专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012094312A1 METHODS AND SYSTEMS FOR MEASUREMENT OF TEAR GLUCOSE LEVELS 审中-公开
标题翻译：测量葡萄糖水平的方法和系统
公开(公告)号：WO2012094312A1
公开(公告)日：2012-07-12
申请号：PCT/US2012/020073
申请日：2012-01-03
申请人： EYELAB GROUP, LLC , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MEYERHOFF, Mark E. , COHAN, Bruce E. , YAN, Qinyi , PENG, Bo , FLANDERS, Zvi
发明人： MEYERHOFF, Mark E. , COHAN, Bruce E. , YAN, Qinyi , PENG, Bo , FLANDERS, Zvi
IPC分类号： A61B5/01 , A61B5/1459
CPC分类号： G01N27/3271 , A61B5/1486
摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
摘要翻译：用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分流体样品。或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

2. 发明申请

WO2003087775A2 METHOD AND APPARATUS FOR NON-INVASIVE MONITORING OF BLOOD SUBSTANCES USING SELF-SAMPLED TEARS 审中-公开
标题翻译：使用自拍样本进行非自动监测血液物质的方法和装置
公开(公告)号：WO2003087775A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/009954
申请日：2003-04-01
申请人： EYELAB GROUP,LLC , COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
发明人： COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
IPC分类号： G01N
CPC分类号： C12Q1/006 , A61B5/1486 , A61B2562/0295 , C12Q1/32 , C12Q1/54 , G01N27/3272 , G01N33/528 , G01N2001/1056 , G01N2001/149 , G01N2035/0465 , Y10T436/144444
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.
摘要翻译：用于非侵入性地确定血液中的物质如葡萄糖的浓度的方法和装置包括布置成用于接触使用者的眼睛区域以获得泪液样品的样品部分，与样品部分连通的传感器，用于产生与泪液物质浓度相关的信号，以及处理器，与传感器通信，用于确定对应于泪液物质浓度的血液物质浓度。

3. 发明申请

WO2009155416A1 SYSTEM AND METHOD FOR DETERMINING VOLUME-RELATED PARAMETERS OF OCULAR AND OTHER BIOLOGICAL TISSUES 审中-公开
标题翻译：用于确定卵巢和其他生物组织的体积相关参数的系统和方法
公开(公告)号：WO2009155416A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047792
申请日：2009-06-18
申请人： EYELAB GROUP, LLC , DILWORTH, David, S. , COHAN, Bruce, E. , FLANDERS, Zvi , PESHKIN, Hannah, R.
发明人： DILWORTH, David, S. , COHAN, Bruce, E. , FLANDERS, Zvi , PESHKIN, Hannah, R.
IPC分类号： G01D9/02
CPC分类号： A61B3/1005 , A61B3/0025 , A61B3/12 , A61B5/0075 , A61B5/1072 , A61B5/1079 , A61B5/7235
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.
摘要翻译：用于确定诸如眼组织的生物组织的体积相关参数的系统和方法包括用于将光投射到生物组织的光源，用于接收以两个光谱波长从生物组织反射的光的接收器，以及图像与接收器通信的采集系统，用于从每个波长处的反射光形成图像。处理器将数学模型应用于图像，其比较在两个光谱波长中的每一个处的选定图像点处的生物组织对光的吸收，以确定体积相关参数，例如相对厚度和材料性质生物组织在那个位置。

4. 发明申请

WO2004036268A3 APPARATUS AND METHOD FOR SELF-MEASUREMENT OF INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于自我测量心室压力的装置和方法
公开(公告)号：WO2004036268A3
公开(公告)日：2004-12-23
申请号：PCT/US0333250
申请日：2003-10-20
申请人： EYELAB GROUP LLC , COHAN BRUCE E , PEARCH ANDREW C , FLANDERS ZVI , GILLESPIE DONALD E
发明人： COHAN BRUCE E , PEARCH ANDREW C , FLANDERS ZVI , GILLESPIE DONALD E
IPC分类号： A61B3/16 , A61B3/00 , A61B3/10
CPC分类号： A61B3/16
摘要： An apparatus and method for the self-measurement of intraocular pressure utilize a tonometer disposed within a housing (148) and having a tonometer tip (142). The apparatus further includes an adjustment mechanism (164) in communication with the tonometer for positioning the tonometer tip in contact with a test eye of the user, and an illuminator (138) mounted within the housing adjacent the tonometer tip. A receiver (130) is aligned with the tonometer tip for receiving an applanation pattern created by contact of the tonometer tip with the test eye and a display (128) is provided in communication with the receiver for displaying the applanation pattern to an observing eye of the user. The intraocular pressure of the test eye is determined from a force applied by the tonometer tip upon observation of a selected applanation pattern by the observing eye.
摘要翻译：用于眼压自我测量的装置和方法利用设置在壳体（148）内并具有眼压计尖端（142）的眼压计。该装置还包括与眼压计连通的调节机构（164），用于将眼压计尖端定位成与用户的测试眼接触;以及照明器（138），安装在邻近眼压计尖端的壳体内。接收器（130）与眼压计尖端对准，用于接收通过眼压计尖端与测试眼睛的接触而产生的压平图案，并且提供与接收器通信的显示器（128），用于将压扁图案显示到观察眼用户。通过观察眼观察选定的压平图案，由眼压计尖端施加的力确定测试眼睛的眼内压。

5. 发明专利

PT1891942E INSERÇÃO OFTÁLMICA E MÉTODO PARA LIBERTAÇÃO SUSTENTADA DE MEDICAMENTOS AO OLHO 未知
公开(公告)号：PT1891942E
公开(公告)日：2010-04-21
申请号：PT07012726
申请日：2000-04-07
申请人： EYELAB GROUP LLC
发明人： DIAMOND HOWARD , COHAN BRUCE E
IPC分类号： A61K9/22 , A61F9/00 , A61F9/007 , A61K9/00 , A61K9/20

6. 发明专利

DE60035979T2 未知
公开(公告)号：DE60035979T2
公开(公告)日：2007-12-20
申请号：DE60035979
申请日：2000-04-07
申请人： EYELAB GROUP LLC
发明人： COHAN BRUCE E , DIAMOND HOWARD
IPC分类号： A61K9/22 , A61F9/00 , A61F9/007 , A61K9/00
摘要： An ophthalmic insert (24) and method for sustained release of medication to the eye are provided. The insert (24) includes a body portion (30) sized to pass through a lacrimal punctum (14, 16) and be positioned within a lacrimal canaliculus (18, 20) of the eyelid. The insert further includes a collarette (26) connected to the body portion (30) and sized to rest on the exterior of the lacrimal punctum, the collarette having a pore (42) provided therein. A reservoir (34) is contained at least partially within the body portion (30) and in fluid communication with the pore (42), wherein the reservoir (34) is designed to store and release medication through the pore (42) and onto the eye over time in a controlled manner while the insert (24) is positioned in the eyelid. Preferably, the pore (42) is constructed with a specific geometry appropriate to control the rate of release of the medication onto the eye.

7. 发明申请

WO2004036268A2 APPARATUS AND METHOD FOR SELF-MEASUREMENT OF INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于自我测量心室压力的装置和方法
公开(公告)号：WO2004036268A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/033250
申请日：2003-10-20
申请人： EYELAB GROUP, LLC , COHAN, Bruce, E. , PEARCH, Andrew, C. , FLANDERS, Zvi , GILLESPIE, Donald, E.
发明人： COHAN, Bruce, E. , PEARCH, Andrew, C. , FLANDERS, Zvi , GILLESPIE, Donald, E.
IPC分类号： G02B
CPC分类号： A61B3/16
摘要： An apparatus and method for the self-measurement of intraocular pressure utilize a tonometer disposed within a housing and having a tonometer tip. The apparatus further includes an adjustment mechanism in communication with the tonometer for positioning the tonometer tip in contact with a test eye of the user, and an illuminator mounted within the housing adjacent the tonometer tip. A receiver is aligned with the tonometer tip for receiving an applanation pattern created by contact of the tonometer tip with the test eye, and a display is provided in communication with the receiver for displaying the applanation pattern to an observing eye of the user. The intraocular pressure of the test eye is determined from a force applied by the tonometer tip upon observation of a selected applanation pattern by the observing eye.
摘要翻译：用于眼压自我测量的装置和方法利用设置在壳体内并具有眼压计尖端的眼压计。该装置还包括与眼压计通信的调节机构，用于将眼压计尖端定位成与用户的测试眼接触，以及安装在邻近眼压计尖端的壳体内的照明器。接收器与眼压计尖端对准，用于接收通过眼压计尖端与测试眼接触而产生的压平图案，并且提供与接收器通信的显示器，用于向用户的观察眼睛显示压平图案。由观察眼观察选定的压平图案时，由眼压计尖端施加的力确定测试眼睛的眼内压。

8. 发明申请

WO2003087775A3 MONITORING BLOOD SUBSTANCES USING SELF-SAMPLED TEARS 审中-公开
公开(公告)号：WO2003087775A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/009954
申请日：2003-04-01
申请人： EYELAB GROUP,LLC , COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
发明人： COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
IPC分类号： A61B05/00
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion (12) arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor (21) in communication with the sample portion (12) for generating a signal related to the tear substance concentration, and a processor (44) in communication with the sensor (21) for determining a blood substance concentration corresponding to the tear substance concentration.

9. 发明专利

CA2743458C SYSTEM AND METHOD FOR DETERMINING VOLUME-RELATED PARAMETERS OF OCULAR AND OTHER BIOLOGICAL TISSUES 未知
公开(公告)号：CA2743458C
公开(公告)日：2016-08-16
申请号：CA2743458
申请日：2009-06-18
申请人： EYELAB GROUP LLC
发明人： DILWORTH DAVID S , COHAN BRUCE E , FLANDERS ZVI , PESHKIN HANNAH R
IPC分类号： A61B3/12 , A61B3/10 , G01B11/06 , G01N21/25
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.

10. 发明专利

CA2743458A1 SYSTEM AND METHOD FOR DETERMINING VOLUME-RELATED PARAMETERS OF OCULAR AND OTHER BIOLOGICAL TISSUES 未知
公开(公告)号：CA2743458A1
公开(公告)日：2009-12-23
申请号：CA2743458
申请日：2009-06-18
申请人： EYELAB GROUP LLC
发明人： DILWORTH DAVID S , COHAN BRUCE E , FLANDERS ZVI , PESHKIN HANNAH R
IPC分类号： G01D9/02
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式