 GLUCOSE STRIP SENSOR AND GLUCOSE MEASUREMENT METHOD USING THE GLUCOSE STRIP SENSOR 审中-公开
标题翻译：葡萄糖条纹传感器和使用葡萄糖条纹传感器的葡萄糖测量方法
公开(公告)号：WO2003005015A1
公开(公告)日：2003-01-16
申请号：PCT/KR2001/001702
申请日：2001-10-10
申请人： INFOPIA CO., LTD. , BAE, Byung-woo , KANG, Byung-soo , PARK, Seong-gi , LEE, Seong-dong , KWON, Mi-joong
发明人： BAE, Byung-woo , KANG, Byung-soo , PARK, Seong-gi , LEE, Seong-dong , KWON, Mi-joong
IPC分类号： G01N27/403
CPC分类号： G01N27/3272 , G01N33/66
摘要： Disclosed is a disposable glucose strip sensor configured to rapidly and conveniently measure the concentration of glucose in blood and a glucose measurement method using the glucose strip sensor. In the glucose strip sensor, at least one checking electrode (33) is additionally provided at an electrode section (30) including an operating electrode (31) and a counter electrode (32). The checking electrode (33) serves to check whether or not it is electrically connected with the counter electrode (32), upon measuring the concentration of glucose in a blood sample introduced in the sensor. Where two checking electrodes are provided, it may be checked whether or not an electrical connection is established between those checking electrodes. Based on the result of the checking, it is possible to determine whether or not a sufficient amount of blood sample is filled in the sensor. Accordingly, the measurement of glucose concentration can be accurately achieved.
摘要翻译：公开了一种一次性葡萄糖条传感器，其被配置为快速且方便地测量血液中葡萄糖的浓度和使用葡萄糖条带传感器的葡萄糖测量方法。在葡萄糖条传感器中，在包括操作电极（31）和对电极（32）的电极部（30）处另外设置至少一个检查电极（33）。检测电极（33）用于在测量导入传感器的血液样本中的葡萄糖浓度时，检查其是否与对电极（32）电连接。在设置两个检查电极的情况下，可以检查在这些检查电极之间是否建立电连接。基于检查结果，可以确定传感器中是否填充有足够量的血样。因此，可以准确地实现葡萄糖浓度的测定。

7. 发明申请

WO2010140762A3 CHOLESTEROL-MEASURING STRIP AND METHOD FOR MEASURING CHOLESTEROL USING SAME 审中-公开
标题翻译：胆固醇测定条和使用其测量胆固醇的方法
公开(公告)号：WO2010140762A3
公开(公告)日：2011-01-13
申请号：PCT/KR2010002037
申请日：2010-04-02
申请人： INFOPIA CO LTD , BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM
发明人： BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM
IPC分类号： A61B5/145
CPC分类号： G01N33/526 , C12Q1/60 , G01N33/92
摘要： Disclosed is a strip for measuring cholesterol data, as well as a method for measuring cholesterol using same. The measuring strip according to one aspect of the present invention comprises: a red blood cell and low density lipoprotein (LDL) cholesterol filtering layer which hemagglutinates red blood cells and deposits low density lipoprotein (LDL) cholesterol at the same time from injected blood to perform red blood cell isolation and low density lipoprotein (LDL) cholesterol isolation at the same time; and a reaction layer which performs a reaction with the blood in which the red blood cells and the low density lipoprotein (LDL) cholesterol are isolated, in order to obtain cholesterol data. The present invention enables red blood cell isolation and low density lipoprotein (LDL) cholesterol isolation to be performed at the same time in a single layer, to thereby reduce the thickness of the strip and the amount of blood required for measurement at the same time.
摘要翻译：公开了一种用于测量胆固醇数据的条带，以及使用其测量胆固醇的方法。根据本发明的一个方面的测量条包括：红血细胞和低密度脂蛋白（LDL）胆固醇过滤层，其从注射的血液同时血凝红细胞并沉积低密度脂蛋白（LDL）胆固醇，以执行红细胞分离和低密度脂蛋白（LDL）胆固醇同时分离; 以及与分离出红细胞和低密度脂蛋白（LDL）胆固醇的血液进行反应的反应层，以获得胆固醇数据。本发明能够在单层中同时进行红细胞分离和低密度脂蛋白（LDL）胆固醇分离，从而同时减少条带的厚度和测量所需的血量。

8. 发明申请

WO2010140763A2 BIOSENSOR 审中-公开
标题翻译：生物传感器
公开(公告)号：WO2010140763A2
公开(公告)日：2010-12-09
申请号：PCT/KR2010002126
申请日：2010-04-07
申请人： INFOPIA CO LTD , BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM , AHN KU-CHEOL
发明人： BAE BYEONG-WOO , LEE SUNG-DONG , KHO BYUNG-HOON , RYU JI-EON , KIM JIN-KYEONG , JOUNG HYOU-ARM , AHN KU-CHEOL
IPC分类号： G01N33/52 , G01N21/77
CPC分类号： C12Q1/006
摘要： The present invention relates to a biosensor for measuring biomedical data. The biosensor comprises a measurement layer into which a biosample is injected and which reacts with the biosample to obtain biodata of the biosample. In addition, the biosensor comprises a lower cover which is arranged beneath the lower surface of the measurement layer, and which has a lower opening window exposed so as to serve as a measurement area for obtaining reaction data of the biosample, and a lower protrusion protruding upwardly in the peripheral area of the lower opening window. Further, the biosensor comprises an upper cover which is arranged on the upper surface of the measurement layer, and which has an upper opening window exposed so as to be fed with the biosample, and an upper protrusion protruding downwardly in the area away from the upper opening window and the area corresponding to the lower protrusion. Here, the upper cover and the lower cover are pressed against each other with the measurement layer therebetween to form a capillary gap by means of the upper surface of the measurement layer, the lower surface of the upper cover, and the upper protrusion. Consequently, not only can the amount of the biosample required for the measurement by the biosensor be minimized, but measurement errors caused by the volume of red blood cells can be minimized as well.
摘要翻译：本发明涉及用于测量生物医学数据的生物传感器。生物传感器包括测量层，生物样品被注入其中并与生物样品反应以获得生物样品的生物量。此外，生物传感器包括下盖，其布置在测量层的下表面下方，并且具有暴露的下开口窗，以用作用于获得生物样本的反应数据的测量区域，以及下突出突出部向上在下开口窗的周边区域。此外，生物传感器包括布置在测量层的上表面上的上盖，并且具有暴露于供给生物样本的上部开口窗，并且在远离上部的区域中向下突出的上部突起打开窗口和对应于下突出部分的区域。这里，上盖和下盖通过其间的测量层彼此挤压以通过测量层的上表面，上盖的下表面和上突起形成毛细管间隙。因此，生物传感器的测量所需的生物样本的量不仅可以最小化，而且由红细胞的体积引起的测量误差也可以最小化。

9. 发明申请

WO2010061992A1 METHOD FOR AMPLIFICATION OF SIGNAL IN IMMUNOCHROMATOGRAPHIC ASSAY AND IMMUNOCHROMATOGRAPHIC KIT USING THE METHOD 审中-公开
标题翻译：免疫荧光测定中信号放大的方法和使用该方法的免疫印迹试剂盒
公开(公告)号：WO2010061992A1
公开(公告)日：2010-06-03
申请号：PCT/KR2008/007049
申请日：2008-11-28
申请人： INFOPIA CO., LTD. , BAE, Byeong-Woo , LEE, Sung-Dong , KIM, Min-Gon , SHIN, Yong-Beom , JANG, Jin-Hee , SHIN, Ji-Hun
发明人： BAE, Byeong-Woo , LEE, Sung-Dong , KIM, Min-Gon , SHIN, Yong-Beom , JANG, Jin-Hee , SHIN, Ji-Hun
IPC分类号： G01N30/90 , G01N33/53 , G01N33/48 , G01N33/487
CPC分类号： G01N33/558 , G01N33/585
摘要： The present invention relates to a method for amplifying a signal in an immunochro- matographic assay for high- sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of a second indicator. According to an aspect of the present invention, a method for amplifying a signal in an im¬ munochromatographic assay includes: binding a primary conjugate body, which has a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, to the analyte; binding the analyte bound to the primary conjugate body to an immobilized second antibody binding specifically to a second epitope of the analyte; and binding a secondary conjugate body, which has a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, to the connector of the primary conjugate body, wherein the primary conjugate body is disposed nearer to the immobilized second antibody than the secondary conjugate body, and the particle of the second indicator is larger than the particle of the first indicator, so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body. According to another aspect of the present invention, an immunochromatographic kit includes: a sample pad to which a liquid sample containing an analyte is applied; a conjugate pad including a primary conjugate body having a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, and a secondary conjugate body having a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, wherein the primary conjugate body is disposed nearer to an immobilized second antibody than the secondary conjugate body and the second indicator is larger than the first indicator so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body; a membrane including a detection site immobilizing thereto the second antibody binding specifically to a second epitope of the analyte to which the primary conjugate body is bound, and a control site for error detection; and an absorbing pad absorbing the liquid sample by a capillary phenomenon. Thus, the present invention can perform signal amplification without separate mechanical control or artificial step-by-step reaction.
摘要翻译：本发明涉及一种在免疫色谱测定中放大信号的方法，用于高分辨率检测分析物和免疫色谱试剂盒，该方法通过以下方法放大信号：通过将第一指示器和第二个指示器的大小。根据本发明的一个方面，用于在致癌色谱测定中扩增信号的方法包括：结合具有特异性结合分析物的第一表位的第一抗体的第一缀合物体，连接体和第一第一抗体和连接体与其结合的指示剂; 将结合到主结合体的分析物结合到特异性结合分析物的第二表位的固定化的第二抗体; 并且将具有特异性结合至第一缀合物的连接体的第三抗体和与第三抗体结合的第二指示剂的第三抗体结合到第一缀合物的连接体上，其中设置第一缀合物体比第二结合体更接近固定化的第二抗体，并且第二指示剂的颗粒大于第一指示剂的颗粒，使得次级缀合物体比第一缀合体晚到达固定的第二抗体。根据本发明的另一方面，免疫色谱试剂盒包括：将含有分析物的液体样品施加到的样品垫; 包含具有与分析物的第一表位特异性结合的第一抗体的第一缀合物的主共轭体，连接体以及与第一抗体和连接体结合的第一指示剂，以及具有第三抗体结合的第二结合体具体地涉及第一结合体的连接体和与第三抗体结合的第二指示剂，其中所述主结合体设置为比所述第二缀合物更接近于固定的第二抗体，并且所述第二指示物比所述第一指示物大次偶合体比第一缀合物晚到达固定的第二抗体; 包含检测部位的膜，其固定有第二抗体，特异性结合与所述主结合体结合的分析物的第二表位，以及用于检测的对照部位; 以及通过毛细管现象吸收液体样品的吸收垫。因此，本发明可以在没有单独的机械控制或人工分步反应的情况下进行信号放大。

10. 发明申请

WO2010008238A2 AN IMMUNOCHROMATOGRAPHY DETECTION SENSOR COMPRISING OPTICAL WAVEGUIDE AND A DETECTION METHOD USING THE SAME 审中-公开
标题翻译：包括光波导的免疫层析检测传感器和使用该检测方法的检测方法
公开(公告)号：WO2010008238A2
公开(公告)日：2010-01-21
申请号：PCT/KR2009003960
申请日：2009-07-17
申请人： KOREA RES INST OF BIOSCIENCE , INFOPIA CO LTD , SHIN YONG BEOM , KIM MIN GON , BAE BYEONG WOO
发明人： SHIN YONG BEOM , KIM MIN GON , BAE BYEONG WOO
IPC分类号： G01N30/95
CPC分类号： G01N33/54373 , G01N21/7703 , G01N30/95 , G01N33/558 , G01N2021/7766
摘要： The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of optical waveguide and the colored conjugate in the band formed on the membrane, and thus the absorbance signal from the colored conjugate is greatly amplified to improve the sample detection sensitivity, and a detection method using the same.
摘要翻译：本发明涉及包括光波导的免疫层析检测传感器和使用其的检测方法，并且更具体地涉及包括光波导的免疫层析检测传感器，其中光波导设置在膜下方，探测光束透过光学波导使在光波导表面上产生的eva逝波和在膜上形成的带中的彩色共轭物之间的相互作用频率最大化，并且因此来自彩色共轭物的吸收信号被极大地放大以提高样品检测灵敏度，以及检测方法使用相同的。

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