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1. 发明申请

US20080032282A1 Methods and applications of molecular beacon imaging for infectious disease and cancer detection 审中-公开
标题翻译：用于感染性疾病和癌症检测的分子信标成像的方法和应用
公开(公告)号：US20080032282A1
公开(公告)日：2008-02-07
申请号：US11644400
申请日：2006-12-22
申请人： Augustine Lin , Pan-Chyr Yang , Cheng-Chung Chou
发明人： Augustine Lin , Pan-Chyr Yang , Cheng-Chung Chou
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a need for signal amplification. The disease marker includes a genetic sequence specific to a pathogen including a flu virus, a cancer cell marker, and a drug resistance-related genetic mutation marker for a drug resistant cancer and infectious pathogen. To detect a disease cell, a specimen containing one or more cells is obtained from a living subject, and fixed by an organic solvent. A molecular beacon is then added to the specimen, followed by staining nuclei of the cells in the specimen. The signal is detectable with a microscope, FACS scan, ELISA plate reader, Scanner, or any combinations thereof.
摘要翻译：用于检测用于诊断和药物基因组学的疾病标记物的感染和/或表达或突变的分子信标。分子信标能够与从活体受试者获得的样本中的疾病标记物的疾病相关的RNA或DNA杂交，从而发出可检测的信号，而不需要信号放大。疾病标记物包括对包括流感病毒，癌细胞标志物和药物抗性相关的耐药性癌症和感染性病原体的耐药相关基因突变标记的病原体特异性的遗传序列。为了检测疾病细胞，从活体受试者获得含有一种或多种细胞的样品，并通过有机溶剂固定。然后将分子信标添加到样品中，随后在样品中染色细胞核。该信号可用显微镜，FACS扫描，ELISA板读数器，扫描仪或其任何组合检测。

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