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1. 发明申请

WO2003087170A1 POLYACRYLAMIDE HYDROGELS 审中-公开
标题翻译：聚丙烯酰胺水凝胶
公开(公告)号：WO2003087170A1
公开(公告)日：2003-10-23
申请号：PCT/AU2003/000431
申请日：2003-04-10
申请人： GRADIPORE LIMITED , SOLOMON, David, Henry , QIAO, Greg, GuangHua , CAULFIELD, Marcus, Julian , HAO, Xiaojuang
发明人： SOLOMON, David, Henry , QIAO, Greg, GuangHua , CAULFIELD, Marcus, Julian , HAO, Xiaojuang
IPC分类号： C08F6/00
CPC分类号： C08F6/006 , C08L33/00
摘要： A polyacrylamide gel network formed from an acrylamide-based cross-linker, the gel network being treated with a chemical scavenger such that the gel is substantially free of labile precursor structures and the treated gel network is not substantially capable of releasing acrylamide monomers under normal handling conditions.
摘要翻译：由基于丙烯酰胺的交联剂形成的聚丙烯酰胺凝胶网络，凝胶网络用化学清除剂处理，使得凝胶基本上不含不稳定的前体结构，经处理的凝胶网络在正常处理下基本上不能释放丙烯酰胺单体条件。

2. 发明申请

WO2003020403A1 REMOVAL OF METABOLIC COMPONENTS FROM BLOOD 审中-公开
标题翻译：从血液中去除代谢组分
公开(公告)号：WO2003020403A1
公开(公告)日：2003-03-13
申请号：PCT/AU2002/001217
申请日：2002-09-04
申请人： GRADIPORE LIMITED
发明人： BOTTO, Steven, Anthony , ROETH, Philip, John , FARAMUS, Ellie, Louise , NAIR, Chenicheri, Hariharan
IPC分类号： B01D57/02
CPC分类号： B01D61/425 , A61M1/16 , A61M1/1605 , A61M2202/0498 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/3344 , A61M2205/3368 , B01D57/02
摘要： An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject, the system comprising: (a) a cathode in a cathode zone; (b) an anode in an anode zone, the anode disposed relative to the cathode so as to be adapted to generate an electric field in an electric field area therebetween upon application of an electric potential between the cathode and the anode; (c) a first ion-permeable barrier having a defined pore size and pore size distribution disposed in the electric field area; (d) a second ion-permeable barrier having a defined pore size and pore size distribution disposed between the cathode zone and the first barrier so as to define a treatment chamber therebetween; (e) means adapted for cooling blood or plasma from the subject; (f) means adapted to provide dialysate to the cathode zone and the anode zone; and (g) means adapted to provide blood or plasma from the subject to the treatment chamber; wherein, upon application of the electric potential, a metabolic component from the blood or plasma is caused to move through at least one barrier into at least one of the cathode or anode zones.
摘要翻译：一种用于从受试者的血液或血浆中去除或降低代谢成分浓度的电泳系统，所述系统包括：（a）阴极区中的阴极; （b）阳极区中的阳极，阳极相对于阴极设置，以便在阴极和阳极之间施加电位时适于在其间的电场区域中产生电场; （c）设置在电场区域中的具有确定的孔径和孔径分布的第一离子可渗透屏障; （d）第二离子可渗透屏障，其具有限定的孔径和孔径分布，设置在阴极区和第一屏障之间，以便在它们之间限定处理室; （e）适于冷却患者血液或血浆的装置; （f）适于向阴极区和阳极区提供透析液的装置; 和（g）适于将血液或血浆从受试者提供给治疗室的装置; 其中，在施加电位时，引起来自血液或血浆的代谢成分通过至少一个屏障移动到至少一个阴极区域或阳极区域中。

3. 发明申请

WO1994006007A1 APPARATUS AND METHOD FOR DETECTING COAGULATION/LYSIS OF LIQUIDS 审中-公开
标题翻译：用于检测液体凝结/分析的装置和方法
公开(公告)号：WO1994006007A1
公开(公告)日：1994-03-17
申请号：PCT/AU1993000459
申请日：1993-09-06
申请人： GRADIPORE LIMITED , EXNER, Thomas
发明人： GRADIPORE LIMITED
IPC分类号： G01N30/74
CPC分类号： G01N33/4905 , G01N33/86
摘要： A method and apparatus for testing the susceptability of a test sample to change between a liquid state and a coagulated state. A test sample (4) is applied to a porous sheet (5). The sample spreads through the porous sheet until it coagulates when the flow stops. By measuring a parameter indicative of the extent of spread or rate of spread of the sample e.g. the conductivity/electrical impedance (8) between thin electrodes (2, 3) on either side of the sheet (1), one may determine when coagulation and/or subsequent lysis of the sample occurs.
摘要翻译：一种用于测试测试样品在液体状态和凝结状态之间变化的易感性的方法和装置。将测试样品（4）施加到多孔片材（5）上。样品通过多孔片材扩散，直到流动停止时凝固。通过测量指示样品的扩散程度或扩散速率的参数，例如，在片材（1）的任一侧的薄电极（2,3）之间的电导率/电阻抗（8）可以确定样品何时发生凝固和/或随后的裂解。

4. 发明申请

WO2003070360A1 LOW VOLUME SEPARATION APPARATUS 审中-公开
标题翻译：低体积分离装置
公开(公告)号：WO2003070360A1
公开(公告)日：2003-08-28
申请号：PCT/AU2003/000209
申请日：2003-02-19
申请人： GRADIPORE LIMITED , TURTON, Thomas , OGLE, David , WANG, Kailing
发明人： TURTON, Thomas , OGLE, David , WANG, Kailing
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , B01D57/02 , G01N27/44769
摘要： An electrophoresis apparatus suitable for processing small sample volumes comprising: (a) an electrolyte reservoir; (b) a first sample reservoir and a second sample reservoir; (c) a separation unit having a first electrolyte chamber, a second electrolyte chamber, a first sample chamber, a second sample chamber, wherein the at least one of the first or second sample chambers has a volume of less than about 2 ml; (d) a first ion-permeable barrier; (e) a second ion-permeable barrier; (f) a third ion-permeable barrier; (g) a plurality of substantially planar spacer elements disposed adjacent the ion-permeable barriers defining the chambers; (h) electrodes; (h) means for supplying electrolyte; and (i) means for supplying sample or liquid.
摘要翻译：一种适于处理小样品体积的电泳装置，包括：电解质储存器第一样品储存器和具有第一电解质室，第二电解质室，第一样品室，第二样品室的第二样品储存器ca分离单元，其中第一或第二样品室中的至少一个具有小于约2ml的体积第一离子可渗透屏障ea第二离子可渗透屏障fa第三离子可渗透屏障ga多个基本上平面的间隔元件邻近离子可渗透限定腔室h电极h的阻挡装置用于供应电解质，并且用于提供样品或液体。

5. 发明申请

WO2003006505A1 FACTOR VIII SEPARATION 审中-公开
标题翻译：因子VIII分离
公开(公告)号：WO2003006505A1
公开(公告)日：2003-01-23
申请号：PCT/AU2002/000950
申请日：2002-07-15
申请人： GRADIPORE LIMITED
发明人： SEABROOK, Elizabeth , TURTON, Thomas, Norman , CONLAN, Brendon
IPC分类号： C07K14/755
CPC分类号： B01D57/02 , B01D61/425 , C07K14/755
摘要： Methods for isolating functionally active Factor VIII using a membrane-based separation system containing a separation membrane to create a first and second interstitial volume between at least two restriction membranes. One or more stabilizing agents are added to the sample and/or an interstitial volume. A solvent in the first interstitial volume maintains FVIII in a desired charge state. Applying a potential between the first and second interstitial volumes separates FVIII on one side of the separation membrane from unwanted molecules on the other side of the separation membrane. These methods may also be used as a substitute for one or more steps in a conventional purification scheme for the separation of native or recombinant FVIII.
摘要翻译：使用含有分离膜的膜基分离系统分离功能活性因子VIII以在至少两个限制性膜之间产生第一和第二间隙体积的方法。将一种或多种稳定剂添加到样品和/或间隙体积中。第一间隙体积中的溶剂维持FVIII为期望的电荷状态。在第一和第二间隙体积之间施加电势将分离膜一侧上的FVIII与分离膜另一侧上的不需要的分子分开。这些方法也可用作用于分离天然或重组FVIII的常规纯化方案中的一个或多个步骤的替代物。

6. 发明申请

WO1997004307A1 CASSETTE FOR ELECTROPHORETIC GELS 审中-公开
标题翻译：电泳胶囊
公开(公告)号：WO1997004307A1
公开(公告)日：1997-02-06
申请号：PCT/AU1996000441
申请日：1996-07-12
申请人： GRADIPORE LIMITED , MANUSU, Howard, Pericles
发明人： GRADIPORE LIMITED
IPC分类号： G01N27/447
CPC分类号： G01N27/44704
摘要： A cassette (10) for use in the formation of an electrophoretic gel comprising two plates with substantially planar walls (11, 13) each having two sides and two ends so arranged in a side-by-side, spaced apart array to form a gel receiving space (15) between them, the improvement consisting of a plurality of projections (16) on one or each of the plates, the projections extending into the gel receiving space and the projections being so sized and so spaced apart over the surface of one or each of the plates that when a gel is introduced into the gel receiving space and a well-forming comb is inserted into the space, a plurality of spaced wells are formed in the gel, at least some of the wells being separated by a tongue of gel which surrounds and engages at least one of the projections, wherein the projections prevent the tongues of the gel from moving relative to the two plates when the electrophoretic gel is in use.
摘要翻译：一种用于形成电泳凝胶的盒（10），包括具有基本平坦的壁（11,13）的两个板，每个板具有两侧和两端，并排布置成间隔开的阵列，以形成凝胶在它们之间的接收空间（15），改进包括在一个或每个板上的多个突起（16），突出部延伸到凝胶容纳空间中，并且突出部的尺寸如此大小并且在一个或每个板，当凝胶被引入凝胶接收空间并且良好形成的梳子被插入到空间中时，在凝胶中形成多个间隔开的孔，至少一些孔被舌部分隔开的凝胶，其围绕并接合至少一个突起，其中当使用电泳凝胶时，突起防止凝胶的舌片相对于两个板移动。

7. 发明申请

WO2005015194A1 ELECTROPHORESIS MEMBRANE SUPPORT AND MANIFOLD UNIT 审中-公开
标题翻译：电泳膜支架和放映单元
公开(公告)号：WO2005015194A1
公开(公告)日：2005-02-17
申请号：PCT/AU2004/001032
申请日：2004-08-04
申请人： GRADIPORE LIMITED , OGLE, David, Bruce
发明人： OGLE, David, Bruce
IPC分类号： G01N27/447
CPC分类号： B01D63/085 , B01D57/02 , B01D2313/20 , B01D2313/345 , B01D2313/44 , G01N27/44704
摘要： An electrophoresis membrane support comprising a substantially planar member having four boundaries, an upper face and a lower face; an inlet port disposed near one boundary; an outlet port disposed opposite the inlet port near an opposite boundary; spacers positioned between the inlet port and outlet port adapted to support a membrane positioned on the upper face or on the lower face of the member; interstitial space disposed between the spacers capable of allowing flow of fluid therein; inlet means in fluid communication with the inlet port and the interstitial space; outlet in fluid communication with the interstitial space and the inlet port, the inlet and outlet means adapted to allow flow of fluid along the interstitial space; first flow port disposed near one boundary; and second flow port disposed opposite the first flow port near an opposite boundary, the first and second flow ports direct flow of fluid to or from the electrophoresis apparatus.
摘要翻译：一种电泳膜支架，包括具有四个边界的基本平坦的构件，上表面和下表面; 设置在一个边界附近的入口; 与入口端口相对设置在靠近相对边界的出口; 位于入口端口和出口端口之间的间隔物，其适于支撑位于构件的上表面或下表面上的膜; 布置在间隔件之间的能够允许流体流动的间隙空间; 入口装置与入口和间隙空间流体连通; 出口与间隙空间和入口流体连通，入口和出口装置适于允许流体沿着间隙空间流动; 第一流动口设置在一个边界附近; 以及与第一流动口相对设置在靠近相对边界的第二流动端口，第一和第二流动口将流体流向或从电泳装置流出。

8. 发明申请

WO2003018633A1 PRION CAPTURE 审中-公开
公开(公告)号：WO2003018633A1
公开(公告)日：2003-03-06
申请号：PCT/AU2002/001198
申请日：2002-09-02
申请人： GRADIPORE LIMITED
发明人： WANG, Kailing , NAIR, Chenicheri, Hariharan , OBRADOVIC, Mina
IPC分类号： C07K14/75
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： A method for capturing prions, the method comprising: (a) providing a prion-binding material in the form of fibrin(ogen), a fibrin(ogen)-related material, a fibrin(ogen)-derived material or mixtures thereof; (b) contacting a sample suspected of containing prions with the prion-binding material; and (c) allowing prions present in the sample to bind to or associate with the prion-binding material.
摘要翻译：一种用于捕获朊病毒的方法，所述方法包括：（a）提供纤维蛋白（ogen），纤维蛋白（ogen）相关材料，纤维蛋白（ogen）衍生物质或其混合物形式的朊病毒结合材料; （b）将怀疑含有朊病毒的样品与朊病毒结合材料接触; 和（c）允许存在于样品中的朊病毒结合或结合朊病毒结合材料。

9. 发明申请

WO2002093168A1 PRION DIAGNOSTIC TEST 审中-公开
标题翻译： PRION诊断测试
公开(公告)号：WO2002093168A1
公开(公告)日：2002-11-21
申请号：PCT/AU2002/000592
申请日：2002-05-15
申请人： GRADIPORE LIMITED
发明人： WANG, Kailing , NAIR, Chenicheri, Hariharan
IPC分类号： G01N33/53
CPC分类号： A61B5/4088 , G01N27/447 , G01N33/6896 , G01N2800/2828
摘要： The invention relates to a method for detecting prions in a sample, the method comprising (a) subjecting a sample suspected of containing prions to membrane-based electrophoresis to separate and/or concentrate at least some prions present in the sample; and (b) detecting the presence of the separated or concentrated prions.
摘要翻译：本发明涉及一种用于检测样品中朊病毒的方法，所述方法包括（a）使怀疑含有朊病毒的样品经膜基电泳对所述样品中存在的至少一些朊病毒进行分离和/或浓缩; 和（b）检测分离或浓缩的朊病毒的存在。

10. 发明申请

WO1996004560A1 IMPROVED ACTIVATED PROTEIN C RESISTANCE TEST 审中-公开
标题翻译：改进的活化蛋白C电阻测试
公开(公告)号：WO1996004560A1
公开(公告)日：1996-02-15
申请号：PCT/AU1995000474
申请日：1995-08-07
申请人： GRADIPORE LIMITED , EXNER, Thomas
发明人： GRADIPORE LIMITED
IPC分类号： G01N33/68
CPC分类号： G01N33/86 , G01N2333/4613 , G01N2333/4616 , G01N2333/96444 , G01N2333/96461 , G01N2333/96463 , Y10T436/25
摘要： A method for determining the functional activity of activated protein C in a human plasma sample. The plasma sample is incubated with (i) exogenous reagents which activate factor V and the common pathway for blood coagulation either through factor X or by inducing the presence of thrombin in a factor V dependent manner, (ii) activated exogenous protein C; and (iii) components, such as phospholipid and calcium ions, that are necessary for efficient clotting of the plasma. The reaction is monitored to detect an end point such as the clotting time or the change in colour of a chromometric or fluorometric substrate. The end point time is compared with that obtained by a normal blood sample under the same conditions and/or with the plasma sample but without the addition of activated protein C. A decrease in clotting time as compared with normal blood is indicative of an impairment of or resistance to activated protein C.
摘要翻译：用于测定人血浆样品中活化蛋白C的功能活性的方法。血浆样品与（i）外源性试剂一起孵育，其通过因子X激活因子V和凝血的共同途径，或以因子V依赖性方式诱导凝血酶的存在，（ii）活化的外源蛋白C; 和（iii）血浆有效凝血所必需的成分，例如磷脂和钙离子。监测反应以检测终点，例如凝血时间或色度或荧光底物的颜色变化。将终点时间与在相同条件下和/或血浆样品中的正常血液样品获得的终点时间进行比较，但不加入活化的蛋白质C.与正常血液相比，凝血时间的减少表明是或抗活化蛋白C.

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