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1. 发明专利

TNSN01018A1 TREATMENT OF NEURODEGENERATIVE DISEASE 未知
公开(公告)号：TNSN01018A1
公开(公告)日：2005-11-10
申请号：TNSN01018
申请日：2001-01-26
申请人： WARNER LAMBERT CO
发明人： RICHARD JOHN BOOTH , THOMAS CHARLES MALONE , ARINDAM CHATTERJEE
IPC分类号： C07D239/48 , A61K31/505 , A61K31/519 , A61K45/00 , A61P21/02 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/02
摘要： THIS INVENTION PROVIDES A METHOD FOR TREATING NEURODEGENERATIVE DISEASES IN MAMMALS COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF A CYCLIN-DEPENDENT KINASE INHIBITOR. A PREFERRED METHOD USES cdk INHIBITORS OF FORMULA I : AND FORMULA II : WHERE W IS NH, S, SO, OR SO2, R1 INCLUDES PHENYL AND SUBSTITUTED PHENYL, R2 INCLUDES ALKYL AND CYCLOALKYL, R3 INCLUDES ALKYL AND HYDROGEN, R8 AND R9 INCLUDE HYDROGEN AND ALKYL, AND Z IS CARBOXY.

2. 发明专利

CR7392A 2- (PIRIDIN-2-ILAMINO)-PIRIDO[2,3-D]PIRIMIDIN-7-ONAS 未知
公开(公告)号：CR7392A
公开(公告)日：2004-12-06
申请号：CR7392
申请日：2004-07-15
申请人： WARNER LAMBERT CO
发明人： MARK ROBERT BARVIAN , RICHARD JOHN BOOTH , JOHN QUIN III , JOSEPH TOMAS REPINE , DEREK JAMES SHEEHAN , PETER LAWERENCE TOOGOOD , SCOTT NORMAN VANDERWELL , HAIRONG ZHOU
IPC分类号： C07D421/04
摘要： Proporciona 2-aminopiridinas sustituidas, utiles para tratar enfermedades proliferativas celulares. Los nuevos compuestos de la presente invencion son potentes inhibidores de las quinasas 4 dependientes de ciclina (cd4k)

3. 发明专利

CR20120129A 2-(PIRIDIN-2-ILAMINO)-PIRIDO[2,3-D]PIRIMIDIN-7-ONAS 未知
公开(公告)号：CR20120129A
公开(公告)日：2012-06-12
申请号：CR20120129
申请日：2012-03-19
申请人： WARNER LAMBERT CO
发明人： MARK ROBERT BARVIAN , RICHARD JOHN BOOTH , JOHN QUIN III , JOSEPH THOMAS REPINE , DEREK JAMES SHEEHAN , PETER LAURENCE TOOGOOD , SCOTT NORMAN VANDERWEL , HARIONG ZHOU
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/675 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07F9/6561
摘要： La presente invención proporciona 2-aminopiridinas sustanciales útiles para tratar enfermedades proliferativas celulares. Los nuevos compuestos de la presente invención son potentes inhibidores de las quinasas 4 dependientes de ciclina (cdk4)

4. 发明专利

MXPA02005485A COMPUESTOS TRICICLICOS Y METODO DE TRATAMIENTO DEL VIRUS DEL HERPES. 未知
公开(公告)号：MXPA02005485A
公开(公告)日：2002-11-29
申请号：MXPA02005485
申请日：2000-11-30
申请人： WARNER LAMBERT CO
发明人： RICHARD JOHN BOOTH
IPC分类号： A61K31/136 , A61K31/137 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/382 , A61K31/39 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/4355 , A61K31/4365 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/4525 , A61K31/47 , A61K31/4709 , A61K31/5415 , A61K31/55 , A61P31/12 , A61P31/22 , C07C211/61 , C07C215/88 , C07C217/94 , C07C317/32 , C07D209/88 , C07D211/58 , C07D213/38 , C07D215/12 , C07D223/22 , C07D279/10 , C07D279/20 , C07D307/91 , C07D319/24 , C07D327/08 , C07D333/20 , C07D333/54 , C07D333/76 , C07D335/02 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D411/12 , C07D417/12 , C07D491/048 , C07D497/04
摘要： La presente invencion proporciona un compuesto de la formula (1) y las sales farmaceuticamente aceptables que tienen actividad antiviral util en contra de los virus de la familia del herpes. En dicha formula, X=O, (CH2)m, S, SO, NH, NR8 o un enlace quimico, Y=O, (CH2)m, S, SO, SO2, NH, NR8: Z=NH, O, NR8, S, SO, SO2. Los substituyentes restantes estan descritos en la especificacion.

5. 发明专利

BR122016021801B1 compostos 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas 未知
公开(公告)号：BR122016021801B1
公开(公告)日：2021-02-09
申请号：BR122016021801
申请日：2003-01-10
申请人： WARNER LAMBERT CO
发明人： DEREK JAMES SHEEHAN , HAIRONG ZHOU , JOHN QUIN III , JOSEPH THOMAS REPINE , MARK ROBERT BARVIAN , PETER LAURENCE TOOGOOD , RICHARD JOHN BOOTH , SCOTT NORMAN VANDERWEL
IPC分类号： A61K31/675 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D471/04 , C07F9/6561
摘要： compostos 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas. a presente invenção refere-se 2-aminopiridinas substituídas úteis no tratamento de distúr-bios proliferativos celulares. os novos compostos da presente invenção são inibidores potentes de quinases 4 dependentes de ciclina (cdk4).

6. 发明专利

TNSN01036A1 5-ALKYLPYRIDO [2,3-d] PYRIMIDINES ARE INHIBITORS OF CYCLIN-DEPENDENT AND TYROSINE KINASES 未知
公开(公告)号：TNSN01036A1
公开(公告)日：2005-11-10
申请号：TNSN01036
申请日：2001-03-02
申请人： WARNER LAMBERT CO
发明人： RICHARD JOHN BOOTH , PETER LAURENCE TOOGOOD , ELLEN MYRA DOBRUSIN , SCOTT NORMAN VANDERWEL
IPC分类号： A61K20060101 , A61K31/505 , A61K31/519 , A61K31/5375 , A61K31/551 , A61P9/10 , A61P17/06 , A61P35/00 , A61P43/00 , C07D20060101 , C07D471/04
摘要： DISCLOSED ARE COMPOUNDS OF THE FORMULA WHERE IN : R2 IS HYDROGEN, ALKYL, OR CYCLOALKYL ; R3 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, HALOGEN, TRIFLUOROMETHYL, LOWER ALKYNYL, LOWER ALKENYL, NITRILE, NITRO, -COR4, -CO2R4, -CONR4R5, -CONR4OR5, -SO2NR4R5, -SO2R4, -SO3R4, P(O)(OR4)(OR5), Y IS N OR CR7 ; R9 IS LOWER ALKYL, HALOALKYL, OR ARYL ; X AND Z ARE INDEPENDENTLY HYDROGEN, HALOGEN, LOWER ALKYL, LOWER ALKOXY,TRIFLUOROMETHYL, HYDROXY, NITRILE, NITRO, -NR4R5, -N(O)R4R5, -NR4R5R6W, -SR4, -C(O)R4, -CO2R4, -CONR4R5, -SO2NR4R5, -SO2R4, -SO3R4, P(O)(OR4)(OR5), -T(CH2)mQR4, -C(O)T(CH2)mQR4, OR –NR4C(O)T(CH2)mQR5 ; m IS 1 TO 6 ; T IS O, S, NR4, N(O)R4, NR4R5W, OR CR4R5 ; Q IS O, S, NR4, N(O)R4, NR4R5W, CO2, OR A CARBOCYCLIC GROUP CONTAINING FROM 3 TO 7 MEMBERS, UP TO FOUR OF WHICH MEMBERS ARE OPTIONALLY HETEROATOMS INDEPENDENTLY SELECTED FROM OXYGEN, SULFUR, AND NITROGEN, WHEREIN THE CARBOCYCLIC GROUP IS UNSUBSTITUTED OR SUBSTITUTED WITH ONE, TWO, OR THREE GROUPS INDEPENDENTLY SELECTED FROM HALOGEN, HYDROXY, HYDROXYALKYL, LOWER ALKYL, LOWER ALKOXY ALKOXYCARBONYL, ALKYLCARBONYL, ALKYLCARBONYLAMINO, AMINOALKYL, TRIFLUOROMETHYL, N-HYDROXYACETAMIDE, TRIFLUOROMETHYLALKYL, AMINO, OR MONO OR DIALKYLAMINO ; R6 LOWER ALYL, HALOALKYL OR ARYL; R7 IS –NR4R5, -N(O)R4R5, -NR4R5R9X, -OH, -OR4, -SR4, HALO, -COR4, (CH2)nR4, CO2R4, CONR4R5, -C(O)NR4SO2R5, -S(O)R4, -SO2R4, -SO2NR4R5, -SO3R4, -(CH2)nP(O)(OR4)2, -NR4SO2R5, ALDEHYDE, NITRILE, NITRO, ALKYL ALKOXYALKYL, -T(CH2)mQR4, -C(O)T(CH2)mQR4, -NR4C(O)T(CH2)mQR5, OR –T(CH2)CO2R4 ; n IS 0 TO 6 ; W IS AN ANION ; R4 AND R5 ARE INDEPENDENTLY HYDROGEN, LOWER ALKYL, LOWER ALKENYL, LOWER ALKYNYL, (CH2) nAr, ARYLALKYL, ARYL, HETEROARYL, HETEROARYLALKYL, CYCLOALKYL, HETEROCYCLOALKYL, OR HETEROARYL, OR R4 AND R5 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED FORM A CARBOCYCLIC RING CONTAINING 3 TO 8 MEMBERS, UP TO FOUR OF WHICH MEMBERS ARE OPTIONALLY CARBONYL GROUPS OR HETEROATOMS INDEPENDENTLY SELECTED FROM O, S, SO, S(O)2, AND N; AND WHEN Y IS CR7 , IT IS PART OF THE PORT STRUCTURE …….. WHEREIN R7 AND Z ARE AS DEFINED ABOVE, OR CAN BE TAKEN TOGETHER WITH THE CARBONS TO WHICH THEY ARE ATTACHED TO FORM… WHEREIN : G AND J ARE INDEPENDENTLY CH2, NH, OR O; B IS NH, S, CH2, OR O; D IS C OR N, PROVIDED THAT R10 IS NOTHING WHEN D IS N; AND R10 AND R11 ARE INDEPENDENTLY HYDROGEN, HALOGEN, LOWER ALKYL, LOWER ALKOXY, OR ALKYLCARBONYL; THESE COMPOUNDS ARE USEFUL FOR TREATING CELL PROLIFERATIVE DISORDERS, SUCH AS CANCER, ATHEROSCLEROSIS, AND RESTENOSIS. THESE COMPOUNDS ARE POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES (CDKS) AND GROWTH FACTOR-MEDIATED KINASES; THE PRESENT INVENTION ALSO PROVIDES A METHOD OF TREATING CELL PROLIFERATIVE DISORDERS; ALSO PROVIDED BY THE PRESENT INVENTION IS A PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND OF FORMULA I TOGETHER WITH A CARRIER OR EXCIPIENT

7. 发明专利

TNSN01014A1 PYRIDO [2, 3-d] PYRIMIDINE-2, 7-DIAMINES INHIBITRICES DE KINASES, ET COMPOSITIONS LES CONTENANT 未知
公开(公告)号：TNSN01014A1
公开(公告)日：2005-11-10
申请号：TNSN01014
申请日：2001-01-24
申请人： WARNER LAMBERT CO
发明人： RICHARD JOHN BOOTH , ELLEN MYRA DOBRUSIN , VARA PRASAD VENKATA NAGENDRA JOSYULA , DENNIS JOSEPH MC NAMARA , PETER LAURENCE TOOGOOD
IPC分类号： A61K31/305 , A61K31/519 , A61P9/10 , A61P17/06 , A61P35/00 , A61P43/00 , C07D471/04 , C07F9/6561
摘要： L'INVENTION CONCERNE DES COMPOSES DE FORMULE DANS LAQUELLE R2, R5, R6, R7 ET R8 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT DES COMPOSITIONS LES CONTENANT ET LEUR UTILISATION POUR LA PREPARATION DE MEDICAMENTS. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, INHIBITEURS DE cdk ET KINASES A MEDIATION PAR DES FACTEURS DE CROISSANCE, POUR LE TRAITEMENT DE MALADIES COMPORTANT UNE PROLIFERATION CELLULAIRE.

8. 发明专利

CR6706A PIRIDO (2,3-D) PIRIMIDIN-2-7-DIAMINAS INHIBIDORES DE CINASAS 未知
公开(公告)号：CR6706A
公开(公告)日：2005-04-04
申请号：CR6706
申请日：2002-07-17
申请人： WARNER LAMBERT CO
发明人： ELLEN MYRA DOBRUSIN , VARA PRASAD VENKATA NAGENDRA JOSYULA , RICHARD JOHN BOOTH , DENNIS JOSEPH MCNAMARA , PETER LAURENCE TOOGOOD
IPC分类号： A61K31/305 , A61K31/519 , A61P9/10 , A61P17/06 , A61P35/00 , A61P43/00 , C07D471/04 , C07F9/6561
摘要： Consiste en compuestos de formula en la cual R2, R7, R13, y R15, son independientemente, hidrogeno o alquilo inferior sustituido o sin sustituir, alquenilo inferior sustituido o sin sustituir, alquinilo inferior sustituido o sin sustituir, o bien -(CH2) nR112 sustituido o sin sustituir y otros compuestos. Estos compuestos y sus composiciones farmaceuticas son utiles para tratar trastornos proliferativos celulares, tales como cancer y restenosis. Estos compuestos son potentes inhibidores de cdks y de cinasas mediadas por factor de crecimiento.

9. 发明专利

CR6736A 5-ALQUILPIRIDO[2,3-D[ PIRIDINAS COMO INHIBIDORES DE TIROSINA KINASA 未知
公开(公告)号：CR6736A
公开(公告)日：2004-03-10
申请号：CR6736
申请日：2002-08-23
申请人： WARNER LAMBERT CO
发明人： RICHARD JOHN BOOTH , ELLEN MYRA DOBRUSIN , PETER LAURENCE TOOGOOD , SCOTT NORMAN VANDERWEL
IPC分类号： A61K20060101 , A61K31/505 , A61K31/519 , A61K31/5375 , A61K31/551 , A61P9/10 , A61P17/06 , A61P35/00 , A61P43/00 , C07D20060101 , C07D471/04
摘要： Se refiere a compuestos utiles para el tratamiento de trastornos de la proliferacion celular como cancer, arteroclerosis, y restenosis. Estos compuestos son inhibidores potentes de kinasas dependientes de ciclina y de kinasas reguladas por factores de crecimiento.

10. 发明专利

BRPI0307057B8 compostos 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas 未知
公开(公告)号：BRPI0307057B8
公开(公告)日：2021-05-25
申请号：BR0307057
申请日：2003-01-10
申请人： WARNER LAMBERT CO
发明人： DEREK JAMES SHEEHAN , HAIRONG ZHOU , JOHN QUIN III , JOSEPH THOMAS REPINE , MARK ROBERT BARVIAN , PETER LAURENCE TOOGOOD , RICHARD JOHN BOOTH , SCOTT NORMAN VANDERWEL
IPC分类号： A61K31/675 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D471/04 , C07F9/6561
摘要： "2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7onas". a presente invenção refere-se 2-aminopiridinas substituídas úteis no tratamento de distúrbios proliferativos celulares. os novos compostos da presente invenção são inibidores potentes de quinases 4 dependentes de ciclina (cdk4).

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