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1. 发明专利

GB201617256D0 Filtration apparatus 未知
公开(公告)号：GB201617256D0
公开(公告)日：2016-11-23
申请号：GB201617256
申请日：2016-10-11
申请人： CYTOSYSTEMS LIMITED

2. 发明申请

WO2012093251A1 DIAGNOSTIC METHOD 审中-公开
标题翻译：诊断方法
公开(公告)号：WO2012093251A1
公开(公告)日：2012-07-12
申请号：PCT/GB2012/000008
申请日：2012-01-06
申请人： CYTOSYSTEMS LIMITED , GALLOWAY, David , COLEMAN, Nick
发明人： GALLOWAY, David , COLEMAN, Nick
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57407
摘要： The invention provides a method of detecting a subject suffering from, or at risk of suffering from, bladder cancer the method comprising i) providing a body fluid sample isolated from a subject; ii) isolating cells from said sample to provide a cell sample; iii) contacting the sample with a specific binding member capable of binding to a minichromosome maintenance (MCM) polypeptide(s); iv) determining the binding of said specific binding member to the cell sample; v) counting those cells in said cell sample which bound to said specific binding member to provide a cell count; vi) determining, based on the cell count, whether the subject has, or is at risk of having, bladder cancer.
摘要翻译：本发明提供一种检测患有或患有膀胱癌风险的受试者的方法，该方法包括：i）提供从受试者分离的体液样品; ii）从所述样品中分离细胞以提供细胞样品; iii）使样品与能够结合微染色体维持（MCM）多肽的特异性结合成员接触; iv）确定所述特异性结合成员与细胞样品的结合; v）计数与所述特异性结合成员结合的所述细胞样品中的细胞以提供细胞计数; vi）基于细胞计数确定受试者是否具有膀胱癌或有膀胱癌的风险。

3. 发明申请

WO2016207632A1 ANTI-MCM2 MONOCLONAL ANTIBODY 审中-公开
标题翻译：抗MCM2单克隆抗体
公开(公告)号：WO2016207632A1
公开(公告)日：2016-12-29
申请号：PCT/GB2016/051873
申请日：2016-06-23
申请人： CYTOSYSTEMS LIMITED
发明人： DHANVIJAY, Sushant
IPC分类号： C07K16/30 , C07K16/18
CPC分类号： C07K16/30 , C07K16/18 , C07K16/3038 , C07K19/00 , C07K2317/24 , C07K2317/92 , G01N33/574 , G01N2800/60 , G01N2800/7028
摘要： The invention relates to an isolated antigenic polypeptide comprising an epitope for binding an MCM2 monoclonal antibody, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of: (a) the amino acid as shown in Figure 1; and (b) the amino acid sequence wherein said sequence is a variant polypeptide modified by addition, deletion or substitution of at least one amino acid residue as represented in Figure 1.
摘要翻译：本发明涉及包含用于结合MCM2单克隆抗体的表位的分离的抗原多肽，其中所述多肽包含选自以下的氨基酸序列：（a）如图1所示的氨基酸; 和（b）氨基酸序列，其中所述序列是通过添加，缺失或取代至少一个如图1所示的氨基酸残基而修饰的变体多肽。

4. 发明申请

WO2017068326A2 FILTRATION APPARATUS 审中-公开
标题翻译：过滤设备
公开(公告)号：WO2017068326A2
公开(公告)日：2017-04-27
申请号：PCT/GB2016/053155
申请日：2016-10-12
申请人： CYTOSYSTEMS LIMITED
发明人： DHANVIJAY, Sushant
IPC分类号： F16K11/02
CPC分类号： G01N1/40 , B01L3/502 , B01L3/563 , B01L2300/0681 , F16K11/022 , G01N2001/4088
摘要： There is provided an apparatus for collecting/isolating cells from a sample including the target cells comprising: a membrane adapted to retain the target cells thereon, a first port in fluid communication with the membrane provided towards a first side of the membrane, a second port in fluid communication with the membrane provided towards a second side of the membrane, a sample container having at least one wall defining an interior space suitable to house the sample, provided on the first side of the membrane, a cell collection container provided towards the first side of the membrane, a filtrate container provided towards the second side of the membrane, a backwash fluid container provided towards the second side of the membrane, wherein the first port is movable between a first position wherein the first port is in fluid communication with the sample container, and a second position wherein the first port is in fluid communication with the cell collection container; and wherein the second port is movable between a first position wherein the second port is in fluid communication with the filtrate container, and a second position wherein the second port is in fluid communication with the backwash fluid container.
摘要翻译：提供了用于从包含靶细胞的样品中收集/分离细胞的设备，其包括：膜，其适于将靶细胞保留在其上;第一端口，其与朝向第一端提供的膜流体连通与所述膜流体连通的第二端口，所述第二端口朝向所述膜的第二侧提供;样本容器，所述样本容器具有限定适于容纳所述样本的内部空间的至少一个壁，所述内部空间设置在所述膜的所述第一侧上，朝膜的第一侧设置的细胞收集容器，朝向膜的第二侧设置的滤液容器，朝向膜的第二侧设置的反洗流体容器，其中第一端口可在第一位置和第二位置之间移动，第一端口与样本容器流体连通，以及第二位置，其中第一端口与细胞收集容器流体连通; 并且其中第二端口可在第二位置与第二位置之间移动，在第一位置第二端口与滤液容器流体连通，在第二位置第二端口与反洗流体容器流体连通。

5. 发明申请

WO2013102757A1 DIAGNOSTIC METHOD AND SYSTEM 审中-公开
标题翻译：诊断方法与系统
公开(公告)号：WO2013102757A1
公开(公告)日：2013-07-11
申请号：PCT/GB2013/000003
申请日：2013-01-04
申请人： CYTOSYSTEMS LIMITED
发明人： GALLOWAY, David , MAYNARD, Daniel Mark
IPC分类号： G01N33/50 , G01N33/68 , G01N21/00
CPC分类号： G01N33/5005 , G01N21/251 , G01N33/6875 , G01N2800/7028 , G02B21/26 , G02B21/361 , G02B21/365 , G06K9/00147
摘要： The present invention relates to a method of diagnosis which identifies one or more individual cells and comprises determining at least one of a cell dimension and a cell area, and determining at least one of dark/light cell contrast characteristics, cell area characteristics, cell colour characteristics, cell roughness characteristics, distances between cell nuclei and cell convexity. A computer readable medium, a computer apparatus and a diagnostic system is also provided.
摘要翻译：本发明涉及一种诊断方法，其识别一个或多个单个细胞，并且包括确定细胞尺寸和细胞区域中的至少一个，以及确定暗/光细胞对比特征，细胞区域特征，细胞颜色特征，细胞粗糙度特征，细胞核与细胞凸起之间的距离。还提供了计算机可读介质，计算机设备和诊断系统。

6. 发明申请

WO2022064422A1 DIAGNOSIS OF CANCER BY IMAGING FLOW CYTOMETRY 审中-公开
公开(公告)号：WO2022064422A1
公开(公告)日：2022-03-31
申请号：PCT/IB2021/058693
申请日：2021-09-23
申请人： CYTOSYSTEMS LIMITED
发明人： FISCHER, Ida , YUECEL, Raif , PERENYI, Peter
IPC分类号： G01N33/574 , G01N33/50
摘要： A method of diagnosis comprising: providing a cell sample; contacting said cell sample with an antibody capable of binding a minichromosome maintenance (MCM) polypeptide(s); introducing the cell sample into an imaging flow cytometer; analysing one or more cells within the imaging flow cytometer; measuring visual properties of the cells in the sample; making a diagnosis based on the measured visual properties. Especially for the diagnosis of bladder cancer.

7. 发明申请

WO2009156711A1 ASSAY 审中-公开
公开(公告)号：WO2009156711A1
公开(公告)日：2009-12-30
申请号：PCT/GB2009/001531
申请日：2009-06-18
申请人： CYTOSYSTEMS LIMITED , GALLOWAY, David, Brian
发明人： GALLOWAY, David, Brian
IPC分类号： G01N33/50
CPC分类号： G01N33/57434
摘要： This invention relates to a method of detecting or determining the presence of prostate cancer cells in a sample of body fluid from a subject comprising: (i) isolating cells from said sample to provide a cell sample; (ii) contacting said cell sample with a specific binding member capable of binding a prostate antigen; and/or (iii) contacting said cell sample with a specific binding member capable of binding a minichromosome maintenance (MCM) polypeptide(s); and (iv) determining the binding of said specific binding member(s) to the cell sample.
摘要翻译：本发明涉及一种检测或确定来自受试者的体液样品中前列腺癌细胞的存在的方法，包括：（i）从所述样品中分离细胞以提供细胞样品; （ii）使所述细胞样品与能够结合前列腺抗原的特异性结合成员接触; 和/或（iii）使所述细胞样品与能够结合微染色体维持（MCM）多肽的特异性结合成员接触; 和（iv）确定所述特异性结合成员与细胞样品的结合。

8. 发明申请

WO2011073619A1 ASSAY 审中-公开
公开(公告)号：WO2011073619A1
公开(公告)日：2011-06-23
申请号：PCT/GB2010/002274
申请日：2010-12-15
申请人： CYTOSYSTEMS LIMITED , LASKEY, Ronald, Arnold
发明人： LASKEY, Ronald, Arnold
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N33/6893 , G01N2333/723
摘要： This disclosure relates to a diagnostic/prognostic assay for prostate cancer and including kits used in said assay.
摘要翻译：本公开涉及前列腺癌的诊断/预后测定，并且包括用于所述测定中的试剂盒。

9. 发明申请

WO2009087375A1 APPARATUS AND METHOD FOR FILTERING BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于过滤生物材料的装置和方法
公开(公告)号：WO2009087375A1
公开(公告)日：2009-07-16
申请号：PCT/GB2009/000029
申请日：2009-01-09
申请人： CYTOSYSTEMS LIMITED , BERRY, Richard, George , GARDYNE, Edward, Alexander
发明人： BERRY, Richard, George , GARDYNE, Edward, Alexander
IPC分类号： G01N1/28 , G01N1/40 , C12M1/12 , G01N33/53
CPC分类号： G01N1/2813 , C12M33/16 , G01N1/4077 , G01N2001/4088
摘要： A method and apparatus for harvesting cells from a fluid so as to preserve the integrity of the cells when used in the diagnosis of cancer. The apparatus comprises a filter adapted to collect cells of a predetermined size, a fluid pathway arranged to transmit fluid to and from the filter, a pump which provide a positive pressure which urges the fluid to the filter along the fluid pathway and a negative pressure which draws the fluid from the filter along the fluid pathway and which operates to pass the sample through the filter in a first direction to collect cells on the filter. A second pump operates to pass a cell preservative fluid through the filter in a second direction to remove cells from the filter for collection. A controller is provided to regulate the flow of fluid along the fluid pathway. The method and apparatus provides a gentle pressure gradient which minimises damage to the cells during the process of filtration and collection.
摘要翻译：一种用于从流体中收获细胞以在用于诊断癌症时保持细胞完整性的方法和装置。该装置包括适于收集预定尺寸的细胞的过滤器，布置成将流体传送到过滤器和从过滤器传送流体的流体通道，提供沿着流体通道将流体推向过滤器的正压力和负压，沿着流体路径从过滤器抽取流体，并且操作以使样品在第一方向上通过过滤器以收集过滤器上的细胞。第二泵操作以使细胞防腐液在第二方向上通过过滤器，以从过滤器中移出细胞用于收集。提供控制器来调节流体沿着流体通道的流动。该方法和装置提供了缓和的压力梯度，其在过滤和收集过程中使细胞的损伤最小化。

10. 发明申请

US20130171662A1 ASSAY 审中-公开
公开(公告)号：US20130171662A1
公开(公告)日：2013-07-04
申请号：US13512823
申请日：2010-12-15
申请人： Ronald Alfred Laskey
发明人： Ronald Alfred Laskey
IPC分类号： G01N33/68
CPC分类号： G01N33/57434 , G01N33/6893 , G01N2333/723
摘要： This disclosure relates to a diagnostic/prognostic assay for prostate cancer and including kits used in said assay.

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