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1. 发明申请

WO2014126558A1 ENCLOSED LASER MEDICAL DEVICE/SYSTEM 审中-公开
标题翻译：封装的激光医疗设备/系统
公开(公告)号：WO2014126558A1
公开(公告)日：2014-08-21
申请号：PCT/US2013/025915
申请日：2013-02-13
申请人： BIOLITEC PHARMA MARKETING LTD.
发明人： NEUBERGER, Wolfgang
IPC分类号： A61B18/20 , A61N5/067
CPC分类号： A61B18/22 , A61B2017/00477 , A61B2018/00053 , A61B2018/00172 , A61B2018/0091 , A61B2018/00964 , A61B2090/0813 , A61B2090/0814
摘要： A fiber optic medical device/system is presented, comprising laser source, connectible to optical fibers and enclosed to ensure sterility and safe operation. It is a single use system enclosed and sterilized, including laser source and, optical fiber attached in a sterile tube. Another embodiment is hermetically sealed laser unit with simple connection system to a properly shaped fiber optic. Joined hand piece and fiber can be directly inserted to treat target tissue. Laser handle is aseptically packaged. In other embodiments, fiber is proximally terminated in solid funnel-shaped end to provide unique directional keyed junction with laser unit. In another embodiment, unit includes fiber joined to it, where a laser module can be added away from the fiber end and laser module need not be sterilized, but entire unit is safe for medical use in sterile fields. Enclosure also serves as handpiece for manipulating device. Another preferred embodiment has laser unit attached to a rigid delivery system for laparoscopic procedures.
摘要翻译：提供了一种光纤医疗设备/系统，包括激光源，可连接到光纤并封闭，以确保无菌性和安全操作。它是一种单一使用的系统，封闭消毒，包括激光源和连接在无菌管中的光纤。另一个实施例是具有简单连接系统的密封激光单元与适当形状的光纤。连接的手工片和纤维可以直接插入以治疗目标组织。激光手柄是无菌包装的。在其他实施例中，纤维在近端终止于固体漏斗形端，以提供与激光单元的独特的方向键合连接。在另一个实施例中，单元包括连接到其上的光纤，其中激光模块可以远离光纤端部被加入，并且激光模块不需要被灭菌，而是整个单元对无菌领域的医疗使用是安全的。外壳也用作操纵装置的手机。另一个优选实施例具有附接到用于腹腔镜手术的刚性输送系统的激光单元。

2. 发明申请

WO2014072806A1 DEVICE AND METHOD FOR LASER TREATMENTS 审中-公开
标题翻译：激光治疗装置和方法
公开(公告)号：WO2014072806A1
公开(公告)日：2014-05-15
申请号：PCT/IB2013/002504
申请日：2013-11-11
申请人： BIOLITEC PHARMA MARKETING LTD.
发明人： NEUBERGER, Wolfgang
IPC分类号： A61N5/067
CPC分类号： A61B18/22 , A61B18/203 , A61B2017/00482 , A61B2018/2065 , A61N5/062 , A61N2005/0626 , A61N2005/063 , A61N2005/067
摘要： Improved, efficient devices/methods for medical and cosmetic applications, involving the delivery of laser energy to tissue are provided. In a preferred embodiment a portable, easy-to-use laser system comprises at least one laser source operating at one or more laser wavelengths; an electronic visual display having a n- dimensional input interface to set/select laser parameters; and at least one waveguide optically coupled to the laser source to convey laser radiation to a treatment site. The n-dimensional input interface inputs/selects lasing parameters which allows the selection of a combination of output wavelengths and powers by simply touching the electronic visual display.. Method of use comprises the steps of placing at least one waveguide at preselected treatment site; selecting a combination of laser wavelengths and power by interacting with an electronic visual display; and irradiating the treatment site.
摘要翻译：提供了用于医疗和化妆品应用的改进的，高效的装置/方法，涉及向组织递送激光能量。在优选实施例中，便携式易于使用的激光系统包括以一个或多个激光波长工作的至少一个激光源; 具有用于设置/选择激光参数的n维输入接口的电子视觉显示器; 以及光学耦合到激光源的至少一个波导，以将激光辐射传送到治疗部位。 n维输入接口输入/选择激光参数，其允许通过简单地触摸电子视觉显示来选择输出波长和功率的组合。使用方法包括以下步骤：将至少一个波导放置在预选的治疗部位; 通过与电子视觉显示器交互来选择激光波长和功率的组合; 并照射治疗部位。

3. 发明申请

WO2013160770A3 FIBER LASER SYSTEM FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：用于医疗应用的光纤激光系统
公开(公告)号：WO2013160770A3
公开(公告)日：2014-02-27
申请号：PCT/IB2013001118
申请日：2013-04-26
申请人： BIOLITEC PHARMA MARKETING LTD
发明人： NEUBERGER WOLFGANG
IPC分类号： H01S3/067 , A61B18/20 , A61N5/067
CPC分类号： A61B18/22 , A61B2018/2222 , A61B2018/2244 , A61B2018/2277 , A61B2018/2294 , G02B1/12 , G02B1/14 , G02B6/262 , H01S3/067 , H01S3/06729 , H01S3/06733 , H01S3/06745
摘要： Improved/efficient fiber laser systems are provided for medical/cosmetic applications, comprising at least one pump source, optically coupled with at least one fiber laser. The fiber laser comprises an irregularly-shaped single-, double- or multiple-clad fiber of unconventional structure and geometry, and means for partially/completely reflecting the pump radiation, such as Bragg gratings. The fiber laser system further comprises at least one fiber optic delivery device optically coupled with the pump source, with the irregularly-shaped single-, double- or multiple-clad fiber laser, or with both, to convey laser radiation to a treatment site. The fiber optic delivery device comprises one or more waveguides, preferably optical fibers. The irregularly-shaped fiber laser and waveguides of the fiber optic delivery device have the same or different tip configurations to perform the treatment according to therapeutic needs. In a preferred embodiment, the fiber laser treatment system operating at 915 + 30 nm, 975 ± 30 nm and/or 1550 ± 40, comprises control means to select delivery of one, two or three output laser beams, and regulates their respective output powers.
摘要翻译：为医疗/化妆品应用提供了改进/高效的光纤激光系统，其包括与至少一个光纤激光器光学耦合的至少一个泵浦源。光纤激光器包括非常规结构和几何形状的不规则形状的单层，双层或多层包层光纤，以及用于部分/完全反射泵浦辐射的装置，例如布拉格光栅。光纤激光系统还包括至少一个与泵浦光源耦合的光纤传输装置，其具有不规则形状的单层，双层或多层包层光纤激光器，或与其两者，以将激光辐射传送到处理部位。光纤传送装置包括一个或多个波导，优选光纤。不规则形状的光纤激光器和光纤传送装置的波导具有相同或不同的尖端配置，以根据治疗需要进行治疗。在优选实施例中，在915±30nm，975±30nm和/或1550±40工作的光纤激光器处理系统包括控制装置，用于选择一个，两个或三个输出激光束的传送，并且调节它们各自的输出功率。

4. 发明申请

WO2014076677A1 FIBER OPTIC CONNECTOR FOR LASER SOURCES 审中-公开
标题翻译：用于激光源的光纤连接器
公开(公告)号：WO2014076677A1
公开(公告)日：2014-05-22
申请号：PCT/IB2013/060222
申请日：2013-11-18
申请人： BIOLITEC PHARMA MARKETING LTD.
发明人： NEUBERGER, Wolfgang
IPC分类号： G02B6/36 , A61B5/06 , A61B18/20
CPC分类号： G02B6/4296 , G02B6/3821 , G02B6/3849 , G02B6/3851 , G02B6/387 , G02B6/3887 , G02B6/3895 , G02B6/4231 , G02B6/4292
摘要： Connectors for optically coupling radiation accurately from radiation sources into waveguides in medical applications are provided. A preferred embodiment for coupling laser sources into optical fibers provides a connector comprising an outer body for handling connector; a two-part ferrule; an inner body which protects ferrule and holds its two parts together; a collet chuck through which an optical fiber is introduced; a spring; a ferrule interlock; and bending protection with a long fiber protection end. Main features are that the inner body moves within the outer body longitudinally, the spring-loaded ferrules move against a fixed position element in the laser housing via the spring load, and their relative shapes are designed to be assembled in only one possible angle position,thus maintaining alignment of elements to reduce/avoid lost power absorbed by the connector's proximal end due to coupling. The ferrule is mounted inside the connector and does not emerge from it for protecting the ferrule. In another embodiment the connector provides an electronic signature such as an RFID tag for waveguide recognition in a position close enough to the laser source to ensure identification. Additionally, the connector has an optional electric power and signal port.
摘要翻译：提供了用于将辐射源中的辐射精确地耦合到医疗应用中的波导的连接器。用于将激光源耦合到光纤中的优选实施例提供了一种连接器，其包括用于处理连接器的外部主体; 两部分套圈; 保护套管并将其两部分保持在一起的内部主体; 引入光纤的夹头卡盘; 一个春天套圈互锁; 并具有长纤维保护端的弯曲保护。主要特征是内体在纵向上在外体内移动，弹簧加载的套圈经由弹簧载荷抵靠激光外壳中的固定位置元件移动，并且它们的相对形状被设计成仅在一个可能的角度位置组装，从而保持元件的对准以减少/避免由于联接而由连接器的近端吸收的功率损失。套圈安装在连接器内部，不会从其中脱出，以保护套圈。在另一个实施例中，连接器提供电子签名，例如用于波导识别的RFID标签，其位置足够靠近激光源以确保识别。此外，连接器具有可选的电力和信号端口。

5. 发明申请

WO2013015774A1 GLYCO-SUBSTITUTED DIHYDROXY-CHLORINS AND B-FUNCTIONALIZED CHLORINS FOR ANTI-MICROBIAL PHOTODYNAMIC THERAPY 审中-公开
标题翻译：用于抗微生物光化学治疗的GLYCO取代的二羟基氯和B官能化氯化物
公开(公告)号：WO2013015774A1
公开(公告)日：2013-01-31
申请号：PCT/US2011/045063
申请日：2011-07-22
申请人： BIOLITEC PHARMA MARKETING LTD , CERAMOPTEC GMBH , AICHER, Daniel , ALBRECHT, Volker , GITTER, Burkhard , STARK, Christian, B. W. , WIEHE, Arno
发明人： AICHER, Daniel , ALBRECHT, Volker , GITTER, Burkhard , STARK, Christian, B. W. , WIEHE, Arno
IPC分类号： A61K31/409 , A61K31/19 , A61K31/185 , A61P31/04 , A61P31/00
CPC分类号： A61K31/185 , A61K31/19 , A61K31/409
摘要： Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is connecting dihydroxychlorins or β- functionalized chlorins to carbohydrate moieties. These conjugates are found to be very effective in combating bacterial infections caused by Gram-positive and Gram- negative bacteria, including their resistant strains. Significantly, they are also effective in complex environments, including blood, serum, and other body fluids which are present in patient's body. A method of use to control pathogenic microorganisms in human and animals is also provided.
摘要翻译：提供了用于治疗和预防人和动物中致病微生物引起的感染性疾病的抗微生物分子缀合物。这些缀合物的关键是将二羟基二氢卟酚或ß-官能化的二氢卟酚连接到碳水化合物部分。发现这些缀合物对抗革兰氏阳性和革兰氏阴性细菌（包括其抗性菌株）引起的细菌感染非常有效。值得注意的是，它们在复杂的环境中也是有效的，包括血液，血清和患者体内存在的其他体液。还提供了用于控制人和动物中的病原微生物的方法。

6. 发明申请

WO2013160770A2 FIBER LASER SYSTEM FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：用于医疗应用的光纤激光系统
公开(公告)号：WO2013160770A2
公开(公告)日：2013-10-31
申请号：PCT/IB2013/001118
申请日：2013-04-26
申请人： BIOLITEC PHARMA MARKETING LTD.
发明人： NEUBERGER, Wolfgang
IPC分类号： H01S3/067
CPC分类号： A61B18/22 , A61B2018/2222 , A61B2018/2244 , A61B2018/2277 , A61B2018/2294 , G02B1/12 , G02B1/14 , G02B6/262 , H01S3/067 , H01S3/06729 , H01S3/06733 , H01S3/06745
摘要： Improved/efficient fiber laser systems are provided for medical/cosmetic applications, comprising at least one pump source, optically coupled with at least one fiber laser. The fiber laser comprises an irregularly-shaped single-, double- or multiple-clad fiber of unconventional structure and geometry, and means for partially/completely reflecting the pump radiation, such as Bragg gratings. The fiber laser system further comprises at least one fiber optic delivery device optically coupled with the pump source, with the irregularly-shaped single-, double- or multiple-clad fiber laser, or with both, to convey laser radiation to a treatment site. The fiber optic delivery device comprises one or more waveguides, preferably optical fibers. The irregularly-shaped fiber laser and waveguides of the fiber optic delivery device have the same or different tip configurations to perform the treatment according to therapeutic needs. In a preferred embodiment, the fiber laser treatment system operating at 915 + 30 nm, 975 ± 30 nm and/or 1550 ± 40, comprises control means to select delivery of one, two or three output laser beams, and regulates their respective output powers.
摘要翻译：为医疗/化妆品应用提供了改进/高效的光纤激光系统，其包括与至少一个光纤激光器光学耦合的至少一个泵浦源。光纤激光器包括非常规结构和几何形状的不规则形状的单层，双层或多层包层光纤，以及用于部分/完全反射泵浦辐射的装置，例如布拉格光栅。光纤激光系统还包括至少一个与泵浦光源耦合的光纤传输装置，其具有不规则形状的单层，双层或多层包层光纤激光器，或与其两者，以将激光辐射传送到处理部位。光纤传送装置包括一个或多个波导，优选光纤。不规则形状的光纤激光器和光纤传送装置的波导具有相同或不同的尖端配置，以根据治疗需要进行治疗。在优选实施例中，在915±30nm，975±30nm和/或1550±40工作的光纤激光器处理系统包括控制装置，用于选择一个，两个或三个输出激光束的传送，并且调节它们各自的输出功率。

7. 发明授权

US08985121B2 Method and device for valve repair 有权
标题翻译：阀门维修方法和装置
公开(公告)号：US08985121B2
公开(公告)日：2015-03-24
申请号：US13102830
申请日：2011-05-06
申请人： Enrique Ferracani , Wolfgang Neuberger
发明人： Enrique Ferracani , Wolfgang Neuberger
IPC分类号： A61B19/00 , A61B18/24 , A61B18/00
CPC分类号： A61B18/24 , A61B2018/00029 , A61B2018/00982
摘要： A method and a device for minimally invasive treatment of diseased deep and superficial venous valves are disclosed. Treatment seeks to repair/rejuvenate dysfunctional valve by reducing the circumference of dilated valve rings and by restoring their original shape and function using laser energy to make physical suture points and shrink collagen in selected points. Real time monitoring is by angioscopic view and endovenous echographic control. In a preferred embodiment, system comprises a specific catheter-like device for endovenous insertion that allows for real time view of energy emission and venous surface to be corrected. Catheter flexibility is such that viewing angle and direct energy emission can be oriented properly. Catheter can comprise channels for irrigation or for interchange of laser fibers according to desired irradiation pattern. A preferred embodiment of catheter device also comprises cuffs for temporary occlusion, by inflation and deflation. In preferred embodiments, 1470 nm, 1550 nm or 1900 nm laser energy is applied. This treatment can be applied to venous valves of the deep venous system, as well as valves of the sapheno-femoral junction, terminal valve and pre-terminal valve.
摘要翻译：公开了用于微创治疗患病深部和浅静脉瓣的方法和装置。治疗旨在通过减小扩张瓣环的周长并通过使用激光能量恢复其原始形状和功能来修复/恢复功能失调的瓣膜，以在选定的点产生物理缝合点和收缩胶原蛋白。实时监测是通过血管镜观察和静态回波控制。在优选实施例中，系统包括用于静脉内插入的特定导管状装置，其允许实时观察要校正的能量排出和静脉表面。导管的灵活性使得视角和直接能量发射可以适当地定向。导管可以包括根据所需照射模式进行冲洗或激光纤维交换的通道。导管装置的优选实施例还包括用于暂时闭塞的袖口，通过充气和放气。在优选实施例中，施加1470nm，1550nm或1900nm的激光能量。这种治疗可以应用于深静脉系统的静脉瓣膜，以及隐静脉股关节，终端阀和前端阀的阀门。

8. 发明授权

US08858989B2 Gel-formulations of hydrophobic photosensitizers for mucosal applications 有权
标题翻译：用于粘膜应用的疏水性光敏剂的凝胶制剂
公开(公告)号：US08858989B2
公开(公告)日：2014-10-14
申请号：US12226895
申请日：2007-05-16
申请人： Volker Albrecht , Dietrich Scheglmann
发明人： Volker Albrecht , Dietrich Scheglmann
IPC分类号： A61K9/127 , A61K41/00
CPC分类号： A61K9/1271 , A61K41/0071
摘要： The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption.
摘要翻译：本发明涉及用于粘膜给药的疏水性光敏剂及其前体制剂的改进方法。本发明的制剂包括已经掺入适当大小的脂质体中的疏水性光敏剂。另外，这些制剂包括将PS负载的脂质体掺入共聚物基质中。本发明的脂质体允许将疏水性光敏剂引入热凝胶基质中，从而促进制剂与粘膜层之间的紧密接触，以增强药物吸收。

9. 发明授权

US08758225B2 Adapter for endoscopes and related method 失效
标题翻译：内镜适配器及相关方法
公开(公告)号：US08758225B2
公开(公告)日：2014-06-24
申请号：US12181248
申请日：2008-07-28
申请人： Brian Foley , William LeBlanc
发明人： Brian Foley , William LeBlanc
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B1/00137 , A61B1/00121 , A61B1/00128 , A61B1/00133 , A61B18/24
摘要： An adapter for endoscopic treatments has a fiber constraint device that is set at a desired maximum fiber retraction distance, and provides a physical barrier to prevent excessive fiber retraction into the endoscope. The restricted retraction prevents the fiber from firing within the endoscope, thus avoiding expensive damage to both the endoscope and fiber. This benefits the patient with potentially shorter treatment time and less exposure to anesthesia. The adapter also limits maximum extension of fibers. Limiting maximum extension protects the fiber tip and avoids patient complications. The adapter is securely attached to the optical fiber with a connecting means. When using directionally radiating fiber tips, fiber orientation can be defined and the fiber can be rotated relative to the initial angular position of the fiber tip.
摘要翻译：用于内窥镜治疗的适配器具有设置在期望的最大光纤回缩距离处的纤维约束装置，并且提供物理屏障以防止过多的纤维缩回到内窥镜中。限制回缩防止纤维在内窥镜内点燃，从而避免对内窥镜和纤维的昂贵损坏。这有利于患者治疗时间更短，麻醉时更少。适配器还限制纤维的最大延伸。限制最大延伸保护纤维尖端，避免患者并发症。适配器用连接装置牢固地连接到光纤上。当使用定向辐射光纤尖端时，可以限定纤维取向并且纤维可以相对于纤维尖端的初始角位置旋转。

10. 发明授权

US08709449B2 Methods and compositions for improving photodynamic therapy through administration of lipids 有权
标题翻译：通过施用脂质改善光动力疗法的方法和组合物
公开(公告)号：US08709449B2
公开(公告)日：2014-04-29
申请号：US11055923
申请日：2005-02-10
申请人： Volker Albrecht , Susanna Gräfe
发明人： Volker Albrecht , Susanna Gräfe
IPC分类号： B32B27/30 , C08K5/04 , C08K5/09
CPC分类号： A61K9/0019 , A61K9/107 , A61K31/409 , A61K31/555 , A61K31/685 , A61K41/0071 , A61K47/24 , A61K47/44 , A61K2300/00 , A61K41/00
摘要： The present invention provides methods and compositions for increasing the effectiveness of photodynamic therapy (“PDT”) and for reducing the duration of skin phototoxicity associated with PDT treatment. The disclosed methods generally include the administration of a lipid composition before, during, or after the administration of photosensitizers used in the PDT treatment protocol. The lipids are preferably phospholipids. It was discovered that the disclosed methods resulted in a more rapid clearance of photosensitizers from the skin and other tissue of patients, which results in a shorter period of skin phototoxicity after PDT treatment. The present invention also provides a composition which is preferably comprised of non-polar photosensitizers and phospholipids.
摘要翻译：本发明提供用于增加光动力疗法（“PDT”）的有效性并减少与PDT治疗相关的皮肤光毒性持续时间的方法和组合物。所公开的方法通常包括在给予PDT治疗方案中使用的光敏剂之前，期间或之后施用脂质组合物。脂质优选为磷脂。发现所公开的方法导致光敏剂从皮肤和患者的其他组织更快速地清除，这导致PDT治疗后皮肤光毒性的时间更短。本发明还提供了优选由非极性光敏剂和磷脂组成的组合物。

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