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1. 发明申请

WO1992012263A1 PROCESS FOR MANUFACTURING TAGATOSE 审中-公开
标题翻译：制造标签的方法
公开(公告)号：WO1992012263A1
公开(公告)日：1992-07-23
申请号：PCT/US1991000064
申请日：1991-01-07
申请人： BIOSPHERICS INCORPORATED
发明人： BIOSPHERICS INCORPORATED , BEADLE, James, R. , SAUNDERS, James, Pl. , WAJDA, Thomas, J., Jr.
IPC分类号： C13J01/06
CPC分类号： C13K13/00 , C07H3/02
摘要： A process is disclosed for the synthesis of D-tagatose by isomerizing a mixture containing D-galactose with a metal hydroxide in the presence of a catalyst at a relatively low temperature to form an intermediate metal hydroxide-D-tagatose complex, and then neutralizing the intermediate with acid to yield D-tagatose. The method is also suitable for the synthesis of L-tagatose from L-galactose, and for the recovery of pure tagatose from crude tagatose syrups. Whey, deproteinized whey, or lactose may be used as the raw material for the D-galactose. The lactose in such cases is hydrolyzed to D-galactose and D-glucose before the isomerization step.
摘要翻译：公开了通过在较低温度下在催化剂存在下用金属氢氧化物异构化含有D-半乳糖的混合物以合成D-塔格糖的方法，以形成中间体金属氢氧化物-D-塔格糖配合物，然后中和用酸中间产生D-塔格糖。该方法也适用于从L-半乳糖合成L-塔格糖，并用于从粗塔塔格糖浆中回收纯塔格糖。乳清，脱蛋白乳清或乳糖可用作D-半乳糖的原料。在这种情况下，乳糖在异构化步骤之前被水解成D-半乳糖和D-葡萄糖。

2. 发明授权

US4200524A Bio-surface separation process 失效
标题翻译：生物表面分离过程
公开(公告)号：US4200524A
公开(公告)日：1980-04-29
申请号：US954534
申请日：1978-10-25
申请人： Gilbert V. Levin
发明人： Gilbert V. Levin
IPC分类号： C02F3/08 , C02F1/72 , C02F3/12 , C02C1/04
CPC分类号： C02F3/085 , C02F1/72 , Y02W10/15
摘要： There is disclosed an activated sludge sewage treatment process which comprises mixing influent sewage material with activated sludge and bio-surface particulates to provide a mixed liquor. The mixed liquor is passed to an aeration zone wherein it is contacted with an oxygen-containing gas to reduce the BOD content thereof. The mixed liquor is then passed to a settling zone in which it is settled to separate bio-surface particulates having sludge particles adherent thereto and a clarified supernatant. The clarified supernatant is removed from the settling zone and is discharged as effluent or routed for further treatment. At least a portion of the bio-surface particulates having sludge adherent thereto is subjected to a treatment to separate at least a portion of the adherent sludge particles. The thus treated portion of the bio-surface particulates, which may still have some sludge particles adherent thereto, and separated sludge particles is then passed to a bio-surface particulate sludge separator. In this separator, the sludge present in the mixture which is not adherent to the bio-surface particulates separates from the bio-surface particulates and at least a portion of the sludge is passed out of the system as waste sludge which is essentially free of the biosurface particulates. The bio-surface particulates and remaining sludge are then recycled for mixing with said influent sewage material.
摘要翻译：公开了一种活性污泥污水处理方法，其包括将流入污水与活性污泥和生物表面微粒混合以提供混合液。将混合液体通入通气区域，其中与含氧气体接触以减少其BOD含量。然后将混合的液体通入沉降区，在该沉淀区中沉降，分离出具有粘附剂的污泥颗粒和澄清的上清液的生物表面颗粒。将澄清的上清液从沉降区中取出，并作为流出物排出或排出进行进一步处理。将附着有污泥的生物表面微粒的至少一部分进行处理以分离至少一部分贴附污泥颗粒。然后将如此处理的生物表面颗粒物（其仍然可能具有粘附剂的一些污泥颗粒）和分离的污泥颗粒传递到生物表面颗粒污泥分离器。在该分离器中，存在于混合物中的不附着于生物表面微粒的污泥与生物表面颗粒分离，并且至少一部分污泥作为废物污泥从系统中排出，其基本上不含生物表面微粒。然后将生物表面颗粒和剩余污泥再循环用于与所述流入污水材料混合。

3. 发明授权

EP1173186B1 USE OF TAGATOSE TO ENHANCE KEY BLOOD FACTORS 有权
标题翻译：塔格糖，可改善其重要性的血液因子
公开(公告)号：EP1173186B1
公开(公告)日：2006-06-14
申请号：EP00921648.2
申请日：2000-04-04
申请人： Biospherics Incorporated
发明人： LEVIN, Gilbert
IPC分类号： A61K31/70
CPC分类号： A61K31/7004
摘要： A method for enhancing the blood factors of a mammal comprising administering to a mammal in need of such enhancement an efficacious amount of tagatose.

4. 发明公开

EP0397027A1 A method for killing insects 失效
标题翻译： Methode zurSchädlingsvernichtung。
公开(公告)号：EP0397027A1
公开(公告)日：1990-11-14
申请号：EP90108356.8
申请日：1990-05-03
申请人： Biospherics Incorporated
发明人： Levin, Gilbert V. , Zehner, Lee R.
IPC分类号： A01N43/08 , A01N43/16 , A01N31/00 , A01N31/02
CPC分类号： A01N43/08 , A01N31/02 , A01N43/16 , A01N61/00 , Y10S424/10 , Y10S424/11 , Y10S514/918
摘要： There is disclosed a method for killing pests, especially insects, which comprises exposing the pests to, and permitting said pests to ingest, a substance which is either not transported or which is poorly transported across the digestive tract membranes of the pests.
摘要翻译：公开了一种杀害害虫，特别是昆虫的方法，其中包括将害虫暴露于未经运输的物质或不被运送到有害生物的消化道膜上的物质，并允许所述害虫摄取。

5. 发明公开

EP1173186A1 USE OF TAGATOSE TO ENHANCE KEY BLOOD FACTORS 有权
标题翻译：塔格糖，可改善其重要性的血液因子
公开(公告)号：EP1173186A1
公开(公告)日：2002-01-23
申请号：EP00921648.2
申请日：2000-04-04
申请人： Biospherics Incorporated
发明人： LEVIN, Gilbert
IPC分类号： A61K31/70
CPC分类号： A61K31/7004
摘要： A method for enhancing the blood factors of a mammal comprising administering to a mammal in need of such enhancement an efficacious amount of tagatose.

6. 发明授权

EP0408878B1 Enhanced phosphate removal in an activated sludge wastewater treatment process 有权
标题翻译：改善与活性污泥法的废水处理去除磷酸盐。
公开(公告)号：EP0408878B1
公开(公告)日：1993-11-10
申请号：EP90110439.8
申请日：1990-06-01
申请人： Biospherics Incorporated
发明人： Levin, Gilbert V. , Wright, Ronald R.
IPC分类号： C02F3/12 , C02F3/30 , C02F1/58
CPC分类号： C02F3/1215 , C02F3/308 , Y02W10/15 , Y10S210/906

7. 发明公开

EP0408878A1 Enhanced phosphate removal in an activated sludge wastewater treatment process 有权
标题翻译： Verbesserte Beseitigung von Phosphaten in der Abwasserbehandlung mit Belebtschlammverfahren。
公开(公告)号：EP0408878A1
公开(公告)日：1991-01-23
申请号：EP90110439.8
申请日：1990-06-01
申请人： Biospherics Incorporated
发明人： Levin, Gilbert V. , Wright, Ronald R.
IPC分类号： C02F3/12 , C02F3/30 , C02F1/58
CPC分类号： C02F3/1215 , C02F3/308 , Y02W10/15 , Y10S210/906
摘要： There is disclosed an activated sludge wastewater treatment process which comprises aerating a mixed liquor comprising phosphate-containing influent wastewater and activated sludge in an aeration or high-purity oxygen zone to reduce the BOD/COD content of the wastewater and to cause the microorganisms present to take up phosphate. A phosphate-enriched sludge in which the phosphorus is present primarily in the sludge solids is separated from the mixed liquor to provide a substantially phosphate-free effluent. At least a portion of said phosphate-enriched sludge is passed to a phosphate pre-stripping zone, either in a separate tank or within the phosphate stripper tank itself, where BOD/COD-containing water, or feedwater, containing at least 50 mg/L of BOD, is added to poise the sludge organisms to begin enhanced rapid release of dissolved phosphate by pre-stripping it from the sludge or poising the sludge for rapid, enhanced release of phosphate. Thence, the sludge is passed to a phosphate stripping zone. In the phosphate stripping zone, the sludge settles to form a supernatant liquor in the stripping zone upper section and settled sludge in the stripping zone lower section. The settled sludge is maintained under anaerobic conditions for a time sufficient to complete the release of the desired amount of phosphate from the sludge solids to the liquid phase of said settled sludge. At least a portion of the anaerobic sludge from the phosphate stripping zone is recycled to the aeration or high-purity oxygen zone as activated sludge. The phosphate-rich supernatant from the phosphate stripping zone may be applied directly to land, or treated with a chemical precipitating agent to precipitate the phosphate therefrom and the precipitated phosphate may then be removed through the use of a reactor/clarifier, primary or secondary clarifier or other tankage, thus preparing the phosphate for final disposal directly or as fresh, digested or otherwise treated sludge.
摘要翻译：公开了一种活性污泥废水处理方法，其特征在于，在曝气或高纯度氧气区域中充气含有含磷酸盐的流出废水和活性污泥的混合液，以降低废水的BOD / COD含量，并使微生物存在摄取磷酸盐其中磷主要存在于污泥固体中的磷酸盐富集污泥从混合液体中分离出来，以提供基本上无磷酸盐的流出物。所述富含磷酸盐的污泥的至少一部分通过磷酸盐预汽提区，或者在分离的罐或磷酸盐汽提塔箱内，其中BOD / COD的水或给水含有至少50mg / L的BOD被添加以使污泥生物体逐渐增加，以便通过从污泥中预先去除污泥或使污泥快速，增加磷酸盐释放来开始增强溶解磷酸盐的快速释放。然后，将污泥送至磷酸盐汽提区。在磷酸盐汽提区，污泥沉降，在汽提区上段形成上清液，在汽提区下段沉淀污泥。沉淀的污泥在厌氧条件下保持足以完成将所需量的磷酸盐从污泥固体释放到所述沉淀污泥的液相的时间。来自磷酸盐汽提区的至少一部分厌氧污泥被再循环到曝气或高纯度氧区作为活性污泥。来自磷酸盐汽提区的富含磷酸盐的上清液可以直接施用于陆地，或用化学沉淀剂处理以从其中沉淀磷酸盐，然后可以通过使用反应器/澄清器，初级或次级澄清器或其他油罐，从而制备磷酸盐，以便最终处置直接或作为新鲜，消化或以其他方式处理的污泥。

8. 发明授权

US6015793A Use of tagatose to enhance key blood factors 失效
标题翻译：使用塔格糖提高关键血液因子
公开(公告)号：US6015793A
公开(公告)日：2000-01-18
申请号：US299023
申请日：1999-04-26
申请人： Gilbert V. Levin
发明人： Gilbert V. Levin
IPC分类号： C07H3/02 , A61K31/70 , A61K31/7004 , A61K45/00 , A61P7/04 , A61P7/06
CPC分类号： A61K31/7004
摘要： A method for enhancing the blood factors of a mammal comprising administering to a mammal in need of such enhancement an efficacious amount of tagatose.
摘要翻译：一种用于增强哺乳动物的血液因子的方法，包括对需要这种增强的哺乳动物施用有效量的塔格糖。

9. 发明授权

US5447917A D-tagatose as anti-hyperglycemic agent 失效
标题翻译： D-塔格糖作为抗高血糖药
公开(公告)号：US5447917A
公开(公告)日：1995-09-05
申请号：US190938
申请日：1994-02-03
申请人： Lee R. Zehner , Gilbert V. Levin , James P. Saunders , James R. Beadle
发明人： Lee R. Zehner , Gilbert V. Levin , James P. Saunders , James R. Beadle
IPC分类号： A61K31/70
CPC分类号： A61K31/7004 , Y10S514/866 , Y10S514/884
摘要： This invention discloses edible formulations and pharmaceutical compositions containing D-tagatose and the effect of consumption of such formulations on blood level of glucose. D-Tagatose was found to be an anti-hyperglycemic agent. In addition, consumption of D-tagatose in sweetened formulations to inhibit formation of advanced glycosylation end-products in mammals is disclosed. The combination of the anti-hyperglycemic effect and the inhibition of formation of glycosylated proteins and nucleic acids make D-tagatose an ideal agent for alleviating the complications resulting from hyperglycemia, including acceleration of the aging process.
摘要翻译：本发明公开了含有D-塔格糖的食用制剂和药物组合物以及这种制剂的消耗对血糖水平的影响。 D塔达糖被发现是一种抗高血糖剂。此外，公开了在甜味制剂中消耗D-塔格糖以抑制哺乳动物中晚期糖基化终产物的形成。抗高血糖作用和抑制糖基化蛋白质和核酸形成的组合使D-塔格糖成为缓解由高血糖引起的并发症的理想药剂，包括加速老化过程。

10. 发明授权

US4786722A D-tagatose as a low-calorie carbohydrate sweetener and bulking agent 失效
标题翻译： D-塔格糖作为低热量碳水化合物甜味剂和填充剂
公开(公告)号：US4786722A
公开(公告)日：1988-11-22
申请号：US901611
申请日：1986-08-29
申请人： Lee R. Zehner
发明人： Lee R. Zehner
IPC分类号： A23L1/09 , A23L1/236
CPC分类号： A23L27/33 , A23L27/32 , A23L29/30
摘要： There is disclosed a process for the preparation of a sweetened edible formulation in which the sweetening agent is less calorific than sucrose which comprises the step of mixing a foodstuff with an amount sufficient to sweeten the foodstuff of D-tagatose.

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