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1. 发明专利

JPH10174711A COMPLIANT TISSUE SEALANT 失效
公开(公告)号：JPH10174711A
公开(公告)日：1998-06-30
申请号：JP1206097
申请日：1997-01-06
申请人： FOCAL INC
发明人： AMAAPURIITO S SOONII , MICHAEL D REIMAN , PETER K GIARETT , RONALD S RUDOUSKI
IPC分类号： A61L26/00 , A61L27/00 , C08F290/00 , C08F299/00 , A61L25/00
摘要： PROBLEM TO BE SOLVED: To improve the adhesiveness of a polymer material to tissue surfaces and other substrates by forming the polymer material by polymerizing an aq. soln. of polymerizable monomers in contact with the tissue surfaces or a suspending liquid and forming the material in such a manner that the standardized compliance ratio of the tissues and the material is confined within a range of specific values. SOLUTION: One or more kinds of initiators or components of an initiation system are directly applied on the surface and the unabsorbed excess components are removed by washing or absorbing. The initiator soln. may further contain one or more kinds of the polymerizable monomers and other useful disposition components including accelerators, coinitiators, sensitizers and comonomers. Next, the liquid contg. the polymerizable monomers together with one or more kinds of the initiators or the components of the initiation system is applied. The standardized compliance ratio of the polymerized material is equiv. in its magnitude to that of the tissues to which the material is applied. The standardized compliance ratio is from about 0.05 to about 3 when the reform of the natural expansion and contraction of the tissues is desired.

2. 发明申请

WO2002044276A3 POLYALKYLENE GLYCOL VISCOSITY-ENHANCING POLYMERIC FORMULATIONS 审中-公开
公开(公告)号：WO2002044276A3
公开(公告)日：2002-06-06
申请号：PCT/US2001/044769
申请日：2001-11-28
申请人： FOCAL, INC.
发明人： AVILA, Luis, Z. , JARRETT, Peter, K. , KRAMER, Hildegard , PHILBROOK, Michael, C.
IPC分类号： C08L71/02
摘要： Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

3. 发明申请

WO1998012243A1 POLYMERIZABLE BIODEGRADABLE POLYMERS INCLUDING CARBONATE OR DIOXANONE LINKAGES 审中-公开
标题翻译：可聚合的可生物降解聚合物，包括碳酸盐或二氧化硅的链接
公开(公告)号：WO1998012243A1
公开(公告)日：1998-03-26
申请号：PCT/US1997016857
申请日：1997-09-23
申请人： FOCAL, INC.
发明人： FOCAL, INC. , JARRETT, Peter, K. , SAWHNEY, Amarpreet , COURY, Arthur, J. , RUDOWSKY, Ronald, S. , POWELL, Michelle, D. , AVILA, Luis, Z. , ENSCORE, David, J. , GOODRICH, Stephen, D. , NASON, William, C. , YAO, Fei , WEAVER, Douglas , BARMAN, Shikha, P.
IPC分类号： C08G65/00
CPC分类号： C08G63/676 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2400/04 , C08G63/64 , C08L67/04
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译：描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。

4. 发明申请

WO1996000102A1 DEVICES AND METHODS FOR APPLICATION OF INTRALUMINAL PHOTOPOLYMERIZED GELS 审中-公开
标题翻译：用于应用内在光致凝胶凝胶的装置和方法
公开(公告)号：WO1996000102A1
公开(公告)日：1996-01-04
申请号：PCT/US1995008067
申请日：1995-06-26
申请人： FOCAL, INC.
发明人： FOCAL, INC. , ROTH, Laurence, A. , HERMAN, Stephen, J. , KHOSRAVI, Farhad , MELANSON, David , DUMONT, Michael , CAMPBELL, Patrick, K. , SPIRIDIGLIOZZI, John, C.
IPC分类号： A61M25/10
CPC分类号： A61F2/82 , A61B17/00491 , A61F2250/0067 , A61M25/1011 , A61M35/00 , A61M2025/0076 , A61M2025/1052
摘要： Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.
摘要翻译：公开了用于在体腔和空间的内表面上提供聚合物层的装置。该装置可以包括近端和远端阻塞元件以限定治疗空间，以及光发射器以提供用于光聚合程序的光。所述装置可以包括用于提供厚聚合物凝胶的模制构件。或者，可以使用没有模制构件的装置来进行界面聚合程序。

5. 发明申请

WO1996029370A2 REDOX AND PHOTOINITIATOR SYSTEMS FOR PRIMING FOR IMPROVED ADHERENCE OF GELS TO SUBSTRATES 审中-公开
标题翻译：用于改善凝胶粘附到基底的红外和光电子系统
公开(公告)号：WO1996029370A2
公开(公告)日：1996-09-26
申请号：PCT/US1996003834
申请日：1996-03-22
申请人： FOCAL, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SAWHNEY, Amarpreet, S. , MELANSON, David, A. , PATHAK, Chandrashekar, P. , HUBBELL, Jeffrey, A. , AVILA, Luis, Z. , KIERAS, Mark, T.
发明人： FOCAL, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C09D04/00
CPC分类号： C09D4/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L2300/00 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C08L2666/02 , C09J151/00 , Y10S602/904 , C08L71/02 , C08L33/04 , C08F220/00
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译：公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施方案中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其他表面，或将组织表面彼此附着。第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

6. 发明申请

WO1997033628A1 POLYMERIC DELIVERY OF RADIONUCLIDES AND RADIOPHARMACEUTICALS 审中-公开
标题翻译：聚合物递送放射性核素和放射性物质
公开(公告)号：WO1997033628A1
公开(公告)日：1997-09-18
申请号：PCT/US1997002075
申请日：1997-02-13
申请人： FOCAL, INC.
发明人： FOCAL, INC. , LEAVITT, Richard, D. , AVILA, Luis, Z.
IPC分类号： A61K51/12
CPC分类号： A61K51/06 , A61K51/0497 , A61K51/1213
摘要： Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.
摘要翻译：本地沉积的聚合物储存库用作固定和局部递送放射性核素或放射性药物的载体。放射性核素作为无机化合物以其元素形式引入，或通过物理或化学方法连接到较大的分子或掺入聚合物中。可以使用辅助结构来控制释放速率。可以使用已经用于局部放射治疗的标准放射性核素，例如碘，铱，镭，铯，钇或其它元素的放射性核素。

7. 发明申请

WO1997005185A2 MULTIBLOCK BIODEGRADABLE HYDROGELS FOR USE AS CONTROLLED RELEASE AGENTS FOR DRUGS DELIVERY AND TISSUE TREATMENT AGENTS 审中-公开
标题翻译：多用途可生物降解的水凝胶作为药物输送和组织治疗剂的控释药剂
公开(公告)号：WO1997005185A2
公开(公告)日：1997-02-13
申请号：PCT/US1996012285
申请日：1996-07-26
申请人： FOCAL, INC.
发明人： FOCAL, INC. , PATHAK, Chandrashekhar, P. , BARMAN, Shikha, P. , PHILBROOK, C., Michael , SAWHNEY, Amarpreet , COURY, Arthur, J. , AVILA, Luis, Z. , KIERAS, Mark, T.
IPC分类号： C08G63/664
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a cross-linkable group are provided. The macromers can be covalently cross-linked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译：提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联的基团。大分子单体可以共价交联以在体内在组织表面上形成凝胶。由大分子单体形成的凝胶具有包括热敏性和亲脂性的性质的组合，并且可用于各种医学应用，包括药物递送和组织包衣。

8. 发明申请

WO1996029987A1 REDUCTION OF ADHESIONS USING CONTROLLED DELIVERY OF ACTIVE OXYGEN INHIBITORS 审中-公开
标题翻译：通过控制输送活性氧气抑制剂减少粘连
公开(公告)号：WO1996029987A1
公开(公告)日：1996-10-03
申请号：PCT/US1996003813
申请日：1996-03-20
申请人： FOCAL, INC.
发明人： FOCAL, INC. , BAKER, Keith , COURY, Arthur, J.
IPC分类号： A61K09/00
CPC分类号： A61K9/0024 , A61K38/44 , A61K38/446 , A61K47/32 , Y10S514/944 , Y10S514/963
摘要： SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.
摘要翻译： SOD和其他活性氧抑制剂直接与局部组织损伤部位的阻隔材料结合使用，以防止或减少粘连的形成和细胞的不希望的分泌。优选的阻隔材料是提供直接施用于受影响组织的AOI的受控释放的聚合物水凝胶。实施例证明当通过腹膜内（I.P.）推注和通过局部持续释放从局部施用的水凝胶系统施用时，SOD对大鼠骨盆粘连的影响。

9. 发明专利

CA2161776C APPARATUS AND METHODS FOR INTRALUMINAL PHOTOTHERMOFORMING 未知
公开(公告)号：CA2161776C
公开(公告)日：2005-12-20
申请号：CA2161776
申请日：1994-04-28
申请人： FOCAL INC
发明人： PATHAK CHANDRASHEKHAR P , HUBBELL JEFFREY A , HERMAN STEPHEN J , ROTH LAURENCE A , CAMPBELL PATRICK K , BERRIGAN KEVIN M , JARRETT PETER K , COURY ARTHUR J , SAWHNEY AMARPREET S
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/04 , A61F2/06 , A61M25/10 , A61L27/14 , A61L27/58
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed . The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter (10) having a shaping element (12) positioned near its distal end. An emitter (15) provided with light fro m at least one optical fiber (18) is positioned within the shaping element. The emitter serves to provide a moldable polymeric article (19) positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desir ed treatment site in a body lumen.

10. 发明专利

DE69813242D1 未知
公开(公告)号：DE69813242D1
公开(公告)日：2003-05-15
申请号：DE69813242
申请日：1998-08-06
申请人： FOCAL INC
发明人： COURY ARTHUR J , SAWHNEY AMARPREET S , HUBBELL JEFFREY A , PHILBROOK C MICHAEL
IPC分类号： A61L27/00 , A61K9/16 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , C08G63/676 , C08G65/00 , C08G85/00 , A61P41/00
摘要： A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can control bleeding at the site and may also provide improved adherence of the sealant to tissue and provide shorter healing times.

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