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1. 发明专利

CA2596923A1 SYSTEMS AND METHODS FOR COLLECTION OF CELL CLUSTERS 未知
公开(公告)号：CA2596923A1
公开(公告)日：2006-07-13
申请号：CA2596923
申请日：2006-01-04
申请人： DIAMICS INC
发明人： DIMONTE GENE , GOMBRICH PETER , EATON EDWARD , LARSON ERIC
IPC分类号： A61B10/00
摘要： A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.

2. 发明专利

AR055709A1 SISTEMA Y METODOS PARA DETECTAR CELULAS ANORMALES 未知
公开(公告)号：AR055709A1
公开(公告)日：2007-09-05
申请号：ARP060100054
申请日：2006-01-06
申请人： DIAMICS INC
发明人： MALTZMAN WARREN , GOMBRICH PETER , DIMONTE GENE , EATON EDWARD , LARSON ERIC
IPC分类号： A61B10/00
摘要： Los sistemas y métodos para analizar los grupos de células para detectar dos o más marcadores biologicos que raramente o nunca ocurren en la misma célula durante el crecimiento, desarrollo y funcion celular normal, para indicar la existencia de células que son parte de un área local donde puede estar presente una lesion pre-neoplásica o neoplásica. La relacion entre las células se mantiene al tiempo que se analizan los grupos de células para facilitar el examen y determinacion de la existencia de posible displasia.

3. 发明专利

AR055555A1 SISTEMAS Y METODOS PARA RECOLECTAR GRUPOS DE CELULAS 未知
公开(公告)号：AR055555A1
公开(公告)日：2007-08-22
申请号：ARP060100053
申请日：2006-01-06
申请人： DIAMICS INC
发明人： GOMBRICH PETER , DIMONTE GENE , EATON EDWARD , LARSON ERIC
IPC分类号： A61B10/00
摘要： Se provee un recolector de células y un método de recoleccion de células para recolectar grupos de células para el análisis posterior de las células para monitorear anormalidades. El recolector de células está disenado para reforzar la capacidad del recolector de tomar grupos o conjuntos de células y facilitar el traspaso de los grupos de células recolectados en una estructura receptora, por ejemplo, un portaobjetos. En una realizacion, una combinacion del material del recolector, la textura de la superficie de recoleccion del recolector, y el uso de expansion y rotacion del recolector durante la recoleccion facilitan la recoleccion de los grupos de células.

4. 发明专利

CA2596918A1 SYSTEMS AND METHODS FOR DETECTING ABNORMAL CELLS 未知
公开(公告)号：CA2596918A1
公开(公告)日：2006-07-13
申请号：CA2596918
申请日：2006-01-04
申请人： DIAMICS INC
发明人： LARSON ERIC , MALTZMAN WARREN , EATON EDWARD , DIMONTE GENE , GOMBRICH PETER
IPC分类号： A61B10/00

5. 发明申请

WO2009042488A3 ADVANCED CERVICAL CELL SCREENING METHODS 审中-公开
标题翻译：先进的宫颈细胞筛选方法
公开(公告)号：WO2009042488A3
公开(公告)日：2009-05-22
申请号：PCT/US2008076813
申请日：2008-09-18
申请人： DIAMICS INC , GOMBRICH PETER , GOLBUS MITCHELL
发明人： GOMBRICH PETER , GOLBUS MITCHELL
IPC分类号： C12N15/37
CPC分类号： G01N33/57411 , C07K14/005 , C07K16/084 , C12N7/00 , C12N2710/20022 , G01N33/56983 , G01N2333/025
摘要： Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to evaluate and follow-up.
摘要翻译：先进的宫颈癌筛查方法，提供检测HPV整合的分子基础过程。所公开的方法允许在相同载玻片上进行Pap测试和免疫组织化学测试的简化方法。所公开的方法提供易于评估和跟踪的便宜，高度敏感，特异性和详细的测试。

6. 发明申请

WO2009042488A2 ADVANCED CERVICAL CELL SCREENING METHODS 审中-公开
标题翻译：先进的细胞筛选方法
公开(公告)号：WO2009042488A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/076813
申请日：2008-09-18
申请人： DIAMICS, INC. , GOMBRICH, Peter , GOLBUS, Mitchell
发明人： GOMBRICH, Peter , GOLBUS, Mitchell
IPC分类号： C12N15/37
CPC分类号： G01N33/57411 , C07K14/005 , C07K16/084 , C12N7/00 , C12N2710/20022 , G01N33/56983 , G01N2333/025
摘要： Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to evaluate and follow-up.
摘要翻译：先进的宫颈癌筛查方法，提供检测HPV整合的基于分子的过程。所公开的方法允许在同一载玻片上进行Pap测试和免疫组织化学测试的流线型方法。所公开的方法提供了便宜的，高度灵敏的，特定的和详细的测试，其易于评估和跟踪。

7. 发明申请

WO2008089266A2 PRODUCTION OF AN ASSAY FOR INDICATING A CELL TISSUE CONDITION 审中-公开
标题翻译：生产用于指示细胞组织条件的测定
公开(公告)号：WO2008089266A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051204
申请日：2008-01-16
申请人： DIAMICS, INC. , GOMBRICH, Peter
发明人： GOMBRICH, Peter
IPC分类号： G01N33/53 , G01N33/48 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/6842

8. 发明申请

WO2006074195A1 SYSTEMS AND METHODS FOR COLLECTION OF CELL CLUSTERS 审中-公开
标题翻译：用于收集细胞簇的系统和方法
公开(公告)号：WO2006074195A1
公开(公告)日：2006-07-13
申请号：PCT/US2006/000136
申请日：2006-01-04
申请人： DIAMICS, INC. , GOMBRICH, Peter , DIMONTE, Gene , EATON, Edward , LARSON, Eric
发明人： GOMBRICH, Peter , DIMONTE, Gene , EATON, Edward , LARSON, Eric
IPC分类号： A61B10/00
CPC分类号： A61B10/02 , A61B10/00 , A61B2010/0074
摘要： A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving . structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.
摘要翻译：提供细胞收集器和细胞收集方法用于收集细胞簇以便随后分析细胞以筛选异常。细胞收集器被设计成增强收集器拾取细胞簇或聚集体的能力，并且有助于将收集的细胞簇转移到接受体上。结构，例如幻灯片。在一个实施例中，收集器的材料，收集器的收集表面的纹理以及在收集器期间收集器的膨胀和旋转的使用的组合有利于收集细胞簇。

9. 发明申请

WO2008147865A1 POINT OF CARE CERVICAL SCREENING SYSTEM 审中-公开
标题翻译：护理点筛选系统
公开(公告)号：WO2008147865A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064500
申请日：2008-05-22
申请人： DIAMICS, INC. , GOMBRICH, Peter , GOLBUS, Mitchell
发明人： GOMBRICH, Peter , GOLBUS, Mitchell
IPC分类号： A61B10/00 , C12Q1/68 , G01N33/574 , C07K16/30
CPC分类号： G01N1/2813 , A61B10/0096 , G01N2035/00138 , G01N2333/025
摘要： A see and treat system and method which involves screening cellular samples for lesions that can be treated at the earliest stages, in a manner where a clinician can treat the patient with information provided by the screening assay in the same visit as the sample is taken. In one embodiment, a sample is collected from the cervix using a collector, the sample is transferred to a receiving structure and assayed so as to detect HPV integration via a biological marker, and the assay results are read via a reporter molecule that associates with the biological marker. The assay results can be read directly or via an instrument. In one example, the instrument is automated or semi- automated, and dispenses liquid into the receiving structure containing cervical cells, detects the presence of marker proteins and then reports the results.
摘要翻译：一种观察和治疗系统和方法，其涉及筛选可在最早阶段治疗的病变的细胞样品，其方式是临床医生可以在与采集样本相同的访问中通过筛选测定提供的信息来治疗患者。在一个实施方案中，使用收集器从子宫颈收集样品，将样品转移到接受结构并进行测定，以便经由生物标记物检测HPV整合，并且通过报告分子读取测定结果，所述报告分子与生物标记。测定结果可以直接读取或通过仪器读取。在一个实例中，仪器是自动化或半自动化的，并将液体分配到含有宫颈细胞的接收结构中，检测标记蛋白的存在，然后报告结果。

10. 发明申请

WO2006074143A1 SYSTEMS AND METHODS FOR DETECTING ABNORMAL CELLS 审中-公开
标题翻译：用于检测异常细胞的系统和方法
公开(公告)号：WO2006074143A1
公开(公告)日：2006-07-13
申请号：PCT/US2006/000049
申请日：2006-01-04
申请人： DIAMICS, INC. , MALTZMAN, Warren , GOMBRICH, Peter , DIMONTE, Gene , EATON, Edward , LARSON, Eric
发明人： MALTZMAN, Warren , GOMBRICH, Peter , DIMONTE, Gene , EATON, Edward , LARSON, Eric
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B2010/0074
摘要： Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion may be present. The relationship among cells is maintained while interrogating the clusters of cells to facilitate the examination and determination of the existence of possible dysplasia.
摘要翻译：询问两个或多个生物标记物的细胞簇的系统和方法，其在正常细胞生长，发育和功能期间不会或很少发生在相同细胞中，以指示作为局部区域的一部分的细胞的存在，其中可能存在肿瘤前或肿瘤前病变。在询问细胞簇时，保持细胞之间的关系，以便于检查和确定可能的发育不良的存在。

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