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1. 发明申请

WO2020099683A1 METABOLITES FOR USE IN OVARIAN CANCER DETECTION AND DIAGNOSIS 审中-公开
公开(公告)号：WO2020099683A1
公开(公告)日：2020-05-22
申请号：PCT/EP2019/081689
申请日：2019-11-18
申请人： BIOCRATES LIFE SCIENCES AG
发明人： KOAL, Therese , BURWINKEL, Barbara , BAO-WEN, Yuan , MÜLLER, Udo , SCHAFFERER, Simon
IPC分类号： G01N33/50 , G01N33/574
摘要： The present invention relates to new metabolite panels for assessing ovarian cancer. Moreover, the present invention relates to a method for assessing ovarian cancer from a subject to be examined, and to a kit for carrying out the method.

2. 发明申请

WO2012113834A1 METHOD AND USE OF METABOLITES FOR THE DIAGNOSIS OF INFLAMMATORY BRAIN INJURY IN PRETERM BORN INFANTS 审中-公开
标题翻译：代谢物对前列腺免疫缺陷性脑损伤诊断的方法与用途
公开(公告)号：WO2012113834A1
公开(公告)日：2012-08-30
申请号：PCT/EP2012/053016
申请日：2012-02-22
申请人： BIOCRATES LIFE SCIENCES AG , KELLER, Matthias , MALLARD, Carina , DEIGNER, Hans-Peter , ENOT, David , IGWE, Emeka I.
发明人： KELLER, Matthias , MALLARD, Carina , DEIGNER, Hans-Peter , ENOT, David , IGWE, Emeka I.
IPC分类号： G01N33/68
CPC分类号： G06F19/10 , G01N33/483 , G01N33/6896 , G01N2800/38
摘要： The present invention relates to novel biomarkers for predicting the likelihood of inflammation-related brain injury in preterm born infants, using a plurality of endogenous target metabolites selected from the group consisting of acyl carnitins, diacylphosphatidylcholines, acyl-alkylphosphatidylchoines, lysophosphatidylcholines and amino acids.
摘要翻译：本发明涉及使用选自酰基肉毒碱，二酰基磷脂酰胆碱，酰基 - 烷基磷脂酰胆碱，溶血磷脂酰胆碱和氨基酸的多种内源性目标代谢物来预测早产婴儿发炎相关脑损伤的可能性的新型生物标志物。

3. 发明申请

WO2018134329A1 METABOLIC BIOMARKER SET FOR ASSESSING OVARIAN CANCER 审中-公开
公开(公告)号：WO2018134329A1
公开(公告)日：2018-07-26
申请号：PCT/EP2018/051254
申请日：2018-01-18
申请人： BIOCRATES LIFE SCIENCES AG
发明人： MÜLLER, Udo , SCHAFFERER, Simon , BURWINKEL, Barbara
IPC分类号： G01N33/574
摘要： The present invention relates to new biomarkers for assessing ovarian cancer being more sensitive, particularly at early stage of disease. Moreover, the present invention relates to a method for assessing ovarian cancer from a patient to be examined, and to a kit for carrying out the method.

4. 发明申请

WO2018049268A1 BIOMARKERS FOR THE DIAGNOSIS AND CHARACTERIZATION OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：生物标志物用于阿尔茨海默病的诊断和表征
公开(公告)号：WO2018049268A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050831
申请日：2017-09-08
申请人： DUKE UNIVERSITY , UNIVERSITY OF PENNSYLVANIA , HOUSTON METHODIST HOSPITAL , HELMHOLTZ ZENTRUM MUNCHEN , GERMAN CENTER FOR DIABETES RESEARCH (DZD) , ROSA & CO LLC , SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE , INDIANA UNIVERSITY SCHOOL OF MEDICINE , BIOCRATES LIFE SCIENCES AG , TOLEDO, Jon, B. , ARNOLD, Matthias , KASTEMULLER, Gabi , BAILLIE, Rebecca, A. , HAN, Xianlin , THOMPSON, Will , ST. JOHN-WILLIAMS, Lisa , KOAL, Therese , NHO, Kwangsik , MOSELEY, M., Arthur , SAYKIN, Andrew, J. , DORAISWAMY, Pudugramam, Murali
发明人： TOLEDO, Jon, B. , ARNOLD, Matthias , KASTEMULLER, Gabi , BAILLIE, Rebecca, A. , HAN, Xianlin , THOMPSON, Will , ST. JOHN-WILLIAMS, Lisa , KOAL, Therese , MOSELEY, M., Arthur , SAYKIN, Andrew, J. , DORAISWAMY, Pudugramam, Murali
IPC分类号： G01N33/50 , A61K31/661 , G01N33/92
摘要： Embodiments of the present disclosure relate generally to the analysis and identification of global metabolic changes in Alzheimer's disease (AD). More particularly, the present disclosure provides materials and methods relating to the use of metabolornics as a biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance. Defining metabolic changes during AD disease trajectory and their relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery.
摘要翻译：本公开的实施方案一般涉及阿尔茨海默病（AD）中全局代谢变化的分析和鉴定。更具体地说，本公开提供了与使用代谢物作为生化方法相关的材料和方法，以鉴定AD患者中的外周代谢变化并将它们与脑脊液流体病理学标记，成像特征和认知表现相关联。定义AD疾病过程中的代谢变化及其与临床表型的关系为药物和生物标志物的发现提供了强有力的路线图。

5. 发明申请

WO2010139341A1 NEW BIOMARKERS FOR ASSESSING KIDNEY DISEASES 审中-公开
标题翻译：新生物标记用于评估KIDNEY病
公开(公告)号：WO2010139341A1
公开(公告)日：2010-12-09
申请号：PCT/EP2009/003926
申请日：2009-06-02
申请人： BIOCRATES LIFE SCIENCES AG , LUNDIN. Ulrika , WEINBERGER, Klaus
发明人： LUNDIN. Ulrika , WEINBERGER, Klaus
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in a mammalian subject which comprises obtaining a biological sample, preferably blood and /or urine, from the subject and measuring in the biological sample the amount of at least two amino acids, of at least two acylcarnitines and of at least two biogenic amines, as well as to a kit adapted to carry out the method. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess kidney disease.
摘要翻译：本发明涉及用于评估肾脏疾病的代谢生物标志物组，其包含至少两种氨基酸，至少两种酰基肉碱和至少两种生物胺。此外，本发明涉及一种用于在哺乳动物受试者中评估肾脏疾病的方法，其包括从受试者获得生物样品，优选血液和/或尿液，并在生物样品中测量至少两个氨基酸的量至少两种酰基肉碱和至少两种生物胺，以及适于实施该方法的试剂盒。通过使用特定的生物标志物和根据本发明的方法，可以更正确和可靠地评估肾脏疾病。

6. 发明申请

WO2011161186A1 METHOD FOR IN VITRO DIAGNOSING SEPSIS UTILIZING BIOMARKER COMPOSED OF MORE THAN TWO DIFFERENT TYPES OF ENDOGENOUS BIOMOLECULES 审中-公开
标题翻译：用于组合多于两种不同类型的内源性生物分子的生物标记物进行血管造影检查的方法
公开(公告)号：WO2011161186A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060495
申请日：2011-06-22
申请人： BIOCRATES LIFE SCIENCES AG , DEIGNER, Hans-Peter , BAUER, Michael , KOHL, Matthias
发明人： DEIGNER, Hans-Peter , BAUER, Michael , KOHL, Matthias
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/5308 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G01N2800/26 , G06F19/24
摘要： The present invention relates to an in vitro method for predicting a likelihood of an onset of a sepsis by a) selecting at least two distinct types of biomolecules, wherein said types of biomolecules are selected from the group consisting of: RNAs and/or their DNA counterparts, mRNAs and/or their DNA counterparts, non-coding RNAs and/or their DNA counterparts, microRNAs and/or their DNA counterparts, and endogenous target metabolites; b) measuring at least one parameter selected from the group consisting of presence or absence, qualitative and/or quantitative molecular pattern and/or molecular signature, level, amount, concentration and expression level of a plurality of biomolecules of each species in said sample using said two sets of distinct types of biomolecules and storing the obtained set of values as raw data in a database; after mathematical processing predict a class label of an obtained data set in order to calculate prognostic likelihoods.
摘要翻译：本发明涉及一种通过以下方式预测脓毒病发作的可能性的体外方法：a）选择至少两种不同类型的生物分子，其中所述类型的生物分子选自：RNA和/或其DNA 对应物，mRNA和/或其DNA对应物，非编码RNA和/或其DNA对应物，微小RNA和/或其DNA对应物和内源性靶标代谢物; b）测量所述样品中每种物质的多个生物分子的存在或不存在，定性和/或定量分子模式和/或分子特征，水平，数量，浓度和表达水平的至少一个参数，所述生物分子使用说两组不同类型的生物分子，并将获得的一组值作为原始数据存储在数据库中; 在数学处理之后预测获得的数据集的类标签，以便计算预后可能性。

7. 发明申请

WO2011012553A1 METHOD FOR PREDICTING THE LIKELIHOOD OF AN ONSET OF AN INFLAMMATION ASSOCIATED ORGAN FAILURE 审中-公开
标题翻译：预测感染相关器官失败发生率的方法
公开(公告)号：WO2011012553A1
公开(公告)日：2011-02-03
申请号：PCT/EP2010/060745
申请日：2010-07-23
申请人： BIOCRATES LIFE SCIENCES AG , DEIGNER, Hans-Peter , KOHL, Matthias , ENOT, David , KOAL, Therese , KELLER, Matthias
发明人： DEIGNER, Hans-Peter , KOHL, Matthias , ENOT, David , KOAL, Therese , KELLER, Matthias
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/26 , G06F19/12 , G06F19/24 , Y10T436/173845
摘要： The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.
摘要翻译：本发明涉及用于通过受试者的定量代谢组学谱来预测来自哺乳动物受试者的体外生物样品的炎症相关器官功能衰竭发作的可能性的可靠和统计学显着的方法，该定量代谢组学特征包括多种内源性代谢物，并将其与多种内源性器官衰竭预测目标代谢物的定量参考代谢组学谱进行比较，以便预测受试者是否可能或不可能发生器官功能衰竭。此外，本发明涉及在这种方法中内源性器官衰竭预测目标代谢物的有用性。

8. 发明申请

WO2011000753A1 METHOD FOR NORMALIZATION IN METABOLOMICS ANALYSIS METHODS WITH ENDOGENOUS REFERENCE METABOLITES 审中-公开
标题翻译：具有内源性参考代谢物的代谢分析方法的正规化方法
公开(公告)号：WO2011000753A1
公开(公告)日：2011-01-06
申请号：PCT/EP2010/058911
申请日：2010-06-23
申请人： BIOCRATES Life Sciences AG , DEIGNER, Hans-Peter , KOHL, Matthias , KELLER, Matthias , KOAL, Therese
发明人： DEIGNER, Hans-Peter , KOHL, Matthias , KELLER, Matthias , KOAL, Therese
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G01N2800/60 , Y10T436/163333 , Y10T436/201666
摘要： The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.
摘要翻译：本发明涉及内源性参考代谢物的使用以及对应于哺乳动物受试者的生物样品中所选靶标代谢物的量和/或浓度的强度数据的归一化方法，其中所述强度数据通过代谢组学分析法与一种或多种内源性参考代谢物，包括在所述生物样品中进行所述选择的目标代谢物的至少一种体外代谢组学分析方法，同时在相同样品中进行一种或多种内源性参考代谢物的定量分析或其衍生物，其中所述内源性参考代谢物是生物样品中以基本恒定水平存在于受试者中的这样的化合物; 并且其中所述内源性参考代谢物或其衍生物具有小于1500Da的分子量。

9. 发明申请

WO2015150360A1 BIOMARKERS FOR ASSESSING HIV 审中-公开
标题翻译：用于评估艾滋病毒的生物标志物
公开(公告)号：WO2015150360A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056977
申请日：2015-03-31
申请人： IDCGS CLINICA DE DIAGNOSTICOS MEDICOS , CENTRO DE GENOMAS , BIOCRATES LIFE SCIENCES AG
发明人： DA SILVA, Ismael Dale Cotrim Guerreiro , LOTURCO, Edson Guimaraes , DIAZ, Ricoardo Soubie , KOAL, Therese
IPC分类号： G01N33/569 , G01N33/92 , G01N33/68
CPC分类号： G01N33/92 , C12Q1/70 , G01N33/56988 , G01N33/6812 , G01N33/6893 , G01N2333/47 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2800/52
摘要： The present invention relates to metabolic biomarker sets for assessing HIV. In preferred embodiments, the present invention relates to the use of biomarker sets for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject.In other embodiments, the invention relates to methods for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject, as well as to a kit adapted to carry out the methods. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess HIV. In particular, it becomes possible to screen for and diagnose HIV in a patient with high accuracy and predict early in advance the patient's therapeutic response to antiretroviral therapy.
摘要翻译：本发明涉及用于评估HIV的代谢生物标志物组。在优选的实施方案中，本发明涉及用于筛选和/或诊断HIV感染的生物标志物组的用途，用于预测哺乳动物受试者的抗逆转录病毒治疗和/或预防HIV疾病进展的免疫应答以及用于监测HIV疾病在其他实施方案中，本发明涉及用于筛选和/或诊断HIV感染的方法，用于预测哺乳动物受试者的抗逆转录病毒治疗和/或预防HIV疾病进展的免疫应答以及HIV的监测哺乳动物受试者的疾病活动，以及适于实施该方法的试剂盒。通过使用特定的生物标志物和根据本发明的方法，可以更正确和可靠地评价HIV。特别地，可以高精度地筛选和诊断患者中的HIV并预先提前预测患者对抗逆转录病毒疗法的治疗反应。

10. 发明申请

WO2014072537A1 VERWENDUNG VON QUALITÄTSINDIKATOREN ZUM NACHWEIS VON AUFTAUPROZESSEN IN GEFRORENEN GEWEBEPROBEN 审中-公开
标题翻译：质量指标体系解冻作者冰冻组织样本检测中使用
公开(公告)号：WO2014072537A1
公开(公告)日：2014-05-15
申请号：PCT/EP2013/073664
申请日：2013-11-12
申请人： BIOCRATES LIFE SCIENCES AG
发明人： ABUJA, Peter M. , ZATLOUKAL, Kurt , DALLMANN, Guido , SONNTAG, Denise
IPC分类号： G01N33/68
CPC分类号： A01N1/0284
摘要： Die vorliegende Erfindung betrifft die Verwendung von Qualitätsindikatoren zum Nachweis von Auftauprozessen in gefrorenen, insbesondere kryokonservierten Proben. Die Erfindung betrifft ausserdem Verfahren zum Nachweis von Auftauprozessen in gefrorenen Proben, insbesondere von kryokonservierten Proben mittels bestimmter Qualitätsindikatoren sowie die Qualitätskontrolle von Gewebeproben, Lebensmitteln und die Erstellung von metabolischen Profilen.
摘要翻译：本发明涉及利用质量指标为特定冷冻保存的样品在冷冻检测解冻。本发明还涉及一种用于检测由特定的质量指标冷冻样品中解冻，特别是冷冻保存的样品的以及质量控制的组织样品，食品和代谢轮廓的创建方法。

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