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1. 发明专利

JP2001261554A PHARMACEUTICAL COMPOSITION INCLUDING CHIROINOSITOL EXTRACT AS AN ACTIVE INGREDIENT 失效
公开(公告)号：JP2001261554A
公开(公告)日：2001-09-26
申请号：JP2000204118
申请日：2000-07-05
申请人： AMICOGEN INC , YONCHEORU SHIN , YOONBAE PAAKU
发明人： YOONBAE PAAKU , YONGEUN HON , YANMEE PAAKU , HIEONSOOKU BAEKU , SANMIN KIM , YONCHEORU SHIN , YANSO KIMU , JONJIN KIMU
IPC分类号： A23L1/30 , A61K31/047 , A61K36/15 , A61K36/48 , A61P3/10 , A61P39/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a medicine, a health auxiliary food and a food additive that has the hypoglycemia action and the like. SOLUTION: This invention relates to a medicine including chiroinositol extract. The chiroinositol extract reveals markedly hypoglycemic action against the elevation of glycemia due to the deficiency of chiroinositol or derivatives thereof and in insulin-dependent or independent diabetes, in addition has the action to inhibit the changes of respiration rate, heart spontaneous rate, blood pressure caused as the side-effect of narcotics. Thus, this extract can be used as a health auxiliary food or as a food additive.

2. 发明专利

JP2001261600A METHOD FOR PRODUCING EXTRACT OF CHIROINOSITOL FROM EDIBLE RESOURCE 失效
公开(公告)号：JP2001261600A
公开(公告)日：2001-09-26
申请号：JP2000204119
申请日：2000-07-05
申请人： AMICOGEN INC , YONCHEORU SHIN , YOONBAE PAAKU
发明人： YANSO KIMU , BIEONDON RII , JONJIN KIMU , YONCHEORU SHIN , YOONBAE PAAKU
IPC分类号： A23L1/30 , A23L27/00 , A61K31/045 , A61P3/10 , C07C29/86 , C07C35/16
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an extract of chiroinositol useful as a therapeutic agent or a dietarily auxiliary therapeutic agent for diabetics and a material for general foods such as a drink, confectionery, a baked bread, an ice cake and gums from edible resources. SOLUTION: This method comprises a step of grinding the edible resources, adding 2-6 times of water in terms of weight ratio thereto to carry out extraction and then collecting the supernatant liquid by a centrifugal separation method or a filtration method, a step of removing proteins from the supernatant liquid by using a solvent sedimentation or an oxidation sedimentation, removing saccharides except the chiroinositol by using an adsorption column chromatography, then adding an acid to subject to acidolysis and collecting the acidolysis liquid, a step of removing salts or acids from the acidolysis liquid by sodium hydroxide or an ion exchange resin to neutralize and a step of applying the liquid in which the salts and the acids are removed to a hydrophobic column chromatography to obtain the chiroinositol fraction and then concentrating and filtering or drying the fraction.

3. 发明专利

AU7463501A Method for generating recombinant dna library using unidirectional single-stranded dna fragments 未知
公开(公告)号：AU7463501A
公开(公告)日：2002-05-21
申请号：AU7463501
申请日：2001-06-16
申请人： AMICOGEN INC
发明人： LEE SI HYOUNG , SHIN YONG CHUL , JEON YEONG JOONG , JUNG KYUNG HWA , RYU EUN JUNG , LEE KO WOON
IPC分类号： C12N15/09 , C12N15/10 , C12Q1/68
摘要： The present invention relates to a method for producing a recombinant polynucleotides comprising the steps of generating a pool of unidirectional single-stranded polynucleotide fragments from two or more homologous double-stranded polynucleotides, conducting a polymerization process comprising multi-cyclic extension reactions using the unidirectional single-stranded polynucleotide fragments as templates and specific oligonucleotides as primers to obtain recombinant polynucleotides, and conducting a polymerase chain reaction using at least one primer to amplify the recombinant polynucleotides; and a method for constructing a recombinant DNA library comprising the steps of inserting the recombinant polynucleotide prepared by the above method into a vector and transforming an expression cell with said vector containing the recombinant polynucleotide to obtain a plurality of mutant clones. The method of the present invention can be used for in vitro recombination of homologous polynucleotides and the directed molecular evolution.

4. 发明授权

KR102194740B1 7-ADCA 제조를 위한 데아세트옥시세팔로스포린 C의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주 有权
公开(公告)号：KR102194740B1
公开(公告)日：2020-12-23
申请号：KR20190114945
申请日：2019-09-18
申请人： AMICOGEN INC
发明人： SHIN YONG CHUL , PIAO ZHE , YOON SANG HWAL , LEE HYEON SEO , KANG MI SUK , PIAO XUEMEI , KIM YOU MI , LI HONG XIAN , JEONG DONG WON , SHIM JAE MIN , JUNG JANG HYUN , SEO DONG IL , KIM SEUNG KI
IPC分类号： C12N9/10 , C12N9/02 , C12P35/00
摘要： 본발명은데아세트옥시세팔로스포린 C(DAOC)의고농도생산재조합아크레모니움크리소제눔균주의제조방법및 이방법으로제조된균주에관한것으로, 보다상세하게는 DAOC 고생산성아크레모니움크리소제눔균주의제조방법, 이방법으로제조된재조합아크레모니움크리소제눔균주, 상기균주를 DAOC를생산할수 있는조건에서배양하고이를회수하는 DAOC 생산방법, 상기제조방법에이용된아크레모니움크리소제눔균주에서의 DAOC 고발현용폴리뉴클레오티드, 아크레모니움크리소제눔균주에서 DAOC 고발현용발현벡터및 상기생산된 DAOC에 CPC 아실라제를처리하여 7-ADCA를생산하는방법에관한것이다. 본발명에의하면 DAOC 고생성능을가진아크레모니움크리소제눔균주를제조할수 있으며, 이들균주에의해생성된 DAOC를 CPC 아실라제로처리함으로써유독부산물없이환경친화적이고효율적인방법으로 7-ADCA를생산할수 있다.

5. 发明申请

WO2009048249A2 COMPOSITION FOR PREVENTING OR TREATING LIPID METABOLIC DISORDERS COMPRISING FUCOXANTHIN OR MARINE PLANT EXTRACT CONTAINING SAME 审中-公开
标题翻译：用于预防或治疗含有FUCOXANTHIN或包含其的海洋植物提取物的脂质代谢紊乱的组合物
公开(公告)号：WO2009048249A2
公开(公告)日：2009-04-16
申请号：PCT/KR2008/005868
申请日：2008-10-07
申请人： AMICOGEN, INC. , SHIN, Yong Chul , CHOI, Myung-Sook , WOO, Myoung-Nam , JUNG, Kyung Hwa , KIM, Ki Seok
发明人： SHIN, Yong Chul , CHOI, Myung-Sook , WOO, Myoung-Nam , JUNG, Kyung Hwa , KIM, Ki Seok
IPC分类号： A61K31/336
CPC分类号： A61K31/336
摘要： The present invention relates to a composition for the prevention or treatment lipid metabolic disorders comprising fucoxanthin or marine plant extract comtaining the same as an effective indredients. Fucoxanthin or a marine plant extract comprising the same is effective in reducing weight increase and reducing triglyceride and cholesterol level in liver tissue, or plasma through inhibiting the synthesis of fatty acid and promoting the oxidation of fatty acid. Therefore, the composition comprising fucoxanthin or a marine plant extract comprising the same as an effective ingredient may be effectively used for the prevention and treatment of lipid metabolic disorders.
摘要翻译：本发明涉及用于预防或治疗脂质代谢紊乱的组合物，其包含与有效成分相同的岩藻黄素或海洋植物提取物。岩藻黄素或其组合物的海洋植物提取物通过抑制脂肪酸的合成和促进脂肪酸的氧化，有效降低肝组织或血浆中的甘油三酯和胆固醇水平的增加和减少。因此，含有岩藻黄素的组合物或与有效成分相同的海洋植物提取物可以有效地用于预防和治疗脂质代谢紊乱。

6. 发明申请

WO2004084875A1 USE OF PINITOL OR CHIROINOSITOL FOR PROTECTING THE LIVER 审中-公开
标题翻译：使用PINITOL或CHIROINOSITOL保护肝脏
公开(公告)号：WO2004084875A1
公开(公告)日：2004-10-07
申请号：PCT/KR2004/000689
申请日：2004-03-26
申请人： AMICOGEN INC. , SHIN, Yong Chul , JEON, Yeong Joong , KIM, Jong Jin
发明人： SHIN, Yong Chul , JEON, Yeong Joong , KIM, Jong Jin
IPC分类号： A61K31/075
CPC分类号： A61K31/075 , A61K36/15 , A61K36/48 , A61K36/483 , A61K36/72
摘要： Disclosed in this invention is a use of pinitol or chiroinositol for protecting the liver.
摘要翻译：在本发明中公开了用于保护肝脏的松果糖或二氢肌醇的用途。

7. 发明专利

AU2006229533A1 Novel use of lignan compounds 未知
公开(公告)号：AU2006229533A1
公开(公告)日：2006-10-05
申请号：AU2006229533
申请日：2006-03-31
申请人： AMICOGEN INC
发明人： HAN KYU-LEE , LEE SUN-HEE , HWANG JAE-KWAN , LIM CHOL-SEUNG , JIN DAQING , HAN JUNG-SOO
IPC分类号： A61K31/357
摘要： The present invention relates to the novel use of lignan compounds represented by Formula I. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a brain disease, comprising a lignan compound represented by Formula I or a Myristica fragrans extract as an active ingredient, as well as the method and use for treating or preventing a brain disease using the lignan compound. The lignan compound represented by Formula I has the effects of antioxidation, brain cell protection and antiinflammation. Accordingly, said lignan compound will be highly useful for treating or preventing a brain disease.

8. 发明专利

BRPI0609608A2 未知
公开(公告)号：BRPI0609608A2
公开(公告)日：2010-04-20
申请号：BRPI0609608
申请日：2006-03-31
申请人： AMICOGEN INC
发明人： HWANG JAE-KWAN , HAN JUNG-SOO , LIM CHOL-SEUNG , JIN DAQING , LEE SUN-HEE , HAN KYU-LEE
IPC分类号： A61K31/357
摘要： The present invention relates to the novel use of lignan compounds represented by Formula I. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a brain disease, comprising a lignan compound represented by Formula I or a Myristica fragrans extract as an active ingredient, as well as the method and use for treating or preventing a brain disease using the lignan compound. The lignan compound represented by Formula I has the effects of antioxidation, brain cell protection and antiinflammation. Accordingly, said lignan compound will be highly useful for treating or preventing a brain disease.

9. 发明申请

WO2009048249A3 COMPOSITION FOR PREVENTING OR TREATING LIPID METABOLIC DISORDERS COMPRISING FUCOXANTHIN OR MARINE PLANT EXTRACT CONTAINING SAME 审中-公开
标题翻译：用于预防或治疗包含氟辛旦或含有海藻植物提取物的脂质代谢病的组合物
公开(公告)号：WO2009048249A3
公开(公告)日：2009-06-04
申请号：PCT/KR2008005868
申请日：2008-10-07
申请人： AMICOGEN INC , SHIN YONG CHUL , CHOI MYUNG-SOOK , WOO MYOUNG-NAM , JUNG KYUNG HWA , KIM KI SEOK
发明人： SHIN YONG CHUL , CHOI MYUNG-SOOK , WOO MYOUNG-NAM , JUNG KYUNG HWA , KIM KI SEOK
IPC分类号： A61K31/336
CPC分类号： A61K31/336
摘要： The present invention relates to a composition for the prevention or treatment lipid metabolic disorders comprising fucoxanthin or marine plant extract comtaining the same as an effective indredients. Fucoxanthin or a marine plant extract comprising the same is effective in reducing weight increase and reducing triglyceride and cholesterol level in liver tissue, or plasma through inhibiting the synthesis of fatty acid and promoting the oxidation of fatty acid. Therefore, the composition comprising fucoxanthin or a marine plant extract comprising the same as an effective ingredient may be effectively used for the prevention and treatment of lipid metabolic disorders.
摘要翻译：本发明涉及用于预防或治疗脂质代谢紊乱的组合物，其包含岩藻黄质或含有其作为有效成分的海洋植物提取物。岩藻黄素或含有它的海洋植物提取物通过抑制脂肪酸的合成并促进脂肪酸的氧化，可有效减少肝组织或血浆中的重量增加和降低甘油三酯和胆固醇水平。因此，包含岩藻黄质的组合物或包含其作为有效成分的海洋植物提取物可以有效地用于预防和治疗脂质代谢紊乱。

10. 发明申请

WO2002077251A1 METHOD OF RECOVERING PINITOL OR CHIRO-INOSITOL IN HIGH YIELD FROM SOY FRACTIONS 审中-公开
标题翻译：从大豆分离回收高密度脂蛋白或酪氨酸激酶的方法
公开(公告)号：WO2002077251A1
公开(公告)日：2002-10-03
申请号：PCT/KR2001/001984
申请日：2001-11-20
申请人： AMICOGEN, INC , SHIN, Yong-Chul , JEON, Yeong-Joong , KIM, Jong-Jin , CHOI, Chi-Man
发明人： SHIN, Yong-Chul , JEON, Yeong-Joong , KIM, Jong-Jin , CHOI, Chi-Man
IPC分类号： C12P7/18
CPC分类号： C12P7/18
摘要： This invention relates to a method for recovering useful products from soy fractions with high efficiency, and more specifically to increasing the recovery yield of pinitol or chiro-inositol from soy fractions, in which it is contained by a process comprising the steps of culturing a microorganism to transform pinitol derivatives into pinitol in soy fractions, thereby to increase the pinitol content in soy fractions, followed by removing microorganisms, insoluble materials and other macromolecules from said fractions by centrifugation or filtration to obtain an aqueous solution containing pinitol or chiro-inositol, contacting said solution with activated carbon to adsorb the pinitol or chiro-inositol, contacting said solution with activated carbon to adsorb the pinitol or chiro-inositol, and then recovering it by stepwise or gradient elution with an organic solvent.
摘要翻译：本发明涉及从大豆馏分中高效回收有用的产品的方法，更具体地说，涉及提高大豆馏分中的松油醇或丙酮肌醇的回收率，其中通过包括以下步骤的方法包含以下步骤：培养微生物将大豆衍生物转化为豆蔻糖醇，从而增加大豆馏分中的松果糖含量，然后通过离心或过滤从所述馏分中除去微生物，不溶物和其它大分子，得到含有松果糖或手性肌醇的水溶液，接触所述溶液用活性炭吸附松果糖或手性肌醇，使所述溶液与活性炭接触以吸附松果糖或手性肌醇，然后通过有机溶剂逐步或梯度洗脱来回收。

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