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    • 3. 发明申请
    • COMPOUNDS FOR REDUCING CELLULAR MELANIN CONTENT
    • 降低细胞色素黑素含量的化合物
    • WO2018046243A1
    • 2018-03-15
    • PCT/EP2017/070550
    • 2017-08-14
    • UNILEVER N.V.UNILEVER PLCCONOPCO, INC., D/B/A UNILEVER
    • STOTT, Ian, PeterCHANDRAMOWLI, GaneshTHIMMAIAH, Sreenivasa
    • A61K8/49A61Q19/02
    • The present invention relates to molecules capable of reducing cellular melanin content; in particular to reducing melanin content for applications in fields such as skin lightening. There is a continuing need for new cosmetic skin lightening agents, with improved overall effectiveness. It is therefore an object of the present invention to provide a compound that acts as a melanin content reducer. It is found that specific indolyl compounds can reduce the melanin content in the melanocytes. Disclosed is use of a compound of formula (I) or a salt thereof, for reducing cellular melanin content of human skin, where, (i) R is: (a) - (CH 2 ) n - A, where n = 1 to 6 and A is -OH or -NH2; or b) - O-(CH 2 ) n - X, where n = 1 to 5 and X is a halogen; (ii) R 2 is -H, alkyl, n-hexyl, aryl, alkoxy or aryloxy group; and, (iii) R 3 is -H, alkyl, aryl, alkoxy or aryloxy group.
    • 本发明涉及能够降低细胞黑色素含量的分子; 特别是减少黑色素含量,适用于皮肤增白等领域。 持续需要新的化妆品亮肤剂,其整体有效性得到改善。 因此,本发明的目的是提供充当黑色素含量降低剂的化合物。 发现特定的吲哚基化合物可以降低黑素细胞中的黑色素含量。 公开了式(I)化合物或其盐用于减少人皮肤的细胞黑色素含量的用途,其中,(i)R为:(a) - (CH 2) > n-A,其中n = 1至6并且A是-OH或-NH 2; 或b)-O-(CH 2)n -X,其中n = 1至5且X是卤素; (ii)R 2是-H,烷基,正己基,芳基,烷氧基或芳氧基; 和(iii)R 3是-H,烷基,芳基,烷氧基或芳氧基。