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1. 发明公开

EP0575923A1 Triazole Derivatives 失效
标题翻译： Triazolderivate。
公开(公告)号：EP0575923A1
公开(公告)日：1993-12-29
申请号：EP93109829.7
申请日：1993-06-19
申请人： Ikeda Mohando Co., Ltd.
发明人： Ogawa, Kazu
IPC分类号： C07D403/06 , C07D207/32 , A61K31/41
CPC分类号： C07D207/323 , C07D207/33 , C07D231/12 , C07D233/56 , C07D249/08
摘要： A triazole derivative having antifungal activity is disclosed. The compounds are represented by the following formula:

wherein Ar represents a phenyl group or a phenyl group substituted with one or two groups selected from the group consisting of halogen atoms and trifluoromethyl group; R¹ and R² independently represent a hydrogen atom, halogen atom, or a lower alkyl group; R³ and R⁴ independently represent a hydrogen atom, halogen atom, nitro group, a lower alkyl group, a lower halogeno-alkyl group, a lower alkoxy group, a lower halogeno-alkoxy group, non-substituted or substituted aryl group, non-substituted or substituted amino group, or a lower alkylthio group.
摘要翻译：公开了具有抗真菌活性的三唑衍生物。该化合物由下式表示：其中Ar表示苯基或被选自卤素原子和三氟甲基的一个或两个基团取代的苯基; R 1和R 2独立地表示氢原子，卤素原子或低级烷基; R 3和R 4独立地表示氢原子，卤素原子，硝基，低级烷基，低级卤代烷基，低级烷氧基，低级卤代烷氧基，未取代或取代的芳基，未取代或取代的氨基或低级烷硫基。

2. 发明授权

EP0319903B1 Pyrimidone compound and pharmaceutically acceptable salts thereof 失效
标题翻译：嘧啶酮化合物和它们的药学上可接受的盐。
公开(公告)号：EP0319903B1
公开(公告)日：1994-08-17
申请号：EP88120340.0
申请日：1988-12-06
申请人： Ikeda Mohando Co., Ltd.
发明人： Nohara, Fujio
IPC分类号： C07D239/46 , C07D401/12 , A61K31/505
CPC分类号： C07D239/47 , C07D401/12 , C07D405/12 , C07D405/14

3. 发明授权

US4673747A Aminoalkylphenoxy derivatives 失效
标题翻译：氨基烷基苯氧基衍生物
公开(公告)号：US4673747A
公开(公告)日：1987-06-16
申请号：US804148
申请日：1985-12-03
申请人： Fujio Nohara , Tomoaki Fujinawa
发明人： Fujio Nohara , Tomoaki Fujinawa
IPC分类号： C07D253/06 , A61K31/135 , A61K31/41 , A61K31/433 , A61K31/505 , A61P1/04 , A61P43/00 , C07C67/00 , C07C213/00 , C07C225/20 , C07D239/46 , C07D239/48 , C07D253/075 , C07D285/10 , C07D285/12 , C07D285/135 , C07D295/08 , C07D295/096 , C07D401/12 , C07D205/04 , C07D207/09 , C07D211/22
CPC分类号： C07D239/48 , C07D253/075 , C07D285/10 , C07D285/135 , C07D295/096
摘要： Substituted aminoalkylphenoxy derivatives represented by the general formula of: ##STR1## wherein the substituting group Z is either one of the following groups of: ##STR2## were prepared. These derivatives exert antagonism against Histamine H.sub.2 -receptors and hence are efficacious for the treatments of digestive ulcers.

4. 发明授权

US4283532A Process for preparation of o-(2,6-dichloroanilino)phenylacetic acid and novel intermediate for use in preparation of the same 失效
标题翻译：制备邻 - （2,6-二氯苯胺基）苯乙酸的方法和用于制备其的新型中间体
公开(公告)号：US4283532A
公开(公告)日：1981-08-11
申请号：US64404
申请日：1979-08-07
申请人： Fujio Nohara
发明人： Fujio Nohara
IPC分类号： C07B61/00 , B01J23/00 , B01J27/00 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/42 , C07C231/00 , C07C231/12 , C07C237/20 , C07D295/185 , C07C51/06 , C07C102/00 , C07D295/18
CPC分类号： C07D295/185
摘要： Disclosed is a process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid (Diclofenac) or its pharmacologically acceptable acid addition salt, which comprises hydrolyzing an N,N-disubstituted-o-(2,6-dichloroanilino)phenylacetamide derivative with an alkali. Also a novel intermediate for use in the preparation of Diclofenac, that is, an N,N-disubstituted-o-halogenophenylacetamide in which the halogen is iodine or bromine, is disclosed.
摘要翻译：公开了一种制备邻 - （2,6-二氯苯胺基）苯乙酸（双氯芬酸）或其药理学上可接受的酸加成盐的方法，其包括水解N，N-二取代邻 - （2,6-二氯苯胺基）苯基乙酰胺衍生物与碱。还公开了一种用于制备双氯芬酸的新型中间体，即其中卤素为碘或溴的N，N-二取代 - 邻 - 卤代苯基乙酰胺。

5. 发明授权

US3989746A Substituted naphthyl anthranilic acids 失效
标题翻译：取代萘基邻氨基苯甲酸
公开(公告)号：US3989746A
公开(公告)日：1976-11-02
申请号：US358291
申请日：1973-05-08
申请人： Fujio Nohara , Tomoaki Fujinawa
发明人： Fujio Nohara , Tomoaki Fujinawa
IPC分类号： A61K31/195 , A61K31/196 , A61P25/04 , A61P29/00 , B01J23/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C17/093 , C07C17/12 , C07C17/26 , C07C45/46 , C07C49/788 , C07C67/00 , C07C205/12 , C07C227/00 , C07C227/08 , C07C227/18 , C07C229/58 , C07C101/70
CPC分类号： C07C17/12 , C07C17/093 , C07C17/2632 , C07C205/12 , C07C45/46 , C07C49/788 , Y10S514/87
摘要： This invention relates to novel N-(substituted-naphthyl-1)anthranilic acids and their salts, and also to a process for the synthesis of these compounds. These compounds and their pharmaceutically acceptable salts are novel and therapeutically useful as anti-inflammatory agents and analgesics, and they may be orally or non-orally applied, or administered by other methods.
摘要翻译：本发明涉及新型N-（取代萘基-1）邻氨基苯甲酸及其盐，也涉及这些化合物的合成方法。这些化合物及其药学上可接受的盐是新的和治疗上用作抗炎剂和镇痛药，并且它们可以是口服或非口服施用，或通过其它方法施用。

6. 发明授权

US4738848A Anti-inflammatory analgesic adhesive preparation 失效
标题翻译：消炎止痛胶制剂
公开(公告)号：US4738848A
公开(公告)日：1988-04-19
申请号：US870464
申请日：1986-06-04
申请人： Yuichi Yoshida , Yoshihisa Nakano , Tetsuo Horiuchi , Toshinobu Tsuda , Mitsuru Tamada
发明人： Yuichi Yoshida , Yoshihisa Nakano , Tetsuo Horiuchi , Toshinobu Tsuda , Mitsuru Tamada
IPC分类号： A61K9/00 , A61K9/70 , A61K31/195 , A61K31/196 , A61K47/12 , A61L15/00
CPC分类号： A61K9/7061 , A61K31/195 , A61K47/12 , A61K9/0014
摘要： An anti-inflammatory analgesic adhesive preparation is disclosed, comprising a flexible support having laminated thereon a pressure-sensitive adhesive material layer which contains Diclofenac Sodium and an organic acid such as citric acid. This adhesive preparation has excellent percutaneous absorption properties.
摘要翻译：公开了一种消炎镇痛粘合剂制剂，其包括在其上层压有包含双氯芬酸钠的压敏粘合剂材料层和有机酸如柠檬酸的柔性载体。该粘合剂具有优异的经皮吸收性能。

7. 发明授权

US4639523A Aminoalkylphenoxy derivatives 失效
标题翻译：氨基烷基苯氧基衍生物
公开(公告)号：US4639523A
公开(公告)日：1987-01-27
申请号：US737489
申请日：1985-05-24
申请人： Fujio Nohara , Tomoaki Fujinawa
发明人： Fujio Nohara , Tomoaki Fujinawa
IPC分类号： C07D253/06 , A61K31/135 , A61K31/41 , A61K31/433 , A61K31/505 , A61P1/04 , A61P43/00 , C07C67/00 , C07C213/00 , C07C225/20 , C07D239/46 , C07D239/48 , C07D253/075 , C07D285/10 , C07D285/12 , C07D285/135 , C07D295/08 , C07D295/096 , C07D401/12 , C07D417/12
CPC分类号： C07D239/48 , C07D253/075 , C07D285/10 , C07D285/135 , C07D295/096
摘要： Substituted aminoalkylphenoxy derivatives represented by the general formula of: ##STR1## wherein the substituting group Z is either one of the following groups of: ##STR2## These derivatives exert antagonism against Histamine H.sub.2 -receptors and hence are efficacious for the treatments of digestive ulcers.
摘要翻译：由以下通式表示的取代的氨基烷基苯氧基衍生物：其中取代基Z是以下基团之一：这些衍生物对组胺H2受体施加拮抗作用，因此对于治疗消化性溃疡。

8. 发明授权

US4710498A Pyridyloxy derivatives 失效
标题翻译：吡啶氧基衍生物
公开(公告)号：US4710498A
公开(公告)日：1987-12-01
申请号：US781881
申请日：1985-09-30
申请人： Fujio Nohara , Tomoaki Fujinawa
发明人： Fujio Nohara , Tomoaki Fujinawa
IPC分类号： A61K31/44 , A61K31/445 , A61K31/505 , A61K31/53 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/12 , A61K31/41
CPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D417/12
摘要： Pyridyloxy derivatives represented by the general formula: ##STR1## wherein the substituted group Z is either one of the following groups: ##STR2## were prepared. These derivatives exert antagonism against Histamine H2-receptors and hence are efficacious for the treatments of digestive ulcers.
摘要翻译：由以下通式表示的吡啶氧基衍生物：其中取代的基团Z是以下基团之一：制备 + TR 。这些衍生物对组胺H2受体产生拮抗作用，因此对消化性溃疡的治疗是有效的。

9. 发明授权

US4550118A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4550118A
公开(公告)日：1985-10-29
申请号：US544591
申请日：1983-10-24
申请人： Toshiya Sugino , Fujio Nohara , Tomoaki Fujinawa , Kazuo Ogawa , Teruo Mizukami , Shunichi Shirai
发明人： Toshiya Sugino , Fujio Nohara , Tomoaki Fujinawa , Kazuo Ogawa , Teruo Mizukami , Shunichi Shirai
IPC分类号： C07D277/62 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61P1/04 , A61P43/00 , C07C205/26 , C07D209/48 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/30 , C07D239/47 , C07D249/14 , C07D263/54 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/54 , C07D413/14
CPC分类号： C07D209/48 , C07C205/26 , C07C323/00 , C07D235/06 , C07D235/14 , C07D235/30 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D401/14 , C07D403/12 , C07D407/14 , C07D413/12 , C07D417/12
摘要： Compounds of Formula I are described ##STR1## in which X and Y are independently --NH--, --O-- or --S--; Z may be a pyrimidine, triazine, triazole, thiazole, thiadiazole ring. The methods of preparation are described. The compounds are useful as antipeptic ulcer agents.
摘要翻译：式I化合物描述为其中X和Y独立地是-NH-，-O-或-S-; Z可以是嘧啶，三嗪，三唑，噻唑，噻二唑环。描述了制备方法。该化合物可用作抗消化性溃疡剂。

10. 发明专利

ES2058223T3 未知
公开(公告)号：ES2058223T3
公开(公告)日：1994-11-01
申请号：ES88120340
申请日：1988-12-06
申请人： IKEDA MOHANDO CO
发明人： NOHARA FUJIO
IPC分类号： A61K31/505 , A61P1/04 , C07D239/46 , C07D239/47 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14
摘要： A pyrimidone compound or a pharmaceutically acceptable salt thereof such as a 5,6-di-substituted-2-[4- -cis-2-butenyla mino ] -4-(1H)-pyrimidone or a 5,6-di-substituted-2-[4- -cis-2- bute nylamino] -4-(1H)-pyrimidone or a pharmaceutically acceptable salt thereof is herein disclosed. Such a compound or a salt thereof simultaneously shows gastric acid secretion inhibiting effect and gastric mucous membrane protecting effect and is useful as medicine for treating gastric diseases such as medicine for inhibiting gastric acid secretion or that for treating digestive ulcers.

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