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1. 发明申请

WO1995016440A1 PERCUTANEOUS ADMINISTRATION PATCH MEDICINE 审中-公开
公开(公告)号：WO1995016440A1
公开(公告)日：1995-06-22
申请号：PCT/JP1993001808
申请日：1993-12-14
申请人： HISAMITSU PHARMACEUTICAL CO., LTD. , YAMAGUCHI, Hisashi , MAEDA, Hiroyuki , KAMIHORIUCHI, Yoshirou
发明人： HISAMITSU PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/70
CPC分类号： A61K9/703 , A61K9/7084
摘要： A percutaneous administration patch medicine used to administer the medicine to a human body through the skin or mucous membrane, consisting of: (1) a backing layer nonpermeable to medicine components; (2) a medicine storage layer positioned on the lower side of the central portion of the backing layer and containing medicine components; (3) a protective film positioned on the lower side of the medicine storage layer and the circumferential portion of the backing layer, having cuts and nonpermeable to the medicine components; (4) a pressure sensitive adhesive layer positioned on the lower side of the protective film; and (5) a separable liner layer positioned on the lower side of the pressure sensitive adhesive layer and nonpermeable to the medicine components; the percutaneous administration patch medicine being capable of effectively minimizing the leakage and volatilization of medicine until the medicine has been administered to a patient through the skin, and maintaining the stability of the medicine during the preservation thereof.
摘要翻译：用于通过皮肤或粘膜将药物施用于人体的经皮给药补片药物，其由以下组成：（1）不可渗透药物成分的背衬层; （2）药物储存层，其位于背衬层的中央部分的下侧，并含有药物成分; （3）保护膜，其位于药物储存层的下侧和背衬层的周向部分上，具有切口并且不能渗透药物成分; （4）位于保护膜下侧的压敏粘合剂层; 和（5）位于所述压敏粘合剂层的下侧并且不能渗透到所述药物成分的可分离衬垫层; 经皮给药补片药物能够有效地最小化药物的渗漏和挥发，直到药物通过皮肤给药给患者，并且在保存药物期间保持药物的稳定性。

2. 发明专利

TWI311054B 指甲用抗真菌外用藥劑 ANTIFUNGAL AND/OR ANTIMYCOTIC EXTERNAL PREPARATION FOR NAIL 有权
简体标题：指甲用抗真菌外用药剂 ANTIFUNGAL AND/OR ANTIMYCOTIC EXTERNAL PREPARATION FOR NAIL
公开(公告)号：TWI311054B
公开(公告)日：2009-06-21
申请号：TW092127649
申请日：2003-10-06
申请人：久光製藥股份有限公司 HISAMITSU PHARMACEUTICAL CO., LTD.
发明人：川瀨一朗 KAWASE ICHIRO , 池田保夫 IKEDA YASUO , 原浩祐 HARA KOSHUKE , 鳴井隆 NARUI, TAKASHI , 金子哲男 KANEKO TETSUO
IPC分类号： A61K
CPC分类号： A61K8/4946 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61Q3/00
摘要：一種指甲用抗真菌外用藥劑,係含有以下成分(a)及(b):(a)奈康唑或其鹽;(b)鹼性物質。
依本發明,有效成分奈康唑對指甲的滲透性高且可以外用的方式安全的治療指甲白癬。
简体摘要：一种指甲用抗真菌外用药剂,系含有以下成分(a)及(b):(a)奈康唑或其盐;(b)碱性物质。依本发明,有效成分奈康唑对指甲的渗透性高且可以外用的方式安全的治疗指甲白癣。

3. 发明授权

US09717893B2 Microneedle array 有权
公开(公告)号：US09717893B2
公开(公告)日：2017-08-01
申请号：US14767138
申请日：2014-02-12
申请人： HISAMITSU PHARMACEUTICAL CO., INC.
发明人： Ryusuke Fudoji , Makoto Ogura
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.

4. 发明授权

US6141582A Iontophoresis system and its control process of current 失效
标题翻译：离子电渗系统及其电流控制过程
公开(公告)号：US6141582A
公开(公告)日：2000-10-31
申请号：US163
申请日：1998-05-05
申请人： Kenji Mori , Katsuhiro Nakamura , Naruhito Higo , Noriyuki Kuzumaki
发明人： Kenji Mori , Katsuhiro Nakamura , Naruhito Higo , Noriyuki Kuzumaki
IPC分类号： A61N1/32 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0448 , A61N1/325
摘要： An iontophoresis system and its control process for current are proposed, which system can decrease variation in drug delivery quantity due to the individual difference of impedance of skin or mucosal membrane, and avoid any decrease of the delivery quantity of drug in a donor device, thereby to obtain excellent medicinal effect, safety, reliability, and productivity, comprising said donor device, a reference device, a current detection unit for measuring as an effective current value the difference between the value of an applied current passing between the donor and reference devices during application of pulse voltage/current and the value of a discharged current whose electric charge which the living body has been equipped with is released by a short-circuit formed between said donor and reference devices when the application of pulse voltage/current is suspended, and a feedback control unit of making the amplitude of the pulse voltage/current variable to control the effective current value. The control process for current of the iontophoresis system of the present invention comprises an effective current measurement step of measuring said effective current value and a feedback control step of controlling said effective current value.
摘要翻译： PCT No.PCT / JP96 / 02286 Sec。 371日期：1998年5月5日 102（e）日期1998年5月5日PCT提交1996年8月12日PCT公布。公开号WO97 / 07853 日期1997年3月6日提出了离子电渗系统及其电流控制过程，由于皮肤或粘膜阻抗的个体差异，该系统可以减少药物输送量的变化，避免药物输送量的下降供体装置，从而获得优异的药物效果，安全性，可靠性和生产率，包括所述供体装置，参考装置，电流检测单元，用于将作为有效电流值的施加电流的值施加脉冲电压/电流时的供体和参考装置以及当所述供体和参考装置之间形成的短路而释放出具有活体的电荷的放电电流的值，当施加脉冲电压/ 电流被暂停，并且使得脉冲电压/电流的幅度可变的反馈控制单元控制t 他有效的当前价值。本发明的离子电渗系统的电流控制过程包括测量所述有效电流值的有效电流测量步骤和控制所述有效电流值的反馈控制步骤。

5. 发明授权

US6104951A Iontophoresis electrode structure 失效
标题翻译：离子电渗电极结构
公开(公告)号：US6104951A
公开(公告)日：2000-08-15
申请号：US29316
申请日：1998-02-13
申请人： Kenji Mori , Takeshi Konno
发明人： Kenji Mori , Takeshi Konno
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0436 , A61N1/0432 , A61N1/044 , A61N1/30
摘要： An iontophoresis electrode structure comprising has both a polarization electrode and a non-polarization electrode, wherein both electrodes can be switched freely while the electricity is turned on. The present electrode structure makes it possible to transfer biologically active substances and drugs into a living body through the skin and the mucous membrane in a sufficient amount and safety by employing both a polarization electrode and a non-polarization electrode as iontophoresis electrodes according to a proper switch, and can transfer biologically active substances and drugs through the skin and the mucous membrane effectively without causing irritation.
摘要翻译： PCT No.PCT / JP95 / 01619 Sec。 371日期1998年2月13日 102（e）1998年2月13日PCT PCT 1995年8月14日PCT公布。公开号WO97 / 06848 日期1997年2月27日具有偏振电极和非极化电极两者的离子电渗电极结构，其中两个电极可以在电接通时自由切换。本电极结构使得可以通过使用偏振电极和非极化电极作为离子电渗电极根据适当的量将活体物质和药物通过皮肤和粘膜以足够的量和安全的方式转移到生物体中切换，并可以有效转移生物活性物质和药物通过皮肤和粘膜，而不会引起刺激。

6. 发明授权

US10369115B2 Cataplasm and method for producing the same 有权
公开(公告)号：US10369115B2
公开(公告)日：2019-08-06
申请号：US14913455
申请日：2014-08-21
申请人： HISAMITSU PHARMACEUTICAL CO., INC.
发明人： Keiichiro Tsurushima , Yasuhisa Kose , Shinji Yamasoto , Seiichiro Tsuru , Takaaki Yoshinaga
IPC分类号： A61K9/70 , A61L15/22 , A61L15/58 , A61L15/60 , C08L71/00 , C08F220/14 , C08L33/02
摘要： A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.

7. 外观设计

USD767398S1 Package 有权
公开(公告)号：USD767398S1
公开(公告)日：2016-09-27
申请号：US29512314
申请日：2014-12-18
申请人： HISAMITSU PHARMACEUTICAL CO., INC.
设计人： Masaki Miyazaki , Shigeo Kusumi

8. 发明授权

US06844007B2 Plaster containing felbinac 有权
标题翻译：含有菲律宾的石膏
公开(公告)号：US06844007B2
公开(公告)日：2005-01-18
申请号：US10607132
申请日：2003-06-27
申请人： Yasunori Takada , Koji Tanaka , Yasuhiro Ikeura
发明人： Yasunori Takada , Koji Tanaka , Yasuhiro Ikeura
IPC分类号： A61K9/70 , A61K31/19 , A61F13/00 , A61L15/16
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/19
摘要： A plaster comprising a styrene-isoprene-styrene block copolymer 10-40 wt %, a rosin-based resin 5-30 wt %, a plasticizer 20-70 wt %, polyisobutylene 6-40 wt %, an antioxidant 0.1-5 wt %, and felbinac as a medicinally effective component 1.1-10 wt %, wherein the plaster does not contain crotamiton which is a solubilizer for the felbinac, the felbinac is uniformly dispersed in a semi-solubilized state in the plaster, wherein solubilized felbinac and microcrystalline felbinac coexist in the plaster, and a thickness of the plaster is 50-300 μm.
摘要翻译：一种石膏，其包含10-40重量％的苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，5-30重量％的松香基树脂，20-70重量％的增塑剂，6-40重量％的聚异丁烯，0.1-5重量％的抗氧化剂，，和联苯乙酸作为药物有效成分为1.1-10重量％，其中石膏不含作为联苯乙酸增溶剂的克罗他米通，联苯乙酸在石膏中以半溶解状态均匀分散，其中溶解的联苯乙酸和微晶联苯乙酸在石膏中共存，石膏的厚度为50-300粒。

9. 发明申请

US20040071765A1 Composition and device structure for iontophoresis 审中-公开
标题翻译：离子电渗法的组成和器件结构
公开(公告)号：US20040071765A1
公开(公告)日：2004-04-15
申请号：US10674419
申请日：2003-10-01
申请人： Hisamitsu Pharmaceutical Co., Ltd.
发明人： Hirotoshi Adachi , Noriyuki Kuzumaki , Tetsuya Arimoto , Naruhito Higo
IPC分类号： A61K009/70
CPC分类号： A61N1/0448 , A61K9/0009 , A61K9/0014 , A61K47/32 , A61N1/0444
摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
摘要翻译：用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置以覆盖背衬103的中空部分。

10. 发明授权

US4895956A 3-aroyl-6,7-dihydro-5H-pyrrolo(1,2-c)imidazole-7-carboxylic acid derivatives 失效
标题翻译： 3-芳酰基-6,7-二氢-5H-吡咯并（1,2-c）咪唑-7-羧酸衍生物
公开(公告)号：US4895956A
公开(公告)日：1990-01-23
申请号：US242331
申请日：1988-09-08
申请人： Masayoshi Tsuji , Hisataka Inoue , Yoshihiro Tanoue , Kouichi Beppu , Masaru Saita , Yasuaki Taniguchi , Kenichi Furuta , Yoshiki Deguchi , Kanji Noda
发明人： Masayoshi Tsuji , Hisataka Inoue , Yoshihiro Tanoue , Kouichi Beppu , Masaru Saita , Yasuaki Taniguchi , Kenichi Furuta , Yoshiki Deguchi , Kanji Noda
IPC分类号： A61K31/415 , A61P25/04 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： A novel 3-aroyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-7-carboxylic acid derivative which is useful as a medicine having excellent analgesic and anti-inflammatory actions with remarkably less toxicity and side-effects.

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