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1. 发明专利

MXPA05007888A COAGULANTE AUTOLOGO Y HOMOLOGO PRODUCIDO A PARTIR DE SANGRE ENTERA ANTICOAGULADA. 未知
公开(公告)号：MXPA05007888A
公开(公告)日：2005-12-15
申请号：MXPA05007888
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC
发明人： BLASETTI LOU
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49 , G01N00/00
摘要： Se describe un metodo para la preparacion de un coagulante autologo u homologo estable a partir de sangre entera. La precipitacion directa de sangre entera anticoagulada hacia obvia la necesidad para una etapa de aislamiento de plasma con resultados inesperados. El coagulante autologo y homologo producido por el metodo de la presente invencion demuestra tiempos de coagulacion equivalentes a preparaciones de trombina humana y trombina de bovino disponibles comercialmente, con cineticas mejoradas de liberacion del factor de crecimiento a partir de plaquetas activadas sobre preparaciones de trombina de bovino.

2. 发明专利

CA2514001A1 AUTOLOGOUS OR HOMOLOGOUS COAGULANT PRODUCED FROM ANTICOAGULATED WHOLE BLOOD 未知
公开(公告)号：CA2514001A1
公开(公告)日：2004-08-12
申请号：CA2514001
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC
发明人： KEVY SHERWIN V , SULLIVAN SHERYL , BLASETTI LOU , JACOBSON MAY
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of th e present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.

3. 发明专利

IL169792D0 AUTOLOGOUS OR HOMOLOGOUS COAGULANT PRODUCED FROM ANTICOAGULATED WHOLE BLOOD 未知
公开(公告)号：IL169792D0
公开(公告)日：2007-07-04
申请号：IL16979205
申请日：2005-07-20
申请人： HARVEST TECHNOLOGIES INC , SHERWIN V KEVY , SHERYL SULLIVAN , MAY JACOBSON , LOU BLASETTI
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K20100101 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of the present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.

4. 发明专利

BRPI0406931A 未知
公开(公告)号：BRPI0406931A
公开(公告)日：2006-01-03
申请号：BRPI0406931
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC
发明人： KEVY SHERWIN V , SULLIVAN SHERYL , JACOBSON MAY , BLASETTI LOU
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of the present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.

5. 发明专利

AU2004207261A1 Autologous or homologous coagulant produced from anticoagulated whole blood 未知
公开(公告)号：AU2004207261A1
公开(公告)日：2004-08-12
申请号：AU2004207261
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC
发明人： KEVY SHERWIN V , SULLIVAN SHERYL , JACOBSON MAY , BLASETTI LOU
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of the present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.

6. 发明申请

WO2004068109A3 AUTOLOGOUS OR HOMOLOGOUS COAGULANT PRODUCED FROM ANTICOAGULATED WHOLE BLOOD 审中-公开
标题翻译：从抗血清全血中生产的自体或同种异体凝血酶
公开(公告)号：WO2004068109A3
公开(公告)日：2005-10-27
申请号：PCT/US2004002191
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC , KEVY SHERWIN V , SULLIVAN SHERYL , JACOBSON MAY , BLASETTI LOU
发明人： KEVY SHERWIN V , SULLIVAN SHERYL , JACOBSON MAY , BLASETTI LOU
IPC分类号： A01N25/02 , A61K35/00 , A61K35/14 , A61K38/48 , A61P7/04 , C07K14/745 , C12N9/74 , G01N20060101 , G01N1/00 , G01N33/49
CPC分类号： C07K14/745 , C12N9/6429 , C12Y304/21005 , Y10T436/107497
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of the present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.
摘要翻译：公开了一种从全血制备稳定的自体或同源凝血剂的方法。抗凝全血的直接沉淀消除了需要等离子体隔离的步骤，具有意想不到的效果。通过本发明的方法产生的自体或同源凝血剂证明凝血时间相当于市售的牛凝血酶和人凝血酶制剂，具有改善的活化血小板释放生物因子与牛凝血酶制剂的动力学。

7. 发明申请

WO2013078334A1 SYSTEM FOR COLLECTING AND PROCESSING BONE MARROW 审中-公开
标题翻译：收集和处理骨骼大小的系统
公开(公告)号：WO2013078334A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066287
申请日：2012-11-21
申请人： HARVEST TECHNOLOGIES, INC.
发明人： AZIMPOOR, Ali FAGHANI , BLASETTI, Lou , KIBBE, Mark
IPC分类号： A61M1/00 , A61M5/32 , A61M39/22 , A61J1/10
CPC分类号： A61B10/0096 , A61B10/025 , A61B10/0283 , A61B2010/0258
摘要： Methods and systems for collecting and processing bone marrow in a closed system are provided. The systems and methods include the use of a bone marrow aspiration needle and guide configured to puncture cortical bone. Tube assembly is in fluid flow communication with the bone marrow aspiration needle. A first syringe is in fluid flow communication with the tube assembly and the bone aspiration. A bone marrow aspirate collection container in fluid flow communication with the first syringe and the tube assembly. A second syringe is connected to the collection container, a bone marrow aspirate filter in fluid flow communication with the tube assembly to filter bone marrow aspirate from the first syringe into the collection container. At least one flow controller is configured to direct the flow of bone marrow aspirate between the aspiration needle, the first syringe and the collection container.
摘要翻译：提供了在封闭系统中收集和处理骨髓的方法和系统。该系统和方法包括使用骨髓抽吸针和构造成穿刺皮质骨的引导件。管组件与骨髓抽吸针流体连通。第一注射器与管组件和骨抽吸成流体流动连通。与第一注射器和管组件流体连通的骨髓抽吸收集容器。第二注射器连接到收集容器，骨髓抽吸过滤器与管组件流体流动连通，以将骨髓抽吸物从第一注射器过滤到收集容器中。至少一个流量控制器构造成引导吸引针，第一注射器和收集容器之间的骨髓抽吸流。

8. 发明申请

WO2013078326A1 BONE MARROW ASPIRATION DEVICE AND NEEDLE 审中-公开
标题翻译：骨髓吸引装置和针头
公开(公告)号：WO2013078326A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066275
申请日：2012-11-21
申请人： HARVEST TECHNOLOGIES, INC.
发明人： AZIMPOOR, Ali Faghani , BLASETTI, Lou , KIBBE, Mark , HART, Russell
IPC分类号： A61M1/00 , A61M5/32 , A61M39/08 , A61J1/10
CPC分类号： A61B10/025 , A61B2010/0258 , A61B2090/034 , Y10T29/49826
摘要： Devices for extracting bone marrow from a bone of a patient are disclosed. The device includes a housing defined in part by a cannula and a hollow needle disposed within the cannula. The hollow needle is movable axially relative to the cannula and extendable therefrom. The hollow needle is configured to aspirate bone marrow within a bone. A depth adjustment mechanism coupled to the hollow needle and the cannula is used to adjust the depth of the hollow needle relative to the cannula to control the distance of the needle within the bone. The device is attachable to an extraction device to extract bone marrow from the patient through the hollow needle. Methods of using these devices and methods of extracting bone marrow are also included.
摘要翻译：公开了从患者骨骼提取骨髓的装置。该装置包括由插管部分地限定的壳体和设置在套管内的中空针。中空针可相对于套管轴向移动并从其延伸。中空针被构造成在骨内吸出骨髓。联接到中空针和插管的深度调节机构用于调节中空针相对于套管的深度，以控制针在骨骼内的距离。该装置可附接到提取装置，以通过中空针从患者提取骨髓。还包括使用这些装置的方法和提取骨髓的方法。

9. 发明申请

WO2004068109A2 AUTOLOGOUS OR HOMOLOGOUS COAGULANT PRODUCED FROM ANTICOAGULATED WHOLE BLOOD 审中-公开
标题翻译：从抗血清全血中产生的自体或同种异体凝血酶
公开(公告)号：WO2004068109A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002191
申请日：2004-01-27
申请人： HARVEST TECHNOLOGIES INC , KEVY, Sherwin, V. , SULLIVAN, Sheryl , JACOBSON, May , BLASETTI, Lou
发明人： KEVY, Sherwin, V. , SULLIVAN, Sheryl , JACOBSON, May , BLASETTI, Lou
IPC分类号： G01N
CPC分类号： C07K14/745 , C12N9/6429 , C12Y304/21005 , Y10T436/107497
摘要： A method for the preparation of a stable autologous or homologous coagulant from whole blood is disclosed. The direct precipitation of anticoagulated whole blood obviates the need for a plasma isolation step with unexpected results. The autologous or homologous coagulant produced by the method of the present invention demonstrated clotting times equivalent to commercially available bovine thrombin and human thrombin preparations, with improved kinetics of growth factor release from activated platelets over preparations of bovine thrombin.
摘要翻译：公开了从全血制备稳定的自体或同源凝血剂的方法。抗凝全血的直接沉淀消除了对具有意想不到的结果的等离子体隔离步骤的需要。通过本发明的方法产生的自体或同源凝血剂证明凝血时间相当于市售的牛凝血酶和人凝血酶制剂，具有改善的活化血小板释放的生物因子与牛凝血酶制剂的动力学。

10. 发明公开

EP2782617A4 SYSTEM FOR COLLECTING AND PROCESSING BONE MARROW 审中-公开
标题翻译：系统收集和处理骨髓
公开(公告)号：EP2782617A4
公开(公告)日：2015-04-22
申请号：EP12851966
申请日：2012-11-21
申请人： HARVEST TECHNOLOGIES INC
发明人： AZIMPOOR ALI FAGHANI , BLASETTI LOU , KIBBE MARK
IPC分类号： A61M1/00 , A61J1/10 , A61M5/32 , A61M39/22
CPC分类号： A61B10/0096 , A61B10/025 , A61B10/0283 , A61B2010/0258

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