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1. 发明公开

KR20180030033A 약물 서방성 담체 및 그의 제조 방법 审中-公开
标题翻译：药物持续载体及其制备方法
公开(公告)号：KR20180030033A
公开(公告)日：2018-03-21
申请号：KR20187000885
申请日：2016-07-13
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING SHU , OOYA TOORU , JIANG RONGRONG , KAMIYAMA FUMIO
IPC分类号： A61K47/36 , A61K8/64 , A61K8/86 , A61K9/00 , A61K38/22 , A61K38/28 , A61K47/10 , A61Q19/00
CPC分类号： A61K8/86 , A61K38/22 , A61K38/28 , A61K47/36 , A61Q19/00
摘要： 약물의서방성을가능하게하는 DDS용담체및 그의제조방법이다. PEG 카르복시기함유고분자그래프트에약물을유지시키는것을특징으로한다. 고분자중에서도카르복시기함유다당류를적합하게사용할수 있다. PEG 카르복시기함유고분자그래프트는, 폴리에틸렌글리콜을카르복시기함유고분자에그래프트시킨화합물이다. 카르복시기함유다당류를사용하는경우, 트리아진계축합제공존하에서의, 아미노화 PEG와카르복시기함유다당류의축합반응을이용하여제조할수 있다. 또한, 산공존하에서 PEG와카르복시기함유다당류의축합반응을이용하여, PEG 카르복시기함유다당류그래프트를제조할수 있다.
摘要翻译： DDS。其特征在于药物保留在含有PEG羧基的聚合物接枝物中。在这些聚合物中，可以合适地使用含羧基的多糖。含PEG羧基的聚合物接枝物是通过将聚乙二醇接枝到含羧基聚合物上而获得的化合物。当使用含羧基的多糖时，其可以通过在三嗪基缩合提供区下使用胺化PEG和含羧基的多糖的缩合反应来制备。此外，含PEG羧基的多糖接枝物可以通过在酸的存在下使用PEG与含羧基的多糖的缩合反应来制备。

2. 发明专利

AU2021280068A1 High-performance micro-needle array 未知
公开(公告)号：AU2021280068A1
公开(公告)日：2022-12-15
申请号：AU2021280068
申请日：2021-05-24
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , LI YING-ZHE , KAJIYAMA KENJI , SAITO MIO , YAMASHITA HIROFUMI , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： Provided is a micro-needle array of which all the fine needles can be more easily inserted into the skin regardless of the positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array comprises a substrate and a plurality of micro-needles disposed on one surface of the substrate, wherein the tip sections of the plurality of the micro-needles have height differences, and the needle lengths are 80-2,000 μm inclusive. It is desirable that the height differences of the plurality of micro-needles be based on the protrusions and recesses of the substrate.

3. 发明专利

CA3067660C DENTAL LOCAL ANESTHETIC MICRONEEDLE ARRAY 未知
公开(公告)号：CA3067660C
公开(公告)日：2022-11-15
申请号：CA3067660
申请日：2018-11-01
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： The invention provides a microneedle array easily applied to an oral cavity and may exert an anesthetic effect according to an application site. Provided are an immediate-acting dental local anesthetic preparation including a microneedle array containing a local anesthetic, in which a needle part dissolves in a mucous membrane when being applied, the microneedle array containing the local anesthetic, in which a height of a microneedle is 50 m or more and 300 m or less, a tip of the microneedle is a circle having a diameter of 1 m or more and 50 m or less or a flat surface having the same area, and a thickness of a substrate of the microneedle array is 5 m or more and 100 m or less, and a microneedle patch including the microneedle array and a support provided on a back surface of the microneedle array.

4. 发明专利

AU2021249948A1 Fast-dissolving microneedle 未知
公开(公告)号：AU2021249948A1
公开(公告)日：2021-12-09
申请号：AU2021249948
申请日：2021-04-02
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： TANAKA HIROSHI , KAMIYAMA FUMIO , QUAN YING-SHU
IPC分类号： A61M37/00
摘要： The purpose of the present invention is quick dermal injection of a dermatologically valuable substance by a microneedle array. This microneedle array is characterized by having a low-molecular-weight, water-soluble polymer component and a dermatologically valuable substance as essential constituents. Preferably, the low-molecular-weight, water-soluble polymer component has a molecular weight of at most 100,000 and at least 2000, or, the viscosity (20°C) of a 5 mass% aqueous solution of the low-molecular-weight component is less than or equal to 6 dPa•S.

5. 发明专利

MY186380A MICRONEEDLE AND METHOD FOR PRODUCING SAME 未知
公开(公告)号：MY186380A
公开(公告)日：2021-07-21
申请号：MYPI2017703471
申请日：2015-12-10
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： YING-SHU QUAN , YING-ZHE LI , MIO SAITO , SHOUTA KITAOKA , FUMIO KAMIYAMA
IPC分类号： A61M37/00
摘要： Provided are a microneedle with excellent performance and a method for manufacturing the microneedle. A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99 % or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230 - 280 ?C, a metal mold temperature of 60 - 130 ?C, and an injection pressure of 1000 - 1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21 % or more and an axial contraction rate of tips is 99 % or more. (Figure 1)

6. 发明专利

CA3143920A1 MICRONEEDLE ARRAY HAVING UNEVEN NEEDLE DENSITY 未知
公开(公告)号：CA3143920A1
公开(公告)日：2020-12-30
申请号：CA3143920
申请日：2020-06-24
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , LI YING-ZHE , YAMASHITA HIROFUMI , KAJIYAMA KENJI , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： The present invention solves the problem in which microneedles positioned at the central section of the microneedle array are not easily inserted into the skin. This microneedle array is characterized by comprising a substrate and a plurality of microneedles disposed vertically and horizontally on one surface of the substrate, wherein the inter-needle gaps and the needle density of the microneedles are different in the peripheral section and the central section of the substrate. The needle density of the microneedles is preferably sparse in the central section compared to that in the peripheral section of the substrate, and the inter-needle gaps of the microneedles are preferably greater in the central section than those in the peripheral section of the substrate.

7. 发明专利

CA3067660A1 DENTAL LOCAL ANESTHETIC MICRONEEDLE ARRAY 未知
公开(公告)号：CA3067660A1
公开(公告)日：2019-05-09
申请号：CA3067660
申请日：2018-11-01
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： Provided is a microneedle array that is easily applied to the oral cavity and can exhibit an anesthetic effect suited to the application site. Provided are: a fast-acting dental local anesthetic preparation which comprises a microneedle array containing a local anesthetic and has needle parts that dissolve within the mucosa when adhered to the oral mucosa or the gingiva; a microneedle array; and a microneedle patch comprising the microneedle array and a support body provided on the back face of the microneedle array. The microneedle array has microneedles, each having a height of 50 to 300 µm and a tip that is a circle with a diameter of 1 to 50 µm or a plane with the same area as the circle, and a backing with a thickness of 5 to 100 µm.

8. 发明专利

CA3050418A1 MICRONEEDLE PATCH APPLYING DEVICE 未知
公开(公告)号：CA3050418A1
公开(公告)日：2018-08-02
申请号：CA3050418
申请日：2018-01-25
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： Provided is a microneedle patch applicator with which a microneedle patch can be easily fitted, and with which there is no risk of skin infection even if administered consecutively to multiple users. This microneedle patch applying device is provided with: a movable cylinder one end of which has an opening portion provided with a catch or a screw for fitting a microneedle patch case; a case body linked to the other end of the movable cylinder; a piston disposed movably in the direction of the opening portion of the movable cylinder, inside the case body; a slide which causes the piston to slide in the opposite direction to the direction of the opening portion; a slide lock which locks the sliding of the slide in said opposite direction; a spring which applies an impact to the piston by means of the sliding in said opposite direction and the locking thereof; a safety shaft which prevents release of the slide lock; and a trigger which is interlocked with the safety shaft. The distal end microneedle patch case is pressed against the skin, but is replaced for each application.

9. 发明专利

AU2016364800A1 Microneedle patch storing tool, bottom pallet, and top pallet 未知
公开(公告)号：AU2016364800A1
公开(公告)日：2018-06-21
申请号：AU2016364800
申请日：2016-10-06
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , LI YING-ZHE , KAMIYAMA FUMIO
IPC分类号： A61M37/00 , B65D85/00
摘要： The purpose of the invention is to suppress operation costs for cleaning microneedles and applying drugs to same. One aspect of this microneedle patch storing tool is a microneedle patch storing tool for storing microneedle patches, wherein the microneedle patch storing tool comprises a plurality of pallets stacked in the vertical direction. Two pallets adjacent in the vertical direction constitute one or more patch holding units that hold the microneedle patches. The patch holding unit comprises, so as to clamp the rim portion of the microneedle patches in the vertical direction: a plurality of bottom projections that are disposed separated from each other along the circumferential direction so as to hold the rim portion of the microneedle patches from the bottom; and a plurality of top projections that are disposed separated from each other along the circumferential direction so as to press the rim portion of the microneedle patch from the top. The patch holding unit is open in at least one of the upper and lower directions.

10. 发明专利

AU2016293784A1 Drug sustained-release carrier and method for producing same 未知
公开(公告)号：AU2016293784A1
公开(公告)日：2018-01-25
申请号：AU2016293784
申请日：2016-07-13
申请人： COSMED PHARMACEUTICAL CO LTD , UNIV KOBE NAT UNIV CORP
发明人： QUAN YING-SHU , OOYA TOORU , JIANG RONGRONG , KAMIYAMA FUMIO
IPC分类号： A61K47/36 , A61K8/86 , A61K38/22 , A61K38/28 , A61P3/10 , A61Q19/00
摘要： A DDS carrier that allows the sustained release of a drug, and a method for producing the same. The present invention is characterized in that a drug is held in a PEG-carboxy-group-containing polymer graft. A carboxy-group-containing polysaccharide can be used suitably among the polymers. The PEG-carboxy-group-containing polymer graft is a compound in which polyethylene glycol is grafted to a carboxy-group-containing polymer. When a carboxy-group-containing polysaccharide is used, a polymer graft can be produced by utilizing a condensation reaction between aminated PEG and a carboxy-group-containing polysaccharide in the presence of a triazine condensing agent. A PEG-carboxy-group-containing polysaccharide graft can also be produced by utilizing a condensation reaction between PEG and a carboxy-group-containing polysaccharide in the presence of an acid.

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