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1. 发明申请

WO1995023845A1 MICRO-ORGANISM CULTURE METHOD 审中-公开
标题翻译：程序进行繁殖的微生物
公开(公告)号：WO1995023845A1
公开(公告)日：1995-09-08
申请号：PCT/EP1995000752
申请日：1995-03-01
申请人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH , BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas
发明人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH
IPC分类号： C12N01/36
CPC分类号： C12N1/26 , C02F3/34 , C12N1/36 , Y10S435/813 , Y10S435/819 , Y10S435/821 , Y10S435/822
摘要： The invention concerns an accelerated micro-organism culture method for decomposing harmful substances. For this purpose, according to the invention the cultivation, mutagenic treatment and stabilisation of the micro-organisms are carried out simultaneously in a mutation fermenter containing a nutrient-rich basic medium (basic medium 1); selection is carried out in a selection fermenter containing a basic medium which is low in nutrients and is enriched with the harmful substance (basic medium 2); small amounts of biomass released from the nutrient-rich basic medium (basic medium 1) of the mutation fermenter are continuously removed from the mutation fermenter and transferred to the selection fermenter; small amounts of biomass released from the basic medium which is low in nutrients (basic medium 2) of the selection fermenter are removed from the selection fermenter and transferred to the mutation fermenter; the entire process is carried out continuously in alternating selection and mutation phases, in the manner of a repeated cycle, and the mutation fermenter and the selection fermenter are associated with computerized control circuits by means of which the fermentation parameters can be adjusted independently of one another in both fermenters.
摘要翻译：本发明涉及一种用于微生物分解毒素的加速培养的方法。为了这个目的，本发明提出栽培，诱变处理和微生物的稳定化同时在含有营养丰富的基础培养基中的突变发酵罐（基础培养基1）进行的，并且该选择在选择发酵罐进行，所述营养贫乏之一，污染物包含富集基础培养基（基础培养基2），并且所述突变发酵罐在从营养丰富的基础培养基不含突变发酵罐的少量生物量（基础培养基1）连续地取出并转移到选择发酵罐中，并且连续地从选择发酵罐以少量的生物质的去除，选择发酵罐的低营养基础培养基（基础培养基2）的释放并转移到发酵罐突变该abläu整个过程重复循环的方式连续地在交替选择和突变相英尺，其中所述突变发酵罐一方面和选择发酵罐被分配给其它计算机控制调整电路，通过该发酵参数是两个发酵罐独立地调节的。

2. 发明申请

WO1995011427A1 METHOD AND DEVICE FOR THE DETERMINATION, IN PARTICULAR THE NON-INVASIVE DETERMINATION, OF AT LEAST ONE FLUID/PIPE SYSTEM PARAMETER OF INTEREST 审中-公开
标题翻译：方法和装置包括流体管道系统至少一个兴趣参数的非侵入性测定
公开(公告)号：WO1995011427A1
公开(公告)日：1995-04-27
申请号：PCT/EP1994003384
申请日：1994-10-13
申请人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH , WOLFF, Elmar, K. , ROSENTHAL, Werner
发明人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH
IPC分类号： G01F01/68
CPC分类号： G01N25/18 , G01F1/6847 , G01F1/6965
摘要： The method and device proposed uses a pipe (12) through which the fluid flows. Mounted along the outside of the pipe (12) is a series of temperature sensors (20 to 38) by means of which the temperature of the pipe (12) is determined at several points. Located in the middle of the pipe (12) is a heater (18) which heats the pipe (12) locally. The temperature profile thus established is scanned by the individual temperature sensors (20 to 38). This temperature profile is typical of each value of the fluid/pipe system parameter of interest, so that the measured values can be used to determine the parameter of interest, which may for instance be the mass flow rate.
摘要翻译：在管的方法和设备（12）被使用，其通过由被测定流体流动。在管（12）的轴向延伸部的外侧依次设置有多个与该管（12）的温度可以在多个测量点来确定温度传感器（20-38）的。在该管的中间部分（12）是加热元件（18），其可局部地通过配管（12）被加热。将所得的温度分布，然后由单个温度传感器（20-38）采样。这个温度分布是对的流体管道系统的感兴趣的参数的每一个值的特性，以使测量值与感兴趣的参数，的基础上，如质量流率可被关闭。

3. 发明申请

WO1997031682A1 PROCESS FOR MICROBIAL DECOMPOSITION OF HARMFUL SUBSTANCES IN MEDIA CHARGED WITH HARMFUL SUBSTANCES, AND MICRO-ORGANISMS SUITABLE FOR THIS PURPOSE 审中-公开
标题翻译：法解SCHADSTOFFBEFRACHTETEN媒体污染物的微生物降解和合适的微生物中
公开(公告)号：WO1997031682A1
公开(公告)日：1997-09-04
申请号：PCT/EP1997001017
申请日：1997-02-28
申请人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH , BARTHOLMES, Peter , HEESCHE-WAGNER, Kerstin , KAUFMANN, Michael , SCHWARZ, Thomas
发明人： BITOP GESELLSCHAFT FÜR BIOTECHNISCHE OPTIMIERUNG MBH
IPC分类号： A62D03/00
CPC分类号： C02F3/34 , B01D53/84 , B09C1/10 , Y02A50/2358
摘要： The invention relates to a process for microbial decomposition of harmful substances in media charged with harmful substances during cleaning of air, sewage and soil. It also relates to a device for performing said process, micro-organisms suitable for performing said process and the use thereof. The object of the invention is to improve said process in such a manner that micro-organism cultures used to break down harmful substances are established on a long-term basis, and at the same time to achieve high rates of decomposition. To attain said object, the invention proposes a process in which there is continuous decomposition fermentation in a decomposition fermenter using micro-organisms, available in the medium charged with harmful substances, and/ or a micro-organism culture added to the medium. During decomposition fermentation the concentration of harmful substances in the decomposition fermenter is controlled to make it toxin-static or toxin-dynamic using a control circuit, as a function of the vitality of the biomass. To decompose formaldehyde, the invention proposes the use of particular micro-organisms which decompose formaldehyde. To decompose phenols, the invention proposes the use of particular micro-organisms which decompose phenol.
摘要翻译：本发明涉及一种用于在媒体schadstoffbefrachteten在空气中，废水或污垢清洁污染物的微生物降解，用于执行该方法和用于执行该方法合适的微生物和它们的用途的设备的过程。本发明的目的是改进这种方法，使得长期建立用于污染物分解微生物的培养物得以实现，同时实现了高的降解速率。为了实现这一目的，本发明提出了在连续采矿机进行发酵使用现有的在schadstoffbefrachteten介质的微生物的方法和/或添加到微生物的降解发酵罐培养基中培养，其中所述降解的发酵过程中，污染物在降解发酵罐的帮助下浓度控制回路是toxinostatisch或toxinodynamisch响应于生物质的生命力控制。用于分解甲醛，本发明提出了使用某些甲醛降解微生物。对于酚的降解，本发明提出了使用某些，苯酚降解微生物的。

4. 发明授权

EP1311238B1 VERWENDUNG VON DI-ZUCKERALKOHOLPHOSPHATEN ZUM SCHUTZ MENSCHLICHER HAUTZELLEN VOR UV- UND/ODER IR-STRAHLUNG 有权
标题翻译： DI-糖醇磷酸盐对人类皮肤细胞之前，UV和/或IR辐射保护利用
公开(公告)号：EP1311238B1
公开(公告)日：2009-10-21
申请号：EP01976087.5
申请日：2001-08-16
申请人： Bitop Gesellschaft für Biotechnische Optimierung mbH
发明人： SCHWARZ, Thomas
IPC分类号： A61K8/14 , A61K8/55 , A61K31/683 , A61Q5/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K8/14 , A61K8/55 , A61K31/683 , A61K2800/522 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/004 , A61Q19/10
摘要： The invention relates to the incorporation of di-sugar alcohol phosphates of C3 to C6 sugar alcohols and/or derivatives of said compounds, e.g. acids, salts, or esters, into cosmetic or dermatological formulations for protecting the skin against environmental influences. The inventive low-molecular compounds of this type take part in the active cell protection of the cells' own free-radical scavengers, antioxidants, DNA, cell membranes and other cell compartments, protecting them against harmful environmental influences, e.g. UV radiation, IR radiation and environmental stress (thermal, chemical and physical). The compatible solution can act as a co-solvent and intensify the penetration of other active ingredients added to the cosmetic formulation, not only to stabilise said ingredients in the formulation, but also to actively transport them into deeper dermal layers.

5. 发明授权

EP0677044B1 VERFAHREN ZUR IN VIVO GEWINNUNG VON INHALTSSTOFFEN AUS ZELLEN 失效
标题翻译：方法的体内恢复细胞的成分
公开(公告)号：EP0677044B1
公开(公告)日：1998-10-28
申请号：EP94903874.9
申请日：1993-12-24
申请人： bitop Gesellschaft für biotechnische Optimierung mbH
发明人： Galinski, Erwin, A. , Truper, Hans, G. , Sauer, Thomas
IPC分类号： C12P1/00 , C12N9/96 , A61K31/505 , A61K31/14 , C07C257/10 , C07D239/06 , C12N1/04 , A61K7/00
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0205 , A61K8/4953 , A61Q19/00 , C07D239/04 , C07D239/06 , C12N1/04 , C12N9/96 , C12P1/00 , C12P17/12

6. 发明公开

EP1125583A1 Verwendung von kompatiblen Soluten als Inhibitoren des enzymatischen Abbaus von makromolekularen Biopolymeren 审中-公开
标题翻译：相容性溶质用作大分子生物聚合物的降解酶的抑制剂
公开(公告)号：EP1125583A1
公开(公告)日：2001-08-22
申请号：EP00102972.7
申请日：2000-02-14
申请人： Bitop Gesellschaft für biotechnische Optimierung MbH
发明人： Galinski, Erwin, Prof. Dr. , Kaufmann, Michael, Dr. , Schwarz, Thomas, Dr. , Vangala, Maya-Devi, Dr.
IPC分类号： A61K31/40 , A61K31/54 , A61K31/205 , A61K31/195 , A61K39/395
CPC分类号： A61K31/7004 , A61K31/131 , A61K31/198 , A61K31/205 , A61K31/401 , A61K31/505 , A61K31/665 , A61K31/683 , A61K31/70 , A61K39/39591
摘要： Verwendung von kompatiblen Soluten zum Schutz von Biopolymeren vor Abbau mit degradierenden Enzymen
摘要翻译：本发明涉及使用相容性溶质的用于防止通过降解酶引起的生物聚合物分解。

7. 发明授权

EP0748373B1 VERFAHREN FÜR DIE ZÜCHTUNG VON MIKROORGANISMEN 失效
标题翻译：程序进行繁殖的微生物
公开(公告)号：EP0748373B1
公开(公告)日：2000-12-27
申请号：EP95912181.5
申请日：1995-03-01
申请人： Bitop Gesellschaft für biotechnische Optimierung MbH
发明人： BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas
IPC分类号： C12N1/36 , C12N1/26 , C02F3/34
CPC分类号： C12N1/26 , C02F3/34 , C12N1/36 , Y10S435/813 , Y10S435/819 , Y10S435/821 , Y10S435/822
摘要： The invention concerns an accelerated micro-organism culture method for decomposing harmful substances. For this purpose, according to the invention the cultivation, mutagenic treatment and stabilisation of the micro-organisms are carried out simultaneously in a mutation fermenter containing a nutrient-rich basic medium (basic medium 1); selection is carried out in a selection fermenter containing a basic medium which is low in nutrients and is enriched with the harmful substance (basic medium 2); small amounts of biomass released from the nutrient-rich basic medium (basic medium 1) of the mutation fermenter are continuously removed from the mutation fermenter and transferred to the selection fermenter; small amounts of biomass released from the basic medium which is low in nutrients (basic medium 2) of the selection fermenter are removed from the selection fermenter and transferred to the mutation fermenter; the entire process is carried out continuously in alternating selection and mutation phases, in the manner of a repeated cycle, and the mutation fermenter and the selection fermenter are associated with computerized control circuits by means of which the fermentation parameters can be adjusted independently of one another in both fermenters.

8. 发明公开

EP0887418A3 Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen 失效
标题翻译：从细胞中体内回收成分的方法
公开(公告)号：EP0887418A3
公开(公告)日：1999-01-13
申请号：EP98113132.9
申请日：1993-12-24
申请人： bitop Gesellschaft für biotechnische Optimierung mbH
发明人： Galinski, Erwin A., Dr. , Trüper, Hans G., Prof. Dr. , Sauer, Thomas
IPC分类号： C12P1/00 , C12P17/12 , C07D239/06 , C07C257/10 , C12N9/96 , C12N1/04 , A61K31/505 , A61K7/00 , A61K35/14
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0205 , A61K8/4953 , A61Q19/00 , C07D239/04 , C07D239/06 , C12N1/04 , C12N9/96 , C12P1/00 , C12P17/12
摘要： Es wird ein Verfahren beschrieben zur in vivo Gewinnung von Inhaltsstoffen aus Zellen, wobei die betreffenden Zellen von einem ersten Zustand, in dem quasi-stationäre Bedingungen zwischen Zelle und umgebendem Medium existieren, plötzlich in einem zweiten Zustand wechseln, wodurch die Zellen gezwungen werden, durch Abgabe von Zellinhaltsstoffen in die Umgebung zu reagieren, um eine Anpassung der Zelle an die Bedingungen des zweiten Zustandes zu erreichen.
摘要翻译：中，描述了从细胞的物质在体内提取的方法，其中所讨论的细胞，突然从第一状态改变存在于细胞，并且在第二状态下的周围介质，由此将细胞通过强制之间的准稳态条件传递细胞成分以在环境中反应以实现细胞适应第二状态的条件。

9. 发明公开

EP1311238A2 KOSMETISCHE FORMULIERUNG ENTHALTEND MINDESTENS EIN DI-ZUCKERALKOHOLPHOSPHAT VON C3 BIS C6 ZUCKERALKOHOLEN 有权
标题翻译： DI-糖醇磷酸盐对人类皮肤细胞之前，UV和/或IR辐射保护利用
公开(公告)号：EP1311238A2
公开(公告)日：2003-05-21
申请号：EP01976087.5
申请日：2001-08-16
申请人： Bitop Gesellschaft für Biotechnische Optimierung mbH
发明人： SCHWARZ, Thomas
IPC分类号： A61K7/48
CPC分类号： A61K8/14 , A61K8/55 , A61K31/683 , A61K2800/522 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/004 , A61Q19/10
摘要： The invention relates to the incorporation of di-sugar alcohol phosphates of C3 to C6 sugar alcohols and/or derivatives of said compounds, e.g. acids, salts, or esters, into cosmetic or dermatological formulations for protecting the skin against environmental influences. The inventive low-molecular compounds of this type take part in the active cell protection of the cells' own free-radical scavengers, antioxidants, DNA, cell membranes and other cell compartments, protecting them against harmful environmental influences, e.g. UV radiation, IR radiation and environmental stress (thermal, chemical and physical). The compatible solution can act as a co-solvent and intensify the penetration of other active ingredients added to the cosmetic formulation, not only to stabilise said ingredients in the formulation, but also to actively transport them into deeper dermal layers.

10. 发明公开

EP1311237A2 VERWENDUNG VON CYCLISCHEM 2,4 DIPHOSPHOGLYCERAT (cDGP) UND/ODER DERIVATEN IN KOSMETISCHEN UND DERMATOLOGISCHEN FORMULIERUNGEN 审中-公开
标题翻译： CYCLIC 2,4-二磷酸甘油酸（CDGP）和/或其衍生物的化妆品和皮肤病学制剂中使用的
公开(公告)号：EP1311237A2
公开(公告)日：2003-05-21
申请号：EP01976086.7
申请日：2001-08-16
申请人： Bitop Gesellschaft für Biotechnische Optimierung mbH
发明人： SCHWARZ, Thomas
IPC分类号： A61K7/48 , A61K31/66
CPC分类号： A61Q19/00 , A61K8/14 , A61K8/27 , A61K8/375 , A61K8/44 , A61K8/49 , A61K8/4913 , A61K8/55 , A61K8/65 , A61K8/678 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/001 , A61Q19/004 , A61Q19/10
摘要： The invention relates to the inclusion of the low molecular weight substance (compatible solute), cyclic 2,4-diphosphoglycerate (cDGP), from extremophilic micro-organisms and/or derivatives of said compound, for example, an acid, a salt, or an ester, in cosmetic or dermatological formulations for protection of the skin from environmental influences and to increase the regeneration capacity. According to the invention, cyclic 2,4-diphosphoglycerate is implicated in active cell protection of the endogenous cell radical traps, antioxidants, the DNA, cell membranes and further cell compartments, by means of a protective effect of the above, against damaging environmental effects, for example, UV radiation, IR radiation, and environmental stress (thermal, chemical and physical). The compatible solute may serve as co-solvent and penetration improver for other active ingredients added to the cosmetic formulation, in order to not only stabilise the above in the cosmetic formulation, but also for active transport into deeper skin layers.

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