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1. 发明申请

US20110293711A1 Utilization of Dialkylfumarates 有权
标题翻译：二烷基富马酸盐的利用
公开(公告)号：US20110293711A1
公开(公告)日：2011-12-01
申请号：US13040914
申请日：2011-03-04
申请人： Rajendra Kumar JOSHI , Hans-Peter STREBEL
发明人： Rajendra Kumar JOSHI , Hans-Peter STREBEL
IPC分类号： A61K9/28 , A61P37/06 , C07C69/60 , A61K31/225 , A61K9/48
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

2. 发明授权

US07915310B2 Utilization of dialkylfumarates 有权
标题翻译：富马酸二烷基酯的利用
公开(公告)号：US07915310B2
公开(公告)日：2011-03-29
申请号：US12405665
申请日：2009-03-17
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： A61K31/225
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

3. 发明授权

US07790916B2 Carbocyclic and oxacarbocyclic fumaric acid oligomers 有权
标题翻译：碳环和恶唑环富马酸低聚物
公开(公告)号：US07790916B2
公开(公告)日：2010-09-07
申请号：US10511564
申请日：2003-04-03
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： C07C69/74 , C07C69/75 , C07D321/12 , A61K31/215 , A61K31/194 , A61K31/357
CPC分类号： C07D321/12 , C07D323/00
摘要： The present invention relates to certain carbocyclic and oxacarbocyclic fumaric acid oligomers and the use thereof for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds.
摘要翻译：本发明涉及某些碳环和恶唑环富马酸低聚物及其制备药物制剂以及含有这些化合物的药物制剂的用途。

4. 发明申请

US20140066505A1 Utilization of Dialkylfumarates 审中-公开
标题翻译：二烷基富马酸盐的利用
公开(公告)号：US20140066505A1
公开(公告)日：2014-03-06
申请号：US13800128
申请日：2013-03-13
申请人： Biogen Idec International GmbH
发明人： Rajendra Kumar JOSHI , Hans-Peter Strebel
IPC分类号： A61K9/48 , A61K9/28 , A61K31/225
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

5. 发明授权

US08980832B2 Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma 有权
标题翻译：使用富马酸衍生物治疗心功能不全和哮喘
公开(公告)号：US08980832B2
公开(公告)日：2015-03-17
申请号：US12884573
申请日：2010-09-17
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel , Christian Zaugg , Michael Tamm
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel , Christian Zaugg , Michael Tamm
IPC分类号： A61P9/00 , A61K31/231 , A61K31/573
CPC分类号： A61K31/225 , A61K31/197 , A61K31/231 , A61K31/573 , A61K2300/00
摘要： According to a first aspect the invention relates to the use of fumaric acid derivatives selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment or prevention of cardiac insufficiency, in particular left ventricular insufficiency, myocardial infarction and angina pectoris.According to a second aspect the invention relates to the use of fumaric acid derivatives, selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment of asthma and chronic obstructive pulmonary diseases, especially asthma caused by allergies, infections, analgesics, job conditions or physical effort, mixed forms of asthma, or asthma cardiale.
摘要翻译：根据第一方面，本发明涉及富马酸衍生物的用途，所述富马酸衍生物选自富马酸二烷基酯，富马酸单烷基酯，富马酸单烷基酯盐，富马酸单酰胺，单酰氨基富马酸盐，富马酸二酰胺，单烷基单酰氨基富马酸盐这些化合物的碳环和氧杂环低聚物及其混合物，用于制备用于治疗或预防心功能不全，特别是左心室功能不全，心肌梗死和心绞痛的药物。根据第二方面，本发明涉及富马酸衍生物的用途，所述富马酸衍生物选自富马酸二烷基酯，富马酸单烷基酯，富马酸单烷基酯盐，富马酸单酰胺，单酰基富马酸盐，富马酸二酰胺，单烷基单酰胺基这些化合物的富马酸盐，碳环和氧杂环低聚物及其混合物，用于制备用于治疗哮喘和慢性阻塞性肺疾病的药物，特别是由过敏，感染，止痛剂，工作条件或体力，哮喘或哮喘混合形式引起的哮喘心脏病

6. 发明申请

US20130004526A1 Utilization of Dialkylfumarates 有权
标题翻译：二烷基富马酸盐的利用
公开(公告)号：US20130004526A1
公开(公告)日：2013-01-03
申请号：US13612221
申请日：2012-09-12
申请人： Rajendra Kumar JOSHI , Hans-Peter Strebel
发明人： Rajendra Kumar JOSHI , Hans-Peter Strebel
IPC分类号： A61K31/225 , A61P25/00
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also he used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可以与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

7. 发明授权

US07803840B2 Utilization of dialkylfumarates 有权
标题翻译：富马酸二烷基酯的利用
公开(公告)号：US07803840B2
公开(公告)日：2010-09-28
申请号：US12405661
申请日：2009-03-17
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： A61K31/225
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

8. 发明授权

US07619001B2 Utilization of dialkylfumarates 有权
标题翻译：富马酸二烷基酯的利用
公开(公告)号：US07619001B2
公开(公告)日：2009-11-17
申请号：US11765578
申请日：2007-06-20
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： A61K31/225
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

9. 发明授权

US07432240B2 Fumaric acid amides 有权
标题翻译：富马酸酰胺
公开(公告)号：US07432240B2
公开(公告)日：2008-10-07
申请号：US11421083
申请日：2006-05-31
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： A61K38/00 , A61K38/02 , C07K2/00 , C07K1/107
CPC分类号： A61K31/198 , A61K31/194 , A61K31/225
摘要： Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6-10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical —NH—CHR5—COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.
摘要翻译：通式（I）的富马酸酰胺，其中R 1代表OR 3或D或L-氨基酸基-NH-CHR 4，其中R 3是氢，直链或支链的任选取代的C 1-24烷基，苯基或 C 6-10芳烷基和R 4是天然或合成氨基酸的侧链，R 2表示D-或L 通过酰胺键或包含通过酰胺键键合的2至100个氨基酸的肽基键合的氨基酸基-NH-CHR 5 -COOH，其中R 5为天然或合成氨基酸的侧链用于制备用于治疗自身免疫性疾病的药物（1）; （2）用于移植药物; （3）治疗线粒体疾病; 或（4）用于治疗NF-kappaB介导的疾病。

10. 发明授权

US08759393B2 Utilization of dialkylfumarates 有权
标题翻译：富马酸二烷基酯的利用
公开(公告)号：US08759393B2
公开(公告)日：2014-06-24
申请号：US13040914
申请日：2011-03-04
申请人： Rajendra Kumar Joshi , Hans-Peter Strebel
发明人： Rajendra Kumar Joshi , Hans-Peter Strebel
IPC分类号： A61K31/225
CPC分类号： A61K9/4891 , A61K9/1652 , A61K9/1676 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/4808 , A61K31/19 , A61K31/225 , Y10S514/825 , Y10S514/903 , Y10S514/96
摘要： The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
摘要翻译：本发明涉及某些二烷基富马酸盐在制备用于移植医学或用于治疗自身免疫性疾病的药物制剂中的用途，以及微片剂或丸剂形式的所述组合物。为此，富马酸二烷基酯也可与用于移植医学和免疫抑制剂，特别是环孢菌素的常规制剂组合使用。

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