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1. 发明申请

WO2021141733A1 METHOD OF MODULATING A FIBROTIC CONDITION 审中-公开
公开(公告)号：WO2021141733A1
公开(公告)日：2021-07-15
申请号：PCT/US2020/065002
申请日：2020-12-15
申请人： THE PROCTER & GAMBLE COMPANY , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)
发明人： ISFORT, Robert, Joseph , BARD, Frederic , WONG, Hui Hui , SEET, Sze Hwee
IPC分类号： A61K38/17 , A61K39/395 , A61K31/7105 , A61K31/713 , A61P17/02 , A61P35/00 , A61P37/00 , A61P27/00 , A61P19/04 , A61P11/00 , A61K38/00 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N2310/14 , G01N33/5044
摘要： A method of modulating fibrosis in a tissue of a subject by increasing or decreasing the expression of C2orf69. C2orf69 expression has been found to inhibit the expression of genes involved in building, repairing, and maintaining the extra-cellular matrix. In particular, C2orf69 inhibits the collagen synthesizing of COL1A1. By modulating the expression of the C2orf69, collagen synthesis can be increased or decreased, which can provide a variety of cosmetic and medical benefits.

2. 发明申请

WO2021061053A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021061053A1
公开(公告)日：2021-04-01
申请号：PCT/SG2020/050545
申请日：2020-09-25
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , KANG, Congbao
发明人： HUNG, Wei , KELLER, Thomas Hugo , WANG, Wei Ling , WANG, Gang
IPC分类号： C07D209/34 , C07D471/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D495/14 , A61K31/404 , A61K31/407 , A61K31/551 , A61P35/00 , A61P25/00
摘要： There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiqutination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction. In various embodiments, the present disclosure relates to a compound of Formula (I) or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof.

3. 发明申请

WO2020005155A1 A DIAMOND HAVING NANOSTRUCTURES ON ONE OF ITS SURFACE TO GENERATE STRUCTURAL COLOURS AND A METHOD OF PRODUCING THEREOF 审中-公开
公开(公告)号：WO2020005155A1
公开(公告)日：2020-01-02
申请号：PCT/SG2019/050300
申请日：2019-06-17
申请人： IIA TECHNOLOGIES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)
发明人： ANSARI MAHABADI, Kambiz , DONG, Zhaogang
IPC分类号： C01B32/28 , C30B33/08 , B82Y40/00 , C30B29/04
摘要： A diamond comprising of: at least one surface; and a plurality of nanostructures formed on the at least one surface of the diamond, wherein the plurality of nanostructures generates one or more structural colours on the surface of the diamond.

4. 发明申请

WO2016032397A1 METHODS AND SYSTEMS FOR ASSESSING RETINAL IMAGES, AND OBTAINING INFORMATION FROM RETINAL IMAGES 审中-公开
标题翻译：用于评估视网膜图像的方法和系统，以及从视网膜图像获取信息
公开(公告)号：WO2016032397A1
公开(公告)日：2016-03-03
申请号：PCT/SG2015/050275
申请日：2015-08-25
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)
发明人： YIN, Fengshou , WONG, Wing Kee, Damon , LIU, Jiang , LEE, Beng Hai , ZHANG, Zhuo , GOPALAKRISHNAN, Kavitha , QUAN, Ying , YOW, Ai Ping
IPC分类号： G06T7/00 , A61B3/14
CPC分类号： G06K9/4676 , A61B3/0025 , A61B3/12 , A61B3/14 , A61B2576/02 , G06K9/0061 , G06K9/036 , G06K9/6269 , G06K2009/00932 , G06K2209/05 , G06T7/0012 , G06T7/0014 , G06T2207/20081 , G06T2207/30041 , G06T2207/30168
摘要： A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of- interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).
摘要翻译：评估视网膜图像（例如眼底图像）的质量的方法包括在对应于眼睛的特定结构（例如视盘或黄斑）的视网膜图像内选择至少一个感兴趣区域，以及质量关于利益区域或每个区域计算得分。每个感兴趣区域通常与病理学相关联，如视盘和黄斑。可选地，也可以针对整个眼睛（即，在整个图像上，如果整个图像对应于视网膜）也可以计算质量得分。

5. 发明申请

WO2013176622A1 A DRY POWDER FORMULATION 审中-公开
标题翻译：干粉配方
公开(公告)号：WO2013176622A1
公开(公告)日：2013-11-28
申请号：PCT/SG2013/000207
申请日：2013-05-21
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD
发明人： HENG, Desmond , HUEY, Lee Sie , TEO, Jeanette , NG, Wai Kiong , TAN, Reginald
IPC分类号： A61K31/4375 , A61K31/496 , A61K31/47 , A61P11/00 , A61P31/04
CPC分类号： A61K31/496 , A61K9/0075 , A61K31/4375 , A61K31/4709 , A61K31/4745 , A61K31/5383 , A61K31/542 , A61K45/06 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： A dry powder formulation comprising a combination of at least a first pharmaceutically active quinolone and a second pharmaceutically active quinolone.
摘要翻译：包含至少第一药学活性喹诺酮和第二药用活性喹诺酮的组合的干粉制剂。

6. 发明申请

WO2013151505A1 METHOD OF MAKING A PROGNOSIS FOR LUNG CANCER 审中-公开
标题翻译：制定肺癌预防方法
公开(公告)号：WO2013151505A1
公开(公告)日：2013-10-10
申请号：PCT/SG2013/000128
申请日：2013-04-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , NATIONAL UNIVERSITY HOSPITAL (S) PTE LTD
发明人： MAH, Tzia Liang , TONG, Joo Chuan , FENG, Mengling , VELLAISAMY, Kuralmani , LI, Nanpu , YAP, Adeline Xin Ning , LIMVIPHUVADH, Vachiranee , MAURER-STROH, Sebastian , ADHIKARI, Sharmila , EISENHABER, Frank , LIEM, Natalia Li Mei , YONG, Wei Peng , SOO, Ross Andrew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156
摘要： The present disclosure relates to single nucleotide polymorphisms (SNP) as genetic markers indicative of a patient's survival from lung cancer and responsiveness to treatment, enabling improved prediction of a patient's risk, prognosis of lung cancer.
摘要翻译：本公开涉及单核苷酸多态性（SNP）作为指示患者从肺癌的存活和对治疗的反应性的遗传标记，能够改善患者风险的预测，预测肺癌。

7. 发明申请

WO2013074044A1 METHODS FOR DIAGNOSIS AND/OR PROGNOSIS OF GYNECOLOGICAL CANCER 审中-公开
标题翻译：用于诊断和/或预防妇科癌症的方法
公开(公告)号：WO2013074044A1
公开(公告)日：2013-05-23
申请号：PCT/SG2012/000435
申请日：2012-11-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)
发明人： BATAGOV, Arsen , IVSHINA, Anna , KUZNETSOV, Vladimir
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to an in vitro method for diagnosing epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or predisposition to epithelial ovarian cancer in a subject, the method comprising determining in a sample of the subject gene expression level of at least one gene in the MDS 1 and EVI1 complex (MECOM) locus; and/or copy number of at least one gene in the MECOM locus; wherein the level against at least one expression cutoff value and/or copy number against at least one copy number cutoff value are indicative of the subject having epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or a predisposition to epithelial ovarian cancer cervical cancer, endometriosis, clear cell renal carcinoma and/or determining whether the ovarian cancer in the subject is primary or secondary ovarian cancer and/or a risk of the disease progression after surgery treatment, and/or an effectiveness of post-surgery chemotherapy.
摘要翻译：本发明涉及用于诊断受试者上皮性卵巢癌，子宫颈癌，子宫内膜异位症，透明细胞肾癌和/或上皮性卵巢癌倾向的体外方法，所述方法包括在样本中测定受试者的基因表达水平 MDS 1和EVI1复合体（MECOM）基因座中至少有一个基因; 和/或MECOM基因座中至少一个基因的拷贝数; 其中针对至少一个拷贝数截止值的至少一个表达截断值和/或拷贝数的水平指示具有上皮性卵巢癌，子宫颈癌，子宫内膜异位症，透明细胞肾癌和/或上皮性卵巢倾向的受试者癌症宫颈癌，子宫内膜异位症，透明细胞肾癌和/或确定受试者中的卵巢癌是原发性还是继发性卵巢癌和/或手术治疗后疾病进展的风险，和/或术后化疗的有效性。

8. 发明申请

WO2012044992A9 METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA 审中-公开
公开(公告)号：WO2012044992A9
公开(公告)日：2012-04-05
申请号：PCT/US2011/054323
申请日：2011-09-30
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , MULTICLONAL THERAPEUTICS, INC , BRIGHAM AND WOMEN'S HOSPITAL , NATIONAL UNIVERSITY OF SINGAPORE , HARVARD UNIVERSITY , XIAN, Wa , MCKEON, Frank , VINCENT, Matthew , CRUM, Christopher , HO, Khek, Yu
发明人： XIAN, Wa , MCKEON, Frank , VINCENT, Matthew , CRUM, Christopher , HO, Khek, Yu
IPC分类号： G01N33/50 , G01N33/574 , C12N5/09
摘要： The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.

9. 发明申请

WO2011149425A1 PHASE SHIFT KEYING TRANSMITTER CIRCUIT 审中-公开
标题翻译：相移键控发射机电路
公开(公告)号：WO2011149425A1
公开(公告)日：2011-12-01
申请号：PCT/SG2011/000191
申请日：2011-05-25
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , DIAO, Shengxi , GAO, Yuan , ZHENG, Yuanjin
发明人： DIAO, Shengxi , GAO, Yuan , ZHENG, Yuanjin
IPC分类号： H04L27/04 , H04L25/49 , H04L27/20
CPC分类号： H04L27/20 , H03B5/1215 , H03B5/1228 , H03B5/124 , H03C3/00 , H04B13/005 , H04L27/2046
摘要： A phase shift keying transmitter circuit that includes: a variable frequency conversion stage adapted to receive a first data signal, wherein the variable frequency conversion stage comprises a plurality of frequency modulating elements, wherein the first data signal controls the number of the plurality of frequency modulating elements that are operated so as to control an operating frequency of the variable frequency conversion stage; and an output stage configured to switch between one of two possible outputs, the signals provided by one of the two possible outputs having an opposite polarity to the other, wherein the output stage is configured to receive a second data signal to control the switching between the two possible outputs, wherein the output stage is coupled to the variable frequency conversion stage and wherein the switching between the two possible outputs changes the phase of a signal from the variable frequency conversion stage by 180°.
摘要翻译：一种相移键控发射机电路，包括：适于接收第一数据信号的可变频率转换级，其中所述可变频率转换级包括多个频率调制元件，其中所述第一数据信号控制所述多个频率调制操作以控制可变变频级的工作频率的元件; 以及输出级，被配置为在两个可能输出中的一个输出之间切换，由两个可能的输出之一提供的信号具有与另一个极性相反的极性，其中所述输出级被配置为接收第二数据信号以控制在两个可能的输出，其中输出级耦合到可变频率转换级，并且其中两个可能输出之间的切换将来自可变频率转换级的信号的相位改变180°。

10. 发明申请

WO2011053257A2 METHODS OF MONITORING CELLULAR STATES 审中-公开
标题翻译：监测细胞状态的方法
公开(公告)号：WO2011053257A2
公开(公告)日：2011-05-05
申请号：PCT/SG2010/000422
申请日：2010-11-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , LIM, Sai Kiang
发明人： LIM, Sai Kiang
IPC分类号： C12Q1/68
CPC分类号： A61K35/28 , C12N5/0662 , C12N2510/00 , C12Q1/6809 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , G01N33/5073 , G01N33/5091 , C12Q2545/114 , C12Q2525/207
摘要： We describe a method of monitoring the state of a cell, the method comprising establishing, for a selected microRNA (miRNA) species secreted by the cell, a ratio of: (a) a precursor form of the miRNA species (pre-miRNA); to (b) a mature form of the miRNA species (mature miRNA); in which the pre- to mature miRNA ratio so established is indicative of the state of the cell. We also describe amethod comprising the steps of: (a) providing a mesenchymal stem cell (MSC); and (b) introducing an oncogene into the mesenchymal stem cell to thereby transform it; in which the transformed mesenchymal stem cell does not secrete a gene product of the oncogene into a medium in which it is grown.
摘要翻译：我们描述了一种监测细胞状态的方法，所述方法包括：针对由细胞分泌的选定的微小RNA（miRNA）物种确定：（a）miRNA物种的前体形式（pre-miRNA）的比例; 到（b）成熟形式的miRNA物种（成熟miRNA）; 其中如此建立的预至成熟miRNA比率指示细胞的状态。我们还描述了包括以下步骤的方法：（a）提供间充质干细胞（MSC）; 和（b）将癌基因导入间充质干细胞，从而将其转化; 其中转化的间充质干细胞不将癌基因的基因产物分泌到其生长的培养基中。

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