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1. 发明申请

WO2012027181A2 MULTILEAF COLLIMATORS WITH TRANSVERSE MOTION 审中-公开
标题翻译：具有横向运动的多用途收缩机
公开(公告)号：WO2012027181A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048203
申请日：2011-08-18
申请人： VARIAN MEDICAL SYSTEMS, INC. , MANSFIELD, Stanley , PRINCE, Steven
发明人： MANSFIELD, Stanley , PRINCE, Steven
IPC分类号： A61N5/10 , G21K1/02 , G21K1/04 , A61B6/10
CPC分类号： G21K1/046 , A61N5/1045
摘要： A collimation assembly includes a multileaf collimator and motion assembly. The multileaf collimator includes a support body and a plurality of pairs of beam blocking leaves supported by the support body. The beam blocking leaves are longitudinally movable in a first direction. The motion assembly includes an actuator and a guide assembly operable to move the support body and thereby allowing the plurality of pairs of beam blocking leaves to move in a second direction generally transverse to the first direction.
摘要翻译：准直组件包括多叶准直器和运动组件。多叶准直器包括支撑体和由支撑体支撑的多对束阻挡叶。梁阻挡叶片可沿第一方向纵向移动。运动组件包括致动器和导向组件，该导向组件可操作以移动支撑体，从而允许多对阻挡树叶沿大致横向于第一方向的第二方向移动。

2. 发明申请

WO2020018904A9 METHODS OF USE OF ULTRA-HIGH DOSE RATE RADIATION AND THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2020018904A9
公开(公告)日：2020-01-23
申请号：PCT/US2019/042603
申请日：2019-07-19
申请人： VARIAN MEDICAL SYSTEMS, INC.
发明人： PARRY, Renate , ABEL, Eric , GIRDHANI, Swati , MANSFIELD, Stanley , KUPELIAN, Patrick , KHUNTIA, Deepak
IPC分类号： A61K31/436 , A61N5/10 , A61K39/395 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4439 , A61P35/00 , G01N33/48 , G01N33/50
摘要： Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

3. 发明申请

WO2019018813A1 METHODS OF USE OF ULTRA-HIGH DOSE RATE RADIATION AND THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2019018813A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/043171
申请日：2018-07-20
申请人： VARIAN MEDICAL SYSTEMS, INC.
发明人： PARRY, Renate , ABEL, Eric , GIRDHANI, Swati , MANSFIELD, Stanley , KUPELIAN, Patrick , KHUNTIA, Deepak
IPC分类号： A61K31/436 , A61N5/10 , A61K39/395 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4439 , A61P35/00
摘要： Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

4. 发明申请

WO2020018904A1 METHODS OF USE OF ULTRA-HIGH DOSE RATE RADIATION AND THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2020018904A1
公开(公告)日：2020-01-23
申请号：PCT/US2019/042603
申请日：2019-07-19
申请人： VARIAN MEDICAL SYSTEMS, INC.
发明人： PARRY, Renate , ABEL, Eric , GIRDHANI, Swati , MANSFIELD, Stanley , KUPELIAN, Patrick , KHUNTIA, Deepak
IPC分类号： A61K31/436 , A61N5/10 , A61K39/395 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4439 , A61P35/00 , G01N33/5005 , G01N33/50
摘要： Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

5. 发明申请

WO2017173443A1 RADIATION THERAPY SYSTEMS AND METHODS 审中-公开
标题翻译：放射治疗系统和方法
公开(公告)号：WO2017173443A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025732
申请日：2017-04-03
申请人： VARIAN MEDICAL SYSTEMS, INC.
发明人： MANSFIELD, Stanley
IPC分类号： A61N5/10
摘要： A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.
摘要翻译：放射治疗系统包括产生粒子束的加速器和射束输送系统。加速器和光束传输系统将光束引导到路径上并进入可操作用于将光束对准物体的喷嘴。喷嘴包括扫描磁体，该扫描磁体可操作用于将光束引导向物体内的不同位置，并且还包括光束能量调节器，该光束能量调节器被配置为通过例如在光束的路径中放置不同厚度的材料来调节光束以影响能量的光束中的粒子。

6. 发明申请

WO2019016305A1 DOSE ASPECTS OF RADIATION THERAPY PLANNING AND TREATMENT 审中-公开
公开(公告)号：WO2019016305A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069605
申请日：2018-07-19
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG , VARIAN MEDICAL SYSTEMS INC
发明人： VANDERSTRATEN, Reynald , ABEL, Eric , SMITH, Christel , MAGLIARI, Anthony , KOPONEN, Timo , MANSFIELD, Stanley , ADELSHEIM, Charles
IPC分类号： A61N5/10
摘要： Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.

7. 发明申请

WO2011103027A2 PRONE PATIENT POSITIONING DEVICES AND METHODS 审中-公开
标题翻译： PROM患者定位装置和方法
公开(公告)号：WO2011103027A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/024433
申请日：2011-02-11
申请人： VARIAN MEDICAL SYSTEMS, INC. , MANSFIELD, Stanley
发明人： MANSFIELD, Stanley
IPC分类号： A61N5/00 , A61N5/01 , A61N5/10
CPC分类号： A61B6/0435 , A61B6/0414 , A61B6/502 , A61B6/541 , A61N5/10
摘要： A radiotherapy couch top includes a cantilevered section adapted to support at least a portion of a prone patient's upper body. The cantilevered section may be provided with an opening configured to allow at least a portion of the body portion to extend into from above and to allow a radiation beam to pass through from below.
摘要翻译：放射治疗沙发顶部包括适于支撑易患者上身的至少一部分的悬臂部分。悬臂部分可以设置有开口，该开口被配置为允许主体部分的至少一部分从上方延伸并允许辐射束从下方通过。

8. 发明申请

WO2018194796A1 DUAL-AXIS RING GANTRY RADIOTHERAPY SYSTEMS 审中-公开
公开(公告)号：WO2018194796A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/024342
申请日：2018-03-26
申请人： VARIAN MEDICAL SYSTEMS, INC.
发明人： HUMBER, David , STAR-LACK, Josh , MANSFIELD, Stanley , HANNIBAL, Ross
IPC分类号： A61N5/10
摘要： A radiation system includes a radiation source providing therapeutic radiation, a first gantry supporting a second gantry carrying the radiation source. The first gantry is rotatable about a first axis passing through an isocenter, thereby allowing the radiation source to aim therapeutic radiation at a target volume from a plurality of locations in a first plane. The second gantry carrying the radiation source is rotatable about a second axis passing through the isocenter non-parallel with the first axis, thereby allowing the radiation source to aim therapeutic radiation at the target volume from a plurality of locations in a second plane non-coplanar with the first plane.

9. 发明申请

WO2013066724A1 APPARATUS AND METHOD PERTAINING TO MOVEMENT COMPENSATION DURING RADIATION TREATMENT 审中-公开
标题翻译：放射治疗期间运动补偿的装置和方法
公开(公告)号：WO2013066724A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/061930
申请日：2012-10-25
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG , VARIAN MEDICAL SYSTEMS, INC.
发明人： SILJAMAKI, Sami , NORD, Janne , SVATOS, Michelle Marie , ZANKOWSKI, Corey E. , MANSFIELD, Stanley
IPC分类号： A61N5/00 , A61N5/10 , A61B6/08
CPC分类号： A61N5/1045 , A61N5/1037 , A61N5/1067 , A61N5/107 , A61N2005/105
摘要： A control circuit controls real-time administration of a radiation-treatment plan that administers a therapeutic radiation dose to a patient. This includes compensating for a first movement as regards the application setting using a first treatment-administration modality and responding to detection of a second movement by using a second treatment-administration modality that is different from the first treatment-administration modality.
摘要翻译：控制电路控制对患者施加治疗辐射剂量的放射治疗计划的实时管理。这包括通过使用与第一治疗管理模式不同的第二治疗施用模式来补偿关于使用第一治疗管理模式的应用设置的第一动作并且响应于第二运动的检测。

10. 发明申请

WO2012027180A3 MULTI LEVEL MULTILEAF COLLIMATORS 审中-公开
公开(公告)号：WO2012027180A3
公开(公告)日：2012-03-01
申请号：PCT/US2011/048201
申请日：2011-08-18
申请人： VARIAN MEDICAL SYSTEMS, INC. , PRINCE, Steven , MANSFIELD, Stanley
发明人： PRINCE, Steven , MANSFIELD, Stanley
IPC分类号： A61N5/10 , G21K1/02 , G21K1/04 , A61B6/10
摘要： A multilevel MLC includes a first set and a second set of a plurality of pairs of beam blocking leaves arranged adjacent one another. Leaves of each pair in the first set are disposed in an opposed relationship and longitudinally movable relative to each other in a first direction. Leaves of each pair in the second set are disposed in an opposed relationship and longitudinally movable relative to each other in a second direction generally parallel to the first direction. The first and second sets of pairs of leaves are disposed in different planes.

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