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1. 发明专利

JP2010099041A Recombinant measles virus useful as bivalent vaccine for measles and malaria infection 审中-公开
标题翻译：用作测量和疟疾感染的双重疫苗的重组测量病毒
公开(公告)号：JP2010099041A
公开(公告)日：2010-05-06
申请号：JP2008275477
申请日：2008-10-27
申请人： Arigen Pharmaceuticals Inc , アリジェン製薬株式会社
发明人： KAI CHIEKO , YONEDA MISAKO
IPC分类号： C12N15/09 , A61K35/76 , A61K39/002 , A61K39/165 , A61K39/295 , A61P31/14 , A61P33/06 , C07K16/10 , C12N7/02
CPC分类号： Y02A50/412
摘要： PROBLEM TO BE SOLVED: To provide a vaccine safe and effective against malaria infections, and a vector used for producing the vaccine, and to further provide a bivalent vaccine exhibiting excellent protective effects on measles virus and the malaria infections, and eliminating complicatedness during inoculation.
SOLUTION: A recombinant measles virus in which a gene encoding a protein associated with onset protection against the malaria infections is inserted into a measles virus genome is provided. The protein associated with the onset protection against the malaria infections is preferably selected from among pfEMP-1, MAEBL, AMA-1, MSP-1, LSA-1, Pfs230 etc. Furthermore, there is provided the bivalent vaccine for the measles and malaria infections containing the recombinant measles virus, and even an antiserum obtained from a body fluid collected from an animal infected with the recombinant measles virus. In addition, there is provided a method for producing the vaccine for the malaria infections including using the measles virus as the vaccine vector in producing the vaccine for the malaria infections.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种安全有效地抵抗疟疾感染的疫苗，以及用于生产疫苗的载体，并进一步提供对麻疹病毒和疟疾感染具有优异保护作用的二价疫苗，并消除复杂性在接种期间。解决方案：提供重组麻疹病毒，其中将编码与抗疟疾感染的起始保护相关的蛋白质的基因插入麻疹病毒基因组中。与抗疟疾感染的发作保护相关的蛋白质优选选自pfEMP-1，MAEBL，AMA-1，MSP-1，LSA-1，Pfs230等。此外，还提供了用于麻疹和疟疾的二价疫苗含有重组麻疹病毒的感染，甚至是从用重组麻疹病毒感染的动物收集的体液获得的抗血清。此外，提供了一种用于生产疟疾感染疫苗的方法，包括在生产用于疟疾感染的疫苗中使用麻疹病毒作为疫苗载体。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010115154A Recombinant measles virus useful as bivalent vaccine against measles and nipah virus infectious disease 审中-公开
标题翻译：重组测量病毒有效作为双重疫苗对抗和尼泊尔病毒感染性疾病
公开(公告)号：JP2010115154A
公开(公告)日：2010-05-27
申请号：JP2008290964
申请日：2008-11-13
申请人： Arigen Pharmaceuticals Inc , アリジェン製薬株式会社
发明人： KAI CHIEKO , YONEDA MISAKO
IPC分类号： C12N15/09 , A61K39/155 , A61K39/295 , A61P31/12 , C12N7/00
摘要： PROBLEM TO BE SOLVED: To provide a vaccine safe and effective against nipah virus infectious diseases, and to provide a vector used for producing such a vaccine, further, to provide a bivalent vaccine exhibiting excellent prophylactic effects on measles and nipah virus infectious diseases and eliminated in troublesomeness in its inoculation as well.
SOLUTION: Such a recombinant measles virus that a measles virus genom is transferred with a gene encoding a protein involved in the onset prophylaxis of nipah virus infectious diseases is provided; wherein the protein is preferably a G-protein or F-protein as a membrane protein. Further, the bivalent vaccine against measles and nipah virus infectious diseases, including the recombinant measles virus, and an antiserum obtained from a body fluid taken from an animal infected with the recombinant measles virus, are also provided. Besides, in a production of a vaccine against nipah virus infectious diseases a method for producing the vaccine against nipah virus infections diseases using measles virus as a vaccine vector is provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供对尼泊尔病毒感染性疾病的安全和有效的疫苗，并且提供用于生产这种疫苗的载体，此外，提供对麻疹和尼帕病毒感染具有优异预防效果的二价疫苗疾病也因其接种麻烦而消除。解决方案：提供麻疹病毒基因组与编码参与预防尼克病毒感染性疾病的蛋白质的基因转移的重组麻疹病毒; 其中所述蛋白质优选为作为膜蛋白质的G蛋白或F蛋白质。此外，还提供了针对麻疹和尼帕病毒感染性疾病的二价疫苗，包括重组麻疹病毒，以及从感染重组麻疹病毒的动物取得的体液获得的抗血清。另外，在针对尼泊尔病毒感染性疾病的疫苗的生产中，提供了使用麻疹病毒作为疫苗载体产生针对尼泊尔病毒感染疾病的疫苗的方法。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2012097060A Novel dihydroxybenzene derivative and antiprotozoal agent comprising the same as active ingredient 审中-公开
标题翻译：新型二羟基苯甲醛衍生物和抗真菌药物，包括其主动成分
公开(公告)号：JP2012097060A
公开(公告)日：2012-05-24
申请号：JP2010258343
申请日：2010-11-01
申请人： Arigen Pharmaceuticals Inc , Tottori Univ , アリジェン製薬株式会社 , 国立大学法人鳥取大学
发明人： SAIMOTO HIROYUKI , KITA KIYOSHI , YABU YOSHISADA , YAMAMOTO MASAKAZU
IPC分类号： C07C69/73 , A61K31/11 , A61K31/12 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/235 , A61K31/277 , A61K31/336 , A61K31/341 , A61K31/351 , A61K31/357 , A61P33/00 , C07C47/56 , C07C49/86 , C07C59/74 , C07C69/527 , C07C255/55 , C07D303/14 , C07D307/20 , C07D307/32 , C07D309/12 , C07D317/36
CPC分类号： C07C255/53 , A61K31/047 , A61K45/06 , C07C47/27 , C07C47/56 , C07C47/575 , C07C49/248 , C07C49/258 , C07C49/835 , C07C49/84 , C07C59/74 , C07C59/90 , C07C69/738 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a novel compound for preventing or treating diseases caused by protozoans.SOLUTION: A compound represented by formula (I), optical isomers of the compound, and one or more kinds of pharmaceutically acceptable salts of the compound are used. In formula (I), X represents a hydrogen atom or a halogen atom; Rrepresents a hydrogen atom; Rrepresents a hydrogen atom or a 1-7C alkyl group; Rrepresents -CHO, -C(=O)R, -COOR(where Rrepresents a 1-7C alkyl group), -CHOH or -COOH; and Rrepresents a 1-16C alkyl group having various substituents on a terminal carbon atom and/or a non-terminal carbon atom, a 2-16C alkenyl group having various substituents on a terminal carbon atom and/or a non-terminal carbon atom, or a 2-16C alkynyl group having various substituents on a terminal carbon atom and/or a non-terminal carbon atom.
摘要翻译：要解决的问题：提供用于预防或治疗由原生动物引起的疾病的新型化合物。解决方案：使用由式（I）表示的化合物，该化合物的光学异构体和化合物的一种或多种药学上可接受的盐。在式（I）中，X表示氢原子或卤素原子; R 1 表示氢原子; R 2 表示氢原子或1-7C烷基; R 3 表示-CHO，-C（= O）R 5 ，-COOR 5 （其中R 5 表示1-7C烷基），-CH 4 表示在末端碳原子和/或非末端碳原子上具有各种取代基的1-16C烷基，具有各种取代基的2-16个烯基末端碳原子和/或非末端碳原子，或在末端碳原子和/或非末端碳原子上具有各种取代基的2-16C炔基。版权所有（C）2012，JPO＆INPIT

4. 发明专利

BRPI0713080A2 未知
公开(公告)号：BRPI0713080A2
公开(公告)日：2012-10-09
申请号：BRPI0713080
申请日：2007-06-28
申请人： ARIGEN PHARMACEUTICALS INC
发明人： NAKAJIMA HIDROFUMI , MACHIDA HARUHIKO
IPC分类号： A61K38/00 , A61K9/08 , A61K47/04 , A61K47/26 , A61K47/40 , A61P31/04
摘要： A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A 2 , as an active ingredient, which is stable and contains WAP-8294A 2 in high concentrations is provided. This composition comprises WAP-8294A 2 of the following structural formula (1) as an active ingredient and is characterized in that 2-hydroxypropyl-²-cyclodextrin or ²-cyclodextrin is contained as a stabilizer or solubilizer and the pH of the composition is not adjusted. This composition is mixed with a pH-adjusting agent such as dextrose and with an infusion or diluent comprising a solution of disodium hydrogen phosphate, sodium dihydrogen phosphate, and sodium hydroxide at the time of use to prepare a solution for intravenous administration of WAP-8294A 2 .

5. 发明专利

DK2103608T3 HELICOBACTER PYLORI ERADIKERENDE MIDDEL MED INHIBERENDE VIRKNING PÅ MAVESYRESEKRETION 未知
公开(公告)号：DK2103608T3
公开(公告)日：2012-09-17
申请号：DK07849849
申请日：2007-12-18
申请人： ARIGEN PHARMACEUTICALS INC
发明人： ITO MASAHARU , YAMAMOTO MASAICHI
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/00 , A61P1/04 , A61P1/18 , A61P31/04

6. 发明专利

PT2003130E NOVO DERIVADO DE PIRIDINA POSSUINDO ACTIVIDADE ANTI-HELICOBACTER PYLORI 未知
公开(公告)号：PT2003130E
公开(公告)日：2012-01-10
申请号：PT07715278
申请日：2007-03-07
申请人： ARIGEN PHARMACEUTICALS INC
发明人： ITO MASAHARU , YAMAMOTO MASAICHI
IPC分类号： C07D401/12 , A61K31/4439 , A61K45/00 , A61K47/36 , A61P1/04 , A61P1/18 , A61P31/04 , A61P35/00 , A61P43/00

7. 发明专利

CA2671949C HELICOBACTER PYLORI ERADICATING AGENT HAVING INHIBITORY ACTIVITY ON GASTRIC ACID SECRETION 未知
公开(公告)号：CA2671949C
公开(公告)日：2011-11-01
申请号：CA2671949
申请日：2007-12-18
申请人： ARIGEN PHARMACEUTICALS INC
发明人： ITO MASAHARU , YAMAMOTO MASAICHI
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/00 , A61P1/04 , A61P1/18 , A61P31/04
摘要： Disclosed are: a compound which is stable in an acid, has an antibacterial effect against a bacterium Helicobacter pylori, can exert a satisfactory level of an antibacterial effect when used singly, does not affect an enteric bacterium, has an antibacterial effect against a bacterium resistant to an antibacterial agent, and has an inhibitory effect on gastric acid secretion; and a pharmaceutical composition comprising the compound. Specifically disclosed are: a compound represented by the general formula (I) or a salt thereof; and a pharmaceutical composition comprising the compound or the salt thereof: (see formula I) wherein R represents a linear alkyl group having 4 to 8 carbon atoms, preferably 5 to 7 carbon atoms.

8. 发明专利

MX2011010663A DERIVADO DE PIRIDINA-TIO, Y COMPOSICION FARMACEUTICA QUE CONTIENE EL MISMO Y TIENE ACCION ANTI-HELICOBACTER PYLORI. 未知
公开(公告)号：MX2011010663A
公开(公告)日：2011-10-28
申请号：MX2011010663
申请日：2010-04-08
申请人： ARIGEN PHARMACEUTICALS INC
发明人： ITO MASAHARU , YAMAMOTO MASAICHI , TSUJII MASAHIKO , HAMAZAKI MITSUNORI
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/04 , A61P31/04 , A61P35/00
摘要： Se describen un derivado novedoso de piridina-tio y una composición farmacéutica que utiliza el derivado novedoso de piridina-tio, particularmente una composición que tiene actividad selectiva antibacteriana contra Helicobacter pylori. Específicamente se describe un derivado de piridina-tio representado por la fórmula general (I), (en donde R1 y R2 cada uno representa un átomo de hidrógeno, un grupo alquilo de 1 a 8 átomos de carbono, o similares; R3 y R4 cada uno representa un átomo de hidrógeno, un grupo alquilo de 1 a 8 átomos de carbono, o similares; X representa -O-. -S-, o similares; Y representa un grupo alquilo de 1 a 12 átomos de carbono, el cual puede estar substituido por un substituyente o -(R5-O)n-R6 (en donde R5 representa un grupo alquilo de 1 a 5 átomos de carbono; R6 representa un grupo alquilo de 1 a 8 átomos de carbono, el cual puede estar substituido por un substituyente, y n representa un entero de 1-10); y Z representa un átomo de hidrógeno o similares), o una sal farmacológicamente aceptable del mismo. También específicamente se describe una composición farmacéutica que contiene el derivado de piridina-tio o una sal del mismo.

9. 发明专利

MX2009006638A AGENTE PARA ERRADICAR HELICOBACTER PYLORI QUE TIENE ACTIVIDAD INHIBIDORA SOBRE LA SECRECION DE ACIDO GASTRICO. 未知
公开(公告)号：MX2009006638A
公开(公告)日：2009-07-02
申请号：MX2009006638
申请日：2007-12-18
申请人： ARIGEN PHARMACEUTICALS INC
发明人： ITO MASAHARU , YAMAMOTO MASAICHI
IPC分类号： A61K31/4439 , C07D401/12 , A61P1/00 , A61P1/04 , A61P1/18 , A61P31/04
摘要： Se describe: un compuesto que es estable en un ácido, tiene un efecto antibacteriano contra una bacteria Helicobacter py!ori, puede ejercer un nivel satisfactorio de un efecto antibacteriano cuando se usa solo, no afecta una bacteria entérica, tiene un efecto antibacteriano contra una bacteria resistente a un agente antibacteriano, y tiene un efecto inhibidor sobre la secreción de ácido gástrico; y una composición farmacéutica que contiene el compuesto. Se describe específicamente: un compuesto representado por la fórmula general (I) o una sal de él; y una composición farmacéutica que contiene el compuesto (I) o la sal de él, caracterizado además porque R representa un grupo alquilo lineal que tiene de 4 a 8 átomos de carbono, preferiblemente de 5 a 7 átomos de carbono.

10. 发明专利

AT426587T 未知
公开(公告)号：AT426587T
公开(公告)日：2009-04-15
申请号：AT04792559
申请日：2004-10-18
申请人： ARIGEN PHARMACEUTICALS INC
发明人： SAIMOTO HIROYUKI , SHIGEMASA YOSHIHIRO , KITA KIYOSHI , YABU YOSHISADA , HOSOKAWA TOMOYOSHI , YAMAMOTO MASAICHI
IPC分类号： C07C47/565 , A61K31/11 , A61K31/12 , A61K31/235 , A61K31/341 , A61K47/10 , C07C47/56 , C07C47/575 , C07C65/01 , C07C69/84 , C07D307/32
摘要： A compound represented by formula (I): [wherein, for example, X is a hydrogen atom or a halogen atom; R 1 is a hydrogen atom; R 2 is a hydrogen atom or a C 1-4 alkyl group; R 3 is -CHO or -COOH; and R 4 is -CH=CH-(CH 2 ) p -CH 3 (wherein p is an integer of 1 to 12), -CH(OH)-(CH 2 ) q -CH 3 (wherein q is an integer of 1 to 13), -CH(OH)-CH 2 -CH(CH 3 )-(CH 2 ) 2 -CH=C(CH 3 ) 2 , -CH=CH-CH(CH 3 )-(CH 2 ) 3- CH(CH 3 ) 2 , -(CH 2 ) 2 -CH(CH 3 )-(CH 2 ) 3 -CH(CH 3 ) 2 or -(CH 2 ) 8 -CH 3 ], an optical isomer thereof and a pharmaceutically acceptable salt thereof. These compounds have antitrypanosoma activity, and accordingly are useful as drugs for preventing or treating the diseases caused by trypanosoma.

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