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1. 发明授权

US4046881A Fungicidally active antibiotic from streptomyces tendae Ettlinger et al. Tu 901 失效
标题翻译：来自链霉菌腱炎的杀真菌活性抗生素Ettlinger et al。 Tu 901
公开(公告)号：US4046881A
公开(公告)日：1977-09-06
申请号：US669780
申请日：1976-03-24
申请人： Ursula Dahn , Hanspaul Hagenmaier , Helmut Hohne , Wilfried Konig , Hans Scheinpflug , Hans Zahner
发明人： Ursula Dahn , Hanspaul Hagenmaier , Helmut Hohne , Wilfried Konig , Hans Scheinpflug , Hans Zahner
IPC分类号： A01N63/02 , A01N43/54 , C07H19/06 , C07H19/067 , C12P1/06 , C12P19/38 , C12P19/40 , C12R1/465 , A61K31/71
CPC分类号： C07H19/06 , Y10S435/886
摘要： The new antibiotic Nikkomycin is produced by culturing the strain Streptomyces tendae Ettlinger et al Tu 901 in a nutrient medium at a pH of about 5.5 to 8 under aerobic conditions and isolation by cation exchange from the culture filtrate, followed by elution. The antibiotic is believed to have the structural formula ##STR1## and is characterized by fungicidal activity.
摘要翻译：通过在有氧条件下在约5.5至8的pH下培养营养培养基中的链霉菌Ettlinger等人Tu 901菌株产生新的抗生素尼科霉素，并通过阳离子交换从培养滤液中分离，然后洗脱。抗生素被认为具有结构式“IMAGE”+“TR”图像，其特征在于杀真菌活性。

2. 发明授权

US4158608A Fungicidally active antibiotic from Streptomyces tendae Ettlinger 失效
标题翻译：来自{i Streptomyces tendae {b Ettlinger。）的杀真菌活性抗生素
公开(公告)号：US4158608A
公开(公告)日：1979-06-19
申请号：US785729
申请日：1977-04-07
申请人： Ursula Dahn , Hanspaul Hagenmaier , Helmut Hohne , Wilfried Konig , Hans Scheinpflug , Hans Zahner
发明人： Ursula Dahn , Hanspaul Hagenmaier , Helmut Hohne , Wilfried Konig , Hans Scheinpflug , Hans Zahner
IPC分类号： C07H19/06 , C12P19/38 , C12D9/14
CPC分类号： C07H19/06 , C12P19/385
摘要： The new antibiotic Nikkomycin is produced by culturing the strain Streptomyces tendae Ettlinger et al Tu 901 in a nutrient medium at a pH of about 5.5 to 8 under aerobic conditions and isolation by cation exchange from the culture filtrate, followed by elution. The antibiotic is believed to have the structural formula ##STR1## and is characterized by fungicidal activity.
摘要翻译：通过在有氧条件下在约5.5至8的pH下培养营养培养基中的链霉菌Ettlinger等人Tu 901菌株产生新的抗生素尼科霉素，并通过阳离子交换从培养滤液中分离，然后洗脱。抗生素被认为具有结构式“IMAGE”，其特征在于杀真菌活性。

3. 发明授权

US4315922A Nikkomicins, a process for their preparation and their use as agents for combating pests 失效
标题翻译：尼克霉素，它们的制备过程及其作为防治害虫的药剂
公开(公告)号：US4315922A
公开(公告)日：1982-02-16
申请号：US167291
申请日：1980-07-10
申请人： Hans-Paul Hagenmaier , Wilfried Konig , Hans Zahner , Hans-Peter Fiedler , Wolfgang Dehler , Adelinde Keckeisen , Hartwig Holst , Gerhard Zoebelein
发明人： Hans-Paul Hagenmaier , Wilfried Konig , Hans Zahner , Hans-Peter Fiedler , Wolfgang Dehler , Adelinde Keckeisen , Hartwig Holst , Gerhard Zoebelein
IPC分类号： A01N43/50 , A01N43/54 , C07H19/052 , C07H19/06 , C12P19/28 , C12P19/38 , C12P21/02 , A61K31/71
CPC分类号： C07H19/06 , A01N43/50 , A01N43/54 , C07H19/052 , C12P19/28 , C12P19/385 , C12R1/465
摘要： Pesticidally active substantially pure nikkomicin fractions obtained from Streptomyces tendae Ettlinger et al Tu 901, the fractions being selected from the group consisting of ##STR1## a mixture of nikkomicin I and J, and a mixture of nikkomicin M and N.
摘要翻译：从Streptomyces tende Ettlinger等人T + E，uml / u 901获得的杀虫活性基本上纯的尼克西米星级分，选自下列组分：（i）图像（M）图像（N）nikkomicin I和J的混合物，以及nikkomicin M和N的混合物

4. 发明授权

US4211787A Antibacterial agents effective in growth promotion and increased feed utilization 失效
标题翻译：抗菌剂有效促进生长，提高饲料利用率
公开(公告)号：US4211787A
公开(公告)日：1980-07-08
申请号：US960206
申请日：1978-11-13
申请人： Martin Scheer , Heidrun Anke , Wilfried Konig , Hans Zahner
发明人： Martin Scheer , Heidrun Anke , Wilfried Konig , Hans Zahner
IPC分类号： A61K31/35 , A23K20/195 , A23K50/30 , A61K9/20 , A61K31/335
CPC分类号： A23K50/30 , A23K20/195
摘要： The invention provides compositions containing cladosporin and/or analogs of cladosporin. Said composition in the form of treated feed compositions or treated drinking water promote and accelerate the growth of animals and improve feedstuff utilization.
摘要翻译：本发明提供含有分支杆菌素和/或分支杆菌素类似物的组合物。经处理的饲料组合物或经处理的饮用水形式的所述组合物促进和加速动物的生长并提高饲料利用率。

5. 发明授权

US5231013A Polycyclic peptide antibiotic gallidermin 失效
标题翻译：多环肽类抗生素GALLIDERMIN
公开(公告)号：US5231013A
公开(公告)日：1993-07-27
申请号：US353719
申请日：1989-05-18
申请人： Gunther Jung , Roland Kellner , Hans Zahner , Friedrich Gotz , Thomas Horner , Rolf G. Werner , Hermann Allgaier
发明人： Gunther Jung , Roland Kellner , Hans Zahner , Friedrich Gotz , Thomas Horner , Rolf G. Werner , Hermann Allgaier
IPC分类号： C12P21/02 , A61K38/00 , A61P17/00 , A61P31/04 , C07K1/20 , C07K14/195 , C07K14/31 , C07K14/41 , C12P21/04 , C12R1/44
CPC分类号： C07K14/31 , A61K38/00 , Y10S435/882
摘要： A new polycyclic peptide antibiotic termed gallidermin is disclosed and described, together with a process for producing such antibiotic by fermination of a new microorganism, Staphylococcus gallinarum (DSM 4616).

6. 发明授权

US4859655A Urdamycin G and derivatives thereof, a process for their preparation and their use 失效
标题翻译：尿绿霉素G及其衍生物，其制备方法及其应用
公开(公告)号：US4859655A
公开(公告)日：1989-08-22
申请号：US89434
申请日：1987-08-26
申请人： Axel Zeeck , Thomas Ciesiolka , Jurgen Rohr , Hans Zahner , Hannelore Drautz
发明人： Axel Zeeck , Thomas Ciesiolka , Jurgen Rohr , Hans Zahner , Hannelore Drautz
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H15/24 , C07H15/244 , C07H17/04 , C12P19/56 , C12R1/54
CPC分类号： C12R1/54 , C07H15/244 , C12P19/56 , Y10S435/896
摘要： A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.
摘要翻译：已经发现了一种新物质urdamycin G，与其O-酰基衍生物一样，表现出抗生素或抗肿瘤活性。

7. 发明授权

US4406905A 2-Pyridyl-2-thiazoline-4-carboxylic acid derivatives 失效
标题翻译： 2-吡啶基-2-噻唑啉-4-羧酸衍生物
公开(公告)号：US4406905A
公开(公告)日：1983-09-27
申请号：US285909
申请日：1981-07-23
申请人： Hans Zahner , Hans-Ulrich Naegeli , Heinrich Peter
发明人： Hans Zahner , Hans-Ulrich Naegeli , Heinrich Peter
IPC分类号： C07D213/79 , C07D417/04 , C07F7/08 , C12P17/16 , A61K31/44 , C07D409/04
CPC分类号： C07D213/79 , C07D417/04 , C07F7/0812 , C12P17/167 , C12R1/48
摘要： The invention relates especially to 2-(3'-hydroxypyrid-2'-yl)-2-thiazoline-4-carboxylic acid derivatives of the formula (I) and salts and also certain metal complexes of these compounds, processes for their manufacture, pharmaceutical agents containing such compounds and the use of these compounds. ##STR1## In the formula, R.sup.1 represents free, etherified or esterified hydroxy, R.sup.2 represents hydrogen or an aliphatic, carbocyclic or carbocyclic-aliphatic radical having 1-12 carbon atoms, and R.sup.3 represents hydrogen or an unsubstituted aliphatic radical having 1-7 carbon atoms.The compounds of the formula (I) can be used, for example, for the abstraction of heavy metals from the organism of warm-blooded animals and/or they have an antibiotic action.
摘要翻译：本发明特别涉及式（I）的2-（3'-羟基吡啶-2'-基）-2-噻唑啉-4-羧酸衍生物及其盐以及这些化合物的某些金属配合物，其制备方法，含有这些化合物的药剂和这些化合物的用途。（I）式中，R1表示游离的醚化或酯化的羟基，R 2表示氢或具有1-12个碳原子的脂族，碳环或碳环脂族基，R3表示氢或未取代的具有1个 -7个碳原子。式（I）的化合物可用于例如从温血动物的生物体中提取重金属和/或具有抗生素作用。

8. 发明授权

US5874262A Microbiological process for the preparation of (S,S)-N,N'-ethylenediaminedisuccinic acid 失效
标题翻译：制备（S，S）-N，N'-乙二胺二琥珀酸的微生物过程
公开(公告)号：US5874262A
公开(公告)日：1999-02-23
申请号：US952274
申请日：1997-11-17
申请人： Hans Zahner , Ingeborg Cebulla , Michael Harder
发明人： Hans Zahner , Ingeborg Cebulla , Michael Harder
IPC分类号： C09K3/00 , C11D3/33 , C12P13/00 , C12R1/01
CPC分类号： C12P13/04 , Y10S435/822
摘要： A microbiological process for the preparation of N,N'-ethylenediaminedisuccinic acid of formula (1), by (a) precultivation of a strain of the genus Amycolatopsis orientalis on a specified nutrient medium (1st preculture), (b) inoculation of a nutrient solution of the same composition as the base of the production fermenter by the 1st preculture (2nd preculture), (c) inoculation of the base nutrient solution in the production fermenter with the 2nd preculture and incubation in accordance with a specified timetable, (d) feeding of the production fermenter in the fed-batch process with a feeding solution under aerobic conditions at a pH of from 2 to 8 and at a temperature of from 15.degree. to 40.degree. C., wherein the base nutrient and feeding solutions are free of zinc-containing compounds, is described. The compound prepared by the process according to the invention is suitable as complexing agent with good biodegradability in detergents. ##STR1##
摘要翻译： PCT No.PCT / EP96 / 01868 Sec。 371日期1998年1月23日 102（e）日期1998年1月23日PCT提交1996年5月4日PCT公布。公开号WO96 / 36725 日期：1996年11月21日制备式（1）的N，N'-乙二胺二琥珀酸的微生物方法，通过（a）在特定的营养培养基（第一预培养物）上预先培养东方双歧杆菌属菌株）通过第一次预培养（第二次预培养）接种与生产发酵罐底部相同组成的营养液，（c）用第二次预培养接种生产发酵罐中的基础营养液并根据指定的温育时间表，（d）在补充分批过程中的生产发酵罐在需氧条件下在pH为2至8和在15至40℃的温度下用进料溶液进料，其中所述基础营养物和进料溶液中不含含锌化合物。通过本发明方法制备的化合物适用于洗涤剂中具有良好生物降解性的络合剂。（1）

9. 发明授权

US4939125A Acyl derivatives of urdamycin A, their preparation and their use 失效
标题翻译：尿素霉素A的酰基衍生物，其制备及其用途
公开(公告)号：US4939125A
公开(公告)日：1990-07-03
申请号：US89442
申请日：1987-10-05
申请人： Axel Zeeck , Thomas Ciesiolka , Hans Zahner , Hannelore Drautz
发明人： Axel Zeeck , Thomas Ciesiolka , Hans Zahner , Hannelore Drautz
IPC分类号： C07H15/252 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/244
CPC分类号： C07H15/244 , Y10S435/896 , Y10S514/908
摘要： The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
摘要翻译：尿绿霉素A的O-酰基衍生物显示抗生素或抗肿瘤活性。

10. 发明授权

US4585761A Antibiotics, a process for their preparation and their use as plant protection agents 失效
标题翻译：抗生素，它们的制备过程及其作为植物保护剂的用途
公开(公告)号：US4585761A
公开(公告)日：1986-04-29
申请号：US265523
申请日：1981-05-20
申请人： Hans Zahner , Hartwig Holst , Gerhard Zoebelein , Adelinde Keckeisen
发明人： Hans Zahner , Hartwig Holst , Gerhard Zoebelein , Adelinde Keckeisen
IPC分类号： A01N63/02 , A01N43/50 , A01N43/54 , C07H19/052 , C07H19/06 , C12P19/28 , C12P19/38 , C12P19/40 , C12R1/465 , A01N31/00 , C07H17/00
CPC分类号： C07H19/06 , A01N43/50 , A01N43/54 , C07H19/052 , C12P19/28 , C12P19/385 , C12R1/465
摘要： A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very readily soluble in water and in pyridine but insoluble in other customary organic solvents, gives a positive reaction with ninhydrin, sodium metaperiodate/benzidine and potassium permanganate and gives a yellow coloration with iron (III) chloride, (b) has the UV and IR spectra substantially as shown in FIGS. 1 and 2, (c) on chemical degradation yields uracil, an amino-hexuronic acid and an amino-acid containing a pyridine ring, (d) on paper electrophoresis proves to be an amphoteric substance and has an isoelectric point at about pH 6 and (e) consists of the elements carbon, hydrogen, oxygen and nitrogen, or one or more active components of the antibiotic mixture, the active agent being applied alone or in admixture with a diluent or carrier. The antibiotic is known as Nikkomycin which is apparently a mixture of components of the formula ##STR1## in which R.sub.1 is ##STR2## and R.sub.2 is hydrogen, ##STR3##
摘要翻译：一种防治节肢动物的方法，包括向节肢动物或其感染的栖息地施用节肢动物有效量的抗生素，该抗生素（a）为无色，非常易于溶于水和吡啶，但不溶于其它常规的有机溶剂，得到与茚三酮，偏高碘酸钠/联苯胺和高锰酸钾发生阳性反应，并与氯化铁（III）发生黄色着色，（b）基本上具有如图1和2所示的UV和IR光谱。 1和2，（c）化学降解产生尿嘧啶，氨基 - 己糖醛酸和含有吡啶环的氨基酸，（d）在纸电泳上证明是两性物质，并具有约pH 6的等电点，（e）由碳，氢，氧和氮的元素或抗生素混合物的一种或多种活性组分组成，活性剂单独施用或与稀释剂或载体混合。抗生素被称为尼科霉素，其显然是式（IMAGE）的组分的混合物，其中R1是，R2是氢， + TR

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