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1. 发明申请

WO0158904A9 APOPTOSIS-INDUCING COMPOUNDS 审中-公开
标题翻译：杀虫剂诱导化合物
公开(公告)号：WO0158904A9
公开(公告)日：2002-02-21
申请号：PCT/IE0100020
申请日：2001-02-09
申请人： TRINITY COLLEGE DUBLIN , UNI DI SIENA , WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61P35/00 , C07D498/04 , C07D498/14 , C07D513/04 , A61K31/554
CPC分类号： C07D513/04
摘要： The invention relates to a pharmaceutical composition comprising an apoptosis-inducing amount of a compound having general formula (I), wherein: (i) R1 represents an unsubstituted C6 or C10 aryl group; or a C6 aryl group substituted with Me or OMe; (ii) A represents O, S or S partially oxidized to sulfoxide; (iii) the cyclic group labelled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused system substituted with ethoxycarbonyl function; (iv) and Y represents the group (A) wherein R2 and R3 are independently hydrogen; or methyl; or Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom). The compositions may be used for the treatment of tumours or other cancerous conditions, such as CML (chronic myeloid leukaemia), AML, in AIDS-related lymphomas (such as Karpowski's sarcoma, a sub-cutaneous lymphoma) and used as apoptotic agents in the treatment of cancers generally.
摘要翻译：本发明涉及包含细胞凋亡诱导剂量的具有通式（I）的化合物的药物组合物，其中：（i）R 1表示未取代的C 6或C 10芳基; 或被Me或OMe取代的C6芳基; （ii）A表示O，S或S部分氧化成亚砜; （iii）标记为F的环状基团表示未取代的C6或C10芳基稠合基团或C5杂芳基稠合基团（氮作为杂原子）或被乙氧基羰基官能团取代的苯并稠合体系; （ⅳ），Y表示其中R2和R3独立地为氢的基团（A）; 或甲基; 或Y表示基团CH 3或（CH 2）2 CH 3基团; 或未取代的C5杂芳基（氮作为杂原子）。组合物可用于治疗肿瘤或其它癌症病症，例如艾滋病相关淋巴瘤（如卡尔波夫斯基氏肉瘤，亚皮肤淋巴瘤）中的CML（慢性骨髓性白血病），AML，并用作细胞凋亡剂一般治疗癌症。

2. 发明申请

WO9956736A2 APOPTOSIS-INDUCING COMPOUNDS 审中-公开
标题翻译：细胞凋亡诱导化合物
公开(公告)号：WO9956736A2
公开(公告)日：1999-11-11
申请号：PCT/IE9900030
申请日：1999-05-06
申请人： TRINITY COLLEGE DUBLIN , UNI DI SIENA , WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61K31/472 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/675 , A61K31/00
CPC分类号： A61K31/675 , A61K31/472 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554
摘要： The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.
摘要翻译：本发明涉及具有诱导细胞凋亡能力的吡咯并苯并氧杂吖庚因，吡咯并苯并噻唑类和相关化合物，涉及包含这些化合物的药物组合物以及它们作为抗肿瘤剂的用途。

3. 发明申请

WO2007104696A1 ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 审中-公开
标题翻译：具有多结构结构的抗菌剂
公开(公告)号：WO2007104696A1
公开(公告)日：2007-09-20
申请号：PCT/EP2007/052176
申请日：2007-03-08
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CAMPIANI, Giuseppe , GEMMA, Sandra , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra Prasad , TAGLIALATELA SCAFATI, Orazio , SAVINI, Luisa , DE ANGELIS, Meri , FATTORUSSO, Ernesto
发明人： CAMPIANI, Giuseppe , GEMMA, Sandra , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra Prasad , TAGLIALATELA SCAFATI, Orazio , SAVINI, Luisa , DE ANGELIS, Meri , FATTORUSSO, Ernesto
IPC分类号： C07D295/08 , C07D233/54 , A61K31/4725 , A61K31/435 , A61K31/41 , A61P33/06 , C07D249/08 , C07C211/27 , C07D235/06 , C07D401/06 , C07D409/06 , C07D407/06 , C07D417/06
CPC分类号： C07D295/08 , C07D233/54 , C07D235/06 , C07D249/08 , C07D295/096 , C07D401/06 , C07D405/06 , C07D417/06
摘要： Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum (Pf ). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.
摘要翻译：本文描述了具有式（I）的新型药效团的抗疟剂。这些多环化合物能够抑制恶性疟原虫（Pf）的氯喹敏感和氯喹抗性菌株。此外，这些化合物的合成涉及从低成本生产的商品的步骤。

4. 发明申请

WO2007104695A1 QUINOLIN-4-YLHYDRAZINE DERIVATIVES AS ANTIMALARIAL AGENT 审中-公开
标题翻译：喹诺酮-4-甲基衍生物作为抗真菌剂
公开(公告)号：WO2007104695A1
公开(公告)日：2007-09-20
申请号：PCT/EP2007/052174
申请日：2007-03-08
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , GEMMA, Sandra , CAMPIANI, Giuseppe , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra Prasad , FATTORUSSO, Ernesto , DE ANGELIS, Meri
发明人： CAMPIANI, Giuseppe , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra Prasad , FATTORUSSO, Ernesto , DE ANGELIS, Meri
IPC分类号： C07D401/12 , C07D413/12 , C07D405/12 , C07D215/42 , C07D219/08 , A61K31/4709 , A61P33/06
CPC分类号： C07D401/12 , C07D215/42 , C07D219/08 , C07D405/12 , C07D413/12
摘要： Novel quinolyl and acridinylhydrazone compounds of formula (I), which present remarkable biological activity especially against the choloroquine-resistant Plasmodium falciparum strains, useful for the treatment and prevention of malaria infection are described herein.
摘要翻译：本文描述了可用于治疗和预防疟疾感染的新颖的具有显着的生物学活性的式（I）的喹啉基和吖啶基腙化合物，特别是抗氯喹抗性恶性疟原虫菌株。

5. 发明授权

EP1932852B1 Novel taxane related peptides and uses thereof 有权
标题翻译：相关新的紫杉烷肽及其使用
公开(公告)号：EP1932852B1
公开(公告)日：2010-02-24
申请号：EP06026026.2
申请日：2006-12-15
申请人： Campiani, Giuseppe , Fattorusso, Caterina , Universita Cattolica Del Sacro Cuore
发明人： Scambia, Giovanni , Ferlini, Cristiano , Campiani, Giuseppe , Fattorusso, Caterina
IPC分类号： C07K7/02 , C07K7/06 , C07K14/47 , C07K14/705 , A61K38/08 , A61K38/17
CPC分类号： C07K14/4747 , C07K7/02 , C07K7/06 , C07K14/70567

6. 发明申请

WO2008101891A1 NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 审中-公开
标题翻译：新型4-氨基喹啉衍生物作为抗疟药物有用
公开(公告)号：WO2008101891A1
公开(公告)日：2008-08-28
申请号：PCT/EP2008/051923
申请日：2008-02-18
申请人： CAMPIANI, Giuseppe , GEMMA, Sandra , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra, Prasad , BUTINI, Stefania , PERSICO, Marco , COCCONE, Salvator, Sanna , BERNETTI, Matteo
发明人： CAMPIANI, Giuseppe , GEMMA, Sandra , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra, Prasad , BUTINI, Stefania , PERSICO, Marco , COCCONE, Salvator, Sanna , BERNETTI, Matteo
IPC分类号： C07D215/42
CPC分类号： C07D215/42
摘要： The present invention relates to clotrimazole/quinoline hybrids useful as active ingredients of anti-malaria drugs. The compounds show a remarkable in vitro biological activity especially against the chloroquine-resistant Plasmodium falciparum strains and in vivoactivity against P.berghei.
摘要翻译：本发明涉及可用作抗疟药物的活性成分的克霉唑/喹啉杂合物。这些化合物显示出显着的体外生物学活性，特别是针对氯喹抗性恶性疟原虫菌株和体内对P.berghei的活性。

7. 发明申请

WO2010105930A1 CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：特别用于治疗神经疾病的碳酸盐衍生物
公开(公告)号：WO2010105930A1
公开(公告)日：2010-09-23
申请号：PCT/EP2010/052884
申请日：2010-03-08
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CABRI, Walter , MINETTI, Patrizia , CAMPIANI, Giuseppe , BUTINI, Stefania
发明人： CABRI, Walter , MINETTI, Patrizia , CAMPIANI, Giuseppe , BUTINI, Stefania
IPC分类号： C07D207/34 , C07D307/56 , C07D333/26 , A61K31/341 , A61K31/40 , A61K31/095 , A61P25/22
CPC分类号： C07D207/34 , C07D307/56 , C07D333/26
摘要： The present invention relates to new carbamate derivatives of formula I, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of neurological disorders, such as neuropathic pain and anxiety.
摘要翻译：本发明涉及式I的新型氨基甲酸酯衍生物，其制备方法，以及含有它们用于治疗神经性疾病如神经性疼痛和焦虑症的药物组合物。

8. 发明申请

WO2008043839A1 ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS 审中-公开
标题翻译：用于治疗神经阻滞性疾病的ARYL PIPERAZINE衍生物
公开(公告)号：WO2008043839A1
公开(公告)日：2008-04-17
申请号：PCT/EP2007/060888
申请日：2007-10-12
申请人： Università degli Studi di Siena , CAMPIANI, Giuseppe , BUTINI, Stefania , FATTORUSSO, Caterina , FRANCESCHINI, Silvia , THALE, Zia, Irene , NIELSEN, Karin, Sandager , SCHEEL-KRÜGER, Jørgen , MADSEN, Lars, Siim
发明人： CAMPIANI, Giuseppe , BUTINI, Stefania , FATTORUSSO, Caterina , FRANCESCHINI, Silvia , THALE, Zia, Irene , NIELSEN, Karin, Sandager , SCHEEL-KRÜGER, Jørgen , MADSEN, Lars, Siim
IPC分类号： C07D215/48 , A61K31/4709 , A61P25/18
CPC分类号： C07D215/48
摘要： This invention provides novel aryl piperazine derivatives represented by Formula (I) having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D 3 , 5HT 1A and 5-HT 2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
摘要翻译：本发明提供了具有医疗效用的由式（I）表示的新型芳基哌嗪衍生物，特别是作为多巴胺和5-羟色胺受体的调节剂，优选D 3，5HT 1A和5 受体亚型，特别可用于治疗神经精神障碍，包括。精神分裂症。

9. 发明申请

WO2008031888A2 COMPOUNDS ACTIVE ON GLUTAMATERGIC RECEPTORS 审中-公开
标题翻译：在谷氨酰胺受体上活化的化合物
公开(公告)号：WO2008031888A2
公开(公告)日：2008-03-20
申请号：PCT/EP2007/059721
申请日：2007-09-14
申请人： CAMPIANI, Giuseppe , BUTINI, Stefania , FATTORUSSO, Caterina , GEMMA, Sandra , SANNA COCCONE, Salvatore , BORRIELLO, Marianna
发明人： CAMPIANI, Giuseppe , BUTINI, Stefania , FATTORUSSO, Caterina , GEMMA, Sandra , SANNA COCCONE, Salvatore , BORRIELLO, Marianna
IPC分类号： C07D239/70 , C07D495/04 , A61K31/517 , A61K31/519 , A61P25/28 , A61P25/04 , A61P25/18
CPC分类号： C07D239/70 , C07D495/04
摘要： The present invention relates to a compound of Formula (I) process for its preparation and uses thereof.
摘要翻译：本发明涉及式（I）化合物及其制备方法。

10. 发明授权

EP2121616B1 NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 有权
标题翻译：小说作为抗疟疾物质匹配的4氨基喹啉
公开(公告)号：EP2121616B1
公开(公告)日：2010-09-15
申请号：EP08709064.3
申请日：2008-02-18
申请人： Campiani, Giuseppe
发明人： GEMMA, Sandra , FATTORUSSO, Caterina , KUKREJA, Gagan , JOSHI, Bhupendra, Prasad , BUTINI, Stefania , PERSICO, Marco , COCCONE, Salvator, Sanna , BERNETTI, Matteo
IPC分类号： C07D215/42
CPC分类号： C07D215/42

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