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1. 发明申请

WO2020101499A1 METHOD FOR MATRIX EFFECT CORRECTION IN QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF ANALYTES IN COMPLEX MATRICES 审中-公开
公开(公告)号：WO2020101499A1
公开(公告)日：2020-05-22
申请号：PCT/NL2019/050752
申请日：2019-11-18
申请人： UNIVERSITEIT LEIDEN
发明人： HANKEMEIER, Thomas , DUBBELMAN, Anne Charlotte , HARMS, Amy C. , GONZÁLEZ, Oskar
IPC分类号： G01N30/72 , G01N30/86 , G01N30/04 , G01N30/84
摘要： The present invention relates to a method for quantifying one or more analytes in a sample by an analysis system comprising a separation unit (LC column), a means of adding a solution post-column (Connector), and a detection unit comprising a mass spectrometer coupled through an ionization source, the method comprising: • (i) inducing matrix effect on the analytes in the sample and on the post-column infused internal standards (PCI-ISs); • (ii) matching one or more post-column infused internal standard (PCI-IS) to each analyte that best matches the analyte's response to the matrix effect, and • (iii) storing the analyte-matched PCI-IS identification and, optionally, associated response data in a library; and • (iv) applying the analyte-matched PCI-IS to the analyte in other samples to correct the analyte peak responses for the matrix effect during ionization and to obtain (absolute) quantitation of the analyte using the response data.

2. 发明申请

WO2021255266A1 APPARATUS COMPRISING A GUARD COLUMN 审中-公开
公开(公告)号：WO2021255266A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066673
申请日：2021-06-18
申请人： UNIVERSITEIT LEIDEN
发明人： HARMS, Amy C. , HANKEMEIER, Thomas , VAN DER LAAN, Tom
IPC分类号： B01D15/12 , B01D15/22 , G01N30/08 , G01N30/60 , G01N30/46 , B01D15/125 , B01D15/325 , B01D15/362 , B01D15/363 , G01N2030/085 , G01N30/468
摘要： A chromatography analysis apparatus (30) comprises: a fractionation device (32) for receiving a sample, the fractionation device (32) defining a sample flow path that includes a guard column; and a fractionation output analyser (34), wherein a fractionation output of the guard column is provided to an input of the fractionation output analyser (34) for enabling subsequent analysis of the fractionation output by the fractionation output analyser (34).

3. 发明申请

WO2022167498A1 MASS-SPECTROMETRIC METHOD FOR PATHOGEN DETECTION 审中-公开
公开(公告)号：WO2022167498A1
公开(公告)日：2022-08-11
申请号：PCT/EP2022/052509
申请日：2022-02-02
申请人： UNIVERSITEIT LEIDEN
发明人： HANKEMEIER, Thomas , HARMS, Amy C , DROUIN, Nicolas FP
IPC分类号： G01N33/569 , G01N33/68
摘要： The invention relates to a mass-spectrometry method for detecting pathogens. The method is highly sensitive and is therefore particularly useful for detecting peptides that are present in only low concentrations, such as pathogen peptides in a swab sample obtained from a subject.

4. 发明申请

WO2014204312A2 METHOD AND DEVICE FOR RECEIVING A DROPLET 审中-公开
标题翻译：用于接收滴液的方法和装置
公开(公告)号：WO2014204312A2
公开(公告)日：2014-12-24
申请号：PCT/NL2014/050406
申请日：2014-06-19
申请人： UNIVERSITEIT LEIDEN
发明人： SCHOONEN, Jan-Willem , LINDENBURG, Peter , VULTO, Paul , HANKEMEIER, Thomas
IPC分类号： G01N1/28
CPC分类号： G01N30/12 , G01N1/28 , G01N1/34 , G01N1/4022 , G01N30/06 , G01N30/463 , G01N30/64 , G01N30/7233
摘要： The present invention relates to a droplet receiver, comprising a receptacle for receiving a droplet, a fluid conduit connected at a first end thereof to the droplet receptacle thereby providing a course within which the droplet received in the droplet receptacle moves, the conduit at its distal end in communication with a reservoir,and a fluid layer wetting the internal walls of the receptacle and conduit in such a way as permit reception of the droplet without loss of the received droplet due to wetting of the internal receptacle and conduit walls.
摘要翻译：本发明涉及一种液滴接收器，包括用于接收液滴的容器，在其第一端处连接到液滴容器的流体导管，从而提供容纳在液滴容器中的液滴移动的过程，其远端处的导管与储存器连通，并且液体层以允许接收液滴而不会由于内部容器和导管壁的润湿而损失所接收的液滴的方式润湿容器和导管的内壁。

5. 发明申请

WO2012120101A4 APPARATUS FOR AND METHODS OF PROCESSING LIQUIDS OR LIQUID-BASED SUBSTANCES 审中-公开
公开(公告)号：WO2012120101A4
公开(公告)日：2012-09-13
申请号：PCT/EP2012/054053
申请日：2012-03-08
申请人： UNIVERSITEIT LEIDEN , VULTO, Paul , TRIETSCH, Sebastiaan Johannes , VAN DER LINDEN, Heiko Jan , HANKEMEIER, Thomas
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , VAN DER LINDEN, Heiko Jan , HANKEMEIER, Thomas
IPC分类号： B01L3/00 , B01F13/00 , F16K99/00
摘要： Apparatus for processing liquids or liquid-based substances includes a plurality of volumes at least two of which are defined at least in part by one or more phaseguides inside the volume and/or in a conduit connected thereto for controlling aliquoting of one or more liquids or liquid-based substances inside the volume. Each volume has an upstream and downstream side with respect to meniscus advancement direction via which it may be filled with or emptied of one or more liquids or liquid-based substances. The apparatus also includes at least one common upstream-side conduit connected to supply a liquid or liquid-based substance via a plurality of the inlet or extraction conduits, a plurality of the phaseguides exhibiting a predetermined level of stability and one or more of the phaseguides exhibiting a predetermined different stability compared with the stability of at least one of the other phaseguides whereby to control the preference order in which the volumes fill and/or empty. The stability is determined by the value and radius of an acute angle along a said phaseguide at the downstream side of the phaseguide.

6. 发明申请

WO2014092566A1 PROCESS AND DEVICE FOR MINIMALLY INVASIVE DEEP TISSUE PROBING 审中-公开
标题翻译：最小入侵深度组织探测的方法和装置
公开(公告)号：WO2014092566A1
公开(公告)日：2014-06-19
申请号：PCT/NL2013/050883
申请日：2013-12-10
申请人： UNIVERSITEIT LEIDEN
发明人： VAN DER MAADEN, Koen , TRIETSCH, Sebastiaan Johannes , VAN DER LINDEN, Heiko Jan , BOUWSTRA, Johanna Aaltje , HANKEMEIER, Thomas
IPC分类号： A61B5/042 , A61B17/34 , A61B17/20
CPC分类号： A61B17/205 , A61B17/3421 , A61B2017/00526 , A61M2025/0042
摘要： The present invention relates to an ultra- high aspect ratio needle cannula with pointed, tissue penetrating distal end for deep tissue probing, having an inner diameter in the range of from 5 to 50 pm, an outer diameter in the range of from 50 to 2500 pm, and an aspect ratio of the width 1/1/ measured at the tip of the pointed distal end to the length L measured from the tip to the beginning of a continuous contraction of the outer diameter of the cannula, in the range of from 1 : 100 to 1 : 1x10 10
摘要翻译：本发明涉及一种具有尖锐组织穿透性远端用于深部组织探测的超高纵横比针套管，其内径在5-50μm范围内，外径范围为50-2500 pm，并且在尖端远端的尖端处测量的宽度1/1 /从套管的外径的连续收缩的尖端到开始测量的长度L的宽高比在从 1：100至1：1×10 10

7. 发明申请

WO2013137726A2 METHOD AND DEVICE FOR SOLVENT EVAPORATION FROM A LIQUID FEED 审中-公开
标题翻译：用于从液体进料的溶剂蒸发的方法和装置
公开(公告)号：WO2013137726A2
公开(公告)日：2013-09-19
申请号：PCT/NL2013/050163
申请日：2013-03-12
申请人： UNIVERSITEIT LEIDEN
发明人： HANKEMEIER, Thomas , SCHOONEN, Jan-Willem , VAN DER LINDEN, Heiko Jan , VULTO, Paul
IPC分类号： G01N1/40
CPC分类号： G01N1/4022 , B01D1/0082 , G01N2001/4027
摘要： The present invention relates to a device and an arrangement for selective solvent evaporation from a liquid feed, the feed comprising one or more components diluted in at least a first solvent or a solvent blend, comprising: a) a first tubular vessel having a distal end or a channel suitable for the formation of a droplet of a first volume, at an inflow rate n, at the tip or in the lumen of the tubular vessel, and b) means for subjecting the droplet to a solvent removal step at an evaporation rate r 2 to evaporate at least part of the first solvent or solvent blend, to accumulate the components in the feed in the droplet during the evaporation process at an accumulation rate r 3 , to obtain a concentrated feed volume in a concentrated droplet, wherein the evaporation and/or inflow rates are continuously adjusted to achieve a desired accumulation rate. The invention further relates to a method for selective solvent removal from an analyte mixture obtained in a chromatographic separation process.
摘要翻译：本发明涉及一种用于从液体进料选择性溶剂蒸发的装置和装置，所述进料包含在至少第一溶剂或溶剂共混物中稀释的一种或多种组分，所述组分包括：a）第一管状容器，其具有远端或适于在管状容器的尖端或内腔中以流入速率n形成第一体积的液滴的通道，以及b）使液滴以蒸发速率进行溶剂去除步骤的装置 r2蒸发至少部分第一溶剂或溶剂共混物，以在堆积速率r3的蒸发过程中将液体中的组分积聚在液滴中，以获得浓缩液滴中的浓缩进料体积，其中蒸发和/ 或流入速率连续调整以达到所需的累积率。本发明还涉及从色谱分离过程中获得的分析物混合物中选择性溶剂去除的方法。

8. 发明申请

WO2012120102A1 APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES 审中-公开
标题翻译：装置和处理细胞的方法及相关结构
公开(公告)号：WO2012120102A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/054056
申请日：2012-03-08
申请人： UNIVERSITEIT LEIDEN , KOPLA B.V. , VULTO, Paul , TRIETSCH, Sebastiaan Johannes , VAN DER LINDEN, Heiko Jan , JOORE, Adrianus Theodorus , HANKEMEIER, Thomas
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , VAN DER LINDEN, Heiko Jan , JOORE, Adrianus Theodorus , HANKEMEIER, Thomas
IPC分类号： C12M3/00
CPC分类号： C12M27/18 , B01F13/0083 , B01L3/502746 , B01L3/56 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0816 , B01L2300/0851 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , C12M23/16 , C12M23/34 , C12M29/10 , C12M35/08 , Y10T137/0318
摘要： Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume (10) that (a) is internally divided into at least first (14), second (16) and third (17) sub-volumes by at least two phaseguides (12, 13) formed inside the volume and (b) includes parts that are relatively upstream and relatively downstream when judged with reference to the movement of a meniscus or a bulk liquid in the volume (10). The apparatus includes at least first, second and third fluid conduits (19, 21, 22) connected to permit fluid communication between the upstream exterior of the volume (10) and a respective said sub-volume (14, 16, 17); and at least one further conduit (24) connected to permit fluid communication between the downstream exterior of the volume (10) and a said sub-volume. The first sub-volume (14) contains one or more life-based particles supported in or by a gel or gel-like substance; and the second sub-volume (16) communicates with the first sub-volume so as to permit transport of substances between the first and second sub-volumes (14, 16) and contains at least one gel or gel-like substance.
摘要翻译：用于处理基于生命的有机颗粒的装置，包括选自包括细胞，细胞球体，组织，真核生物，微生物，器官或胚胎的颗粒的颗粒，包括中空体积（10），其中（a）至少内部分为第一（14），第二（16）和第三（17）子体积，形成在容积内形成的至少两个相位导体（12,13），（b）包括相对上游和相对下游的部分，弯液面或大量液体在体积（10）中的移动。该装置包括至少第一，第二和第三流体导管（19,21,22），其被连接以允许容积（10）的上游外部与相应的所述子体积（14,16,17）之间的流体连通。以及至少一个另外的导管（24），其连接以允许容积（10）的下游外部与所述子体积之间的流体连通。第一子体积（14）包含一种或多种在凝胶或凝胶状物质中或由凝胶或类似物质负载的基于生命的颗粒; 并且所述第二子体积（16）与所述第一子体积连通以允许物质在所述第一和第二子体积（14,16）之间运输并且包含至少一种凝胶或凝胶状物质。

9. 发明申请

WO2011102728A1 RAMAN SPECTROMETER, SENSOR ELEMENT FOR A RAMAN SPECTROMETER AND A METHOD FOR OBTAINING A RAMAN SPECTRUM USING THE SENSOR ELEMENT 审中-公开
标题翻译：拉曼光谱仪，拉曼光谱仪的传感器元件和使用传感器元件获得拉曼光谱的方法
公开(公告)号：WO2011102728A1
公开(公告)日：2011-08-25
申请号：PCT/NL2011/050124
申请日：2011-02-22
申请人： Universiteit Leiden , JANSSEN, Kjeld Gertrudus Hendrikus , HANKEMEIER, Thomas
发明人： JANSSEN, Kjeld Gertrudus Hendrikus , HANKEMEIER, Thomas
IPC分类号： G01N21/64 , G01N21/65 , G01N21/77
CPC分类号： G01N21/658 , G01N21/648 , G01N21/7703 , G01N2021/6484 , G01N2021/772
摘要： The invention relates to a Raman spectrometer, comprising a light source (12), sensor element (14 ) and a detector (10), wherein the sensor element (14) comprises an active surface (24), which active surface (24) is coated with a layer (26) of inert material to be placed in contact with the sample (4). The invention also relates to a sensor element (14), comprising an active surface (24) which is coated with a layer (26) of inert material, and a method for obtaining a Raman spectrum using such a sensor element (14), comprising the following steps: a) providing a sensor element (14), comprising an active surface (24) which is coated with a layer (26) of inert material and placing the layer (26) of inert material in contact with a sample to be analysed; b) illuminating the sensor element (14) with monochromatic light; c) detecting surface enhanced Raman scattering by the sensor element (14).
摘要翻译：本发明涉及一种拉曼光谱仪，其包括光源（12），传感器元件（14）和检测器（10），其中所述传感器元件（14）包括有源表面（24），所述有源表面（24）涂覆有待与样品（4）接触的惰性材料层（26）。本发明还涉及一种传感器元件（14），其包括涂覆有惰性材料层（26）的活性表面（24），以及使用这种传感器元件（14）获得拉曼光谱的方法，包括以下步骤：a）提供传感器元件（14），其包括被涂覆有惰性材料层（26）的活性表面（24），并将惰性材料层（26）放置在与样品接触的位置分析; b）用单色光照射传感器元件（14）; c）通过传感器元件（14）检测表面增强的拉曼散射。

10. 发明申请

WO2021239871A2 FLUIDIC ASSEMBLIES AND METHODS 审中-公开
公开(公告)号：WO2021239871A2
公开(公告)日：2021-12-02
申请号：PCT/EP2021/064200
申请日：2021-05-27
申请人： UNIVERSITEIT LEIDEN
发明人： HANKEMEIER, Thomas , MIGGIELS, Anthonius Lambertus Wilhelmus , WOUTERS, Bert
IPC分类号： B01L3/00 , G01R33/30 , G01N35/10 , B01L2200/027 , B01L2200/0673 , B01L2300/0838 , B01L2300/165 , B01L3/502707 , B01L3/502784 , G01N35/1095 , G01R33/307 , G01R33/46
摘要： A fluidic assembly comprising a fluid analysis apparatus (30), the fluid analysis apparatus (30) comprising: a fluid measurement device (34); a fluidic device including a flow cell (36) arranged in a measurement region of the fluid measurement device (34), the flow cell (36) constructed of at least one first fluoropolymer material, the flow cell (36) including a channel, the channel containing a sample segment (52) that is carried in a fluorinated fluid carrier (54), wherein the sample segment (52) and fluorinated fluid carrier (54) are immiscible.

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