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1. 发明授权

US4914797A Axially centering apparatus for fusion-bonding optical fibers 失效
标题翻译：用于熔接光纤的轴向定心装置
公开(公告)号：US4914797A
公开(公告)日：1990-04-10
申请号：US114659
申请日：1987-10-23
申请人： Yoshio Tsuchida , Tomoki Takahashi , Shuji Kajitani
发明人： Yoshio Tsuchida , Tomoki Takahashi , Shuji Kajitani
IPC分类号： G02B6/255 , G02B6/38
CPC分类号： G02B6/2557 , G02B6/2551 , Y10S269/903 , Y10T29/53961
摘要： A pair of guides having long grooves on the upper surfaces thereof for engaging optical fibers, a pair of fulcra formed in parallel with the long grooves of the guides for supporting the guides, a pair of centering stands having substrates for supporting the fulcra, a pair of centering mechanisms having load imparting mechanism sections having telescopic output ends, load imparting mechanism sections, and transmitting mechanism sections for the adjusting mechanism sections so that the long grooves of said centering stands are disposed adjacent to each other to align in a rectilinear line. The centering mechanisms are associated with the centering stands to contact the output ends of the centering mechanisms with the guides of the centering stands.
摘要翻译：一对在其上表面具有用于接合光纤的长槽的引导件，与用于支撑引导件的引导件的长槽平行地形成的一对支点，一对具有用于支撑支架的基板的定心架，一对具有伸缩输出端的负载施加机构部分的定心机构，负载施加机构部分和用于调节机构部分的传动机构部分，使得所述定心架的长槽彼此相邻设置成直线对齐。定心机构与定心架相关联，使定心机构的输出端与定心架的导轨接触。

2. 发明授权

US5168617A Axially centering apparatus for fusion-bonding optical fibers 失效
公开(公告)号：US5168617A
公开(公告)日：1992-12-08
申请号：US688389
申请日：1991-04-22
申请人： Yoshio Tsuchida , Tomoki Takahashi , Shuji Kajitani
发明人： Yoshio Tsuchida , Tomoki Takahashi , Shuji Kajitani
IPC分类号： G02B6/255 , G02B6/38 , G02B21/06
CPC分类号： G02B6/2557 , G02B21/06 , G02B6/2551 , Y10T29/53961 , Y10T29/53978
摘要： An axially centering apparatus for fusion-bonding optical fibers comprising a pair of guides having long grooves on the upper surfaces thereof for engaging optical fibers, a pair of fulcra formed in parallel with the long grooves of the guides for supporting the guides, a pair of centering stands having substrates for supporting the fulcra, a pair of centering mechanisms having load imparting mechanism sections having telescopic output ends, load imparting mechanism sections, and transmitting mechanism sections for the adjusting mechanism sections so that the long grooves of said centering stands are disposed adjacent to each other to align in a rectilinear line, said centering mechanisms are associated with the centering stands to contact the output ends of the centering mechanisms with the guides of the centering stands, wherein said one centering stand satisfies the conditions that the fulcrum 3A and the long groove 4A are relatively positioned so that the crossing angle .alpha. (alpha) between a line segment AL.sub.1 and a perpendicular AL.sub.2 becomes 45.degree., where AO.sub.1 is the center of the fulcrum as seen from the plane perpendicular to the long groove, AO.sub.2 is the center of the long groove, AL.sub.1 is the line segment passing the centers AO.sub.1 and AO.sub.2, and AL.sub.2 is a perpendicular passing the center AO.sub.1 of the long groove, and similarly, the other centering stand satisfies the conditions that the crossing angle .beta. (beta) between a line segment LB.sub.1 and a perpendicular AL.sub.2 becomes 45.degree., where BO.sub.1 is the center of the fulcrum, BO.sub.2 is the center of the long groove, BL.sub.1 is the line segment passing the centers BO.sub.1 and BO.sub.2, and BL.sub.2 is a perpendicular passing the center BO.sub.1 of the long groove, and the pair of centering stands disposed adjacent to each other are perpendicularly crossed at both line segments AL.sub.1 and BL.sub.1, and the output ends of the pair of centering mechanisms are disposed on the same plane to be contacted with the guides of the centering stands.

3. 发明授权

US07750001B2 Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient 失效
标题翻译：免疫抑制剂和包含杂环化合物作为活性成分的抗肿瘤剂
公开(公告)号：US07750001B2
公开(公告)日：2010-07-06
申请号：US11847593
申请日：2007-08-30
申请人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
发明人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/04
CPC分类号： C07D403/04 , A61K31/5377 , C07D403/14 , C07D413/14
摘要： A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.
摘要翻译：一种在患有免疫疾病的哺乳动物中免疫抑制的新方法，包括向哺乳动物施用治疗有效量的由通式（I）表示的杂环化合物（其中X或其它变量如说明书中所定义）或公开了其药学上可接受的盐。还公开了由通式（II）表示的新型杂环化合物（其中X或其它变量如本说明书中所定义）或其药学上可接受的盐。

4. 发明申请

US20080113987A1 IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT 失效
标题翻译：含有作为活性成分的杂环化合物的免疫抑制剂和抗肿瘤剂
公开(公告)号：US20080113987A1
公开(公告)日：2008-05-15
申请号：US11847593
申请日：2007-08-30
申请人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
发明人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
IPC分类号： A61K31/5377 , A61P35/00
CPC分类号： C07D403/04 , A61K31/5377 , C07D403/14 , C07D413/14
摘要： A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.
摘要翻译：一种在患有免疫疾病的哺乳动物中免疫抑制的新方法，包括向哺乳动物施用治疗有效量的由通式（I）表示的杂环化合物（其中X或其它变量如说明书中所定义）或公开了其药学上可接受的盐。还公开了由通式（II）表示的新型杂环化合物（其中X或其它变量如本说明书中所定义）或其药学上可接受的盐。

5. 发明授权

US06294527B1 Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US06294527B1
公开(公告)日：2001-09-25
申请号：US09331183
申请日：1999-07-20
申请人： Hideaki Hanaki , Hiroaki Yamazaki , Yoshio Tsuchida , Hideki Sato , Keiichi Hiramatsu , Seiichiro Kawashima
发明人： Hideaki Hanaki , Hiroaki Yamazaki , Yoshio Tsuchida , Hideki Sato , Keiichi Hiramatsu , Seiichiro Kawashima
IPC分类号： C07D50124
CPC分类号： C07D501/00
摘要： An antibacterial compound wherein represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting atom), there being no R4 where represents 5-membered aromatic heterocycle; X and Y respectively represent hydrogen atom or CXY represents C═N—OR5 wherein R5 represents hydrogen atom, halo C1-C6 alkyl or C3-C7 cycloalkyl; R1 represents phenyl, furyl, thienyl, thiazolyl (which may be substituted by amino group), tetrazolyl or thiadiazolyl, R2, R3 and R4 respectively represent hydrogen atom, halogen, hydroxyl group, nitro, C1-C6 alkoxy, trifluoromethyl, isothiuronium C1-C6 alkyl, amino C1-C6 alkyl, halo C1-C6 alkyl, morpholino, piperidino or piperazinyl.
摘要翻译：一种抗菌化合物，其代表苯环，吡啶环，吡嗪环或5元芳族杂环（具有一个氧或硫原子作为构成环的原子），不存在表示5元芳族杂环的R 4，X和Y分别表示氢原子或CXY表示C = N-OR5，其中R5表示氢原子，卤代C1-C6烷基或C3-C7环烷基; R1表示苯基，呋喃基，噻吩基，噻唑基（其可被氨基取代），四唑基或噻二唑基， R 3和R 4分别表示氢原子，卤素，羟基，硝基，C 1 -C 6烷氧基，三氟甲基，异硫脲C 1 -C 6烷基，氨基C 1 -C 6烷基，卤代C 1 -C 6烷基，吗啉代，哌啶子基或哌嗪基。

6. 发明授权

US08338414B2 Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient 有权
标题翻译：免疫抑制剂和包含杂环化合物作为活性成分的抗肿瘤剂
公开(公告)号：US08338414B2
公开(公告)日：2012-12-25
申请号：US12785683
申请日：2010-05-24
申请人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
发明人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
IPC分类号： A61K31/535 , A61K31/44 , A61K31/55 , C07D413/14 , A61P35/04 , A01N43/40 , A01N43/62
CPC分类号： C07D403/04 , A61K31/5377 , C07D403/14 , C07D413/14
摘要： A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.
摘要翻译：一种在患有免疫疾病的哺乳动物中免疫抑制的新方法，包括向哺乳动物施用治疗有效量的由通式（I）表示的杂环化合物（其中X或其它变量如说明书中所定义）或公开了其药学上可接受的盐。还公开了由通式（II）表示的新型杂环化合物（其中X或其它变量如本说明书中所定义）或其药学上可接受的盐。

7. 发明授权

US07855199B2 Heterocyclic compound and anti-malignant-tumor agent containing the same as active ingredient 有权
标题翻译：含有与活性成分相同的杂环化合物和抗恶性肿瘤剂
公开(公告)号：US07855199B2
公开(公告)日：2010-12-21
申请号：US10594994
申请日：2005-03-30
申请人： Seiichiro Kawashima , Mitsuko Kawashima, legal representative , Hiroto Kawashima, legal representative , Masato Kawashima, legal representative , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Tetsuo Watanabe
发明人： Seiichiro Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Tetsuo Watanabe
IPC分类号： A61K31/4184 , A61K31/506 , A61K31/53 , A61K31/5377 , C07D413/14 , C07D235/10 , C07D251/18 , C07D265/30
CPC分类号： A61K31/5377 , C07D403/04
摘要： Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.
摘要翻译：由式I表示的杂环化合物和含有杂环化合物的抗恶性肿瘤剂作为有效成分：其中X表示氮原子或CH; Y表示C1-C6烷基; R1表示吗啉代（其可以被一至四个C 1 -C 6烷基取代）; 并且R 2和R 3各自表示氢原子或C 1 -C 6烷基。

8. 发明申请

US20080287431A1 Heterocyclic Compound and Anti-Malignant-Tumor Agent Containing the Same as Active Ingredient 有权
标题翻译：含有与活性成分相同的杂环化合物和抗恶性肿瘤剂
公开(公告)号：US20080287431A1
公开(公告)日：2008-11-20
申请号：US10594994
申请日：2005-03-30
申请人： Seiichiro Kawashima , Mitsuko Kawashima , Hiroto Kawashima , Masato Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Tetsuo Watanabe
发明人： Seiichiro Kawashima , Mitsuko Kawashima , Hiroto Kawashima , Masato Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Tetsuo Watanabe
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/04
CPC分类号： A61K31/5377 , C07D403/04
摘要： Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.
摘要翻译：由式I表示的杂环化合物和含有杂环化合物的抗恶性肿瘤剂作为有效成分：其中X表示氮原子或CH; Y表示C 1 -C 6烷基; R 1表示吗啉代（其可以被一至四个C 1 -C 6烷基取代）; R 2和R 3各自表示氢原子或C 1 -C 6烷基。

9. 发明授权

US07153853B2 Heterocyclic compounds and antitumor drugs containing the same as the active ingredient 有权
公开(公告)号：US07153853B2
公开(公告)日：2006-12-26
申请号：US10532245
申请日：2003-10-24
申请人： Seiichiro Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Hiroya Sasahara , Tetsuo Watanabe
发明人： Seiichiro Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Hiroya Sasahara , Tetsuo Watanabe
IPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/5377 , C07D403/04 , C07D403/14
摘要： The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1–C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) or NR6R7 [R6 represents C1–C6 alkyl and R7 represents piperidinyl (which may be substituted with C1–C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1–C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) when R1 is hydroxyl

10. 发明申请

US20100267700A1 IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT 有权
标题翻译：含有作为活性成分的杂环化合物的免疫抑制剂和抗肿瘤剂
公开(公告)号：US20100267700A1
公开(公告)日：2010-10-21
申请号：US12785683
申请日：2010-05-24
申请人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
发明人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
IPC分类号： A61K31/551 , A61K31/5377 , C07D413/14 , A61P37/06 , A61P35/00 , A61P17/00 , A61P19/02
CPC分类号： C07D403/04 , A61K31/5377 , C07D403/14 , C07D413/14
摘要： A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.
摘要翻译：一种在患有免疫疾病的哺乳动物中免疫抑制的新方法，包括向哺乳动物施用治疗有效量的由通式（I）表示的杂环化合物（其中X或其它变量如说明书中所定义）或公开了其药学上可接受的盐。还公开了由通式（II）表示的新型杂环化合物（其中X或其它变量如本说明书中所定义）或其药学上可接受的盐。

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