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1. 发明申请

WO2007011216A3 BIFUNCTIONAL PROTEIN ANCHORS 审中-公开
标题翻译：双功能蛋白锚
公开(公告)号：WO2007011216A3
公开(公告)日：2007-03-08
申请号：PCT/NL2006000382
申请日：2006-07-20
申请人： APPLIED NANOSYSTEMS BV , LEENHOUTS CORNELIS JOHANNES , VAN ROSMALEN MAARTEN LEONARDUS , BOSMA TJIBBE
发明人： LEENHOUTS CORNELIS JOHANNES , VAN ROSMALEN MAARTEN LEONARDUS , BOSMA TJIBBE
IPC分类号： C07K14/335 , A61K39/385 , A61K39/39 , A61P31/00 , A61P33/00 , A61P35/00 , A61P37/00
CPC分类号： A61K47/48369 , A61K39/385 , A61K47/68 , A61K2039/541 , A61K2039/55555 , A61K2039/6056 , A61K2039/6068 , A61K2039/622 , C07K14/335 , C07K16/18 , C07K2319/70 , C07K2319/705
摘要： The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
摘要翻译：本发明涉及免疫学和疫苗递送领域。更具体地说，本发明涉及具有内在免疫刺激性质的细菌疫苗递送技术，其允许固定目标抗原，而无需先前的抗原修饰。提供了一种抗原负载的免疫原性载体复合物，其包含连接至免疫原性载体的至少一种双功能多肽，所述双功能多肽包含肽聚糖结合结构域（PBD），多肽与所述载体连接，融合至抗原结合域（ABD ），至少一种感兴趣的抗原被结合到其上。还提供了包含本发明的抗原负载的免疫原性载体复合物的药物（例如疫苗）组合物。

2. 发明申请

WO2005068087A2 METHOD FOR COATING AN OBJECT WITH HYDROPHOBIN AT LOW TEMPERATURES 审中-公开
标题翻译：在低温下用嗜水气溶蛋白涂覆物体的方法
公开(公告)号：WO2005068087A2
公开(公告)日：2005-07-28
申请号：PCT/NL2005000022
申请日：2005-01-14
申请人： APPLIED NANOSYSTEMS BV , RINK RICK , SCHOLTMEIJER KARIN
发明人： RINK RICK , SCHOLTMEIJER KARIN
IPC分类号： B05D3/10 , B05D5/00 , B05D5/04 , B05D5/08 , B05D7/00 , C07K4/04 , C07K4/06 , C07K17/00 , C08J7/04 , C09D5/00 , C09D7/12
CPC分类号： B05D7/00 , B05D5/00 , B05D5/04 , B05D5/08 , C07K17/00 , C08J7/047 , C08J2327/18 , C08J2489/00 , C08K5/09 , C09D5/00 , C09D7/63
摘要： The invention relates to methods for coating objects with hydrophobins. Provided is a method for providing the surface of an object with a hydrophobin coating, comprising contacting at least a part of an object with a hydrophobin-containing solution to form a hydrophobin layer on the surface of said object and exposing said layer to a pH below 7, preferably below 4, more preferably below 2, optionally in the presence of a detergent. Said contacting can be performed at around room temperature and said hydrophobin-containing solution can be a supernatant of a culture medium of an organism that secretes a hydrophobin.
摘要翻译：本发明涉及用疏水蛋白涂覆物体的方法。提供了一种为物体表面提供疏水蛋白涂层的方法，包括使物体的至少一部分与含疏水蛋白的溶液接触以在所述物体的表面上形成疏水蛋白层，并将所述层暴露于低于pH 7，优选低于4，更优选低于2，任选在洗涤剂存在下。所述接触可以在大约室温下进行，并且所述含有疏水蛋白的溶液可以是分泌疏水蛋白的生物体的培养基的上清液。

3. 发明申请

WO0157066A3 METHOD OF STABILIZING A HYDROPHOBIN-CONTAINING SOLUTION AND A METHOD OF COATING A SURFACE WITH A HYDROPHOBIN 审中-公开
标题翻译：含有含氢化氢的溶液的稳定化方法以及用HYDROPHOBIN涂布表面的方法
公开(公告)号：WO0157066A3
公开(公告)日：2002-03-14
申请号：PCT/NL0100082
申请日：2001-02-02
申请人： APPLIED NANOSYSTEMS BV , VOCHT MARCEL LEO DE , WOESTEN HERMAN ABEL BERNARD , WESSELS JOSEPH GERARD HUBERT , ROBILLARD GEORGE THOMAS
发明人： DE VOCHT MARCEL LEO , WOESTEN HERMAN ABEL BERNARD , WESSELS JOSEPH GERARD HUBERT , ROBILLARD GEORGE THOMAS
IPC分类号： C07K1/14 , C07K1/113 , C07K2/00 , C07K14/375
CPC分类号： C07K2/00 , C07K1/1136
摘要： The invention relates to a method of stabilizing a hydrophobin-containing solution. According to the present invention, the hydrophobin is subjected to a treatment with a disulphide bridge-cleaving agent to yield unfolded hydrophobin, said treatment involving the prevention of the formation of disulphide bridges from cleaved disulphide bridges. The invention also relates to a method for coating a surface with a stabilized hydrophobin according to the present invention.
摘要翻译：本发明涉及稳定含疏水蛋白的溶液的方法。根据本发明，将疏水蛋白用二硫键切割剂进行处理以产生未折叠的疏水蛋白，所述处理涉及防止从裂解的二硫桥形成二硫键。本发明还涉及根据本发明用稳定的疏水蛋白涂覆表面的方法。

4. 发明申请

WO2006062398A3 METHODS FOR THE PRODUCTION AND SECRETION OF MODIFIED PEPTIDES 审中-公开
标题翻译：改性肽的生产和分泌方法
公开(公告)号：WO2006062398A3
公开(公告)日：2006-10-19
申请号：PCT/NL2005000842
申请日：2005-12-07
申请人： APPLIED NANOSYSTEMS BV , MOLL GERT NIKOLAAS , KUIPERS ANNEKE , RINK RICK , DRIESSEN ARNOLD JACOB MATHIEU , KUIPERS OSCAR PAUL
发明人： MOLL GERT NIKOLAAS , KUIPERS ANNEKE , RINK RICK , DRIESSEN ARNOLD JACOB MATHIEU , KUIPERS OSCAR PAUL
IPC分类号： C12N15/62 , C12P21/02
CPC分类号： C12N15/625
摘要： The invention relates to the production of heterologous polypeptides in a recombinant host cell. More specifically, it relates to the production and secretion of peptides, such as biologically active peptides, that are modified by one or more lantibiotic-synthesizing enzymes. Provided is a nucleic acid construct encoding a polypeptide comprising 1) a non-lantibiotic export signal that is recognized by a non-lantibiotic export system; 2) a lantibiotic leader peptide that is recognized by at least a lantibiotic dehydratase such as LanB and, C-terminally of said export signal and said leader peptide, 3) a peptide of interest containing one or more serine or threonine residue(s) which can be posttranslationally dehydrated by said dehydratase. Also provided is a method for producing a polypeptide in a host cell, comprising providing a host cell with a nucleic acid construct according to the invention and allowing expression and secretion of the encoded polypeptide by said host cell, wherein said host cell comprises at least a dehydratase capable of modifying said encoded polypeptide and a non-lantibiotic export system capable of secreting said modified polypeptide.
摘要翻译：本发明涉及在重组宿主细胞中产生异源多肽。更具体地，本发明涉及由一种或多种羊毛硫素合成酶修饰的肽（例如生物活性肽）的产生和分泌。本发明提供了编码多肽的核酸构建体，其包括1）非耐药物生物出口信号，其被非拉丁生物出口系统识别; 2）由至少一种羊毛硫抗生素脱水酶（例如LanB）和所述出口信号和所述前导肽的C-末端识别的羊毛硫素前导肽，3）感兴趣的肽含有一个或多个丝氨酸或苏氨酸残基，其中可以通过所述脱水酶进行翻译后脱水。还提供了在宿主细胞中产生多肽的方法，其包括向宿主细胞提供根据本发明的核酸构建体，并允许所述宿主细胞表达和分泌编码的多肽，其中所述宿主细胞至少包含能够修饰所述编码的多肽的脱水酶和能够分泌所述修饰的多肽的非拉链菌素出口系统。

5. 发明申请

WO03097587A2 GELLING AGENTS 审中-公开
标题翻译：胶凝剂
公开(公告)号：WO03097587A2
公开(公告)日：2003-11-27
申请号：PCT/NL0300381
申请日：2003-05-22
申请人： APPLIED NANOSYSTEMS BV , VAN BOMMEL KJELD JACOBUS CORNE , VAN ESCH JOHANNES HENRICUS , DE LOOS MAAIKE , HEERES ANDRE , FERINGA BERNARD LUCAS
发明人： VAN BOMMEL KJELD JACOBUS CORNE , VAN ESCH JOHANNES HENRICUS , DE LOOS MAAIKE , HEERES ANDRE , FERINGA BERNARD LUCAS
IPC分类号： C09K3/00 , B01J20/291 , C07C229/08 , C07C229/36 , C07C233/63 , C07C233/83 , C07C233/87 , C07C237/20 , C07C237/22 , C07C271/22 , C07C275/26 , C07C275/40 , C07D213/40 , C07D233/54 , C07F5/02 , C07K5/06
CPC分类号： B01J20/291 , B01J20/22 , B01J20/281 , B01J2220/54 , C07C229/08 , C07C229/36 , C07C237/20 , C07C237/22 , C07C271/22
摘要： The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.
摘要翻译：本发明涉及一类新颖的胶凝剂，制备所述试剂的方法，所述试剂用于制备凝胶以及所得凝胶。根据本发明的胶凝剂或增稠剂包括通过酰胺或脲键与三个氨基酸衍生基团官能化的核心。它可用于使许多溶剂凝胶化或增稠。

6. 发明申请

WO2005051902A8 MODIFIED MSCL PROTEIN CHANNEL 审中-公开
标题翻译：修饰的MSCL蛋白质通道
公开(公告)号：WO2005051902A8
公开(公告)日：2005-08-11
申请号：PCT/NL2004000812
申请日：2004-11-25
申请人： APPLIED NANOSYSTEMS BV , KOCER ARMAGAN , WALKO MARTIN , ROBILLARD GEORGE THOMAS
发明人： KOCER ARMAGAN , WALKO MARTIN , ROBILLARD GEORGE THOMAS
IPC分类号： A61K9/127 , A61K47/48 , C07C381/04 , C07C381/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04
摘要： The invention relates to the field of drug delivery, in particular to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/ or localised release of therapeutic molecules (e.g. small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E.coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
摘要翻译：本发明涉及药物递送领域，具体涉及化学修饰用于药物递送载体中的蛋白质通道的化合物和方法，用于控制和/或局部释放治疗分子（例如小分子，肽，蛋白质或其他大分子）。提供了能够控制机械敏感通道的通道活性的pH和/或光响应性化合物，例如大肠杆菌的MscL通道蛋白或其功能等同物，以及使用这些化合物将机械敏感性通道蛋白进入pH和/或光响应通道。还提供了包含pH和/或光响应性通道蛋白的药物递送载体。

7. 发明申请

WO0238386B1 A PROCESS AND AN APPARATUS FOR THE FORMATION OF PATTERNS IN FILMS USING TEMPERATURE GRADIENTS 审中-公开
标题翻译：使用温度梯度在膜中形成图案的方法和设备
公开(公告)号：WO0238386B1
公开(公告)日：2002-09-06
申请号：PCT/EP0112944
申请日：2001-11-08
申请人： APPLIED NANOSYSTEMS BV , SCHAEFFER ERIK , STEINER ULLRICH
发明人： SCHAEFFER ERIK , STEINER ULLRICH
IPC分类号： B81C99/00 , B41C1/10 , B41M5/26 , B41M5/36 , B82B3/00 , G05D23/19 , H01L21/027
CPC分类号： B82Y30/00 , B41C1/1041 , B41M5/26 , B41M5/36 , G05D23/1935
摘要： The present invention relates to a process and an apparatus for producing patterns, particularly high-resolution patterns, in films which are exposed to temperature gradients. In particular, there is provided a process for producing lithographic structures by exposing at least one film on a substrate to a temperature gradient, the temperature gradient generating forces in the film which cause a mass transfer in the film to thereby produce a lithographic pattern.
摘要翻译：本发明涉及用于在暴露于温度梯度的膜中产生图案，特别是高分辨率图案的方法和设备。具体地说，提供了一种通过将至少一个基片暴露在温度梯度上来产生平版印刷结构的方法，该温度梯度在膜中产生使膜中的传质产生光刻图案的力。

8. 发明申请

WO02070463A8 GELLING AGENTS OR THICKENERS 审中-公开
标题翻译：胶凝剂或更厚的
公开(公告)号：WO02070463A8
公开(公告)日：2003-11-20
申请号：PCT/NL0200151
申请日：2002-03-06
申请人： APPLIED NANOSYSTEMS BV , VAN ESCH JOHANNES HENRICUS , HEERES ANDRE
发明人： VAN ESCH JOHANNES HENRICUS , HEERES ANDRE
IPC分类号： A23L29/288 , A61K8/02 , A61K8/04 , A61K8/42 , A61Q19/00 , C07C235/06 , C07C235/14
CPC分类号： A61K8/042 , A23L29/288 , A61K8/42 , A61Q19/00 , C07C235/06 , C07C235/14 , C07C2601/14 , C07C2601/20
摘要： The invention relates to novel class of gelling agents or thickeners, to a process for preparing said gelling agents or thickeners and to their use to prepare gels. The present gelling agents or thickeners have the form of a N,N'-disubstituted aldaramide or N,N'-disubstituted pentaramide.
摘要翻译：本发明涉及新型胶凝剂或增稠剂，涉及制备所述胶凝剂或增稠剂的方法及其用于制备凝胶的方法。本发明的胶凝剂或增稠剂具有N，N'-二取代的醛二酰胺或N，N'-二取代的五
胺的形式。

9. 发明申请

WO03000233A3 DELIVERY OF SMALL HYDROPHILIC MOLECULES PACKAGED INTO LIPID VESICLES 审中-公开
标题翻译：将小型水解分散体输送到脂肪体内
公开(公告)号：WO03000233A3
公开(公告)日：2003-10-16
申请号：PCT/NL0200412
申请日：2002-06-21
申请人： APPLIED NANOSYSTEMS BV , FRIESEN ROBERT HEINZ EDWARD , POOLMAN BEREND , FERINGA BERNARDM LUCAS , ENGBERTS JAN BERNARD FREDERIK
发明人： FRIESEN ROBERT HEINZ EDWARD , POOLMAN BEREND , FERINGA BERNARDM LUCAS , ENGBERTS JAN BERNARD FREDERIK
IPC分类号： A61K9/127
CPC分类号： A61K9/1271
摘要： Means and methods are provided for the generation and use of delivery vehicles for small molecules. In one aspect of the invention lipid vesicles comprising proteinaceous channel and said small molecules are generated. Said proteinaceous channel and/or said lipid vesicle are formulated such that said small molecule is released in the vicinity of a target cell. Said target cell may be present in vitro or in vivo.
摘要翻译：提供了用于生成和使用小分子递送载体的方法和方法。在本发明的一个方面，产生包含蛋白质通道和所述小分子的脂质囊泡。所述蛋白质通道和/或所述脂质囊泡配制成使得所述小分子在靶细胞附近释放。所述靶细胞可以在体外或体内存在。

10. 发明申请

WO2008018792A3 CYCLIC ANGIOTENSIN ANALOGS 审中-公开
标题翻译：循环血管紧张素类似物
公开(公告)号：WO2008018792A3
公开(公告)日：2008-04-03
申请号：PCT/NL2007050396
申请日：2007-08-07
申请人： APPLIED NANOSYSTEMS BV , STICHTING TECH WETENSCHAPP , HAAS MARIJKE , KLUSKENS LEONARDUS DOROTHEA , KUIPERS ANNEKE , RINK RICK , NELEMANS SIEGER ADRIAAN , MOLL GERT NIKOLAAS
发明人： HAAS MARIJKE , KLUSKENS LEONARDUS DOROTHEA , KUIPERS ANNEKE , RINK RICK , NELEMANS SIEGER ADRIAAN , MOLL GERT NIKOLAAS
IPC分类号： C07K7/14 , A61K38/08 , A61L31/16
CPC分类号： C07K7/14 , A61L31/16 , A61L2300/25
摘要： The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(l-8) agonistic or antagonistic activity and to cyclised Ang(l-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr 4 and Pro 7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.
摘要翻译：本发明涉及血管紧张肽类似物，特别是涉及具有Ang（1-8）激动或拮抗活性的环化类似物和具有激动或拮抗活性的环化Ang（1-7）类似物，并且与其线性对应物相比显示出改善的蛋白水解抗性。提供了一种环状血管紧张素肽类似物，其在对应于天然存在的血管紧张素中的Tyr 4和Pro 7的氨基酸之间包含硫醚 - 桥键。还提供了类似物在治疗中的用途，例如高血压。

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