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1. 发明申请

WO2011034917A2 IMPLANTABLE ELECTROCHEMICAL BIOSENSOR SYSTEM AND METHOD 审中-公开
标题翻译：可植入的电化学生物传感器系统和方法
公开(公告)号：WO2011034917A2
公开(公告)日：2011-03-24
申请号：PCT/US2010048931
申请日：2010-09-15
申请人： AGAMATRIX INC , IYENGAR SRIDHAR , HARDING IAN
发明人： IYENGAR SRIDHAR , HARDING IAN
IPC分类号： G01N27/327 , G01N27/26
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7225 , C12Q1/001 , C12Q1/006
摘要： Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor which provides a substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.
摘要翻译：校正聚合物层厚度的初始变化以及植入生物传感器之后发生的涂层厚度变化，其提供可植入传感器的准确度和寿命的显着提高，这是利用由电位衰减导出的因子完成的。

2. 发明申请

WO2010005908A3 INTEGRATED BLOOD GLUCOSE MEASUREMENT DEVICE 审中-公开
标题翻译：集成血液葡萄糖测量装置
公开(公告)号：WO2010005908A3
公开(公告)日：2010-04-01
申请号：PCT/US2009049712
申请日：2009-07-06
申请人： AGAMATRIX INC , RAO ANOOP
发明人： RAO ANOOP
IPC分类号： G01N33/49 , A61B5/145
CPC分类号： G01N27/3273 , A61B5/14532 , A61B5/6898 , A61B2560/0204 , G01N33/48785 , G16H10/40 , G16H40/63 , H01M10/44 , H01M2220/30
摘要： A portable combination for measuring a glucose concentration value in a sample has a portable glucose meter (GM) having a test strip port for receiving a disposable electrochemical test strip, means for calculating a glucose concentration value in a sample applied to a test strip received in the test strip port, and optionally a rechargeable GM battery. Next the combination has a portable rechargeable supplemental battery pack (SBP). The combination also has a web enabled portable device (WEPD) having a rechargeable WEPD battery and a wireless connection to the internet. The GM, the SBP, and the WEPD are electrically coupled to allow power transfer between the GM, the SBP, and the WEPD. The GM and the WEPD are communicatively coupled to allow for data transfer between the GM and the WEPD. The GM and SBP are detachable from and reattachable to the WEPD to form the portable combination. Lastly the combination has means for managing battery operations of the combination. These means are effective to cause the GM to draw operating power first from the SBP, second from the WEPD battery, and third from the GM battery, if the GM battery is present.
摘要翻译：用于测量样品中的葡萄糖浓度值的便携式组合具有便携式葡萄糖计（GM），其具有用于接收一次性电化学测试条的测试条端口，用于计算施加到接收到的测试条的样品中的葡萄糖浓度值的装置测试条端口，以及可选的可充电GM电池。接下来，该组合具有便携式可充电补充电池组（SBP）。该组合还具有具有可充电WEPD电池的web启用便携式设备（WEPD）和到因特网的无线连接。 GM，SBP和WEPD电耦合，以允许GM，SBP和WEPD之间的电力传输。 GM和WEPD通信耦合，以允许GM和WEPD之间的数据传输。 GM和SBP可以从WEPD拆卸并重新连接，形成便携式组合。最后，该组合具有用于管理组合的电池操作的手段。如果GM电池存在，这些手段有效地使GM从SBP开始，第二次从WEPD电池中抽取工作电力，第三次从GM电池中抽出第三个。

3. 发明申请

WO2009049015A9 IDENTIFICATION METHOD FOR ELECTROCHEMICAL TEST STRIPS 审中-公开
标题翻译：电化学试验片的鉴定方法
公开(公告)号：WO2009049015A9
公开(公告)日：2009-10-01
申请号：PCT/US2008079294
申请日：2008-10-09
申请人： AGAMATRIX INC , BOITEAU CHARLES , FOREST MARTIN , IYENGAR SRIDHAR , WEI BAOGUO
发明人： BOITEAU CHARLES , FOREST MARTIN , IYENGAR SRIDHAR , WEI BAOGUO
IPC分类号： G01N27/26 , C12M1/34 , C12Q1/00
CPC分类号： G01N27/307 , G01N33/48771
摘要： The present invention provides a method and apparatus for creating test strips that may be identified based on differences in electrical conduction or resistance between contact point on the test strip. This is achieved by creating a base test strip with contact points that may be connected to other contact points by an electrical connection. These base test strips may be modified to create a difference in electrical conductivity between contact points, or a contact point may be eliminated. This modification can be used to distinguish different types of test strips based on electrical signature. Additionally, the base test strip may be created such that multiple modifications are possible to distinguish numerous characteristics of test strips.
摘要翻译：本发明提供了一种用于产生测试条的方法和装置，所述测试条可以基于测试条上的接触点之间的电传导或电阻的差异来识别。这可以通过创建带有接触点的基座测试条来实现，该接触点可以通过电气连接与其他接触点连接。这些基础测试条可以被修改以产生接触点之间的电导率差异，或者可以消除接触点。此修改可用于根据电子签名来区分不同类型的测试条。另外，可以创建基础测试条，使得可以进行多种修改以区分测试条的许多特征。

4. 发明申请

WO2009015292A1 ELECTROCHEMICAL TEST STRIPS 审中-公开
标题翻译：电化学测试条
公开(公告)号：WO2009015292A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071075
申请日：2008-07-24
申请人： AGAMATRIX, INC. , IYENGAR, Sridhar
发明人： IYENGAR, Sridhar
IPC分类号： G01N27/327 , G01N27/26 , C12M1/34
CPC分类号： G01N27/3272
摘要： An easily manufactured electrochemical test strip is made with facing electrode but side by side connectors for insertion into an electrochemical test meter. Current is conducted from the electrode on one layer to a connector on the other by a conductive layer disposed adjacent the end of a spacer layer, or by displacing the layer to bring a conductive surface on it into contact with the connector.
摘要翻译：制造易于制造的电化学测试条，其具有面对电极但并排连接器用于插入电化学测试仪。电流从一层的电极通过邻近隔离层的端部设置的导电层传导到另一层上，或通过移动该层以使其上的导电表面与连接器接触。

5. 发明申请

WO2008057754A1 LANCET CARTRIDGES AND LANCING DEVICES 审中-公开
标题翻译： LANCET CARTRIDGES和LANCING DEVICES
公开(公告)号：WO2008057754A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/082220
申请日：2007-10-23
申请人： AGAMATRIX, INC. , IYENGAR, Sridhar G. , BERKOVITCH, Frederick , BOOZER, Brad , FLAHERTY, Joseph , GOLNIK, Timothy , KILPINEN, Malia , VU, Sonny
发明人： IYENGAR, Sridhar G. , BERKOVITCH, Frederick , BOOZER, Brad , FLAHERTY, Joseph , GOLNIK, Timothy , KILPINEN, Malia , VU, Sonny
IPC分类号： A61B5/15
CPC分类号： A61B5/15163 , A61B5/150022 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15146 , A61B5/15151 , A61B5/15161
摘要： A lancet cartridge has a U-shaped support with a pair of anchor portions, a base portion, and a pair of deformable leg portions connecting the anchor portions to the base portion. The pair of deformable leg portions change shape from an initial shape to an extended shape in response to an external applied force and recover to a retracted shape upon removal of the force. The lancet cartridge also has a lancet having a tip end, an opposing base end, and an axis extending between the tip end and the base end. A portion of the lancet is disposed between the pair of deformable leg portions of the U-shaped support. The lancet is movable between a starting position, an extended puncturing position, and an ending position along the axis of the lancet in a path defined by the U-shaped support. When the lancet is in the starting position, the tip end of the lancet is disposed at least partially through the base portion of the U-shaped support, and the U-shaped support is in the initial shape. When the lancet is in the extended puncturing position, the tip end of the lancet is extended through the base of the U-shaped support, and the U-shaped support is in the extended shape. When the U-shaped support recovers to its retracted shape upon removal of the force, the lancet is retracted to the end position.
摘要翻译：柳叶刀盒具有U形支撑件，其具有一对锚固部分，基部部分和将锚固部分连接到基部部分的一对可变形腿部。一对可变形的腿部部分响应于外部施加的力将形状从初始形状改变为延伸形状，并且在去除力时恢复到缩回形状。柳叶刀盒还具有具有尖端，相对的基端以及在顶端和基端之间延伸的轴线的刺血针。柳叶刀的一部分设置在U形支撑件的一对可变形腿部之间。柳叶刀可以在由U形支撑件限定的路径中沿着柳叶刀的轴线在起始位置，延伸穿刺位置和终止位置之间移动。当柳叶刀处于起始位置时，柳叶刀的前端至少部分地配置在U形支撑体的基部上，U形支撑体处于初始形状。当柳叶刀处于延伸穿刺位置时，柳叶刀的前端延伸穿过U形支撑件的基部，并且U形支撑件处于延伸形状。当U形支撑件在移除力时恢复到其缩回形状时，柳叶刀缩回到最终位置。

6. 发明申请

WO2008007277A2 DETECTION OF ANALYTES IN A DUAL-MEDIATOR ELECTROCHEMICAL TEST STRIP 审中-公开
标题翻译：双中介电化学测试仪中分析仪的检测
公开(公告)号：WO2008007277A2
公开(公告)日：2008-01-17
申请号：PCT/IB2007/052474
申请日：2007-06-26
申请人： AGAMATRIX, INC. , HARDING, Ian , IYENGAR, Sridhar G.
发明人： HARDING, Ian , IYENGAR, Sridhar G.
CPC分类号： C12Q1/004 , C12Q1/006 , G01N27/3271
摘要： Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer electrons between the enzyme and the electrodes. The first electron transfer agent is a mediator that interacts with the enzyme after it has acted on the analyte to regenerate enzyme in its active form. The second electron transfer agent is a shuttle that interacts with the electrodes and optionally the mediator. The oxidation and reduction of the shuttle serves as the major source of current that is measured as an indication of analyte.
摘要翻译：使用多个电子转移试剂（例如两个电子转移试剂）来测定样品中的分析物如葡萄糖，其共同作用以在酶和电极之间传递电子。第一个电子转移剂是一种介质，它在酶作用于分析物以使其活性形式再生之后与酶相互作用。第二电子转移剂是与电极和任选的介体相互作用的穿梭体。梭子的氧化和还原作为主要的电流来源，被测量为分析物的指示。

7. 发明申请

WO2007116367A2 LANCING DEVICE 审中-公开
标题翻译： LANCING设备
公开(公告)号：WO2007116367A2
公开(公告)日：2007-10-18
申请号：PCT/IB2007/051260
申请日：2007-04-10
申请人： AGAMATRIX, INC , FLAHERTY, Joseph , GOLNIK, Timothy , BOOZER, Brad
发明人： FLAHERTY, Joseph , GOLNIK, Timothy , BOOZER, Brad
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15111 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/157
摘要： A lancing device is used with a lancet for lancing body tissue to result in a wound for bleeding. The lancing device has a cantilevered priming arm having a first arm portion that is generally parallel to an internal channel of the device and a second arm portion that is generally perpendicular to the internal channel. The second arm portion is connected to a lancet carrier and movement of the first arm portion toward the internal channel draws the lancet carrier to a primed position and stores energy in a lancet driver.
摘要翻译：刺血装置与刺血针一起用于刺激身体组织以导致出血伤口。柳叶刀切开装置具有悬臂的起动臂，该起动臂具有大致平行于装置的内部通道的第一臂部分和大致垂直于内部通道的第二臂部分。第二臂部分连接到刺血针载体并且第一臂部分朝向内部通道的运动将刺血针载体牵拉到启动位置并将能量存储在刺血针驱动器中。

8. 发明申请

WO2006109278A3 METHOD FOR DETERMINATION OF ANALYTE CONCENTRATIONS AND RELATED APPARATUS 审中-公开
标题翻译：用于确定分析浓度和相关装置的方法
公开(公告)号：WO2006109278A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006051181
申请日：2006-04-15
申请人： AGAMATRIX INC , DIAMOND STEVEN , HARDING IAN , IYENGAR SRIDHAR , WEI BAOGUO
发明人： DIAMOND STEVEN , HARDING IAN , IYENGAR SRIDHAR , WEI BAOGUO
IPC分类号： G01N27/49 , C12Q1/00
CPC分类号： G01N27/4166 , C12Q1/006 , G01N27/307 , G01N27/3272 , G01N27/3273 , G01N27/4161 , G01N33/48707
摘要： A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the current peak-time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.
摘要翻译：提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时在高原地区。动态确定进行测量的当前峰值时间允许每个条带在最短的适当时间范围内运行，从而避免使用可能长于某些条带所需的平均测量时间，而对于其他条带来说太短。

9. 发明申请

WO2005114159A1 ELECTROCHEMICAL CELL AND METHOD OF MAKING AN ELECTROCHEMICAL CELL 审中-公开
标题翻译：电化学细胞和制备电化学细胞的方法
公开(公告)号：WO2005114159A1
公开(公告)日：2005-12-01
申请号：PCT/IB2005/051657
申请日：2005-05-20
申请人： AGAMATRIX Inc. , HARDING, Ian , IYENGAR, Sridhar G , LARSON, Marina, T , OPPEDAHL, Carl
发明人： HARDING, Ian , IYENGAR, Sridhar G , LARSON, Marina, T , OPPEDAHL, Carl
IPC分类号： G01N27/30
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/30 , G01N27/3272 , Y10T29/49002 , Y10T29/49114 , Y10T29/49117 , Y10T156/1052 , Y10T156/1062 , Y10T156/1074
摘要： Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.
摘要翻译：通过将具有结合开口的电阻片粘附到第一导电片上，精确地和精确地制造电化学测试电池。然后通过电阻片和第一导电片冲切开切口。开槽开口与电阻薄片中的第一个开口相交，并将第一个结合开口转变成电阻薄片中的凹口。第二导电片被冲压成具有对应于第一导电片的开口开口，并且这被粘接到电阻片的另一侧，使得开槽开口对准。这种结构从周围的材料上被切割成一个电化学电池，该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。

10. 发明专利

ES2581779T3 Método para ensayo de propiedades electroquímicas 未知
公开(公告)号：ES2581779T3
公开(公告)日：2016-09-07
申请号：ES03739729
申请日：2003-02-10
申请人： AGAMATRIX INC , IYENGAR SRIDHAR G , HARDING IAN S
发明人： IYENGAR SRIDHAR , HARDING IAN
IPC分类号： G01N27/327 , G01N33/483 , G01N27/22 , G01N27/26 , G01N27/333 , G01N27/416 , G01N27/48 , G01N27/49
摘要： Un método para determinar un área efectiva de electrodo y/o un grado de suciedad de electrodo en un sistema electroquímico que contiene una muestra, en el que el sistema electroquímico incluye un electrodo que tiene una superficie, en el que la superficie incluye una porción de contacto y una porción de no contacto, en el que la porción de contacto del electrodo se encuentra en contacto electrolítico con la muestra, y la porción de no contacto del electrodo no se encuentra en contacto con la muestra, caracterizado por que el método comprende las etapas de aplicar un estímulo de potencial variable con el tiempo de alta frecuencia de pequeña amplitud al sistema para generar una respuesta de señal a partir de la muestra que tiene una relación aproximadamente lineal con el potencial aplicado, medir la respuesta de señal, computar una información de capacidad a partir de la respuesta de señal a partir de la muestra que se puede aproximar por una relación lineal con el potencial aplicado, y determinar un valor indicativo de un área efectiva de electrodo y/o un grado de suciedad de electrodo a partir de la información de capacidad.

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