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1. 发明申请

WO2008060666A2 CHEMICAL SAMPLING AND MULTI-FUNCTION DETECTION METHODS AND APPARATUS 审中-公开
标题翻译：化学取样和多功能检测方法及装置
公开(公告)号：WO2008060666A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/066801
申请日：2007-04-17
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching
IPC分类号： G06K7/10
CPC分类号： G01N1/14 , G01N1/2214 , G01N1/405 , G01N2001/022 , G01N2001/028
摘要： This invention describes a sample collection method that could release and collect residues of explosives and other chemicals from a surface; the described method is implemented into a compact detection system that can be used as a "wand" for screening chemicals residues on a subject. The wand configuration includes multi-function for sampling and detecting multiple threads. The invention further describes a method of inspecting a subject using an interrogating apparatus in a sweeping motion; the near range closed loop particle sampling arrangement allows effective collection of particle and vapor residues from a targeted surface. The invention also describes a sampling and detecting apparatus for on-the-fly threat detection using compact ion mobility based detectors.
摘要翻译：本发明描述了可以从表面释放和收集爆炸物和其他化学物质的残留物的样品收集方法; 所描述的方法被实现为紧凑的检测系统，其可以用作用于筛选受试者上的化学物质残留物的“杖”。魔杖配置包括用于采样和检测多个线程的多功能。本发明还描述了一种使用询问装置以清扫动作检查对象的方法; 近程闭环颗粒采样装置允许从目标表面有效收集颗粒和蒸汽残留物。本发明还描述了一种用于使用基于紧密离子移动性的检测器进行飞行中威胁检测的采样和检测装置。

2. 发明申请

WO2010051518A1 ION MOBILITY BASED SEPARATION METHODS AND APPARATUS 审中-公开
标题翻译：离子移动基于分离方法和装置
公开(公告)号：WO2010051518A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062905
申请日：2009-10-31
申请人： EXCELLIMS CORPORATION , WU, Ching , KRUEGER, Clinton, Alawn
发明人： WU, Ching , KRUEGER, Clinton, Alawn
IPC分类号： H01J49/00
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and / or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and / or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译：本发明描述了使用离子迁移率光谱仪中的样品中的组分，其中使用除了惰性漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。通过改变IMS的漂移介质来实现基于匹配特性的分离。除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质和优化能级以便实现最佳性能的调谐方法。

3. 发明申请

WO2010042881A1 METHOD AND APPARATUS FOR CHEMICAL AND BIOLOGICAL SAMPLE SEPARATION 审中-公开
标题翻译：化学与生物样品分离方法与装置
公开(公告)号：WO2010042881A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060258
申请日：2009-10-09
申请人： EXCELLIMS CORPORATION , KRUEGER, Clinton, Alawn , WU, Ching , HILTON, Christopher, K.
发明人： KRUEGER, Clinton, Alawn , WU, Ching , HILTON, Christopher, K.
IPC分类号： H01J49/00
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译：本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来增强样品分辨率。此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。

4. 发明申请

WO2010124019A1 INTELLIGENTLY CONTROLLED SPECTROMETER METHODS AND APPARATUS 审中-公开
标题翻译：智能控制光谱仪的方法和设备
公开(公告)号：WO2010124019A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031934
申请日：2010-04-21
申请人： EXCELLIMS CORPORATION , OSGOOD, Mark, A. , WU, Ching
发明人： OSGOOD, Mark, A. , WU, Ching
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译：本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。快速切换宏观主义可以用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

5. 发明申请

WO2008067395A3 PRACTICAL ION MOBILITY SPECTROMETER APPARATUS AND METHODS FOR CHEMICAL AND/OR BIOLOGICAL DETECTION 审中-公开
公开(公告)号：WO2008067395A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085785
申请日：2007-11-28
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching
IPC分类号： B01D59/44
摘要： This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.

6. 发明申请

WO2008008826A3 METHODS AND APPARATUS FOR THE ION MOBILITY BASED SEPARATION AND COLLECTION OF MOLECULES 审中-公开
公开(公告)号：WO2008008826A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/073244
申请日：2007-07-11
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching
IPC分类号： B01D59/44 , H01J49/00
摘要： This invention describes an apparatus for the separation and collection of components in a sample of interest comprising: an ionization source; an ion mobility separator and an ion collector positioned to receive ions leaving the ion mobility separator. The ion mobility separator having an inlet to supply at least one separating substance which comprises particles which selectively interact with at least one analyte component of interest to certain degree different from the others. The analyte component of interest may be enantiomers, diastereomers, stereoisomers, isomers, etc. The ion collector can be used to conduct analytical, preparative, and semi-preparative separation. In addition, a combined primary electrospray and secondary electrospray ionization source is disclosed to enhance ionization efficiency of interest.

7. 发明申请

WO2009052176A1 COMPACT PYROELECTRIC SEALED ELECTRON BEAM 审中-公开
标题翻译：紧凑型电子密封电子束
公开(公告)号：WO2009052176A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/079986
申请日：2008-10-15
申请人： EXCELLIMS CORPORATION , WU, Ching , BROMBERG, Leslie
发明人： WU, Ching , BROMBERG, Leslie
IPC分类号： H01J27/00
CPC分类号： H01J49/147
摘要： A non-radioactive source for Atmospheric Pressure Ionization is described. The electron-beam sealed tube uses a pyroelectric crystal (s). One end of the crystal is grounded while the other end has a metallic cap with sharp feature to generate an electron beam of a given energy. The rate of heating and/or cooling of the crystal is used to control the current generated from a tube. A heating and/or cooling element such as a Peltier element is useful for controlling the rate of cooling of the crystal. A thin window that is transparent to electrons but impervious to gases is needed in order to prolong the life of the tube and allow the extraction of the electrons. If needed, multiple crystals with independent heaters can be used to provide continuous operation of the device.
摘要翻译：描述了用于大气压电离的非放射源。电子束密封管使用热电晶体。晶体的一端接地，而另一端具有尖锐特征的金属盖，以产生给定能量的电子束。使用晶体的加热和/或冷却速度来控制从管产生的电流。诸如珀尔帖元件的加热和/或冷却元件可用于控制晶体的冷却速率。需要对电子透明但不透气体的薄窗，以延长管的寿命并允许电子的提取。如果需要，可以使用具有独立加热器的多个晶体来提供设备的连续操作。

8. 发明申请

WO2008097962A2 METHODS AND APPARATUS OF ION MOBILITY SPECTROMETER 审中-公开
标题翻译：离子移动光谱仪的方法和装置
公开(公告)号：WO2008097962A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/053041
申请日：2008-02-05
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching , BROMBERG, Leslie
IPC分类号： H01J49/00 , H01J49/28
CPC分类号： G01N27/624
摘要： The present invention describes apparatuses and methods that provide energy to ions in a non-thermal manner. The elevated ion energy minimizes or eliminates interferences due to clustering with polar molecules, such as water. The energized ions are separated in an ion mobility spectrometer. During the ion transportation and separation process, the elevated energy level of ions prevents them from clustering with neutral molecule inside the spectrometer. The additional electric field component only causes ions to reach elevated energy level, whereby the spectrometer can preserve its normal performance, meanwhile avoiding interference from water and other neutral molecules. A RF electric field is applied to the ions in ionization, reaction and separation region of ion mobility spectrometers.
摘要翻译：本发明描述了以非热方式向离子提供能量的装置和方法。升高的离子能量最小化或消除由于与极性分子（例如水）聚集的干扰。激发离子在离子迁移谱仪中分离。在离子运输和分离过程中，提高的离子能级防止它们与分光计内部的中性分子聚集。额外的电场分量仅使离子达到提高的能量水平，由此光谱仪可以保持其正常性能，同时避免水和其他中性分子的干扰。离子迁移谱仪的电离，反应和分离区域中的离子被施加RF电场。

9. 发明申请

WO2007095203A2 ION MOBILITY SPECTROMETER APPARATUS AND METHODS 审中-公开
标题翻译：离子移动光谱仪装置和方法
公开(公告)号：WO2007095203A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003726
申请日：2007-02-13
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching
CPC分类号： G01N27/622 , H01J49/062
摘要： An ion mobility spectrometer includes a protective housing. A drift tube including a helical resistive wire coil confines ions in a drift gas. The drift tube also includes at least one inlet and at least one outlet for passing the drift gas. An ion gate positioned in the drift tube defines a reaction region and a drift region in the drift tube. An ion detector is positioned in the drift tube downstream of the ion gate at an end of the drift region. A helical resistive wire coil is positioned around the drift tube. A power supply generates an electric field in the helical resistive wire coil that controls the temperature of the ions in the drift gas.
摘要翻译：离子迁移谱仪包括保护壳体。包括螺旋电阻线圈的漂移管将离子限制在漂移气体中。漂移管还包括用于通过漂移气体的至少一个入口和至少一个出口。位于漂移管中的离子门限定漂移管中的反应区和漂移区。离子检测器位于漂移管的漂移区末端的离子门下游。螺旋电阻线圈位于漂移管周围。电源在螺旋电阻线圈中产生电场，其控制漂移气体中的离子的温度。

10. 发明申请

WO2007079234A2 MULTI-DIMENSIONAL ION MOBILITY SPECTROMETRY APPARATUS AND METHODS 审中-公开
标题翻译：多维离子移动光谱仪器和方法
公开(公告)号：WO2007079234A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049594
申请日：2006-12-29
申请人： EXCELLIMS CORPORATION , WU, Ching
发明人： WU, Ching
CPC分类号： G01N27/622
摘要： Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.
摘要翻译：公开了具有多于一个漂移室的多维离子迁移率分析仪的各种实施方案，并且可以获得物质的多维离子迁移谱。该装置的漂移室可以例如在独立操作条件下操作，以根据其可区分的化学/物理性质分离带电粒子。该装置的第一尺寸漂移室可以根据分析仪的操作模式用作存储装置，反应室和/或漂移室。还提出了操作离子迁移谱仪的各种方法，包括但不限于连续的第一维电离方法，其能够使得样品中的所有化学组分电离，而不管其电荷亲和力如何。

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