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    • 2. 发明申请
    • METHOD AND KIT FOR DETECTION OF MYCOBACTERIA
    • 用于检测MYCOBACTERIA的方法和工具箱
    • WO2016024118A1
    • 2016-02-18
    • PCT/GB2015/052340
    • 2015-08-13
    • BANGOR UNIVERSITY
    • BAIRD, Mark StephenGWENIN, Christopher DavidGWENIN, Vanessa ValerieJONES, Alison
    • G01N33/543G01N33/569
    • G01N33/5695G01N33/543G01N33/54366G01N33/553G01N33/558G01N33/92G01N2333/35G01N2405/00G01N2800/50
    • A method of determining whether an individual is infected with mycobacteria. The method comprising the steps of (a) providing a system which comprises at least two different mycolic- acid derived antigens; (b) introducing a sample obtained from the individual into the system and into contact with each of the at least two different mycolic-acid derived antigens; and (c) detecting the presence or absence of the binding of a biomarker in the sample with each antigen in the system. The method may be particularly suitable for determining the presence or absence of a disease antibody indicative of infection with any disease caused by infection with mycobacteria, for example tuberculosis, leprosy, pulmonary disease, burili ulcer, Johne's disease and bovine tuberculosis. A kit and device are also described. The present invention may provide an over the counter device to allow individuals to check on a routine basis that they have normal immune responses.
    • 确定个体是否感染分枝杆菌的方法。 该方法包括以下步骤:(a)提供包含至少两种不同的霉酚酸衍生的抗原的系统; (b)将从个体获得的样品引入系统并与至少两种不同的霉酚酸衍生的抗原接触; 和(c)检测样品中的生物标志物与系统中每种抗原的结合的存在或不存在。 该方法可以特别适用于确定指示感染由分枝杆菌感染引起的任何疾病的疾病抗体的存在或不存在,例如结核病,麻风病,肺部疾病,布鲁利溃疡,约翰氏病和牛结核病。 还描述了套件和装置。 本发明可以提供一种超过对抗装置,以允许个体在常规的基础上检查它们具有正常的免疫应答。